mPGES-1 knock-out mice are resistant to cancer-induced anorexia despite the absence of central mPGES-1 up-regulation in wild-type anorexic mice.

No abstract is available for this paper.

• Publication year

  2008

• Venue

  Journal of Neuroimmunology

• Publication date

  2008-08-13

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.jneuroim.2008.05.012PMID 18602702
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• IL-1beta and LPS induce anorexia by distinct mechanisms differentially dependent on microsomal prostaglandin E synthase-1.

  2007cited by this paper
• c-Fos immunoreactivity induced by intraperitoneal LPS administration is reduced in the brain of mice lacking the microsomal prostaglandin E synthase-1 (mPGES-1).

  2007cited by this paper
• Sequential induction of pro- and anti-inflammatory prostaglandins and peroxisome proliferators-activated receptor-gamma during normal wound healing: a time course study.

  2007cited by this paper
• Interleukin-6 is a candidate molecule that transmits inflammatory information to the CNS.

  2007cited by this paper
• Evidence that lipopolysaccharide-induced anorexia depends upon central, rather than peripheral, inflammatory signals.

  2007cited by this paper
• Membrane Prostaglandin E Synthase-1: A Novel Therapeutic Target

  2007cited by this paper
• IL-1beta treatment does not co-ordinately up-regulate mPGES-1 and COX-2 mRNA expression, but results in higher degree of cellular and intracellular co-localization of their immunoreactive proteins in human placenta trophoblast cells.

  2006cited by this paper
• Involvement of central microsomal prostaglandin E synthase-1 in IL-1beta-induced anorexia.

  2006cited by this paper
• Brainstem mechanisms integrating gut-derived satiety signals and descending forebrain information in the control of meal size.

  2006cited by this paper
• Expression of melanocortin-4 receptor by rat parabrachial neurons responsive to immune and aversive stimuli.

  2006cited by this paper
• Inhibitors of COX activity preserve muscle mass in mice bearing the Lewis lung carcinoma, but not the B16 melanoma.

  2006cited by this paper
• PROSTAGLANDINS AND CANCER

  2005cited by this paper
• Contrasting effects of peroxisome-proliferator-activated receptor (PPAR)γ agonists on membrane-associated prostaglandin E2 synthase-1 in IL-1β-stimulated rat chondrocytes: evidence for PPARγ-independent inhibition by 15-deoxy-Δ12,14prostaglandin J2

  2005cited by this paper
• Redirection of Eicosanoid Metabolism in mPGES-1-deficient Macrophages*

  2005cited by this paper
• The regulation of feeding and metabolic rate and the prevention of murine cancer cachexia with a small-molecule melanocortin-4 receptor antagonist.

  2005cited by this paper
• Inhibition of Cyclooxygenase-2 by Celecoxib Reverses Tumor-Induced Wasting

  2004cited by this paper
• Interleukin-1β system in anorectic catabolic tumor-bearing rats

  2004cited by this paper
• Up-regulation of microsomal prostaglandin E synthase 1 in osteoarthritic human cartilage: critical roles of the ERK-1/2 and p38 signaling pathways.

  2004cited by this paper
• Reversible inactivation of the dorsal vagal complex blocks lipopolysaccharide-induced social withdrawal and c-Fos expression in central autonomic nuclei.

  2004cited by this paper
• Evidence for a role of the 5-HT2C receptor in central lipopolysaccharide-, interleukin-1 beta-, and leptin-induced anorexia.

  2003cited by this paper
• Impaired inflammatory and pain responses in mice lacking an inducible prostaglandin E synthase

  2003cited by this paper
• Up-regulation of Prostaglandin E2 Synthesis by Interleukin-1β in Human Orbital Fibroblasts Involves Coordinate Induction of Prostaglandin-Endoperoxide H Synthase-2 and Glutathione-dependent Prostaglandin E2 Synthase Expression*

  2002cited by this paper
• Coexpression of microsomal prostaglandin E synthase with cyclooxygenase-2 in human rheumatoid synovial cells.

  2002cited by this paper
• Neural-immune gut-brain communication in the anorexia of disease.

  2002cited by this paper
• Eicosanoid-dependent cancer cachexia and wasting

  2002cited by this paper
• Prostaglandin E synthase.

  2002cited by this paper
• Role of the central melanocortin system in cachexia.

  2001cited by this paper
• Feeding-related immune responsive brain stem neurons: association with CGRP

  2001cited by this paper
• Cytokine and cyclooxygenase-2 protein in brain areas of tumor-bearing mice with prostanoid-related anorexia.

  2001cited by this paper
• Specific Inhibition of Cyclooxygenase 2 Restores Antitumor Reactivity by Altering the Balance of IL-10 and IL-12 Synthesis1

  2000cited by this paper
• Human Vascular Smooth Muscle Cells but Not Endothelial Cells Express Prostaglandin E Synthase

  2000cited by this paper
• Effects of Intra-VMN Mianserin and IL-1ra on Meal Number in Anorectic Tumor-Bearing Rats

  2000cited by this paper
• Experimental cancer cachexia: the role of host-derived cytokines interleukin (IL)-6, IL-12, interferon-gamma, and tumor necrosis factor alpha evaluated in gene knockout, tumor-bearing mice on C57 Bl background and eicosanoid-dependent cachexia.

  2000cited by this paper
• Effect of cyclooxygenase and nitric oxide synthase inhibitors on tumor growth in mouse tumor models with and without cancer cachexia related to prostanoids.

  2000cited by this paper
• Coordinate up- and down-regulation of glutathione-dependent prostaglandin E synthase and cyclooxygenase-2 in A549 cells. Inhibition by NS-398 and leukotriene C4.

  2000cited by this paper
• Functional coupling of cyclooxygenase 1 and 2 to discrete prostanoid synthases in liver macrophages.

  2000cited by this paper
• Central nervous system mechanisms contributing to the cachexia-anorexia syndrome.

  2000cited by this paper
• Anorexia of infection: current prospects.

  2000cited by this paper
• Hypothalamic dopamine and serotonin in the regulation of food intake.

  2000cited by this paper
• Central nervous system control of food intake

  2000cited by this paper
• Identification of human prostaglandin E synthase: a microsomal, glutathione-dependent, inducible enzyme, constituting a potential novel drug target.

  1999cited by this paper
• Cancer anorexia-cachexia syndrome: are neuropeptides the key?

  1999cited by this paper
• Protein turnover in skeletal muscle of tumour-bearing transgenic mice overexpressing the soluble TNF receptor-1.

  1998cited by this paper
• Brain cytokine mRNAs in anorectic rats bearing prostate adenocarcinoma tumor cells.

  1998cited by this paper
• Cytokines and cachexia.

  1997cited by this paper
• Anorexia during acute and chronic disease.

  1996cited by this paper
• Correlation between food intake and cerebrospinal fluid interleukin 1 alpha in anorectic tumor-bearing rats.

  1995cited by this paper
• Relationship between interleukin-1 and cancer anorexia.

  1995cited by this paper
• Anti-interferon-gamma antibody treatment, growth of Lewis lung tumours in mice and tumour-associated cachexia.

  1991cited by this paper
• Tumor necrosis factor-alpha and interleukin-1 alpha production in cachectic, tumor-bearing mice.

  1990cited by this paper
• Tumor necrosis factor‐α and interleukin‐1α production in cachectic, tumor‐bearing mice

  1990cited by this paper
• The effect of indomethacin on food and water intake, motor activity and survival in tumour-bearing rats.

  1990cited by this paper

• Inhibition of mPGES-1 as therapeutic strategy in inflammation and cancer

  2019cites this paper
• A review on mPGES-1 inhibitors: From preclinical studies to clinical applications.

  2019cites this paper
• Invalidation of Microsomal Prostaglandin E Synthase-1 (mPGES-1) Reduces Diet-Induced Low-Grade Inflammation and Adiposity

  2018cites this paper
• The involvement of prostaglandin E2 in interleukin-1β evoked anorexia is strain dependent.

  2017cites this paper
• Interleukin-1β signaling in fenestrated capillaries is sufficient to trigger sickness responses in mice

  2017cites this paper
• Mechanisms Behind Illness-Induced Anorexia

  2016cites this paper
• Kamikihito Ameliorates Lipopolysaccharide-Induced Sickness Behavior via Attenuating Neural Activation, but Not Inflammation, in the Hypothalamic Paraventricular Nucleus and Central Nucleus of the Amygdala in Mice.

  2016cites this paper
• The food born mycotoxin deoxynivalenol induces low-grade inflammation in mice in the absence of observed-adverse effects.

  2015cites this paper
• Nonmuscle Tissues Contribution to Cancer Cachexia

  2015cites this paper
• Modification of energy balance induced by the food contaminant T-2 toxin: a multimodal gut-to-brain connection.

  2014cites this paper
• Central CRTH2, a Second Prostaglandin D2 Receptor, Mediates Emotional Impairment in the Lipopolysaccharide and Tumor-Induced Sickness Behavior Model

  2014cites this paper
• PGE2 signaling and its biosynthesis-related enzymes in cholangiocarcinoma progression

  2014cites this paper
• Cancer-induced anorexia in tumor-bearing mice is dependent on cyclooxygenase-1.

  2013cites this paper
• Implication des neurones exprimant NUCB2/nesfatine-1 dans la régulation de l'homéostasie énergétique

  2013influential citation
• Regulation of human microsomal prostaglandin E synthase-1 by IL-1β requires a distal enhancer element with a unique role for C/EBPβ.

  2012cites this paper
• Molecular mechanisms of cachexia in chronic disease

  2012cites this paper
• ExpressionandSignificanceofMicrosomalProstaglandin Synthase-1(mPGES-1)andBeclin-1intheDevelopmentof ProstateCancer

  2012cites this paper
• Central Nervous System and Innate Immune Mechanisms for Inflammation- and Cancer-induced Anorexia

  2012cites this paper
• Expression and significance of microsomal prostaglandin synthase-1 (mPGES-1) and Beclin-1 in the development of prostate cancer.

  2012cites this paper
• Inflammatory regulation of hypothalamic neurons in sickness behavior

  2011cites this paper
• The Food-Contaminant Deoxynivalenol Modifies Eating by Targeting Anorexigenic Neurocircuitry

  2011cites this paper
• Central inflammation and sickness-like behavior induced by the food contaminant deoxynivalenol: a PGE2-independent mechanism.

  2011influential citation
• Stress responses: the contribution of prostaglandin E2 and its receptors

  2011cites this paper
• contaminant Deoxynivalenol : A PGE2-independent mechanism.

  2011cites this paper
• Prostaglandin E2 synthases in neurologic homeostasis and disease.

  2010cites this paper
• Hypothalamic mechanisms in cachexia.

  2010cites this paper
• Pathophysiology and treatment of inflammatory anorexia in chronic disease

  2010cites this paper
• Participación de la anandamida en la reabsorción embrionaria murina inducida por lipopolisacárido

  2010cites this paper
• [mPGES-1: it makes us sick!].

  2009cites this paper
• Probing cancer cachexia–anorexia: recent results with knockout, transgene and polymorphisms

  2009cites this paper
• Prostaglandin E2 synthase inhibition as a therapeutic target

  2009cites this paper
• Prostaglandins and sickness behavior: old story, new insights.

  2009influential citation
• Inhibitors of the microsomal prostaglandin E(2) synthase-1 as alternative to non steroidal anti-inflammatory drugs (NSAIDs)--a critical review.

  2009cites this paper