Inhibitors of the microsomal prostaglandin E(2) synthase-1 as alternative to non steroidal anti-inflammatory drugs (NSAIDs)--a critical review.

No abstract is available for this paper.

• Publication year

  2009

• Venue

  Current Medicinal Chemistry

• Publication date

  2009-10-31

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.2174/092986709789578178PMID 19754418
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Identification of 5-lipoxygenase and microsomal prostaglandin E2 synthase-1 as functional targets of the anti-inflammatory and anti-carcinogenic garcinol.

  2009cited by this paper
• MK-886, an inhibitor of the 5-lipoxygenase-activating protein, inhibits cyclooxygenase-1 activity and suppresses platelet aggregation.

  2009cited by this paper
• Mutation of a Critical Arginine in Microsomal Prostaglandin E Synthase-1 Shifts the Isomerase Activity to a Reductase Activity That Converts Prostaglandin H2 into Prostaglandin F2α*

  2009cited by this paper
• Myrtucommulone, a natural acylphloroglucinol, inhibits microsomal prostaglandin E2 synthase‐1

  2009cited by this paper
• Genetic deletion of mPGES-1 accelerates intestinal tumorigenesis in APC(Min/+) mice.

  2008cited by this paper
• Tumor-growth-promoting cyclooxygenase-2 prostaglandin E2 pathway provides medulloblastoma therapeutic targets.

  2008cited by this paper
• Microsomal Prostaglandin Synthase-1–Derived Prostaglandin E2 Protects Against Angiotensin II–Induced Hypertension via Inhibition of Oxidative Stress

  2008cited by this paper
• The roles of the prostaglandin D2 receptors DP1 and CRTH2 in promoting allergic responses

  2008cited by this paper
• 15-Deoxy-delta12,14-prostaglandin-J(2) up-regulates cyclooxygenase-2 but inhibits prostaglandin-E(2) production through a thiol antioxidant-sensitive mechanism.

  2008cited by this paper
• Regulation of prostaglandin E2 synthase expression in activated primary rat microglia: Evidence for uncoupled regulation of mPGES‐1 and COX‐2

  2008cited by this paper
• Development of a second generation of inhibitors of microsomal prostaglandin E synthase 1 expression bearing the gamma-hydroxybutenolide scaffold.

  2008cited by this paper
• Human Microsomal Prostaglandin E Synthase-1 (mPGES-1) Binding with Inhibitors and the Quantitative Structure-Activity Correlation

  2008cited by this paper
• Microsomal Prostaglandin E2 Synthase-1 Deletion Leads to Adverse Left Ventricular Remodeling After Myocardial Infarction

  2008cited by this paper
• Microsomal prostaglandin E synthase‐1 inhibition in cardiovascular inflammatory disease

  2008cited by this paper
• Structural basis for induced formation of the inflammatory mediator prostaglandin E2

  2008cited by this paper
• 15-Deoxy-Delta12,14-prostaglandin J2 induces COX-2 expression through Akt-driven AP-1 activation in human breast cancer cells: a potential role of ROS.

  2008cited by this paper
• 15‐deoxy‐delta 12,14‐prostaglandin J2 inhibits the synthesis of the acute phase protein SIP24 in cartilage: Involvement of COX‐2 in resolution of inflammation

  2008cited by this paper
• Expression Analysis of the Prostaglandin E2 Production Pathway in Human Pancreatic Cancers

  2008cited by this paper
• Genetic deletion of mPGES-1 suppresses intestinal tumorigenesis.

  2008cited by this paper
• Differential expression of E‐prostanoid receptors in human hepatocellular carcinoma

  2008cited by this paper
• Novel and potent inhibitors of 5-lipoxygenase product synthesis based on the structure of pirinixic acid.

  2008cited by this paper
• MF63 [2-(6-Chloro-1H-phenanthro[9,10-d]imidazol-2-yl)-isophthalonitrile], a Selective Microsomal Prostaglandin E Synthase-1 Inhibitor, Relieves Pyresis and Pain in Preclinical Models of Inflammation

  2008cited by this paper
• mPGES-1 knock-out mice are resistant to cancer-induced anorexia despite the absence of central mPGES-1 up-regulation in wild-type anorexic mice.

  2008cited by this paper
• Dimethylcelecoxib inhibits prostaglandin E2 production.

  2008cited by this paper
• Photo-crosslinking of proteins in intact cells reveals a dimeric structure of cyclooxygenase-2 and an inhibitor-sensitive oligomeric structure of microsomal prostaglandin E2 synthase-1.

  2008cited by this paper
• Increased dietary NaCl induces renal medullary PGE2 production and natriuresis via the EP2 receptor.

  2008cited by this paper
• Association of microsomal prostaglandin E synthase 1 deficiency with impaired fracture healing, but not with bone loss or osteoarthritis, in mouse models of skeletal disorders.

  2008cited by this paper
• Licofelone Suppresses Prostaglandin E2 Formation by Interference with the Inducible Microsomal Prostaglandin E2 Synthase-1

  2008cited by this paper
• Elevated microsomal prostaglandin‐E synthase‐1 in Alzheimer's disease

  2008cited by this paper
• Expression of prostaglandin E synthase in Barrett's cancer.

  2008cited by this paper
• Defective Generation of a Humoral Immune Response Is Associated with a Reduced Incidence and Severity of Collagen-Induced Arthritis in Microsomal Prostaglandin E Synthase-1 Null Mice1

  2008cited by this paper
• Pirinixic acid derivatives as novel dual inhibitors of microsomal prostaglandin E2 synthase-1 and 5-lipoxygenase.

  2008cited by this paper
• Membrane Prostaglandin E Synthase-1: A Novel Therapeutic Target

  2007cited by this paper
• Effects of immunosuppressive treatment on microsomal prostaglandin E synthase 1 and cyclooxygenases expression in muscle tissue of patients with polymyositis or dermatomyositis

  2007cited by this paper
• Resveratrol potently reduces prostaglandin E2 production and free radical formation in lipopolysaccharide-activated primary rat microglia

  2007cited by this paper
• Topical anti‐inflammatory activity of extracts and compounds from Hypericum perforatum L.

  2007cited by this paper
• Antihypertensive effects of selective prostaglandin E2 receptor subtype 1 targeting.

  2007cited by this paper
• IL-1beta and LPS induce anorexia by distinct mechanisms differentially dependent on microsomal prostaglandin E synthase-1.

  2007cited by this paper
• Structural basis for synthesis of inflammatory mediators by human leukotriene C4 synthase

  2007cited by this paper
• Clinical significance of prostaglandin E synthase expression in gastric cancer tissue.

  2007cited by this paper
• Leukotrienes.

  2007cited by this paper
• Increase in PGE2 biosynthesis induces a Bax dependent apoptosis correlated to patients’ survival in glioblastoma multiforme

  2007cited by this paper
• The molecular mechanism of the inhibition by licofelone of the biosynthesis of 5‐lipoxygenase products

  2007cited by this paper
• Substituted phenanthrene imidazoles as potent, selective, and orally active mPGES-1 inhibitors.

  2007cited by this paper
• Prostaglandin E Receptors*

  2007cited by this paper
• Consequences of altered eicosanoid patterns for nociceptive processing in mPGES-1-deficient mice

  2007cited by this paper
• Crystal structure of a human membrane protein involved in cysteinyl leukotriene biosynthesis

  2007cited by this paper
• Expression of microsomal prostaglandin E synthase‐1 in human hepatocelluar carcinoma

  2007cited by this paper
• 3D-QSAR study of microsomal prostaglandin E2 synthase (mPGES-1) inhibitors.

  2007cited by this paper
• Induction of prostaglandin E synthase by gastroesophageal reflux contents in normal esophageal epithelial cells and esophageal cancer cells.

  2007cited by this paper
• Microsomal prostaglandin E synthase‐1, which is not coupled to a particular cyclooxygenase isoenzyme, is essential for prostaglandin E2 biosynthesis in vascular smooth muscle cells

  2007cited by this paper
• Regulation of prostaglandin E synthases: effects of siRNA-mediated inhibition of microsomal prostaglandin E synthase-1.

  2007cited by this paper
• Synthesis and pharmacological evaluation of a selected library of new potential anti-inflammatory agents bearing the gamma-hydroxybutenolide scaffold: a new class of inhibitors of prostanoid production through the selective modulation of microsomal prostaglandin E synthase-1 expression.

  2007cited by this paper
• Licofelone--a novel analgesic and anti-inflammatory agent.

  2007cited by this paper
• Role of microsomal prostaglandin E synthase 1 in the kidney.

  2007cited by this paper
• Shunting of prostanoid biosynthesis in microsomal prostaglandin E synthase‐1 null embryo fibroblasts: regulatory effects on inducible nitric oxide synthase expression and nitrite synthesis

  2006cited by this paper
• Cyclooxygenases, microsomal prostaglandin E synthase-1, and cardiovascular function.

  2006cited by this paper
• IL-4 regulates COX-2 and PGE2 production in human non-small cell lung cancer.

  2006cited by this paper
• Expression of cyclo‐oxygenase 1 and 2, prostaglandin E synthase and transforming growth factor β1, and their relationship with vascular endothelial growth factors A and C, in primary adenocarcinoma of the small intestine

  2006cited by this paper
• Ovarian epithelial cancer: a role for PGE2-synthesis and signalling in malignant transformation and progression

  2006cited by this paper
• Clinical Implications of Microsomal Prostaglandin E Synthase-1 Overexpression in Human Non–Small-Cell Lung Cancer

  2006cited by this paper
• Simultaneous expression of cyclooxygenase-2 and microsomal prostaglandin E synthase in squamous cell carcinoma of the larynx

  2006cited by this paper
• Membrane-Bound Prostaglandin E Synthase-1-Mediated Prostaglandin E2 Production by Osteoblast Plays a Critical Role in Lipopolysaccharide-Induced Bone Loss Associated with Inflammation

  2006cited by this paper
• Hyperforin: more than an antidepressant bioactive compound?

  2006cited by this paper
• Overexpression of COX-2, Prostaglandin E synthase-1 and prostaglandin E receptors in blood mononuclear cells and plaque of patients with carotid atherosclerosis: regulation by nuclear factor-kappaB.

  2006cited by this paper
• Prostacyclin-IP signaling and prostaglandin E2-EP2/EP4 signaling both mediate joint inflammation in mouse collagen-induced arthritis

  2006cited by this paper
• Prostacyclin Antagonism Reduces Pain and Inflammation in Rodent Models of Hyperalgesia and Chronic Arthritis

  2006cited by this paper
• Substituted trans-stilbenes, including analogues of the natural product resveratrol, inhibit the human tumor necrosis factor alpha-induced activation of transcription factor nuclear factor kappaB.

  2006cited by this paper
• Deletion of Microsomal Prostaglandin E Synthase-1 Increases Sensitivity to Salt Loading and Angiotensin II Infusion

  2006cited by this paper
• Is mPGES-1 a promising target for pain therapy?

  2006cited by this paper
• Structural and functional characterization of human microsomal prostaglandin E synthase-1 by computational modeling and site-directed mutagenesis.

  2006cited by this paper
• Microsomal prostaglandin E synthase-1 is a critical factor of stroke-reperfusion injury.

  2006cited by this paper
• Therapeutic options for 5-lipoxygenase inhibitors.

  2006cited by this paper
• Establishment of a cell-based drug screening system for identifying selective down-regulators of mPGES-1

  2006cited by this paper
• Microsomal prostaglandin E2 synthase‐1 in breast cancer: a potential target for therapy

  2006cited by this paper
• Cardiovascular risk and inhibition of cyclooxygenase: a systematic review of the observational studies of selective and nonselective inhibitors of cyclooxygenase 2.

  2006cited by this paper
• Microsomal prostaglandin E synthase-1 regulates human glioma cell growth via prostaglandin E2–dependent activation of type II protein kinase A

  2006cited by this paper
• Deletion of microsomal prostaglandin E synthase-1 augments prostacyclin and retards atherogenesis

  2006cited by this paper
• Nanomolar and micromolar effects of 15-deoxy-delta 12,14-prostaglandin J2 on amnion-derived WISH epithelial cells: differential roles of peroxisome proliferator-activated receptors gamma and delta and nuclear factor kappa B.

  2005cited by this paper
• Leukotriene modifiers as potential therapeutics for cardiovascular disease

  2005cited by this paper
• Redirection of Eicosanoid Metabolism in mPGES-1-deficient Macrophages*

  2005cited by this paper
• Identification of Molecular Targets of the Oligomeric Nonprenylated Acylphloroglucinols from Myrtus communis and Their Implication as Anti-Inflammatory Compounds

  2005cited by this paper
• Impaired febrile responses to immune challenge in mice deficient in microsomal prostaglandin E synthase-1.

  2005cited by this paper
• Inhibition of interleukin-1beta-induced cyclooxygenase 2 expression in human synovial fibroblasts by 15-deoxy-Delta12,14-prostaglandin J2 through a histone deacetylase-independent mechanism.

  2005cited by this paper
• Prostaglandin E2 production in ovarian cancer cell lines is regulated by cyclooxygenase-1, not cyclooxygenase-2.

  2005cited by this paper
• Crystal structure and possible catalytic mechanism of microsomal prostaglandin E synthase type 2 (mPGES-2).

  2005cited by this paper
• Prostaglandin E synthase, a terminal enzyme for prostaglandin E2 biosynthesis.

  2005cited by this paper
• The Janus Face of Cyclooxygenase-2 in Ischemic Stroke: Shifting Toward Downstream Targets

  2005cited by this paper
• Sensitization of TRPV1 by EP1 and IP reveals peripheral nociceptive mechanism of prostaglandins

  2005cited by this paper
• Inhibitors of the inducible microsomal prostaglandin E2 synthase (mPGES-1) derived from MK-886.

  2005cited by this paper
• PROSTAGLANDINS AND CANCER

  2005cited by this paper
• Thromboxane A2 and prostaglandin F2alpha mediate inflammatory tachycardia.

  2005cited by this paper
• Induced microsomal PGE synthase-1 is involved in cyclooxygenase-2-dependent PGE2 production in gastric fibroblasts.

  2005cited by this paper
• Renal effects of non-steroidal anti-inflammatory drugs and selective cyclooxygenase-2 inhibitors.

  2005cited by this paper
• Suppression of allergic inflammation by the prostaglandin E receptor subtype EP3

  2005cited by this paper
• Reduced Pain Hypersensitivity and Inflammation in Mice Lacking Microsomal Prostaglandin E Synthase-1*

  2004cited by this paper
• The antidepressant mechanism of Hypericum perforatum.

  2004cited by this paper
• Intraparenchymal administration of interleukin-1beta induces cyclooxygenase-2-mediated expression of membrane- and cytosolic-associated prostaglandin E synthases in mouse brain.

  2004cited by this paper
• Resveratrol is a Peroxidase-mediated Inactivator of COX-1 but Not COX-2

  2004cited by this paper
• Prostaglandin Receptors EP2, EP3, and IP Mediate Exudate Formation in Carrageenin-Induced Mouse Pleurisy

  2004cited by this paper

• 2‐Phenylbenzothiazoles featuring heteroaryl sulfonamide end‐capping substructures as developable mPGES‐1 inhibitors

  2025cites this paper
• Resveratrol from grape pomace: Mitigation of lead-induced oxidative stress-related renal toxicity: In silico and In vivo studies

  2025cites this paper
• Botulinum toxin type A is a potential therapeutic drug for chronic orofacial pain.

  2024cites this paper
• Comprehensive review on advanced antipyretic and anti-nociceptic agents: Efficacy; safety and emerging therapies

  2024cites this paper
• Novel Benzimidazole Derivatives as Potent Inhibitors of Microsomal Prostaglandin E2 Synthase 1 for the Potential Treatment of Inflammation, Pain, and Fever.

  2024cites this paper
• Anti-Inflammatory and Vasorelaxant Effects Induced by an Aqueous Aged Black Garlic Extract Supplemented with Vitamins D, C, and B12 on Cardiovascular System

  2023cites this paper
• The Role of Web-Based Adaptive Choice-Based Conjoint Analysis Technology in Eliciting Patients’ Preferences for Osteoarthritis Treatment

  2023cites this paper
• The standardized herbal combination BNO 2103 contained in Canephron N 1 alleviates inflammatory pain in experimental cystitis and prostatitis 2

  2022cites this paper
• Effects of 2-carba-cyclic phosphatidic acid derivatives on IL-1β-stimulated human chondrocytes.

  2022cites this paper
• Insights into the Pathophysiology of Alzheimer’s Disease and Potential Therapeutic Targets: A Current Perspective

  2022cites this paper
• Rotational constriction of curcuminoids impacts 5-lipoxygenase and mPGES-1 inhibition and evokes a lipid mediator class switch in macrophages.

  2022cites this paper
• Traditional Chinese Medicine for Treatment of Urinary Tract Infection in Acute Phase—A Case Report

  2022cites this paper
• Novel potent benzimidazole-based microsomal prostaglandin E2 synthase-1 (mPGES-1) inhibitors derived from BRP-201 that also inhibit leukotriene C4 synthase.

  2022cites this paper
• Phenolic Characterization and Neuroprotective Properties of Grape Pomace Extracts

  2021cites this paper
• Simple heteroaryl modifications in the 4,5-diarylisoxazol-3-carboxylic acid scaffold favorably modulates the activity as dual mPGES-1/5-LO inhibitors with in vivo efficacy.

  2021cites this paper
• Discovery of N-Amido-Phenylsulfonamide Derivatives as Novel Microsomal Prostaglandin E2 Synthase-1 (mPGES-1) Inhibitors.

  2021cites this paper
• Considerations to Be Taken When Carrying Out Medicinal Plant Research—What We Learn from an Insight into the IC50 Values, Bioavailability and Clinical Efficacy of Exemplary Anti-Inflammatory Herbal Components

  2021cites this paper
• Microsomal prostaglandin E2 synthase-1 and its inhibitors: molecular mechanisms and therapeutic significance.

  2021cites this paper
• Values of natural products to future antiinflammatory pharmaceutical discovery

  2021cites this paper
• From Vietnamese plants to a biflavonoid that relieves inflammation by triggering the lipid mediator class switch to resolution

  2021cites this paper
• Improved bioactivity of the natural product 5-lipoxygenase inhibitor hyperforin by encapsulation into polymeric nanoparticles.

  2020cites this paper
• Licofelone, a dual cyclooxygenase/5-lipoxygenase inhibitor, reverses endotoxin-induced impaired atrial chronotropic responsiveness to cholinergic stimulation in rats.

  2020cites this paper
• Plant triterpenoids with bond-missing skeletons: biogenesis, distribution and bioactivity.

  2020cites this paper
• Present Status and Future Trends of Natural-Derived Compounds Targeting T Helper (Th) 17 and Microsomal Prostaglandin E Synthase-1 (mPGES-1) as Alternative Therapies for Autoimmune and Inflammatory-Based Diseases

  2020cites this paper
• The Anti-Inflammatory and Antimicrobial Potential of Selected Ethnomedicinal Plants from Sri Lanka

  2020cites this paper
• Phenolic Content and Antimicrobial and Anti-Inflammatory Effects of Solidago virga-aurea, Phyllanthus niruri, Epilobium angustifolium, Peumus boldus, and Ononis spinosa Extracts

  2020cites this paper
• Integral membrane enzymes in eicosanoid metabolism: Structures, mechanisms and inhibitor design.

  2020cites this paper
• The Effect Ofmeloxicam and Piroxicamon the Fertility of Male Rats

  2019cites this paper
• Ginkgolic Acid is a Multi-Target Inhibitor of Key Enzymes in Pro-Inflammatory Lipid Mediator Biosynthesis

  2019cites this paper
• Lipoxygenase inhibitors as cancer chemopreventives: discovery, recent developments, and future perspectives.

  2019cites this paper
• The standardized herbal combination BNO 2103 contained in Canephron® N alleviates inflammatory pain in experimental cystitis and prostatitis.

  2019cites this paper
• New pyrazole derivatives: Synthesis, anti-inflammatory activity, cycloxygenase inhibition assay and evaluation of mPGES.

  2019cites this paper
• Discovery and optimization of pyridyl-cycloalkyl-carboxylic acids as inhibitors of microsomal prostaglandin E synthase-1 for the treatment of endometriosis.

  2019cites this paper
• Nardochinoid B Inhibited the Activation of RAW264.7 Macrophages Stimulated by Lipopolysaccharide through Activating the Nrf2/HO-1 Pathway

  2019cites this paper
• Natural products as inhibitors of prostaglandin E2 and pro-inflammatory 5-lipoxygenase-derived lipid mediator biosynthesis.

  2018cites this paper
• Structural insight into the optimization of ethyl 5-hydroxybenzo[g]indol-3-carboxylates and their bioisosteric analogues as 5-LO/m-PGES-1 dual inhibitors able to suppress inflammation.

  2018cites this paper
• Lipophilic extracts of Leucas zeylanica, a multi-purpose medicinal plant in the tropics, inhibit key enzymes involved in inflammation and gout.

  2018cites this paper
• Synthesis, characterization and spectroscopic studies of binuclear lanthanide complexes containing the anti-inflammatory drug Ibuprofen and CH 3 -disubstituted bipyridine ligands: Influence of methyl group position in the photoluminescence

  2018cites this paper
• Anti-Inflammatory Functional Foods

  2018cites this paper
• RATIONAL DESIGN, SYNTHESIS, AND CHARACTERIZATION OF NOVEL mPGES-1 INHIBITORS AS NEXT GENERATION OF ANTI-INFLAMMATORY DRUGS

  2017cites this paper
• METHOD DEVELOPMENT AND VALIDATION OF STABILITY INDICATING RP-HPLC METHOD FOR SIMULTANEOUS ESTIMATION OF THIOCOLCHICOSIDE AND ACECLOFENAC IN BULK AND ITS PHARMACEUTICAL DOSAGE FORMULATIONS

  2017cites this paper
• Computational models for the classification of mPGES-1 inhibitors with fingerprint descriptors

  2017cites this paper
• Tricyclic 4,4-dimethyl-3,4-dihydrochromeno[3,4-d]imidazole derivatives as microsomal prostaglandin E2 synthase-1 (mPGES-1) inhibitors: SAR and in vivo efficacy in hyperalgesia pain model.

  2017cites this paper
• Microsomal prostaglandin E2 synthase-1 inhibitors: a patent review

  2017cites this paper
• Chapter 24 – Prostaglandins, Leukotrienes, and Related Compounds

  2017cites this paper
• Substrate-specific effects of pirinixic acid derivatives on ABCB1-mediated drug transport

  2016cites this paper
• L-Nω-Nitroarginine Inhibits the Induction of Nitric Oxide Synthase (iNOS) and Cyclooxygenase-2 (COX-2) by Inhibiting NF-κB and AP-1 Activation in RAW 264.7 Cells

  2016cites this paper
• Aminothiazoles inhibit RANKL‐ and LPS‐mediated osteoclastogenesis and PGE 2 production in RAW 264.7 cells

  2016cites this paper
• Expression of prostaglandin receptors in Chlamydia trachomatis-infected recurrent spontaneous aborters.

  2016cites this paper
• Humudifucol and Bioactive Prenylated Polyphenols from Hops (Humulus lupulus cv. "Cascade").

  2016cites this paper
• Recent Advances in Anti-inflammatory Potential of Pyridazinone Derivatives.

  2016cites this paper
• Structure‐Based Design of Microsomal Prostaglandin E2 Synthase‐1 (mPGES‐1) Inhibitors using a Virtual Fragment Growing Optimization Scheme

  2016cites this paper
• MOLECULAR DOCKING STUDIES OF PERGULARIA DAEMIA BIOACTIVE COMPOUNDS WITH THERAPEUTIC TARGETS OF ARTHRITIS

  2016cites this paper
• Microsomal Prostaglandin E Synthase-1 Expression by Aortic Smooth Muscle Cells Attenuates the Differentiated Phenotype

  2016cites this paper
• Deleció condicional de C/EBPß a les cèl·lules de la micròglia. Nova eina per a l'estudi i la modulació de l'activació glial en models de neurodegeneració

  2016cites this paper
• Design and Development of Microsomal Prostaglandin E2 Synthase-1 Inhibitors: Challenges and Future Directions.

  2016cites this paper
• Characterization of 3,3-dimethyl substituted N-aryl piperidines as potent microsomal prostaglandin E synthase-1 inhibitors.

  2016cites this paper
• SYNTHESIS OF DISUBSTITUTED ISOXAZOLES FROM 2-PROPYN-1-OL THROUGH PROPARGYLIC N-HYDROXYLAMINES

  2016cites this paper
• Perspective of microsomal prostaglandin E2 synthase-1 as drug target in inflammation-related disorders.

  2015cites this paper
• Anti-inflammatory tirucallane triterpenoids from Anopyxis klaineana Pierre (Engl.), (Rhizophoraceae).

  2015cites this paper
• Synthesis and biological evaluation of novel myrtucommulones and structural analogues that target mPGES-1 and 5-lipoxygenase.

  2015cites this paper
• A COX/5-LOX Inhibitor Licofelone Revealed Anticonvulsant Properties Through iNOS Diminution in Mice

  2015cites this paper
• Paradoxical Increase in Mortality and Rupture of Intracranial Aneurysms in Microsomal Prostaglandin E2 Synthase Type 1-Deficient Mice: Attenuation by Aspirin.

  2015cites this paper
• SAR-studies of γ-secretase modulators with PPARγ-agonistic and 5-lipoxygenase-inhibitory activity for Alzheimer's disease.

  2015cites this paper
• Effect of firocoxib on cyclooxygenase 2, microsomal prostaglandin E2 synthase 1, and cytosolic phospholipase A2 gene expression in equine mononuclear cells.

  2015cites this paper
• Discovery of novel, non-acidic mPGES-1 inhibitors by virtual screening with a multistep protocol

  2015cites this paper
• Targeting microsomal prostaglandin E2 synthase-1 (mPGES-1): the development of inhibitors as an alternative to non-steroidal anti-inflammatory drugs (NSAIDs)

  2015cites this paper
• Expression of prostaglandin E synthase-1 in periodontitis : in vivo and in vitro studies

  2014cites this paper
• Cannflavins from hemp sprouts, a novel cannabinoid-free hemp food product, target microsomal prostaglandin E2 synthase-1 and 5-lipoxygenase

  2014cites this paper
• Munronia pinnata (Wall.) Theob.: unveiling phytochemistry and dual inhibition of 5-lipoxygenase and microsomal prostaglandin E2 synthase (mPGES)-1.

  2014cites this paper
• SAR studies on curcumin's pro-inflammatory targets: discovery of prenylated pyrazolocurcuminoids as potent and selective novel inhibitors of 5-lipoxygenase.

  2014cites this paper
• EP4 and EP2 Receptor Activation of Protein Kinase A by Prostaglandin E2 Impairs Macrophage Phagocytosis of Clostridium sordellii

  2014cites this paper
• Tetra- and Pentacyclic Triterpene Acids from the Ancient Anti-inflammatory Remedy Frankincense as Inhibitors of Microsomal Prostaglandin E2 Synthase-1

  2014cites this paper
• Multi-target approach for natural products in inflammation.

  2014cites this paper
• Expression of mPGES-1 and IP mRNA is reduced by LLLT in both subplantar and brain tissues in the model of peripheral inflammation induced by carrageenan

  2014cites this paper
• Interactions between glia, the immune system and pain processes during early development.

  2014cites this paper
• Anti-Pyretic and Analgesic Potentials of Aqueous Extract of Phragmanthera capitata S. Balle in Albino Rats

  2014cites this paper
• Synthesis and pharmacological characterization of benzenesulfonamides as dual species inhibitors of human and murine mPGES-1.

  2013cites this paper
• CCAAT/Enhancer binding protein β regulates prostaglandin E synthase expression and prostaglandin E2 production in activated microglial cells

  2013cites this paper
• Potent inhibition of human 5-lipoxygenase and microsomal prostaglandin E₂ synthase-1 by the anti-carcinogenic and anti-inflammatory agent embelin.

  2013influential citation
• Imbricaric Acid and Perlatolic Acid: Multi-Targeting Anti-Inflammatory Depsides from Cetrelia monachorum

  2013cites this paper
• Fragment-based discovery of novel and selective mPGES-1 inhibitors Part 1: identification of sulfonamido-1,2,3-triazole-4,5-dicarboxylic acid.

  2013cites this paper
• Eicosanoids and Their Drugs in Cardiovascular Diseases: Focus on Atherosclerosis and Stroke

  2013cites this paper
• β-Boswellic Acid , A Safe and Clinically Effective Inhibitor of Prostaglandin E Synthase-1 , Has Potential for Prevention of Cancer , Alzheimer ’ s Disease , and Vascular Disorders , and for Control of Inflammatory Pain

  2013cites this paper
• Research Article In Vitro Evaluation of Three Different Tablet Formulations of Diclofenac

  2013cites this paper
• Inhibition of microsomal prostaglandin E synthase-1 by aminothiazoles decreases prostaglandin E2 synthesis in vitro and ameliorates experimental periodontitis in vivo

  2013cites this paper
• Synthesis and biological evaluation of substituted benzoxazoles as inhibitors of mPGES-1: use of a conformation-based hypothesis to facilitate compound design.

  2013cites this paper
• Inflammatory mediators in the pathogenesis of periodontitis

  2013cites this paper
• The role of bioactive lipids in pain and inflammation

  2012cites this paper
• Molecular docking studies of withanolides against Cox-2 enzyme.

  2012cites this paper
• Carnosol and Carnosic Acids from Salvia officinalis Inhibit Microsomal Prostaglandin E2 Synthase-1

  2012cites this paper
• Microwave-Assisted Synthesis of 1,3-Benzothiazol-2(3H)-one Derivatives and Analysis of Their Antinociceptive Activity

  2012cites this paper
• Discovery of Depsides and Depsidones from Lichen as Potent Inhibitors of Microsomal Prostaglandin E2 Synthase‐1 Using Pharmacophore Models

  2012cites this paper
• Identification of new γ-hydroxybutenolides that preferentially inhibit the activity of mPGES-1.

  2012cites this paper
• Design and synthesis of a second series of triazole-based compounds as potent dual mPGES-1 and 5-lipoxygenase inhibitors.

  2012cites this paper
• Lead Optimization of Thiazolo[5,4‐c]piperidines: 3‐Cyclobutoxy Linker as a Key Spacer for H3R Inverse Agonists

  2012cites this paper
• Chemotaxonomic investigations on resins of the frankincense species Boswellia papyrifera, Boswellia serrata and Boswellia sacra, respectively, Boswellia carterii : a qualitative and quantitative approach by chromatographic and spectroscopic methodology

  2012cites this paper
• Chemotaxonomic Investigations on Resins of the Frankincense Species Boswellia papyrifera, Boswellia serrata and Boswellia sacra, respectively, Boswellia carterii

  2012cites this paper
• Drug design for mPGES-1 from traditional Chinese medicine database: A screening, docking, QSAR, molecular dynamics, and pharmacophore mapping study

  2011cites this paper
• Evaluation of the Anti-Inflammatory Effects of Novel Pirinixic Acid Derivatives

  2011cites this paper