Overview and introduction: The blood–brain barrier in health and disease

No abstract is available for this paper.

• Publication year

  2012

• Venue

  Epilepsia

• Publication date

  2012-11-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1111/j.1528-1167.2012.03696.xPMID 23134489PMCID PMC3625728
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The blood-brain barrier hypothesis in drug resistant epilepsy.

  2012cited by this paper
• Inflammatory events at blood–brain barrier in neuroinflammatory and neurodegenerative disorders: Implications for clinical disease

  2012cited by this paper
• Blood‐brain barrier dysfunction, TGFβ signaling, and astrocyte dysfunction in epilepsy

  2012influential reference
• Blood–brain barrier dysfunction–induced inflammatory signaling in brain pathology and epileptogenesis

  2012cited by this paper
• Blood–brain barrier dysfunction in brain diseases: Clinical experience

  2012cited by this paper
• Mechanisms underlying blood–brain barrier dysfunction in brain pathology and epileptogenesis: Role of astroglia

  2012cited by this paper
• Imaging blood–brain barrier dysfunction in animal disease models

  2012cited by this paper
• Acetylcholinesterase loosens the brain's cholinergic anti-inflammatory response and promotes epileptogenesis

  2012cited by this paper
• Cliniconeuropathologic correlations show astroglial albumin storage as a common factor in epileptogenic vascular lesions

  2012cited by this paper
• The Hedgehog Pathway Promotes Blood-Brain Barrier Integrity and CNS Immune Quiescence

  2011cited by this paper
• Mechanisms of leukocyte transendothelial migration.

  2011cited by this paper
• MicroRNA regulation in angiogenesis.

  2011cited by this paper
• Engaging neuroscience to advance translational research in brain barrier biology

  2011cited by this paper
• Interplay of drug metabolizing CYP450 enzymes and ABC transporters in the blood-brain barrier.

  2011cited by this paper
• Microglial cell origin and phenotypes in health and disease

  2011cited by this paper
• Review: Leucocyte–endothelial cell crosstalk at the blood–brain barrier: A prerequisite for successful immune cell entry to the brain

  2011cited by this paper
• Impact of seizure activity on free extracellular phenytoin concentrations in amygdala-kindled rats.

  2011cited by this paper
• ole of pro-inflammatory cytokines released from microglia in eurodegenerative diseases

  2011cited by this paper
• A differential proteomic approach identifies structural and functional components that contribute to the differentiation of brain capillary endothelial cells.

  2011cited by this paper
• Transcriptomic and quantitative proteomic analysis of transporters and drug metabolizing enzymes in freshly isolated human brain microvessels.

  2011cited by this paper
• Fluids and barriers of the CNS establish immune privilege by confining immune surveillance to a two-walled castle moat surrounding the CNS castle

  2011cited by this paper
• Getting to know the cast - cellular interactions and signaling at the neurovascular unit.

  2011cited by this paper
• Do ATP-binding cassette transporters cause pharmacoresistance in epilepsy? Problems and approaches in determining which antiepileptic drugs are affected.

  2011cited by this paper
• Blood–brain barrier dysfunction, status epilepticus, seizures, and epilepsy: A puzzle of a chicken and egg?

  2011cited by this paper
• The molecular basis of the blood brain barrier differentiation and maintenance. Is it still a mystery?

  2011cited by this paper
• Methods to study glycoproteins at the blood-brain barrier using mass spectrometry.

  2011cited by this paper
• Astrocyte-derived thrombospondin-2 is critical for the repair of the blood-brain barrier.

  2011cited by this paper
• Molecular biology of nucleoside transporters and their distributions and functions in the brain.

  2011cited by this paper
• MicroRNAs and vascular (dys)function.

  2011cited by this paper
• The role of free radical generation in increasing cerebrovascular permeability.

  2011cited by this paper
• Transporter hypothesis of drug-resistant epilepsy: challenges for pharmacogenetic approaches.

  2010cited by this paper
• Regulation of P-glycoprotein and other ABC drug transporters at the blood-brain barrier.

  2010influential reference
• Pericytes regulate the blood–brain barrier

  2010cited by this paper
• Blood–brain barrier breakdown as a therapeutic target in traumatic brain injury

  2010cited by this paper
• Structure and function of the blood-brain barrier.

  2010influential reference
• Pericytes are required for blood–brain barrier integrity during embryogenesis

  2010cited by this paper
• Blood–brain barrier breakdown and repair by Src after thrombin‐induced injury

  2010cited by this paper
• Kinetic Analysis of the Cooperation of P-Glycoprotein (P-gp/Abcb1) and Breast Cancer Resistance Protein (Bcrp/Abcg2) in Limiting the Brain and Testis Penetration of Erlotinib, Flavopiridol, and Mitoxantrone

  2010cited by this paper
• Wnt/β-catenin signaling is required for CNS, but not non-CNS, angiogenesis

  2009cited by this paper
• Reflex control of immunity

  2009cited by this paper
• Predicting Ligand Interactions with ABC Transporters in ADME

  2009cited by this paper
• Wnt/β-catenin signaling controls development of the blood–brain barrier

  2008cited by this paper
• P-glycoprotein senses its substrates and the lateral membrane packing density: consequences for the catalytic cycle.

  2008influential reference
• The tight junction protein complex undergoes rapid and continuous molecular remodeling at steady state

  2008cited by this paper
• All vertebrates started out with a glial blood‐brain barrier 4–500 million years ago

  2008cited by this paper
• Blood-brain barrier leakage may lead to progression of temporal lobe epilepsy.

  2007cited by this paper
• Glial regulation of the cerebral microvasculature

  2007cited by this paper
• The Role of Size and Charge for Blood–Brain Barrier Permeation of Drugs and Fatty Acids

  2007cited by this paper
• Astrocyte–endothelial interactions at the blood–brain barrier

  2006influential reference
• Chronic cholinergic imbalances promote brain diffusion and transport abnormalities

  2005cited by this paper
• Mini‐review: Transendothelial migration of leukocytes: through the front door or around the side of the house?

  2004cited by this paper
• Evidence for bulk flow of brain interstitial fluid: significance for physiology and pathology.

  2004cited by this paper
• FLUIDS AND BARRIERS OF THE CNS REVIEW Open Access

  year unknowncited by this paper
• Cellular and Molecular Life Sciences REVIEW Membrane vesicles, current state-of-the-art: emerging role of extracellular vesicles

  year unknowncited by this paper
• Fluids and Barriers of the CNS

  year unknowncited by this paper

• Chronic salicylate administration induces transcriptomic and metabolomic remodeling in the rat cochlear nucleus and hippocampus.

  2026cites this paper
• Quantitative ASL Perfusion and Vessel Wall MRI in Tuberculous Meningitis: A Pre- and Post-Treatment Study

  2026cites this paper
• Micro/nanoplastics and eye health: a review.

  2026cites this paper
• NIR‐II Fluorescent Protein Created by In Situ Albumin‐Tagging for Sensitive and Specific Imaging of Blood‐Brain Barrier Disruption

  2025cites this paper
• A Cost-Effective and Easy to Assemble 3D Human Microchannel Blood–Brain Barrier Model and Its Application in Tumor Cell Adhesion Under Flow

  2025cites this paper
• Impact of APOE on cerebrovascular lipid profile in Alzheimer’s disease

  2025cites this paper
• Vascular depression: A comprehensive exploration of the definition, mechanisms, and clinical challenges.

  2025cites this paper
• Endothelial tight junctions and cell-matrix adhesions reciprocally control blood-brain barrier integrity

  2025cites this paper
• Non-invasive neuromodulation assisted by exogenous stimuli-responsive nanoplatforms for Alzheimer’s disease and Parkinson's disease therapy

  2025cites this paper
• Brendo: an open resource for uniquely transcribed genes in brain endothelial cells

  2025cites this paper
• Glutamatergic argonaute2 promotes the formation of the neurovascular unit in mice.

  2025cites this paper
• Refinement of a Poroelastic Model for Zero Porosity: Finite Element Implementation and Investigation of Fluid Mechanics in the Perivascular Space

  2025cites this paper
• In vivo and In vitro assessment of the retinal toxicity of polystyrene nanoplastics.

  2025cites this paper
• Advances in understanding the role of inflammatory factors and immune cells in the pathology of epilepsy, mediated by neuroimmune interactions within the gut-brain axis

  2025cites this paper
• Biomarkers of neuroinflammation and microcirculatory dysfunction in Alzheimer's disease: a comprehensive assessment of the pathogenetic and diagnostic role

  2025cites this paper
• Material considerations for delivering therapeutics across the blood–brain barrier

  2025cites this paper
• Breaking boundaries: role of the brain barriers in metastatic process

  2025cites this paper
• Modular cone-and-plate device for mechanofluidic assays in Transwell inserts

  2025cites this paper
• Nanoparticle Interactions with the Blood Brain Barrier: Insights from Drosophila and Implications for Human Astrocyte Targeted Therapies

  2025cites this paper
• Blood–Brain and Blood–Gill Barrier Disruption in Coho Salmon Exposed to Roadway Runoff and 6PPD-Quinone

  2025cites this paper
• Endothelial mitochondria in the blood-brain barrier

  2025cites this paper
• Interactive effects of blood–brain barrier breakdown and Alzheimer's disease biomarker status on cognitive decline in older adults without dementia

  2025cites this paper
• Isolation of Capillaries from Small Amounts of Mouse Brain Tissue.

  2024cites this paper
• Cardiorenal Syndromes and Their Role in Water and Sodium Homeostasis.

  2024cites this paper
• Neurotoxicities induced by micro/nanoplastics: A review focusing on the risks of neurological diseases.

  2024cites this paper
• Blood‐brain barrier dysfunction and decreased transcription of tight junction proteins in epileptic dogs

  2024cites this paper
• Something to talk about; crosstalk disruption at the neurovascular unit during HIV infection of the CNS

  2024cites this paper
• Nanomedicine in Neuroprotection, Neuroregeneration, and Blood–Brain Barrier Modulation: A Narrative Review

  2024cites this paper
• Advances and Challenges of Bioassembly Strategies in Neurovascular In Vitro Modeling: An Overview of Current Technologies with a Focus on Three-Dimensional Bioprinting

  2024cites this paper
• Histopathological and Immunohistochemical study of ovine encephalitis

  2024cites this paper
• Regulation of the blood-brain barrier function by peripheral cues in health and disease

  2024cites this paper
• Exploring the Potential of Nasal Drug Delivery for Brain Targeted Therapy: A Detailed Analysis

  2024cites this paper
• The blood-brain barrier: a focus on neurovascular unit components

  2024cites this paper
• Zinc-modulated bidirectional copper transfer across the blood-brain barrier in a porcine brain capillary endothelial cell culture model system.

  2024cites this paper
• Targeted opening of the blood-brain barrier using VCAM-1 functionalised microbubbles and “whole brain” ultrasound

  2024cites this paper
• The Role of the Gut Microbiome in Bipolar Disorder and its Common Comorbidities.

  2023cites this paper
• Blood–Brain Barrier Dysfunction and Exposure to Head Impacts in University Football Players

  2023cites this paper
• Insights into Exosome Transport through the Blood–Brain Barrier and the Potential Therapeutical Applications in Brain Diseases

  2023cites this paper
• Transport of nanocarriers to brain for treatment of glioblastoma multiforme: Routes and challenges

  2023cites this paper
• Nanomaterials disrupting cell-cell junctions towards various diseases

  2023cites this paper
• Spectrum and Mimics of Brain Surface Enhancement on Postcontrast FLAIR Images

  2023cites this paper
• Non-Invasive Drug Delivery across the Blood–Brain Barrier: A Prospective Analysis

  2023cites this paper
• Extracellular vesicle-Serpine-1 affects neural progenitor cell mitochondrial functions and synaptic density: modulation by amyloid beta and HIV-1

  2023cites this paper
• Effects of bacterial and viral pathogen-associated molecular patterns (PAMPs) on multidrug resistance (MDR) transporters in brain endothelial cells of the developing human blood–brain barrier

  2023cites this paper
• Segmentation and Quantification of Venous Structures and Perivascular Spaces in the Thalamus in Epilepsy using 7 Tesla MRI

  2023cites this paper
• The Blood-Brain Barrier: Implications for Experimental Cancer Therapeutics

  2023cites this paper
• Loss of Blood-Brain Barrier Integrity in an In Vitro Model Subjected to Intermittent Hypoxia: Is Reversion Possible with a HIF-1α Pathway Inhibitor?

  2023cites this paper
• Extracellular Vesicle-Serpine-1 Affects Neural Progenitor Cell Mitochondrial Networks and Synaptic Density: Modulation by Amyloid Beta and HIV-1

  2023cites this paper
• Nose-to-brain drug delivery for the treatment of glioblastoma multiforme: nanotechnological interventions

  2023cites this paper
• Analysis of tigecycline in cerebrospinal fluid and serum of patients with multidrug-resistant acinetobacter baumannii central nervous system infection by HPLC-MS/MS

  2023cites this paper
• The Drosophila blood–brain barrier regulates sleep via Moody G protein-coupled receptor signaling

  2023cites this paper
• Quantitative analysis of magnetic resonance images for characterization of blood‐brain barrier dysfunction in dogs with brain tumors

  2023cites this paper
• Analysis of tigecycline in the cerebrospinal fluid and serum of patients with Acinetobacter baumannii central nervous system infection.

  2023cites this paper
• Ultrasound Triggered Bubble-Induced Blood-Brain Barrier Opening: A Monodisperse Microbubble and Organ-On-Chip Study

  2023cites this paper
• Polyphenols and Their Impact on the Prevention of Neurodegenerative Diseases and Development

  2023cites this paper
• Neuroinflammatory Dysfunction of the Blood–Brain Barrier and Basement Membrane Dysplasia Play a Role in the Development of Drug-Resistant Epilepsy

  2023cites this paper
• Damage mechanism and therapy progress of the blood-brain barrier after ischemic stroke

  2023cites this paper
• Research progress in role of exosomes exosomes in mental disorders.

  2023cites this paper
• Characterization of an iPSC-based barrier model for blood-brain barrier investigations using the SBAD0201 stem cell line

  2023cites this paper
• Czech Technical University in Prague Faculty of Electrical Engineering Department of Circuit Theory Image processing pipelines for analysis of clinical human MRI

  2022cites this paper
• Development of Microneedle Patch Loaded with Bacopa monnieri Solid Lipid Nanoparticles for the Effective Management of Parkinson's Disease

  2022cites this paper
• Melanoma Mediated Disruption of Brain Endothelial Barrier Integrity Is Not Prevented by the Inhibition of Matrix Metalloproteinases and Proteases

  2022cites this paper
• Effects of choline containing phospholipids on the neurovascular unit: A review

  2022cites this paper
• Functional Expression of Multidrug-Resistance (MDR) Transporters in Developing Human Fetal Brain Endothelial Cells

  2022cites this paper
• Rab27a‐dependent exosomes protect against cerebral ischemic injury by reducing endothelial oxidative stress and apoptosis

  2022cites this paper
• Inorganic Nanomaterials versus Polymer-Based Nanoparticles for Overcoming Neurodegeneration

  2022cites this paper
• Elevated Cerebrospinal Fluid Proteins and Albumin Determine a Poor Prognosis for Spinal Amyotrophic Lateral Sclerosis

  2022cites this paper
• In Vitro Reversal and Characterization of Multidrug Resistance in In Vitro Reversal and Characterization of Multidrug Resistance in Human Cancer Cells Human Cancer Cells

  2022cites this paper
• Time Course of Changes in the Neurovascular Unit after Hypoxic-Ischemic Injury in Neonatal Rats

  2022cites this paper
• Prediction Models for Brain Distribution of Drugs Based on Biomimetic Chromatographic Data

  2022cites this paper
• Overcoming Blood-Brain Barrier Resistance: Implications for Extracellular Vesicle-Mediated Drug Brain Delivery

  2022influential citation
• Lipocalin-2 and Cerebral Stroke

  2022cites this paper
• Neutrophil Recruitment and Leukocyte Response Following Focused Ultrasound and Microbubble Mediated Blood-Brain Barrier Treatments

  2022cites this paper
• Electroacupuncture of the trigeminal nerve causes N-methyl-D-aspartate receptors to mediate blood-brain barrier opening and induces neuronal excitatory changes

  2022cites this paper
• Telmisartan as an add-on treatment for dogs with refractory idiopathic epilepsy: a nonrandomized, uncontrolled, open-label clinical trial.

  2022cites this paper
• A neurovascular unit-on-a-chip: culture and differentiation of human neural stem cells in a three-dimensional microfluidic environment

  2022cites this paper
• Blood–brain barrier dysfunction in l-ornithine induced acute pancreatitis in rats and the direct effect of l-ornithine on cultured brain endothelial cells

  2022cites this paper
• Detection of blood‐brain barrier dysfunction using advanced imaging methods to predict seizures in dogs with meningoencephalitis of unknown origin

  2022cites this paper
• Membrane Transport

  2022cites this paper
• Linking analgesia, epidural oxycodone, pain, and laparoscopy

  2022cites this paper
• A Multimodal MR Imaging Study of the Effect of Hippocampal Damage on Affective and Cognitive Functions in a Rat Model of Chronic Exposure to a Plateau Environment

  2022cites this paper
• Hemorrhagic Cerebral Insults and Secondary Takotsubo Syndrome: Findings in a Novel In Vitro Model Using Human Blood Samples

  2022cites this paper
• In Vitro to In Vivo Extrapolation Linked to Physiologically Based Pharmacokinetic Models for Assessing the Brain Drug Disposition

  2022cites this paper
• Drug Nanocrystals: Focus on Brain Delivery from Therapeutic to Diagnostic Applications

  2022cites this paper
• Exosomes in Ageing and Motor Neurone Disease: Biogenesis, Uptake Mechanisms, Modifications in Disease and Uses in the Development of Biomarkers and Therapeutics

  2021cites this paper
• In silico investigation of Alliin as potential activator for AMPA receptor

  2021cites this paper
• Nature-inspired dynamic gene-loaded nanoassemblies for the treatment of brain diseases.

  2021cites this paper
• Differential Impact of Severity and Duration of Status Epilepticus, Medical Countermeasures, and a Disease-Modifier, Saracatinib, on Brain Regions in the Rat Diisopropylfluorophosphate Model

  2021cites this paper
• Losartan and Traumatic Brain Injury: Why Is a Retrospective Study Urgent?

  2021cites this paper
• The Potential Roles of Glial Cells in the Neuropathogenesis of Cerebral Malaria

  2021cites this paper
• The Blood–Brain Barrier: Much More Than a Selective Access to the Brain

  2021cites this paper
• Functional and structural alternations in the choroid plexus upon Methamphetamine exposure.

  2021cites this paper
• Liposomes loaded with polyphenol-rich grape pomace extracts protect from neurodegeneration in a rotenone-based in vitro model of Parkinson's disease.

  2021cites this paper
• Cell-to-Cell Interactions Mediating Functional Recovery after Stroke

  2021cites this paper
• SARS-CoV-2: is there neuroinvasion?

  2021cites this paper
• Electrolytes in the ICU

  2021cites this paper
• The Impacts of Surgery and Intracerebral Electrodes in C57BL/6J Mouse Kainate Model of Epileptogenesis: Seizure Threshold, Proteomics, and Cytokine Profiles

  2021cites this paper
• Acute and Chronic Hyponatremia

  2021cites this paper
• Assessment of Blood–Brain Barrier Integrity in Tuberculous Meningitis Using Dynamic Contrast-Enhanced MR Perfusion

  2021cites this paper
• Oxidative Stress and the Neurovascular Unit

  2021cites this paper