Oncogenic signaling by tyrosine kinases of the SRC family in advanced colorectal cancer.

No abstract is available for this paper.

• Publication year

  2012

• Venue

  American Journal of Cancer Research

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine

• Identifiers
  PMID 22860228PMCID PMC3410585
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Targeting MET in cancer: rationale and progress

  2012influential reference
• Inhibition of Collagen Receptor Discoidin Domain Receptor-1 (DDR1) Reduces Cell Survival, Homing, and Colonization in Lung Cancer Bone Metastasis

  2012cited by this paper
• Targeting MET in cancer: rationale and progress

  2012cited by this paper
• The 'ins' and 'outs' of podosomes and invadopodia: characteristics, formation and function

  2011cited by this paper
• Breast cancer cells produce tenascin C as a metastatic niche component to colonize the lungs

  2011cited by this paper
• Direct reprogramming of stem cell properties in colon cancer cells by CD44

  2011cited by this paper
• Oncogenic Ras/Src cooperativity in pancreatic neoplasia

  2011cited by this paper
• Twist1-induced invadopodia formation promotes tumor metastasis.

  2011cited by this paper
• Interactions between cancer stem cells and their niche govern metastatic colonization

  2011influential reference
• Quantitative phosphoproteomics revealed interplay between Syk and Lyn in the resistance to nilotinib in chronic myeloid leukemia cells.

  2011cited by this paper
• Down-regulation of the Tumor Suppressor C-terminal Src Kinase (Csk)-binding Protein (Cbp)/PAG1 Is Mediated by Epigenetic Histone Modifications via the Mitogen-activated Protein Kinase (MAPK)/Phosphatidylinositol 3-Kinase (PI3K) Pathway*

  2011cited by this paper
• Specific Oncogenic Activity of the Src-Family Tyrosine Kinase c-Yes in Colon Carcinoma Cells

  2011cited by this paper
• Nuclear PKM2 regulates β-catenin transactivation upon EGFR activation

  2011cited by this paper
• Receptor tyrosine kinases exert dominant control over PI3K signaling in human KRAS mutant colorectal cancers.

  2011influential reference
• Activation of Src and transformation by an RPTPα splice mutant found in human tumours

  2011cited by this paper
• Curcumin enhances dasatinib‐induced inhibition of growth and transformation of colon cancer cells

  2011cited by this paper
• The role of the epidermal growth factor receptor in the mechanism and treatment of colorectal cancer.

  2011influential reference
• MicroRNA-145 Targets YES and STAT1 in Colon Cancer Cells

  2010cited by this paper
• Src family tyrosine kinases-driven colon cancer cell invasion is induced by Csk membrane delocalization

  2010cited by this paper
• c-Src differentially regulates the functions of microtentacles and invadopodia

  2010cited by this paper
• Actin, microtubules, and vimentin intermediate filaments cooperate for elongation of invadopodia

  2010cited by this paper
• The long road to colorectal cancer therapy: searching for the right signals.

  2010influential reference
• Dasatinib sensitizes KRAS mutant colorectal tumors to cetuximab

  2010cited by this paper
• Metastatic growth from dormant cells induced by a col-I-enriched fibrotic environment.

  2010cited by this paper
• Gene Array and Fluorescence In situ Hybridization Biomarkers of Activity of Saracatinib (AZD0530), a Src Inhibitor, in a Preclinical Model of Colorectal Cancer

  2010influential reference
• Pseudopodium-enriched atypical kinase 1 regulates the cytoskeleton and cancer progression

  2010influential reference
• STAT3 activation of miR-21 and miR-181b-1 via PTEN and CYLD are part of the epigenetic switch linking inflammation to cancer.

  2010cited by this paper
• Latent bone metastasis in breast cancer tied to Src-dependent survival signals.

  2009cited by this paper
• Src kinases as therapeutic targets for cancer

  2009cited by this paper
• Reversion-induced LIM interaction with Src reveals a novel Src inactivation cycle

  2009cited by this paper
• FAK alters invadopodia and focal adhesion composition and dynamics to regulate breast cancer invasion

  2009cited by this paper
• SRC-induced disassembly of adherens junctions requires localized phosphorylation and degradation of the rac activator tiam1.

  2009cited by this paper
• Synergistic activity of the SRC family kinase inhibitor dasatinib and oxaliplatin in colon carcinoma cells is mediated by oxidative stress.

  2009influential reference
• Epithelial-mesenchymal transitions in development and disease.

  2009influential reference
• Transforming Potential of Src Family Kinases Is Limited by the Cholesterol-Enriched Membrane Microdomain

  2009cited by this paper
• Quantitative phosphoproteomics reveals a cluster of tyrosine kinases that mediates SRC invasive activity in advanced colon carcinoma cells.

  2009cited by this paper
• The Tensin-3 protein, including its SH2 domain, is phosphorylated by Src and contributes to tumorigenesis and metastasis.

  2009cited by this paper
• The role of Eph receptors and ephrin ligands in colorectal cancer

  2009influential reference
• TWIST1 Overexpression is Associated with Nodal Invasion and Male Sex in Primary Colorectal Cancer

  2008cited by this paper
• Gab2 and Src co-operate in human mammary epithelial cells to promote growth factor independence and disruption of acinar morphogenesis

  2008cited by this paper
• The Csk-binding protein PAG regulates PDGF-induced Src mitogenic signaling via GM1

  2008cited by this paper
• Cell growth, global phosphotyrosine elevation, and c-Met phosphorylation through Src family kinases in colorectal cancer cells

  2008cited by this paper
• Focal adhesion kinase is not required for Src-induced formation of invadopodia in KM12C colon cancer cells and can interfere with their assembly.

  2008cited by this paper
• Oncogenic association of the Cbp/PAG adaptor protein with the Lyn tyrosine kinase in human B-NHL rafts.

  2008cited by this paper
• Proteomic identification of ZO-1/2 as a novel scaffold for Src/Csk regulatory circuit.

  2008influential reference
• Evidence that resistance to nilotinib may be due to BCR-ABL, Pgp, or Src kinase overexpression.

  2008cited by this paper
• Regulation of FynT Function by Dual Domain Docking on PAG/Cbp*

  2008cited by this paper
• Apoptosis of estrogen‐receptor negative breast cancer and colon cancer cell lines by PTPα and src RNAi

  2008cited by this paper
• The lipid raft-anchored adaptor protein Cbp controls the oncogenic potential of c-Src.

  2008influential reference
• Roles of plasma membrane-associated sialidase NEU3 in human cancers.

  2008cited by this paper
• WNT signaling in the normal intestine and colorectal cancer.

  2007cited by this paper
• Genetic alterations in the tyrosine kinase transcriptome of human cancer cell lines.

  2007cited by this paper
• Patterns of somatic mutation in human cancer genomes

  2007cited by this paper
• MicroRNA-143 and -145 in Colon Cancer

  2007cited by this paper
• PTP1B contributes to the oncogenic properties of colon cancer cells through Src activation.

  2007cited by this paper
• The Tom1L1-Clathrin Heavy Chain Complex Regulates Membrane Partitioning of the Tyrosine Kinase Src Required for Mitogenic and Transforming Activities

  2007cited by this paper
• In vivo observation of pulmonary micrometastasis of colon cancer in normal rats.

  2007cited by this paper
• A novel negative regulatory function of the phosphoprotein associated with glycosphingolipid-enriched microdomains: blocking Ras activation.

  2007cited by this paper
• Src Continues Aging: Current and Future Clinical Directions

  2007cited by this paper
• P68 RNA helicase mediates PDGF-induced epithelial mesenchymal transition by displacing Axin from beta-catenin.

  2006cited by this paper
• Deficient E-cadherin adhesion in C57BL/6J-Min/+ mice is associated with increased tyrosine kinase activity and RhoA-dependent actomyosin contractility.

  2006cited by this paper
• Src kinase phosphorylates Caspase‐8 on Tyr380: a novel mechanism of apoptosis suppression

  2006cited by this paper
• Identification of potential biomarkers for measuring inhibition of Src kinase activity in colon cancer cells following treatment with dasatinib

  2006cited by this paper
• Two distinct pools of Src family tyrosine kinases regulate PDGF-induced DNA synthesis and actin dorsal ruffles

  2006cited by this paper
• Csk-binding Protein Mediates Sequential Enzymatic Down-regulation and Degradation of Lyn in Erythropoietin-stimulated Cells*

  2006cited by this paper
• Dok-1 Independently Attenuates Ras/Mitogen-Activated Protein Kinase and Src/c-Myc Pathways To Inhibit Platelet-Derived Growth Factor-Induced Mitogenesis

  2006cited by this paper
• Identification of Src-specific phosphorylation site on focal adhesion kinase: dissection of the role of Src SH2 and catalytic functions and their consequences for tumor cell behavior.

  2005cited by this paper
• Intracellular Reactive Oxygen Species Activate Src Tyrosine Kinase during Cell Adhesion and Anchorage-Dependent Cell Growth

  2005cited by this paper
• SKI-606, a Src/Abl inhibitor with in vivo activity in colon tumor xenograft models.

  2005cited by this paper
• Association of Csk to VE‐cadherin and inhibition of cell proliferation

  2005cited by this paper
• Newest findings on the oldest oncogene; how activated src does it

  2004influential reference
• Structure and regulation of Src family kinases

  2004cited by this paper
• Transmembrane adaptor proteins: organizers of immunoreceptor signalling

  2004influential reference
• The interplay between Src family kinases and receptor tyrosine kinases

  2004influential reference
• SRC gene expression in human cancer: the role of transcriptional activation.

  2004cited by this paper
• Combination of an Src Kinase Inhibitor with a Novel Pharmacological Antagonist of the Urokinase Receptor Diminishes in Vitro Colon Cancer Invasiveness

  2004cited by this paper
• Endothelial barrier disruption by VEGF-mediated Src activity potentiates tumor cell extravasation and metastasis

  2004cited by this paper
• Drosophila C-Terminal Src Kinase Negatively Regulates Organ Growth and Cell Proliferation through Inhibition of the Src, Jun N-Terminal Kinase, and STAT Pathways

  2004cited by this paper
• Shp2 regulates SRC family kinase activity and Ras/Erk activation by controlling Csk recruitment.

  2004influential reference
• A renaissance for SRC

  2004influential reference
• Periostin potently promotes metastatic growth of colon cancer by augmenting cell survival via the Akt/PKB pathway.

  2004cited by this paper
• Transmembrane adaptor proteins: organizers of immunoreceptor signalling

  2004cited by this paper
• Epidermal Growth Factor-induced DNA Synthesis

  2003cited by this paper
• Src family kinases in tumor progression and metastasis

  2003influential reference
• A genetic screen for modifiers of the lats tumor suppressor gene identifies C-terminal Src kinase as a regulator of cell proliferation in Drosophila

  2003cited by this paper
• Increased Src activity disrupts cadherin/catenin-mediated homotypic adhesion in human colon cancer and transformed rodent cells.

  2002cited by this paper
• EphrinB phosphorylation and reverse signaling: regulation by Src kinases and PTP-BL phosphatase.

  2002cited by this paper
• Activation of Src kinase in primary colorectal carcinoma

  2002cited by this paper
• Src family kinase inhibitor PP2 restores the E-cadherin/catenin cell adhesion system in human cancer cells and reduces cancer metastasis.

  2002influential reference
• Src activation regulates anoikis in human colon tumor cell lines

  2002cited by this paper
• Src-induced de-regulation of E-cadherin in colon cancer cells requires integrin signalling

  2002cited by this paper
• Reduced C‐terminal Src kinase activity is correlated inversely with pp60c‐src activity in colorectal carcinoma

  2001cited by this paper
• The COOH-terminal Src kinase Csk is a tumor antigen in human carcinoma.

  2001cited by this paper
• Stat3-mediated Myc expression is required for Src transformation and PDGF-induced mitogenesis

  2001cited by this paper
• SRC transcriptional activation in a subset of human colon cancer cell lines

  2001cited by this paper
• Selected glimpses into the activation and function of Src kinase

  2000cited by this paper
• Phosphoprotein Associated with Glycosphingolipid-Enriched Microdomains (Pag), a Novel Ubiquitously Expressed Transmembrane Adaptor Protein, Binds the Protein Tyrosine Kinase Csk and Is Involved in Regulation of T Cell Activation

  2000cited by this paper
• Constitutive and growth factor-regulated phosphorylation of caveolin-1 occurs at the same site (Tyr-14) in vivo: identification of a c-Src/Cav-1/Grb7 signaling cassette.

  2000cited by this paper
• Transmembrane phosphoprotein Cbp regulates the activities of Src-family tyrosine kinases

  2000influential reference
• Deregulation of the cytoplasmic tyrosine kinase cSrc in the absence of a truncating mutation at codon 531 in human bladder carcinoma.

  2000cited by this paper

• Multiomics-driven discovery of predictive biomarkers and strategies to overcome resistance to SFK-YAP inhibition in cholangiocarcinoma

  2026cites this paper
• Progastrin Promotes Colorectal Cancer Stem Cell‐Like Properties via the Receptor PZR

  2025cites this paper
• Identification of SRC, AKT1 and MAPK3 as Therapeutic Targets of Apigenin and Luteolin in Colorectal and Colon Carcinoma through Network Pharmacology

  2025cites this paper
• Abnormal phosphorylation of protein tyrosine in neurodegenerative diseases.

  2023cites this paper
• Setting sail: Maneuvering SHP2 activity and its effects in cancer.

  2023cites this paper
• Integrating network pharmacology approaches for the investigation of multi-target pharmacological mechanism of 6-shogaol against cervical cancer

  2023cites this paper
• Modulation of Functional Phosphorylation Sites by Basic Residues in the Unique Domain of c-Src

  2023cites this paper
• Proscillaridin A inhibits lung cancer cell growth and motility through downregulation of the EGFR-Src-associated pathway.

  2023cites this paper
• SH3-domain mutations selectively disrupt Csk homodimerization or PTPN22 binding

  2022cites this paper
• High-Throughput Profiling of Colorectal Cancer Liver Metastases Reveals Intra- and Inter-Patient Heterogeneity in the EGFR and WNT Pathways Associated with Clinical Outcome

  2022cites this paper
• Oncogenic Signalling of PEAK2 Pseudokinase in Colon Cancer

  2022cites this paper
• Signaling by the tyrosine kinase Yes promotes liver cancer development

  2022cites this paper
• Apoptosis regulation by the tyrosine-protein kinase CSK

  2022influential citation
• The Src-family kinase Lyn in immunoreceptor signaling.

  2021cites this paper
• CSK-homologous kinase (CHK/MATK) is a potential colorectal cancer tumour suppressor gene epigenetically silenced by promoter methylation

  2021cites this paper
• Regulation of Src tumor activity by its N-terminal intrinsically disordered region

  2021cites this paper
• Exploring the Mechanism of Scutellaria baicalensis Georgi Efficacy against Oral Squamous Cell Carcinoma Based on Network Pharmacology and Molecular Docking Analysis

  2021cites this paper
• Identification of Oncogenes in Breast Cancer Development

  2020cites this paper
• Peruvoside is a novel Src inhibitor that suppresses NSCLC cell growth and motility by downregulating multiple Src-EGFR-related pathways.

  2020cites this paper
• Depletion of Csk preferentially reduces the protein level of LynA in a Cbl-dependent manner in cancer cells

  2020cites this paper
• Src Family Tyrosine Kinases in Intestinal Homeostasis, Regeneration and Tumorigenesis

  2020influential citation
• Current and emerging therapeutic targets for Parkinson’s disease

  2020cites this paper
• Control of Tyrosine Kinase Signalling by Small Adaptors in Colorectal Cancer

  2019influential citation
• Microenvironmental Factors Drive Tenascin C and Src Cooperation to Promote Invadopodia Formation in Ewing Sarcoma

  2019cites this paper
• GPR35 promotes glycolysis, proliferation, and oncogenic signaling by engaging with the sodium potassium pump

  2019cites this paper
• A Myristoyl-Binding Site in the SH3 Domain Modulates c-Src Membrane Anchoring

  2019cites this paper
• SHEDding light on the role of Pragmin pseudo-kinases in cancer.

  2019cites this paper
• Roles of exosomes in metastatic colon cancer.

  2019cites this paper
• Inflammatory genes are novel prognostic biomarkers for colorectal cancer

  2018cites this paper
• Inhibition of DDR1‐BCR signalling by nilotinib as a new therapeutic strategy for metastatic colorectal cancer

  2018cites this paper
• The Unique Domain Forms a Fuzzy Intramolecular Complex in Src Family Kinases.

  2017cites this paper
• MicroRNA-146a promote cell migration and invasion in human colorectal cancer via carboxypeptidase M/src-FAK pathway

  2017cites this paper
• Dimerization of the Pragmin pseudo-kinase regulates protein tyrosine phosphorylation

  2017cites this paper
• Syntenin mediates SRC function in exosomal cell-to-cell communication

  2017cites this paper
• The role of small adaptor proteins in the control of oncogenic signaling driven by tyrosine kinases in human cancer

  2016cites this paper
• Protein Kinases and Parkinson’s Disease

  2016cites this paper
• Tyrosine Kinase Inhibitors and Neurodegenerative Disorders

  2016cites this paper
• UNC119 mediates gambogic acid-induced cell-cycle dysregulation through the Gsk3&bgr;/&bgr;-catenin pathway in hepatocellular carcinoma cells

  2016cites this paper
• Csk-homologous kinase (Chk/Matk): a molecular policeman suppressing cancer formation and progression

  2015cites this paper
• Src family kinases and their role in hematological malignancies

  2015cites this paper
• Hematopoietic cell kinase (HCK) as a therapeutic target in immune and cancer cells

  2015cites this paper
• The importance of Src signaling in sarcoma.

  2015cites this paper
• The SH3 Domain Acts as a Scaffold for the N-Terminal Intrinsically Disordered Regions of c-Src.

  2015cites this paper
• Contribution of phosphoproteomics in understanding SRC signaling in normal and tumor cells

  2015cites this paper
• YES oncogenic activity is specified by its SH4 domain and regulates RAS/MAPK signaling in colon carcinoma cells.

  2015cites this paper
• Membrane Androgen Receptor Down-Regulates c-Src-Activity and Beta-Catenin Transcription and Triggers GSK-3beta-Phosphorylation in Colon Tumor Cells

  2014cites this paper
• c-Abl phosphorylates α-synuclein and regulates its degradation: implication for α-synuclein clearance and contribution to the pathogenesis of Parkinson's disease.

  2014cites this paper
• Genetic unraveling of colorectal cancer

  2014cites this paper
• Role of PTPRT in obesity and its substrate paxillin tyrosine-88 in colorectal cancer

  2014cites this paper
• SLAP displays tumour suppressor functions in colorectal cancer via destabilization of the SRC substrate EPHA2

  2014cites this paper
• Regulation and Targeting of Fyn in Human Cutaneous Squamous Cell Carcinoma

  2014cites this paper
• Functional characterization of non-receptor tyrosine kinase dependent signal transduction in acute lymphoblastic leukemia of childhood

  2014cites this paper
• [Analysis of oncogenic signaling induced by tyrosine kinases in tumors by SILAC-based quantitative proteomic approach].

  2014cites this paper
• Epithelial regeneration and cancer: news from the Src front

  2014cites this paper
• The molecular rationale of Src inhibition in colorectal carcinomas

  2014cites this paper
• Bruton's Tyrosine Kinase: Structure and Functions, Expression and

  2013cites this paper
• CHARACTERIZATION OF A GP130 SIGNALING RECEPTOR POLYMORPHISM

  2013cites this paper
• Endogenous Factors Causative of Spontaneous DNA Damage that Leads to Random Integration in Human Cells

  2013cites this paper
• c-Src-dependent MAPKs/AP-1 activation is involved in TNF-α-induced matrix metalloproteinase-9 expression in rat heart-derived H9c2 cells.

  2013cites this paper
• Drugs for solid cancer: the productivity crisis prompts a rethink

  2013cites this paper
• Analysis of SRC Oncogenic Signaling in Colorectal Cancer by Stable Isotope Labeling with Heavy Amino Acids in Mouse Xenografts*

  2012influential citation