Targeted disruption of the α1,3-galactosyltransferase gene in cloned pigs

No abstract is available for this paper.

• Publication year

  2002

• Venue

  Nature Biotechnology

• Publication date

  2002-03-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/nbt0302-251
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• Production of α-1,3-Galactosyltransferase Knockout Pigs by Nuclear Transfer Cloning

  2002cited by this paper
• Deletion of the α(1,3)galactosyl transferase (GGTA1) gene and the prion protein (PrP) gene in sheep

  2001cited by this paper
• The α-Gal epitope (Galα1-3Galβ1-4GlcNAc-R) in xenotransplantation.

  2001influential reference
• Nuclear transfer in cattle with non‐transfected and transfected fetal or cloned transgenic fetal and postnatal fibroblasts

  2001cited by this paper
• Cloned pigs produced by nuclear transfer from adult somatic cells

  2000cited by this paper
• Production of gene-targeted sheep by nuclear transfer from cultured somatic cells

  2000cited by this paper
• Differential expression of alpha-GAL epitopes (Galalpha1-3Galbeta1-4GlcNAc-R) on pig and mouse organs.

  2000cited by this paper
• Xenotransplantation: the importance of the Galalpha1,3Gal epitope in hyperacute vascular rejection.

  1999cited by this paper
• Production of goats by somatic cell nuclear transfer

  1999cited by this paper
• Cloned transgenic calves produced from nonquiescent fetal fibroblasts.

  1998cited by this paper
• Viable offspring derived from fetal and adult mammalian cells

  1997cited by this paper
• The alpha-1,3-galactosyltransferase knockout mouse. Implications for xenotransplantation.

  1996cited by this paper
• Oocyte Galα1,3Gal Epitopes Implicated in Sperm Adhesion to the Zona Pellucida Glycoprotein ZP3 Are Not Required for Fertilization in the Mouse (*)

  1995cited by this paper
• Galα(1,3)Gal, the Major Xenoantigen(s) Recognised in Pigs by Human Natural Antibodies

  1994cited by this paper
• Problems encountered in detecting a targeted gene by the polymerase chain reaction.

  1991cited by this paper
• RNA template-specific PCR: an improved method that dramatically reduces false positives in RT-PCR.

  1991cited by this paper
• Structure and expression of the duck α-enolase/τ-crystallin-encoding gene

  1991cited by this paper
• The polymerase chain reaction.

  1989cited by this paper
• Man, apes, and Old World monkeys differ from other mammals in the expression of alpha-galactosyl epitopes on nucleated cells.

  1988cited by this paper
• Human natural anti-alpha-galactosyl IgG. II. The specific recognition of alpha (1----3)-linked galactose residues

  1985cited by this paper

• Overcoming xenotransplantation barriers through gene editing and immunomodulation

  2026cites this paper
• Global Research Trends and Current Status of Xenotransplantation: A Bibliometric Analysis.

  2026cites this paper
• Factors Influencing the Production Efficiency of Cloned Pigs: A Large-Scale Retrospective Analysis

  2026cites this paper
• Molecular breeding of pigs in the genome editing era

  2025cites this paper
• Liver Xenotransplantation: A Path to Clinical Reality

  2025cites this paper
• Pig Genome Editing for Agriculture: Achievements and Challenges

  2025cites this paper
• Current status and prospects of genetically modified porcine-to-human cardiac xenotransplantation

  2025cites this paper
• 2025: status of cardiac xenotransplantation including preclinical models

  2025cites this paper
• Gene-modified pig-to-human liver xenotransplantation

  2025cites this paper
• Xenotransplantation in China: Past, Present, and Future

  2025cites this paper
• Biocompatibility of Genetically‐Engineered Pig Cornea in Corneal Xenotransplantation: Preliminary In Vitro Study

  2025cites this paper
• Beyond rodents: The integral role of domestic animals in biomedical research.

  2025cites this paper
• Emerging Logistic Challenges, Health Disparities, and Bioethical Concerns in Kidney Xenotransplantation: A Literature Review

  2024cites this paper
• How should cardiac xenotransplantation be initiated in Japan?

  2024cites this paper
• Pretransplant Screening for Prevention of Hyperacute Graft Loss in Pig-to-primate Kidney Xenotransplantation

  2024cites this paper
• Porcine Kidney Organoids Derived from Naïve-like Embryonic Stem Cells

  2024cites this paper
• Human PD-L1 overexpression decreases xenogeneic human T-cell immune responses towards porcine kidneys

  2024cites this paper
• Animal Models for the Treatment of Human Diseases – A Review

  2024cites this paper
• Piperine improves the quality of porcine oocytes by reducing oxidative stress.

  2023cites this paper
• Perspectives in Genome-Editing Techniques for Livestock

  2023cites this paper
• Decellularized extracellular matrix materials for treatment of ischemic cardiomyopathy

  2023cites this paper
• Genetically engineered pigs for xenotransplantation: Hopes and challenges

  2023cites this paper
• Xenotransplantation – has its time finally arrived?

  2023cites this paper
• Heart transplantation: advances in expanding the donor pool and xenotransplantation

  2023cites this paper
• Immune rejection: current understanding and new solutions

  2023cites this paper
• Perioperative implications of patients with alpha gal allergies.

  2023cites this paper
• The history of cardiac xenotransplantation: early attempts, major advances, and current progress

  2023cites this paper
• Milestones on the path to clinical pig organ xenotransplantation.

  2023cites this paper
• Identification of the Porcine Vascular Endothelial Cell-Specific Promoter ESAM1.0 Using Transcriptome Analysis

  2023cites this paper
• Modificación genética en cerdos destinados a xenotrasplante

  2022cites this paper
• Progress in Xenotransplantation: Immunologic Barriers, Advances in Gene Editing, and Successful Tolerance Induction Strategies in Pig-To-Primate Transplantation

  2022cites this paper
• Multiple gene editing in porcine embryos using a combination of microinjection, electroporation, and transfection methods

  2022cites this paper
• Commentary on achievement of first life‐saving xenoheart transplant

  2022cites this paper
• CRISPR Modeling and Correction of Cardiovascular Disease.

  2022cites this paper
• Xenotransplantation becoming reality

  2022cites this paper
• Ontogeny of cellular organization and LGR5 expression in porcine cochlea revealed using tissue clearing and 3D imaging

  2022cites this paper
• Ethics and Theoretical Issues in Kidney Xenotransplantation.

  2022cites this paper
• Genome Engineering in Livestock: Recent Advances and Regulatory Framework

  2022cites this paper
• Progressive genetic modifications of porcine cardiac xenografts extend survival to 9 months

  2022cites this paper
• Effects of human TFPI and CD47 expression and selectin and integrin inhibition during GalTKO.hCD46 pig lung perfusion with human blood

  2022cites this paper
• Current Topics of Relevance to the Xenotransplantation of Free Pig Islets

  2022influential citation
• Improvements in pig agriculture through gene editing

  2022cites this paper
• Identification of the CKM Gene as a Potential Muscle-Specific Safe Harbor Locus in Pig Genome

  2022cites this paper
• Current and Future Strategies for the Diagnosis and Treatment of the Alpha-Gal Syndrome (AGS)

  2022cites this paper
• Repair of bone defects in rhesus monkeys with α1,3-galactosyltransferase-knockout pig cancellous bone

  2022influential citation
• Type 1 diabetes and engineering enhanced islet transplantation

  2022cites this paper
• A novel monoclonal IgG1 antibody specific for Galactose-alpha-1,3-galactose questions alpha-Gal epitope expression by bacteria

  2022cites this paper
• Triple gene editing in porcine embryos using electroporation alone or in combination with microinjection

  2022cites this paper
• Progress in islet xenotransplantation: Immunologic barriers, advances in gene editing, and tolerance induction strategies for xenogeneic islets in pig-to-primate transplantation

  2022cites this paper
• Donors for nerve transplantation in craniofacial soft tissue injuries

  2022cites this paper
• Xenotransplantation and interspecies organogenesis: current status and issues

  2022cites this paper
• Xenotransplantation: The Contribution of CRISPR/Cas9 Gene Editing Technology

  2022cites this paper
• Protection of transplants against antibody-mediated injuries: from xenotransplantation to allogeneic transplantation, mechanisms and therapeutic insights

  2022cites this paper
• Cardiac Xenotransplantation: Progress in Preclinical Models and Prospects for Clinical Translation

  2022cites this paper
• Xenotransplantation in transition.

  2022cites this paper
• Efficacy and Safety of Viable Selective Germline Genome Edited Pigs Skin Xenotransplants in Patients with Thermal Burns

  2022cites this paper
• Advance of genetically modified pigs in xeno-transplantation

  2022cites this paper
• CRISPR/Cas-edited pigs for personalized medicine: more than preclinical test-system

  2022cites this paper
• In vitro Electroporation in the Presence of CRISPR/Cas9 Reagents as a Safe and Effective Method for Producing Biallelic Knock-Out Porcine Embryos

  2021cites this paper
• Studies on genome editing techniques using CRISPR/Cas9 in porcine embryos

  2021cites this paper
• New Insights into Xenotransplantation for Cartilage Repair: Porcine Multi-Genetically Modified Chondrocytes as a Promising Cell Source

  2021cites this paper
• Long-term, multidomain analyses to identify the breed and allelic effects in MSTN-edited pigs to overcome lameness and sustainably improve nutritional meat production

  2021cites this paper
• Use of Genome Editing Techniques to Produce Transgenic Farm Animals.

  2021cites this paper
• Practical Approaches for Knock-Out Gene Editing in Pigs

  2021cites this paper
• Importance of the pig as a human biomedical model

  2021cites this paper
• Generation of VEGF knock-in Cashmere goat via the CRISPR/Cas9 system

  2021cites this paper
• RNAi for livestock improvement

  2021cites this paper
• Improvements in Gene Editing Technology Boost Its Applications in Livestock

  2021influential citation
• Extensively edited pigs

  2021cites this paper
• Porcine genome engineering for xenotransplantation.

  2020cites this paper
• Porcine Islet Cell Xenotransplantation

  2020cites this paper
• Regulatory changes in China on xenotransplantation and related products

  2020cites this paper
• Valproic acid enhances in vitro developmental competence of porcine handmade cloned embryos

  2020cites this paper
• Genetically encoded Ca2+‐sensor reveals details of porcine endothelial cell activation upon contact with human serum

  2020cites this paper
• Source and Follicular Fluid Treatment During the In Vitro Maturation of Recipient Oocytes Affects the Development of Cloned Pig Embryo

  2020cites this paper
• Genetic Engineering Application in Animal Breeding-Review

  2020cites this paper
• A New Humanized Mouse Model Mimics Humans in Lacking α-Gal Epitopes and Secreting Anti-Gal Antibodies

  2020cites this paper
• Bioengineering strategies for nephrologists: kidney was not built in a day

  2020cites this paper
• Current progress of genome editing in livestock.

  2020cites this paper
• Highly efficient multiplex genetic engineering of porcine primary fetal fibroblasts

  2020cites this paper
• Expression of human thrombomodulin on porcine endothelial cells can reduce platelet aggregation but did not reduce activation of complement or endothelium – an experimental study

  2020cites this paper
• Gene-edited Pigs for Xenotransplantation

  2020cites this paper
• Antibody reactivity with new antigens revealed in multi‐transgenic triple knockout pigs may cause early loss of pig kidneys in baboons

  2020cites this paper
• Genetically Engineered Pigs to Study Cancer

  2020cites this paper
• Xenotransplantation and Glycomedicine

  2020cites this paper
• Immune risk assessment of residual αGal in xenogeneic decellularized cornea using GTKO mice

  2020cites this paper
• Xenotransplantation: Current Status in Preclinical Research

  2020cites this paper
• Cytokine‐inducible promoters to drive dynamic transgene expression: The “Smart Graft” strategy

  2020cites this paper
• Recent Advance in Genome Editing-Based Gene Modification in Pigs

  2019cites this paper
• The role of industry in advancing xenotransplantation.

  2019cites this paper
• Circulating pig‐specific DNA as a novel biomarker for monitoring xenograft rejection

  2019cites this paper
• Genetically Engineered Nonhuman Animals: A Global Overview and Research Agenda

  2019cites this paper
• Disabling of nephrogenesis in porcine embryos via CRISPR/Cas9‐mediated SIX1 and SIX4 gene targeting

  2019cites this paper
• Identification of Glyceraldehyde-3-Phosphate Dehydrogenase Gene as an Alternative Safe Harbor Locus in Pig Genome

  2019cites this paper
• Generation of an MC3R knock-out pig by CRSPR/Cas9 combined with somatic cell nuclear transfer (SCNT) technology

  2019cites this paper
• Targeting αGal epitopes for multi-species embryo immunosurgery.

  2019cites this paper
• Application of genome-editing systems to enhance available pig resources for agriculture and biomedicine.

  2019cites this paper
• Genome editing in large animals: current status and future prospects

  2019cites this paper
• Establishment and characterization of immortalized porcine neonatal hepatocytes without the use of viral components

  2019cites this paper
• Advances on transgenic and gene-edited pigs

  2019cites this paper