Receptors and Signaling Mechanisms Required for Prostaglandin E2-Mediated Regulation of Mast Cell Degranulation and IL-6 Production1

No abstract is available for this paper.

• Publication year

  2002

• Venue

  Journal of Immunology

• Publication date

  2002-10-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.4049/jimmunol.169.8.4586PMID 12370397
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Mast cells

  2004cited by this paper
• Prostanoid receptors: subtypes and signaling.

  2001cited by this paper
• The prostaglandin E2 EP1 receptor mediates pain perception and regulates blood pressure.

  2001cited by this paper
• Prostaglandin E2 Selectively Enhances the IgE-Mediated Production of IL-6 and Granulocyte-Macrophage Colony-Stimulating Factor by Mast Cells Through an EP1/EP3-Dependent Mechanism1

  2000influential reference
• Characterization of prostanoid receptors mediating inhibition of histamine release from anti‐IgE‐activated rat peritoneal mast cells

  2000cited by this paper
• Signalling through the high-affinity IgE receptor Fc epsilonRI.

  1999cited by this paper
• Prostanoid receptors: structures, properties, and functions.

  1999influential reference
• The high-affinity IgE receptor (Fc epsilon RI): from physiology to pathology.

  1999cited by this paper
• Signalling through the high-affinity IgE receptor FcεRI

  1999cited by this paper
• The high-affinity IgE receptor (Fc epsilon RI): from physiology to pathology.

  1999cited by this paper
• Reproductive failure and reduced blood pressure in mice lacking the EP2 prostaglandin E2 receptor.

  1999cited by this paper
• Urinary concentrating function in mice lacking EP3 receptors for prostaglandin E2.

  1998cited by this paper
• Urinary concentrating function in mice lacking EP3 receptors for prostaglandin E2.

  1998cited by this paper
• Regulation of human mast cell and basophil function by cAMP.

  1998cited by this paper
• Mast cells.

  1997cited by this paper
• Three isoforms of the prostaglandin E receptor EP3 subtype different in agonist-independent constitutive Gi activity and agonist-dependent Gs activity.

  1997cited by this paper
• The prostaglandin receptor EP4 triggers remodelling of the cardiovascular system at birth

  1997cited by this paper
• Identification of prostaglandin E receptor ‘EP2’ cloned from mastocytoma cells as EP4 subtype

  1995cited by this paper
• Prostanoid enhancement of interleukin-6 production by rat peritoneal mast cells.

  1995cited by this paper
• Mouse prostaglandin E receptor EP3 subtype mediates calcium signals via Gi in cDNA-transfected Chinese hamster ovary cells.

  1994cited by this paper
• Signal transduction by Fc receptors: the Fc epsilon RI case.

  1993cited by this paper
• Characterization of the prostaglandin E receptor expressed on a cultured mast cell line, BNu-2cl3.

  1993cited by this paper
• Characterization of the prostaglandin E receptor expressed on a cultured mast cell line, BNu-2c13

  1993cited by this paper
• Cloning and expression of a cDNA for mouse prostaglandin E receptor EP2 subtype.

  1993cited by this paper
• Cloning and expression of cDNA for a mouse EP1 subtype of prostaglandin E receptor.

  1993cited by this paper
• Third isoform of the prostaglandin-E-receptor EP3 subtype with different C-terminal tail coupling to both stimulation and inhibition of adenylate cyclase.

  1993cited by this paper
• Signal transduction by Fc receptors: the Fc&RI case

  1993cited by this paper
• Prostaglandins inhibit inflammatory mediator release from rat mast cells.

  1993cited by this paper
• Release of 15-hydroxyeicosatetraenoic acid (15-HETE) and prostaglandin E2 (PGE2) by cultured human bronchial epithelial cells.

  1989cited by this paper
• Regulation of human basophil and lung mast cell function by cyclic adenosine monophosphate.

  1988cited by this paper
• A new generation of Ca2+ indicators with greatly improved fluorescence properties.

  1985cited by this paper
• The mechanism of the calcium signal and correlation with histamine release in 2H3 cells.

  1984cited by this paper
• Long-term in vitro culture of murine mast cells. I. Description of a growth factor-dependent culture technique.

  1981cited by this paper
• Metabolism of arachidonic acid in rabbit alveolar macrophages

  1977cited by this paper
• The effect of anti-inflammatory agents on human synovial fibroblast prostaglandin synthetase.

  1976cited by this paper
• Cyclic AMP, ATP, and reversed anaphylactic histamine release from rat mast cells.

  1974cited by this paper

• The role of prostanoids in regulatory T cells and their implications in inflammatory diseases and cancers.

  2025cites this paper
• Acetylsalicylic acid aggravates anaphylaxis in a PGE2-dependent manner

  2025cites this paper
• Oxytocin Attenuates Sympathetic Innervation with Inhibition of Cardiac Mast Cell Degranulation in Rats after Myocardial Infarction

  2024cites this paper
• Carnosic acid inhibits secretion of allergic inflammatory mediators in IgE-activated mast cells via direct regulation of Syk activation.

  2023cites this paper
• International Union of Basic and Clinical Pharmacology. CIX. Differences and Similarities between Human and Rodent Prostaglandin E2 Receptors (EP1–4) and Prostacyclin Receptor (IP): Specific Roles in Pathophysiologic Conditions

  2020cites this paper
• The ingenious mast cell: Contemporary insights into mast cell behavior and function

  2020cites this paper
• PGE2 deficiency predisposes to anaphylaxis by causing mast cell hyper-responsiveness.

  2020cites this paper
• TAK1 signaling activity links the mast cell cytokine response and degranulation in allergic inflammation

  2020cites this paper
• mDia1 coordinates mast cell migration and secretion through its actin nucleating activity.

  2019cites this paper
• Genomic and transcriptomic comparison of allergen and silver nanoparticle-induced mast cell degranulation reveals novel non-immunoglobulin E mediated mechanisms

  2018cites this paper
• Assessment of the effects of rosemary extract on mast cell-mediated allergic inflammation

  2018cites this paper
• Meloxicam Improves Cognitive Impairment of Diabetic Rats through COX2-PGE2-EPs-cAMP/pPKA Pathway.

  2018cites this paper
• Changing the threshold—Signals and mechanisms of mast cell priming

  2018cites this paper
• TNFα Increases RANKL Expression via PGE2-Induced Activation of NFATc1

  2017cites this paper
• Frontline Science: Corticotropin‐releasing factor receptor subtype 1 is a critical modulator of mast cell degranulation and stress‐induced pathophysiology

  2017cites this paper
• Inhibition of allergen-mediated mast cell activation by TAK1 inhibitor 5Z-7-oxozeaenol

  2017cites this paper
• Mast Cells in Allergy, Host Defense, and Immune Regulation

  2016cites this paper
• Prostaglandin E 2-mediated inhibition of antitumor CTL responses

  2016cites this paper
• Leukotriene D4 and prostaglandin E2 signals synergize and potentiate vascular inflammation in a mast cell-dependent manner through cysteinyl leukotriene receptor 1 and E-prostanoid receptor 3.

  2016cites this paper
• Human Mesenchymal Stem Cell‐Derived Microvesicles Prevent the Rupture of Intracranial Aneurysm in Part by Suppression of Mast Cell Activation via a PGE2‐Dependent Mechanism

  2016cites this paper
• IFNγ-Dependent Interactions between ICAM-1 and LFA-1 Counteract Prostaglandin E2–Mediated Inhibition of Antitumor CTL Responses

  2016cites this paper
• Mast Cell: A Multi-Functional Master Cell

  2016cites this paper
• The Role of Macrophage Migration Inhibitory Factor in Mast Cell-Stimulated Fibroblast Proliferation and Collagen Production

  2015cites this paper
• The PGE2-EP2-mast cell axis: an antiasthma mechanism.

  2015cites this paper
• Dynamic model of eicosanoid production with special reference to non-steroidal anti-inflammatory drug-triggered hypersensitivity.

  2015cites this paper
• IgE Antibodies: Generation and Function

  2015cites this paper
• New insights on the signaling and function of the high-affinity receptor for IgE.

  2015cites this paper
• Efeitos da MT-I, uma fosfolipase A2, isolada do veneno de Bothrops asper em mastócitos: ativação e sinalização intracelular envolvida na desgranulação.

  2015cites this paper
• The role of mast cells in ischemia and reperfusion injury

  2014cites this paper
• COX‐2 inhibitors arrest prostate cancer cell cycle progression by down‐regulation of kinetochore/centromere proteins

  2014cites this paper
• Role of the prostaglandin E2/E-prostanoid 2 receptor signalling pathway in TGFβ-induced mice mesangial cell damage

  2014cites this paper
• IgE receptor-mediated mast-cell renin release.

  2014cites this paper
• A Maladaptive Role for EP4 Receptors in Mouse Mesangial Cells

  2014cites this paper
• Gs-Coupled Adenosine Receptors Differentially Limit Antigen-Induced Mast Cell Activation

  2013cites this paper
• Tumor-associated stromal cells expressing E-prostanoid 2 or 3 receptors in prostate cancer: correlation with tumor aggressiveness and outcome by angiogenesis and lymphangiogenesis.

  2013cites this paper
• Locally administered prostaglandin E2 prevents aeroallergen-induced airway sensitization in mice through immunomodulatory mechanisms.

  2013cites this paper
• Editorial: Yin‐Yang of EP receptor expression

  2012cites this paper
• PGE2 produced by the lung augments the effector phase of allergic inflammation

  2012cites this paper
• This information is current as Inflammation Augments the Effector Phase of Allergic Produced by the Lung 2 Prostaglandin E

  2012cites this paper
• The contribution of prostanoids to allergy and lung inflammation

  2012influential citation
• Role of PGE2 in Asthma and Nonasthmatic Eosinophilic Bronchitis

  2012cites this paper
• Selective EP2 agonism attenuates hdm-induced murine airway pathology and mast cell activity, and triggers intracellular inhibitory signaling in mast cells

  2012influential citation
• E‐prostanoid 2 receptors dampen mast cell degranulation via cAMP/PKA‐mediated suppression of IgE‐dependent signaling

  2012cites this paper
• Prostaglandin E2 Produced by the Lung Augments the Effector Phase of Allergic Inflammation

  2012cites this paper
• Editorial: Space flight modifies T cell activation—role of microgravity

  2012cites this paper
• The Role of Prostanoids in Atopic Dermatitis

  2012cites this paper
• Discrepancy between strong cephalic arterial dilatation and mild headache caused by prostaglandin D2 (PGD2)

  2011cites this paper
• Induction of integrin β3 in PGE₂-stimulated adhesion of mastocytoma P-815 cells to the Arg-Gly-Asp-enriched fragment of fibronectin.

  2011cites this paper
• Bone marrow stromal cells inhibit mast cell function via a COX2‐dependent mechanism

  2011cites this paper
• Regulation of mast cell responses in health and disease.

  2011cites this paper
• Distinct PGE2-responder and non-responder phenotypes in human mast cell populations: "all or nothing" enhancement of antigen-dependent mediator release.

  2011cites this paper
• Emerging strategies to preserve renal function.

  2011cites this paper
• Inhibitory effect of Mori Cortex Radicis, Farfarae Flos and Asteris Radix extracts on release of inflammatory mediators in LPS-induced HMC-1 cells

  2011cites this paper
• International Union of Basic and Clinical Pharmacology. LXXXIII: Classification of Prostanoid Receptors, Updating 15 Years of Progress

  2011influential citation
• Regulators of Ca(2+) signaling in mast cells: potential targets for treatment of mast cell-related diseases?

  2011cites this paper
• Prostaglandina E2 en la activación osmótica inducida por manitol en el mastocito

  2011cites this paper
• IL-4 Amplifies the Pro-Inflammatory Effect of Adenosine in Human Mast Cells by Changing Expression Levels of Adenosine Receptors

  2011cites this paper
• Analysis of Two Major Intracellular Phospholipases A2 (PLA2) in Mast Cells Reveals Crucial Contribution of Cytosolic PLA2α, Not Ca2+-independent PLA2β, to Lipid Mobilization in Proximal Mast Cells and Distal Fibroblasts*

  2011cites this paper
• Human embryonic stem cells: a source of mast cells for the study of allergic and inflammatory diseases.

  2010influential citation
• Prostanoid receptors as possible targets for anti-allergic drugs: recent advances in prostanoids on allergy and immunology.

  2010cites this paper
• Prostaglandin E2 Activates and Utilizes mTORC2 as a Central Signaling Locus for the Regulation of Mast Cell Chemotaxis and Mediator Release*

  2010cites this paper
• Prostaglandin E2 Receptor EP2, EP3, and EP4 Agonists Inhibit Antigen-Induced Mucus Hypersecretion in the Nasal Epithelium of Sensitized Rats

  2009cites this paper
• Prostaglandin E(2)-EP(3) signaling suppresses skin inflammation in murine contact hypersensitivity.

  2009cites this paper
• PGE2 Signaling Through the EP4 Receptor on Fibroblasts Upregulates RANKL and Stimulates Osteolysis

  2009cites this paper
• Subcutaneous Prostaglandin E2 Restrains Airway Mast Cell Activity in vivo and Reduces Lung Eosinophilia and Th2 Cytokine Overproduction in House Dust Mite-Sensitive Mice

  2009cites this paper
• Murine bone marrow-derived mast cells express chemoattractant receptor-homologous molecule expressed on T-helper class 2 cells (CRTh2).

  2009cites this paper
• Suppression of immunoglobulin E–mediated allergic responses by regulator of G protein signaling 13

  2008cites this paper
• Essential role of EP3 subtype in prostaglandin E2-induced adhesion of mouse cultured and peritoneal mast cells to the Arg-Gly-Asp-enriched matrix.

  2008cites this paper
• Engagement of the EP2 prostanoid receptor closes the K+ channel KCa3.1 in human lung mast cells and attenuates their migration

  2008cites this paper
• Synergistic activation of phospholipases Cgamma and Cbeta: a novel mechanism for PI3K-independent enhancement of FcepsilonRI-induced mast cell mediator release.

  2008cites this paper
• Fatty acid-binding protein regulates LPS-induced TNF-alpha production in mast cells.

  2008cites this paper
• Prostaglandin F(2alpha) regulates cytokine responses of mast cells through the receptors for prostaglandin E.

  2008cites this paper
• Eicosanoids in asthma, allergic inflammation, and host defense.

  2008cites this paper
• Effect of IL-1 and gustducin expression change on bitter taste during fever

  2008cites this paper
• 15 E Prostanoid Receptors in Brain Physiology and Disease

  2008cites this paper
• G protein-coupled receptors and the modification of FcepsilonRI-mediated mast cell activation.

  2007cites this paper
• G Protein-coupled receptors and the modification of FcεRI-mediated mast cell activation

  2007influential citation
• Enhanced mast cell activation in mice deficient in the A2b adenosine receptor

  2007cites this paper
• Chemotactic action of prostaglandin E2 on mouse mast cells acting via the PGE2 receptor 3

  2007cites this paper
• Prostaglandin E2 is required for ultraviolet B-induced skin inflammation via EP2 and EP4 receptors

  2007cites this paper
• Enhanced mast cell activation in mice deficient in the A2b adenosine receptor

  2007cites this paper
• Mast cells and eicosanoid mediators: a system of reciprocal paracrine and autocrine regulation

  2007cites this paper
• Regulation of mast cell development by inflammatory factors.

  2007cites this paper
• The potential of selected prostanoid receptors as targets in a new therapeutic strategy for allergy and immune diseases.

  2007cites this paper
• Roles of prostaglandin D2 and prostaglandin E2 in allergic reactions: pro-allergic and anti-allergic modulating pathways

  2006cites this paper
• Involvement of cyclooxygenase-2 and prostaglandins in the molecular pathogenesis of inflammatory lung diseases.

  2006cites this paper
• Human mast cells express multiple EP receptors for prostaglandin E2 that differentially modulate activation responses.

  2006cites this paper
• A new cardiac MASTer switch for the renin-angiotensin system.

  2006cites this paper
• Prostaglandin E2 activates EP2 receptors to inhibit human lung mast cell degranulation

  2006cites this paper
• Prostaglandin E2 promotes degranulation‐independent release of MCP‐1 from mast cells

  2006influential citation
• Cardiomyopathy in dystrophin-deficient hearts is prevented by expression of a neuronal nitric oxide synthase transgene in the myocardium.

  2005cites this paper
• Suppression of allergic inflammation by the prostaglandin E receptor subtype EP3

  2005cites this paper
• Fibroblasts Express RANKL and Support Osteoclastogenesis in a COX‐2‐Dependent Manner After Stimulation With Titanium Particles

  2005cites this paper
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  2005cites this paper
• The impact of eicosanoids on the crosstalk between innate and adaptive immunity: the key roles of dendritic cells.

  2005cites this paper
• Age-Induced Reprogramming of Mast Cell Degranulation1

  2005cites this paper
• Einfluß des Cyclooxygenase-2-Inhibitors NS-398 auf Proliferation und Apoptose von Ovarialkarzinomzellinien

  2005cites this paper
• Oxygenation by COX-2 (cyclo-oxygenase-2) of 3-HETE (3-hydroxyeicosatetraenoic acid), a fungal mimetic of arachidonic acid, produces a cascade of novel bioactive 3-hydroxyeicosanoids.

  2005cites this paper
• Tendinosis and Tendon Regeneration: Roles of Apoptosis and Insulin-like Growth Factor- I

  2005cites this paper
• Evaluation of Selective Prostaglandin E2 (PGE2) Receptor Agonists as Therapeutic Agents for the Treatment of Asthma

  2005cites this paper