The gut microbiota engages different signaling pathways to induce Duox2 expression in the ileum and colon epithelium

No abstract is available for this paper.

• Publication year

  2014

• Venue

  Mucosal Immunology

• Publication date

  2014-08-27

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.1038/mi.2014.74PMID 25160818
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Altered Mucus Glycosylation in Core 1 O-Glycan-Deficient Mice Affects Microbiota Composition and Intestinal Architecture

  2014influential reference
• Activation of TLR4 Is Required for the Synergistic Induction of Dual Oxidase 2 and Dual Oxidase A2 by IFN-g and Lipopolysaccharide in Human Pancreatic Cancer Cell Lines

  2013cited by this paper
• Activation of TLR4 Is Required for the Synergistic Induction of Dual Oxidase 2 and Dual Oxidase A2 by IFN-γ and Lipopolysaccharide in Human Pancreatic Cancer Cell Lines

  2013cited by this paper
• Microbial modulation of energy availability in the colon regulates intestinal transit.

  2013cited by this paper
• Dual oxidases control release of hydrogen peroxide by the gastric epithelium to prevent Helicobacter felis infection and inflammation in mice.

  2013cited by this paper
• The gut microbiota — masters of host development and physiology

  2013cited by this paper
• Analysis of gut microbial regulation of host gene expression along the length of the gut and regulation of gut microbial ecology through MyD88

  2011cited by this paper
• Antimicrobial Actions of Reactive Oxygen Species

  2011cited by this paper
• Microenvironmental regulation of stem cells in intestinal homeostasis and cancer

  2011cited by this paper
• Activation of Dual Oxidases Duox1 and Duox2: differential regulation mediated by camp-dependent protein kinase and protein kinase C-dependent phosphorylation

  2010cited by this paper
• Homeostasis and inflammation in the intestine.

  2010cited by this paper
• Bacteria Penetrate the Inner Mucus Layer before Inflammation in the Dextran Sulfate Colitis Model

  2010cited by this paper
• Coordination of multiple dual oxidase–regulatory pathways in responses to commensal and infectious microbes in drosophila gut

  2009cited by this paper
• The Bacterial Fermentation Product Butyrate Influences Epithelial Signaling via Reactive Oxygen Species-Mediated Changes in Cullin-1 Neddylation1

  2009cited by this paper
• The bacterial fermentation product butyrate influences epithelial signaling via reactive oxygen species-mediated changes in cullin-1 neddylation

  2009cited by this paper
• Probiotic and gut lactobacilli and bifidobacteria: molecular approaches to study diversity and activity.

  2009cited by this paper
• Activation of Dual Oxidases Duox1 and Duox2

  2009cited by this paper
• DUOX2-derived reactive oxygen species are effectors of NOD2-mediated antibacterial responses

  2009cited by this paper
• Nox enzymes and oxidative stress in the immunopathology of the gastrointestinal tract

  2008cited by this paper
• Identification and characterization of VPO1, a new animal heme-containing peroxidase.

  2008cited by this paper
• TLR-4, IL-1R and TNF-R signaling to NF-κB: variations on a common theme

  2008cited by this paper
• Regulation of Nox and Duox enzymatic activity and expression.

  2007cited by this paper
• Toll-like receptor signaling in intestinal epithelial cells contributes to colonic homoeostasis

  2007cited by this paper
• Functional genomic delineation of TLR-induced transcriptional networks

  2007cited by this paper
• Expression of the genes dualoxidase2, lipocalin 2 and regenerating islet-derived 1 alpha in Crohn's disease

  2007cited by this paper
• Commensal bacteria modulate cullin‐dependent signaling via generation of reactive oxygen species

  2007cited by this paper
• Organizing cell renewal in the intestine: stem cells, signals and combinatorial control

  2006cited by this paper
• Dual oxidase2 is expressed all along the digestive tract.

  2005cited by this paper
• A Direct Role for Dual Oxidase in Drosophila Gut Immunity

  2005cited by this paper
• Expression of NOX1, a superoxide‐generating NADPH oxidase, in colon cancer and inflammatory bowel disease

  2005cited by this paper
• Structure and regulation of the neutrophil respiratory burst oxidase: comparison with nonphagocyte oxidases

  2004cited by this paper
• Tissue distribution and putative physiological function of NOX family NADPH oxidases.

  2004cited by this paper
• JASPAR: an open-access database for eukaryotic transcription factor binding profiles

  2004cited by this paper
• ConSite: web-based prediction of regulatory elements using cross-species comparison

  2004cited by this paper
• Role of Nicotinamide Adenine Dinucleotide Phosphate Oxidase 1 in Oxidative Burst Response to Toll-Like Receptor 5 Signaling in Large Intestinal Epithelial Cells 1

  2004cited by this paper
• NOX enzymes and the biology of reactive oxygen

  2004cited by this paper
• Cutting Edge: Direct Interaction of TLR4 with NAD(P)H Oxidase 4 Isozyme Is Essential for Lipopolysaccharide-Induced Production of Reactive Oxygen Species and Activation of NF-κB1

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  2004cited by this paper
• Involvement of reactive oxygen species in Toll-like receptor 4-dependent activation of NF-kappa B.

  2004cited by this paper
• NADPH oxidases: not just for leukocytes anymore!

  2003cited by this paper
• Laser capture microdissection of mouse intestine: characterizing mRNA and protein expression, and profiling intermediary metabolism in specified cell populations.

  2002cited by this paper
• Human Neutrophils Use the Myeloperoxidase-Hydrogen Peroxide-Chloride System to Chlorinate but Not Nitrate Bacterial Proteins during Phagocytosis*

  2002cited by this paper
• Variations on a Common Theme?

  2001cited by this paper
• Cutting Edge: Bacterial Flagellin Activates Basolaterally Expressed TLR5 to Induce Epithelial Proinflammatory Gene Expression1

  2001cited by this paper
• Oxidative stress in bacteria and protein damage by reactive oxygen species.

  2000cited by this paper
• Living with a Killer: The Effects of Hypochlorous Acid on Mammalian Cells

  2000cited by this paper
• Evidence of oxidant-induced injury to epithelial cells during inflammatory bowel disease.

  1996cited by this paper
• The respiratory burst oxidase.

  1995cited by this paper
• NADPH-dependent H2O2 generation catalyzed by thyroid plasma membranes. Studies with electron scavengers.

  1989cited by this paper
• The respiratory burst oxidase.

  1988cited by this paper
• Generation of H2O2 in isolated porcine thyroid follicles.

  1984cited by this paper
• Role of the superoxide anion in the myeloperoxidase-mediated antimicrobial system.

  1974cited by this paper

• Reactive oxygen species in the rhizosphere orchestrate the recruitment of beneficial bacteria

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  2025cites this paper
• NADPH Oxidases: Redox Regulation of Cell Homeostasis & Disease.

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• Dysregulated NOX1-NOS2 activity as hallmark of ileitis in mice.

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  2018cites this paper
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  2018cites this paper
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  2018cites this paper
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  2018cites this paper
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  2018cites this paper
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  2018cites this paper
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  2017influential citation
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  2017cites this paper
• Redox signaling in the gastrointestinal tract.

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  2017cites this paper
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  2017cites this paper
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  2016cites this paper
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