Suppression of allergic inflammation by the prostaglandin E receptor subtype EP3

No abstract is available for this paper.

• Publication year

  2005

• Venue

  Nature Immunology

• Publication date

  2005-12-09

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1038/ni1188PMID 15806106
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Advances in Pathogenesis and Management

  2006cited by this paper
• Defective lipoxin-mediated anti-inflammatory activity in the cystic fibrosis airway

  2004cited by this paper
• Interleukin-13-dependent expression of matrix metalloproteinase-12 is required for the development of airway eosinophilia in mice.

  2004cited by this paper
• Expression and regulation of a disintegrin and metalloproteinase (ADAM) 8 in experimental asthma.

  2004cited by this paper
• Role of prostanoid DP receptor variants in susceptibility to asthma.

  2004cited by this paper
• A beta-oxidation-resistant lipoxin A4 analog treats hapten-induced colitis by attenuating inflammation and immune dysfunction.

  2004cited by this paper
• Nasal polyposis: an update

  2003cited by this paper
• Epithelial cells in ocular allergy

  2003cited by this paper
• Multi-pronged inhibition of airway hyper-responsiveness and inflammation by lipoxin A4

  2002cited by this paper
• The Immunomodulatory Actions of Prostaglandin E2 on Allergic Airway Responses in the Rat1

  2002cited by this paper
• Augmentation of allergic inflammation in prostanoid IP receptor deficient mice

  2002cited by this paper
• Receptors and Signaling Mechanisms Required for Prostaglandin E2-Mediated Regulation of Mast Cell Degranulation and IL-6 Production1

  2002cited by this paper
• Role of gob-5 in mucus overproduction and airway hyperresponsiveness in asthma

  2001cited by this paper
• Lipid mediator class switching during acute inflammation: signals in resolution

  2001cited by this paper
• Intervention of Thymus and Activation-Regulated Chemokine Attenuates the Development of Allergic Airway Inflammation and Hyperresponsiveness in Mice1

  2001cited by this paper
• Interleukin-13 upregulates eotaxin expression in airway epithelial cells by a STAT6-dependent mechanism.

  2001cited by this paper
• Regulated production of the T helper 2-type T-cell chemoattractant TARC by human bronchial epithelial cells in vitro and in human lung xenografts.

  2001cited by this paper
• The Diverse Roles of Mast Cells

  2001cited by this paper
• The role of IgE in allergen‐induced inflammation and the potential for intervention with a humanized monoclonal anti‐IgE antibody

  2001cited by this paper
• Prostaglandin E2 Selectively Enhances the IgE-Mediated Production of IL-6 and Granulocyte-Macrophage Colony-Stimulating Factor by Mast Cells Through an EP1/EP3-Dependent Mechanism1

  2000cited by this paper
• Comparative respiratory system mechanics in rodents.

  2000cited by this paper
• Prostaglandin D2 as a mediator of allergic asthma.

  2000cited by this paper
• Molecular pathology of allergic disease. II: Upper airway disease.

  2000cited by this paper
• The role of prostaglandin E receptor subtypes (EP1, EP2, EP3, and EP4) in bone resorption: an analysis using specific agonists for the respective EPs.

  2000cited by this paper
• Muc-5/5ac mucin messenger RNA and protein expression is a marker of goblet cell metaplasia in murine airways.

  2000cited by this paper
• Characterization of prostanoid receptors mediating inhibition of histamine release from anti‐IgE‐activated rat peritoneal mast cells

  2000cited by this paper
• Induction and regulation of the IgE response

  1999cited by this paper
• Abortive expansion of the cumulus and impaired fertility in mice lacking the prostaglandin E receptor subtype EP(2).

  1999cited by this paper
• Protective effects of inhaled PGE2 on allergen-induced airway responses and airway inflammation.

  1999cited by this paper
• Participation of histamine H1 and H2 receptors in passive cutaneous anaphylaxis-induced scratching behavior in ICR mice.

  1999cited by this paper
• Prostanoid receptors: structures, properties, and functions.

  1999cited by this paper
• Effect of overproduction of interleukin 5 on dinitrofluorobenzene-induced allergic cutaneous response in mice.

  1999cited by this paper
• Aspirin-induced asthma: advances in pathogenesis and management.

  1999cited by this paper
• Patent ductus arteriosus and neonatal death in prostaglandin receptor EP4-deficient mice.

  1998cited by this paper
• Upper airway disease

  1998cited by this paper
• Impaired febrile response in mice lacking the prostaglandin E receptor subtype EP3

  1998cited by this paper
• Epidemiology of childhood asthma.

  1997cited by this paper
• Mediators of nasal blockage in allergic rhinitis.

  1997cited by this paper
• The prostaglandin receptor EP4 triggers remodelling of the cardiovascular system at birth

  1997cited by this paper
• Two isoforms of the EP3 receptor with different carboxyl-terminal domains. Identical ligand binding properties and different coupling properties with Gi proteins.

  1993cited by this paper
• Effect of inhaled prostaglandin E2 on allergen-induced asthma.

  1993cited by this paper
• Epidemiology of childhood asthma.

  1991cited by this paper
• Mast cell lines produce lymphokines in response to cross-linkage of FcεRI or to calcium ionophores

  1989cited by this paper
• Mast cell lines produce lymphokines in response to cross-linkage of Fc epsilon RI or to calcium ionophores.

  1989cited by this paper
• Ontogeny of in vitro-differentiated mouse mast cells.

  1987cited by this paper
• Release of prostaglandin D2 into human airways during acute antigen challenge.

  1986cited by this paper
• Rapid extraction of arachidonic acid metabolites from biological samples using octadecylsilyl silica.

  1982cited by this paper
• A method for the fluorometric assay of histamine in tissues.

  1959cited by this paper

• Functional insights into PTGS2 rs689466 polymorphism associated to asthma in West Bengal, India.

  2025cites this paper
• From Vascular Dysfunction to Atherothrombosis: The Pivotal Role of Eicosanoids and Their Receptors in Platelet and Endothelial Imbalance: A Scoping Review

  2025cites this paper
• Prostaglandin E2 alleviates inflammatory response and lung injury through EP4/cAMP/IKK/NF-κB pathway.

  2025cites this paper
• Acetylsalicylic acid aggravates anaphylaxis in a PGE2-dependent manner

  2025influential citation
• Prostanoid receptors in GtoPdb v.2025.3

  2025cites this paper
• Prostaglandin E2 in the Tumor Microenvironment, a Convoluted Affair Mediated by EP Receptors 2 and 4

  2024cites this paper
• Advances in macrophage and T cell metabolic reprogramming and immunotherapy in the tumor microenvironment

  2024cites this paper
• Butyrate, Valerate, and Niacin Ameliorate Anaphylaxis by Suppressing IgE-Dependent Mast Cell Activation: Roles of GPR109A, PGE2, and Epigenetic Regulation.

  2024cites this paper
• Lipid-orchestrated paracrine circuit coordinates mast cell maturation and anaphylaxis through functional interaction with fibroblasts.

  2024cites this paper
• Group III secreted phospholipase A2‐driven lysophospholipid pathway protects against allergic asthma

  2024cites this paper
• Crossing the valley of death: Toward translational research regarding ILC2.

  2023cites this paper
• Susceptibility Genes and HLA for Cold Medicine-Related SJS/TEN with SOC

  2022cites this paper
• Mast Cell–Tumor Interactions: Molecular Mechanisms of Recruitment, Intratumoral Communication and Potential Therapeutic Targets for Tumor Growth

  2022cites this paper
• Regulatory Roles of Phospholipase A2 Enzymes and Bioactive Lipids in Mast Cell Biology

  2022influential citation
• LC-MS-based metabolomics reveals the in vivo effect of Shegan Mahuang Decoction in an OVA-induced rat model of airway hyperresponsiveness.

  2022cites this paper
• Prostanoid receptors in GtoPdb v.2021.2

  2021cites this paper
• Positive and negative roles of lipids in mast cells and allergic responses.

  2021cites this paper
• Prostaglandin regulation of type 2 inflammation: From basic biology to therapeutic interventions

  2021cites this paper
• Intersecting Mechanisms of Hypoxia and Prostaglandin E2-Mediated Inflammation in the Comparative Biology of Oral Squamous Cell Carcinoma

  2021cites this paper
• Eicosanoid receptors as therapeutic targets for asthma.

  2021cites this paper
• Pathogenesis of Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis With Severe Ocular Complications

  2021cites this paper
• Findings by an International Collaboration on SJS/TEN With Severe Ocular Complications

  2021cites this paper
• Synopsis

  2020cites this paper
• Lipidmediatoren und ihre Rolle bei Entzündungen und Allergien

  2020cites this paper
• PGE2 deficiency predisposes to anaphylaxis by causing mast cell hyper-responsiveness.

  2020cites this paper
• Interleukin 3-induced GITR promotes the activation of human basophils.

  2020cites this paper
• Immune metabolism in PD-1 blockade-based cancer immunotherapy

  2020cites this paper
• Stevens-Johnson syndrome/toxic epidermal necrolysis with severe ocular complications

  2020cites this paper
• Prostaglandins as the Agents That Modulate the Course of Brain Disorders

  2020cites this paper
• Is Resolution the End of Inflammation?

  2019cites this paper
• Expression of prostaglandin E2 receptor 3 in the eyelid epidermis of patients with Stevens-Johnson syndrome/toxic epidermal necrolysis

  2019cites this paper
• High Expression of IL-1RI and EP2 Receptors in the IL-1β/COX-2 Pathway, and a New Alternative to Non-Steroidal Drugs—Osthole in Inhibition COX-2

  2019cites this paper
• Modulation of Bronchomotor Tone Pathways in Airway Smooth Muscle Function and Bronchomotor Tone in Asthma.

  2019cites this paper
• Emerging structural biology of lipid G protein‐coupled receptors

  2019cites this paper
• Prostaglandins in asthma and allergic diseases☆

  2019cites this paper
• Prostanoid receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database

  2019cites this paper
• Inhibition of mPGES-1 as therapeutic strategy in inflammation and cancer

  2019cites this paper
• Association of HLA class I and II gene polymorphisms with acetaminophen-related Stevens–Johnson syndrome with severe ocular complications in Japanese individuals

  2019cites this paper
• Prostaglandin E2 Inhibits Group 2 Innate Lymphoid Cell Activation and Allergic Airway Inflammation Through E-Prostanoid 4-Cyclic Adenosine Monophosphate Signaling

  2018cites this paper
• Results of Detailed Investigations Into Stevens-Johnson Syndrome With Severe Ocular Complications.

  2018cites this paper
• Oral administration of oat beta-glucan preparations of different molecular weight results in regulation of genes connected with immune response in peripheral blood of rats with LPS-induced enteritis

  2018cites this paper
• Mucocutaneous inflammation in the Ikaros Family Zinc Finger 1‐keratin 5–specific transgenic mice

  2018cites this paper
• The periodontal stem/progenitor cell inflammatory‐regenerative cross talk: A new perspective

  2018cites this paper
• Role of prostaglandin E2 in bronchoconstriction-triggered cough response in guinea pigs.

  2018cites this paper
• Prostaglandin‐cytokine crosstalk in chronic inflammation

  2018influential citation
• Constitutive ω-3 fatty acid production in fat-1 transgenic mice and docosahexaenoic acid administration to wild type mice protect against 2,4,6-trinitrobenzene sulfonic acid-induced colitis.

  2017cites this paper
• Lipid Mediators in Inflammation

  2017cites this paper
• Cytokine-induced killer cells: A novel treatment for allergic airway inflammation

  2017cites this paper
• Imbalance of endogenous prostanoids in moderate-to-severe asthma.

  2017cites this paper
• Immunological Regulation by Bioactive Lipids.

  2017cites this paper
• Cold medicine-related Stevens–Johnson syndrome/toxic epidermal necrolysis with severe ocular complications–phenotypes and genetic predispositions

  2016cites this paper
• Therapeutic effects of human gingiva-derived mesenchymal stromal cells on murine contact hypersensitivity via prostaglandin E2–EP3 signaling

  2016cites this paper
• overproduction by RGS4 in the airway -induced MUC5AC 2 Suppression of prostaglandin E

  2016cites this paper
• Prostaglandins in Chronic Inflammation

  2016cites this paper
• Whole-Genome Saliva and Blood DNA Methylation Profiling in Individuals with a Respiratory Allergy

  2016cites this paper
• Gingival Mesenchymal Stem/Progenitor Cells: A Unique Tissue Engineering Gem

  2016cites this paper
• Structural and functional characterisation of dioxolane A3, a new eicosanoid generated by cycooxygenase-1 in platelets

  2016cites this paper
• Possible effects of repeated exposure to ibuprofen and acetaminophen on the intestinal immune response in young infants.

  2016influential citation
• Prostaglandin I2 Suppresses Proinflammatory Chemokine Expression, CD4 T Cell Activation, and STAT6-Independent Allergic Lung Inflammation

  2016cites this paper
• STAT 6-Independent Allergic Lung CD 4 T Cell Activation , and Proinflammatory Chemokine Expression , Suppresses 2 Prostaglandin

  2016cites this paper
• E-Prostanoid 2 Receptor Overexpression Promotes Mesenchymal Stem Cell Attenuated Lung Injury

  2016cites this paper
• Prostaglandin regulation of immune responses against coronavirus infections

  2016cites this paper
• Prostaglandins E2 signal mediated by receptor subtype EP2 promotes IgE production in vivo and contributes to asthma development

  2016cites this paper
• Culture medium from TNF-α-stimulated mesenchymal stem cells attenuates allergic conjunctivitis through multiple antiallergic mechanisms.

  2015cites this paper
• Genetic Predisposition to Stevens–Johnson Syndrome With Severe Ocular Surface Complications

  2015cites this paper
• Critical role of phospholipase A2 group IID in age-related susceptibility to severe acute respiratory syndrome–CoV infection

  2015cites this paper
• Anti-inflammatory effects of PGE2 in the lung: role of the EP4 receptor subtype

  2015cites this paper
• Hypodermin A, a potential agent for prevention of allogeneic acute rejection.

  2015cites this paper
• Effect of prostaglandin I 2 analogs on monocyte chemoattractant protein-1 in human monocyte and macrophage

  2015cites this paper
• The role of prostaglandins in allergic lung inflammation and asthma

  2015influential citation
• Study of the Role of Cytosolic Phospholipase A2 Alpha in Eicosanoid Generation and Thymocyte Maturation in the Thymus

  2015cites this paper
• Activation of the Prostaglandin E2 receptor EP2 prevents house dust mite‐induced airway hyperresponsiveness and inflammation by restraining mast cells’ activity

  2015cites this paper
• Microsomal Prostaglandin E Synthase-1 in Respiratory Diseases

  2015cites this paper
• [Prostaglandins and the immune response at the intestinal submucosal level. A potential site for interference with the repeated use of paracetamol and ibuprofen at a young age?].

  2015cites this paper
• Herz-Kreislauf-Medikamente als Kofaktoren der Anaphylaxie

  2015cites this paper
• Les prostaglandines et l’immunité du chorion sous-muqueux intestinal. Questions à propos de l’usage répété du paracétamol et de l’ibuprofène en bas âge

  2015influential citation
• Prostanoids in allergy.

  2015cites this paper
• Prostaglandin D2 modulates calcium signals induced by prostaglandin E2 in neurons of rat dorsal root ganglia.

  2015cites this paper
• Secreted phospholipase A2 and mast cells.

  2015cites this paper
• Effect of prostaglandin I2 analogs on monocyte chemoattractant protein-1 in human monocyte and macrophage

  2015cites this paper
• The PGE2-EP2-mast cell axis: an antiasthma mechanism.

  2015cites this paper
• Oxidized Low-Density Lipoprotein Suppresses Expression of Prostaglandin E Receptor Subtype EP3 in Human THP-1 Macrophages

  2014cites this paper
• Prostaglandin E₂ suppresses allergic sensitization and lung inflammation by targeting the E prostanoid 2 receptor on T cells.

  2014cites this paper
• The role of prostaglandin E2 receptor signaling of dendritic cells in rheumatoid arthritis.

  2014cites this paper
• Prostaglandin E2 resistance in granulocytes from patients with aspirin-exacerbated respiratory disease.

  2014cites this paper
• 9 – Lipid Mediators of Hypersensitivity and Inflammation

  2014cites this paper
• [Emerging roles of phospholipase A2s in mast cell biology].

  2014cites this paper
• Prostaglandin E2 Prevents Hyperosmolar-Induced Human Mast Cell Activation through Prostanoid Receptors EP2 and EP4

  2014cites this paper
• Diverse Functions of Secretory Phospholipases A2

  2014cites this paper
• Effect of Prostaglandin I2 Analogs on Macrophage Inflammatory Protein 1α in Human Monocytes Via I Prostanoid Receptor and Cyclic Adenosine Monophosphate

  2014cites this paper
• Inhibitors of Microsomal Prostaglandin E2 Synthase‐1 Enzyme as Emerging Anti‐Inflammatory Candidates

  2014cites this paper
• Suppression of polyI:C-inducible gene expression by EP3 in murine conjunctival epithelium.

  2014cites this paper
• Mechanisms underlying the resolution of HDM induced allergic airways disease

  2013cites this paper
• Early innate immunity determines outcome of Mycobacterium tuberculosis pulmonary infection in rabbits

  2013cites this paper
• Prostaglandin E2-EP3 Axis in Fine-Tuning Excessive Skin Inflammation by Restricting Dendritic Cell Functions

  2013cites this paper
• Transcriptional Profiling of Human Dendritic Cell Populations and Models - Unique Profiles of In Vitro Dendritic Cells and Implications on Functionality and Applicability

  2013cites this paper
• E-type prostanoid receptor 4 (EP4) in disease and therapy

  2013cites this paper
• Transporters and receptors in the posterior segment of the eye

  2013cites this paper
• Oxidative stress potentially enhances FcεRI-mediated leukotriene C4 release dependent on the late-phase increase of intracellular glutathione in mast cells.

  2013cites this paper
• type 2 cells Beta-agonists modulate T-cell functions via direct actions on type 1 and

  2013cites this paper