Anthrax toxins.

No abstract is available for this paper.

• Publication year

  2004

• Venue

  Reviews of Physiology, Biochemistry and Pharmacology

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1007/s10254-004-0028-2PMID 15549606
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Selective inhibition of anthrax edema factor by adefovir, a drug for chronic hepatitis B virus infection.

  2004cited by this paper
• Crystal structure of the von Willebrand factor A domain of human capillary morphogenesis protein 2: an anthrax toxin receptor.

  2004cited by this paper
• Identification of small molecule inhibitors of anthrax lethal factor

  2004cited by this paper
• Anthrax Lethal Toxin Induces Human Endothelial Cell Apoptosis

  2004cited by this paper
• The roles of anthrax toxin in pathogenesis.

  2004cited by this paper
• Lethality during continuous anthrax lethal toxin infusion is associated with circulatory shock but not inflammatory cytokine or nitric oxide release in rats.

  2004cited by this paper
• The structural basis for substrate and inhibitor selectivity of the anthrax lethal factor

  2004cited by this paper
• Treatment of anthrax infection with combination of ciprofloxacin and antibodies to protective antigen of Bacillus anthracis.

  2004cited by this paper
• Intracellular calcium antagonist protects cultured peritoneal macrophages against anthrax lethal toxin-induced cytotoxicity

  2004cited by this paper
• Protection against Anthrax Toxemia by Hexa-d-Arginine In Vitro and In Vivo

  2004cited by this paper
• Systemic cytokine response in murine anthrax

  2004cited by this paper
• Cutting Edge: Anthrax Lethal Toxin Inhibits Activation of IFN-Regulatory Factor 3 by Lipopolysaccharide 1

  2004cited by this paper
• TEM8 interacts with the cleaved C5 domain of collagen alpha 3(VI).

  2004cited by this paper
• The Metalloproteolytic Activity of the Anthrax Lethal Factor Is Substrate-inhibited*

  2003cited by this paper
• Toxin-induced resistance in Bacillus anthracis lethal toxin-treated macrophages

  2003cited by this paper
• Poly(γ-d-glutamic acid) protein conjugates induce IgG antibodies in mice to the capsule of Bacillus anthracis: A potential addition to the anthrax vaccine

  2003cited by this paper
• Exchange characteristics of calcium ions bound to anthrax protective antigen.

  2003cited by this paper
• Human capillary morphogenesis protein 2 functions as an anthrax toxin receptor

  2003cited by this paper
• The crystal structure of the proprotein processing proteinase furin explains its stringent specificity

  2003cited by this paper
• Anthrax Lethal Factor Proteolysis and Inactivation of MAPK Kinase*

  2003cited by this paper
• Decreased glycogen synthase kinase 3‐beta levels and related physiological changes in Bacillus anthracis lethal toxin‐treated macrophages

  2003cited by this paper
• The Host Cell Chaperone Hsp90 Is Essential for Translocation of the Binary Clostridium botulinum C2 Toxin into the Cytosol*

  2003cited by this paper
• Mapping dominant-negative mutations of anthrax protective antigen by scanning mutagenesis

  2003cited by this paper
• Sensitizing Anthrax Lethal Toxin-resistant Macrophages to Lethal Toxin-induced Killing by Tumor Necrosis Factor-α*

  2003cited by this paper
• Susceptibility to anthrax lethal toxin is controlled by three linked quantitative trait loci.

  2003cited by this paper
• Alanine-scanning Mutations in Domain 4 of Anthrax Toxin Protective Antigen Reveal Residues Important for Binding to the Cellular Receptor and to a Neutralizing Monoclonal Antibody*

  2003cited by this paper
• Structure-based Inhibitor Discovery against Adenylyl Cyclase Toxins from Pathogenic Bacteria That Cause Anthrax and Whooping Cough*

  2003cited by this paper
• The cytosolic entry of diphtheria toxin catalytic domain requires a host cell cytosolic translocation factor complex

  2003cited by this paper
• The history of anthrax.

  2003cited by this paper
• Anthrax toxin triggers endocytosis of its receptor via a lipid raft–mediated clathrin-dependent process

  2003cited by this paper
• Cell Surface Tumor Endothelium Marker 8 Cytoplasmic Tail-independent Anthrax Toxin Binding, Proteolytic Processing, Oligomer Formation, and Internalization*

  2003cited by this paper
• Translocation of botulinum neurotoxin light chain protease through the heavy chain channel

  2003cited by this paper
• Potent antitumor activity of a urokinase-activated engineered anthrax toxin

  2003cited by this paper
• Anthrax lethal factor represses glucocorticoid and progesterone receptor activity

  2003cited by this paper
• Anthrax toxin.

  2003cited by this paper
• Human antibodies from immunized donors are protective against anthrax toxin in vivo

  2003cited by this paper
• A dually active anthrax vaccine that confers protection against both bacilli and toxins

  2003cited by this paper
• Fluorescence resonance energy transfer studies on anthrax lethal toxin

  2003cited by this paper
• Impairment of dendritic cells and adaptive immunity by anthrax lethal toxin

  2003cited by this paper
• Anthrax toxins and the host: a story of intimacy

  2003cited by this paper
• Bacillus anthracis lethal toxin induces TNF-alpha-independent hypoxia-mediated toxicity in mice.

  2003cited by this paper
• Binding of Anthrax Toxin to Its Receptor Is Similar to α Integrin-Ligand Interactions*

  2003cited by this paper
• Conformational fluctuations in anthrax protective antigen: a possible role of calcium in the folding pathway of the protein

  2003cited by this paper
• Protection against anthrax toxin by recombinant antibody fragments correlates with antigen affinity

  2002cited by this paper
• Identification of Amino Acid Residues of Anthrax Protective Antigen Involved in Binding with Lethal Factor

  2002cited by this paper
• The lethal and edema factors of anthrax toxin bind only to oligomeric forms of the protective antigen

  2002cited by this paper
• Structural basis for the activation of anthrax adenylyl cyclase exotoxin by calmodulin

  2002cited by this paper
• Effect of Bacillus anthracis lethal toxin on human peripheral blood mononuclear cells

  2002cited by this paper
• Pharmacology: Screening inhibitors of anthrax lethal factor

  2002cited by this paper
• Calyculin A Sensitive Protein Phosphatase Is Required for Bacillus anthracis Lethal Toxin Induced Cytotoxicity

  2002cited by this paper
• The alveolar macrophage: the Trojan horse of Bacillus anthracis.

  2002cited by this paper
• Macrophage Apoptosis by Anthrax Lethal Factor Through p38 MAP Kinase Inhibition

  2002cited by this paper
• Mapping the lethal factor and edema factor binding sites on oligomeric anthrax protective antigen

  2002cited by this paper
• TNF receptor 1, IL-1 receptor, and iNOS genetic knockout mice are not protected from anthrax infection.

  2002cited by this paper
• PA63 channel of anthrax toxin: an extended beta-barrel.

  2002cited by this paper
• A Recombinant Carboxy-Terminal Domain of the Protective Antigen of Bacillus anthracis Protects Mice against Anthrax Infection

  2002cited by this paper
• Efficiency of Protection of Guinea Pigs against Infection with Bacillus anthracis Spores by Passive Immunization

  2002cited by this paper
• Anthrax Spores Make an Essential Contribution to Vaccine Efficacy

  2002cited by this paper
• Mapping the Anthrax Protective Antigen Binding Site on the Lethal and Edema Factors*

  2002cited by this paper
• Bacillus anthracis genetics and virulence gene regulation.

  2002cited by this paper
• Introduction: anthrax history, disease and ecology.

  2002cited by this paper
• Structure and function of anthrax toxin.

  2002cited by this paper
• Lethal toxin of Bacillus anthracis causes apoptosis of macrophages.

  2002cited by this paper
• Discovery of the anthrax toxin: the beginning of studies of virulence determinants regulated in vivo.

  2002cited by this paper
• Stoichiometry of anthrax toxin complexes.

  2002cited by this paper
• Anthrax vaccines.

  2002cited by this paper
• A peptide-based fluorescence resonance energy transfer assay for Bacillus anthracis lethal factor protease

  2002cited by this paper
• Anthrax toxin: a tripartite lethal combination1

  2002cited by this paper
• Targeting of Tumor Cells by Cell Surface Urokinase Plasminogen Activator-dependent Anthrax Toxin*

  2001cited by this paper
• Involvement of Domain 3 in Oligomerization by the Protective Antigen Moiety of Anthrax Toxin

  2001cited by this paper
• Kif1C, a kinesin-like motor protein, mediates mouse macrophage resistance to anthrax lethal factor.

  2001cited by this paper
• Bioterrorism-related inhalational anthrax: the first 10 cases reported in the United States.

  2001cited by this paper
• Macrophage-Derived Cell Lines Do Not Express Proinflammatory Cytokines after Exposure to Bacillus anthracis Lethal Toxin

  2001cited by this paper
• Fate of germinated Bacillus anthracis spores in primary murine macrophages

  2001cited by this paper
• Point Mutations in Anthrax Protective Antigen That Block Translocation*

  2001cited by this paper
• Dominant-Negative Mutants of a Toxin Subunit: An Approach to Therapy of Anthrax

  2001cited by this paper
• Designing a polyvalent inhibitor of anthrax toxin

  2001cited by this paper
• Suppression of ras-mediated transformation and inhibition of tumor growth and angiogenesis by anthrax lethal factor, a proteolytic inhibitor of multiple MEK pathways

  2001cited by this paper
• Crystal structure of the anthrax lethal factor

  2001cited by this paper
• Identification of the cellular receptor for anthrax toxin

  2001cited by this paper
• Protective Antigen-Mediated Antibody Response against a Heterologous Protein Produced In Vivo by Bacillus anthracis

  2000cited by this paper
• Genetically modified anthrax lethal toxin safely delivers whole HIV protein antigens into the cytosol to induce T cell immunity.

  2000cited by this paper
• Early Bacillus anthracis-macrophage interactions: intracellular survival survival and escape.

  2000cited by this paper
• Proteolytic activation of receptor‐bound anthrax protective antigen on macrophages promotes its internalization

  2000cited by this paper
• Anthrax Toxin Entry into Polarized Epithelial Cells

  1999cited by this paper
• Anthrax lethal factor cleaves MKK3 in macrophages and inhibits the LPS/IFNgamma-induced release of NO and TNFalpha.

  1999cited by this paper
• Activation of phospholipase C and protein kinase C is required for expression of anthrax lethal toxin cytotoxicity in J774A.1 cells.

  1999cited by this paper
• Identification of a Receptor-Binding Region within Domain 4 of the Protective Antigen Component of Anthrax Toxin

  1999cited by this paper
• Translocation of the catalytic domain of diphtheria toxin across planar phospholipid bilayers by its own T domain.

  1999cited by this paper
• Clinical aspects, diagnosis and treatment of anthrax

  1999cited by this paper
• Proteasome Activity Is Required for Anthrax Lethal Toxin To Kill Macrophages

  1999cited by this paper
• Functional Analysis of the Carboxy-Terminal Domain of Bacillus anthracis Protective Antigen

  1999cited by this paper
• Anthrax protective antigen: prepore-to-pore conversion.

  1999cited by this paper
• Identification of residues lining the anthrax protective antigen channel.

  1998cited by this paper
• Anthrax lethal factor cleaves the N-terminus of MAPKKs and induces tyrosine/threonine phosphorylation of MAPKs in cultured macrophages.

  1998cited by this paper
• Proteolytic inactivation of MAP-kinase-kinase by anthrax lethal factor.

  1998cited by this paper
• Characterization of membrane translocation by anthrax protective antigen.

  1998cited by this paper
• Structure and interaction of PA63 and EF (edema toxin) of Bacillus anthracis with lipid membrane.

  1997cited by this paper
• Passive protection by polyclonal antibodies against Bacillus anthracis infection in guinea pigs

  1997cited by this paper
• Crystal structure of the anthrax toxin protective antigen

  1997cited by this paper

• Genomic adaptability and virulence of Bacillus anthracis: a machine learning-based pan-genome and comparative analysis

  2026cites this paper
• Development and evaluation of recombinant protective antigen (rPA)-based indirect-ELISA for sero-monitoring of anthrax-specific antibodies in sheep.

  2026cites this paper
• Dachshund Homolog 1: Unveiling Its Potential Role in Megakaryopoiesis and Bacillus anthracis Lethal Toxin-Induced Thrombocytopenia

  2024cites this paper
• Hydrogen-Deuterium Exchange Mass Spectrometry Reveals a Novel Binding Region of a Neutralizing Fully Human Monoclonal Antibody to Anthrax Protective Antigen

  2022cites this paper
• Insufficient Anthrax Lethal Toxin Neutralization Is Associated with Antibody Subclass and Domain Specificity in the Plasma of Anthrax-Vaccinated Individuals

  2021influential citation
• Nanopore Fabrication and Application as Biosensors in Neurodegenerative Diseases.

  2020cites this paper
• Toxigence of anthrax vaccine strains

  2020cites this paper
• Two approaches for the stabilization of Bacillus anthracis recombinant protective antigen

  2020cites this paper
• Repeat-Dose Toxicity Study of a Lyophilized Recombinant Protective Antigen-Based Anthrax Vaccine Adjuvanted With CpG 7909

  2019cites this paper
• Bacterial Therapeutics

  2019cites this paper
• Calmodulin as a protein linker and a regulator of adaptor/scaffold proteins.

  2018cites this paper
• Simultaneous Immunodetection of Anthrax, Plague, and Tularemia from Blood Cultures by Use of Multiplexed Suspension Arrays

  2018cites this paper
• Immunogenicity of anthrax recombinant peptides and killed spores in goats and protective efficacy of immune sera in A/J mouse model

  2018cites this paper
• Comparative analysis of the immunologic response induced by the Sterne 34F2 live spore Bacillus anthracis vaccine in a ruminant model.

  2016cites this paper
• Effects of metalloprotease anthrax lethal factor on its peptide-based inhibitor R9LF-1

  2015cites this paper
• Efficacy of ETI-204 Monoclonal Antibody as an Adjunct Therapy in a New Zealand White Rabbit Partial Survival Model for Inhalational Anthrax

  2015cites this paper
• Residues involved in the pore‐forming activity of the Clostridium perfringens iota toxin

  2015cites this paper
• Antitoxin Treatment of Inhalation Anthrax: A Systematic Review

  2015cites this paper
• Advances in Anthrax Detection: Overview of Bioprobes and Biosensors

  2015cites this paper
• Erythrocytic Mobilization Enhanced by the Granulocyte Colony-Stimulating Factor Is Associated with Reduced Anthrax-Lethal-Toxin-Induced Mortality in Mice

  2014cites this paper
• RAB11-mediated trafficking in host–pathogen interactions

  2014cites this paper
• RAB 11 ‐ mediated trafficking in host – pathogen interactions

  2014cites this paper
• Vector-Mediated Selective Expression of Lethal Factor, a Toxic Element of Bacillus Anthracis, Damages A549 Cells via Inhibition of MAPK and AKT Pathways

  2013cites this paper
• A Single-Dose PLGA Encapsulated Protective Antigen Domain 4 Nanoformulation Protects Mice against Bacillus anthracis Spore Challenge

  2013cites this paper
• Secretory expression and efficient purification of recombinant anthrax toxin lethal factor with full biological activity in E. coli.

  2013cites this paper
• Erythropoiesis Suppression Is Associated with Anthrax Lethal Toxin-Mediated Pathogenic Progression

  2013cites this paper
• Mechanisms of NK Cell-Macrophage Bacillus anthracis Crosstalk: A Balance between Stimulation by Spores and Differential Disruption by Toxins

  2012cites this paper
• Effects by anthrax toxins on hematopoiesis: a key role for cytokines as mediators.

  2012cites this paper
• Inhibition of anthrax lethal factor: lability of hydroxamate as a chelating group

  2012cites this paper
• Human monoclonal antibodies generated following vaccination with AVA provide neutralization by blocking furin cleavage but not by preventing oligomerization.

  2012cites this paper
• New aspects of the infection mechanisms of Bacillus anthracis.

  2012influential citation
• New insights into the biological effects of anthrax toxins: linking cellular to organismal responses.

  2012cites this paper
• Deconstructing host-pathogen interactions in Drosophila

  2011cites this paper
• Anthrax vaccination induced anti-lethal factor IgG: fine specificity and neutralizing capacity.

  2011cites this paper
• Hemodynamic Effects of Anthrax Toxins in the Rabbit Model and the Cardiac Pathology Induced by Lethal Toxin

  2011cites this paper
• Anthrax Lethal Toxin-Mediated Disruption of Endothelial VE-Cadherin Is Attenuated by Inhibition of the Rho-Associated Kinase Pathway

  2011cites this paper
• Inhibition of anthrax toxins with a bispecific monoclonal antibody that cross reacts with edema factor as well as lethal factor of Bacillus anthracis.

  2011cites this paper
• Contribution of Lethal Toxin and Edema Toxin to the Pathogenesis of Anthrax Meningitis

  2011cites this paper
• Anthrax toxins cooperatively inhibit endocytic recycling by the Rab11/Sec15 exocyst

  2010cites this paper
• Aerosolized Bacillus anthracis infection in New Zealand white rabbits: natural history and intravenous levofloxacin treatment.

  2010cites this paper
• Anthrax Lethal Toxin Impairs CD1d-Mediated Antigen Presentation by Targeting the Extracellular Signal-Related Kinase 1/2 Mitogen-Activated Protein Kinase Pathway

  2010cites this paper
• Select human anthrax protective antigen epitope-specific antibodies provide protection from lethal toxin challenge.

  2010cites this paper
• Factor-1-Dependent Mechanism Expression via an IFN Regulatory TNF-Induced Endothelial VCAM-1 Anthrax Lethal Toxin Enhances

  2010cites this paper
• Anthrax Lethal Toxin Enhances IκB Kinase Activation and Differentially Regulates Pro-inflammatory Genes in Human Endothelium*

  2009cites this paper
• Involvement of TLR2 in innate response to Bacillus anthracis infection

  2009cites this paper
• The physiologic responses of Dutch belted rabbits infected with inhalational anthrax.

  2009cites this paper
• The inhibition of the interaction between the anthrax toxin and its cellular receptor by an anti-receptor monoclonal antibody.

  2009cites this paper
• Anti-toxin antibodies in prophylaxis and treatment of inhalation anthrax.

  2009cites this paper
• Synthesis and assembly of a full‐length human monoclonal antibody in algal chloroplasts

  2009cites this paper
• Efficacy of a Vaccine Based on Protective Antigen and Killed Spores against Experimental Inhalational Anthrax

  2008cites this paper
• Identification of a Surrogate Marker for Infection in the African Green Monkey Model of Inhalation Anthrax

  2008cites this paper
• The Cytoplasmic Domain of Anthrax Toxin Receptor 1 Affects Binding of the Protective Antigen

  2008cites this paper
• Chimeric hepatitis B virus core particles carrying an epitope of anthrax protective antigen induce protective immunity against Bacillus anthracis.

  2008cites this paper
• Role of N-Terminal Amino Acids in the Potency of Anthrax Lethal Factor

  2008cites this paper
• Inactivation of Rho GTPases by Statins Attenuates Anthrax Lethal Toxin Activity

  2008cites this paper
• Transcriptional profiling of murine organ genes in response to infection with Bacillus anthracis Ames spores.

  2008cites this paper
• Both CD4+ and CD8+ T Cells Respond to Antigens Fused to Anthrax Lethal Toxin

  2008cites this paper
• Suppression of Dendritic Cell Activation by Anthrax Lethal Toxin and Edema Toxin Depends on Multiple Factors Including Cell Source, Stimulus Used, and Function Tested

  2008cites this paper
• A fluorimetric assay for real-time monitoring of adenylyl cyclase activity based on terbium norfloxacin.

  2008cites this paper
• Selection and characterization of human antibodies neutralizing Bacillus anthracis toxin.

  2008cites this paper
• In vivo secretome sampling technology for proteomics

  2007cites this paper
• Antigen Delivered by Anthrax Lethal Toxin Induces the Development of Memory CD8+ T Cells That Can Be Rapidly Boosted and Display Effector Functions

  2007cites this paper
• Anthrax Edema Toxin Sensitizes DBA/2J Mice to Lethal Toxin

  2007cites this paper
• Technological advancements for the detection of and protection against biological and chemical warfare agents.

  2007cites this paper
• Expression of furin-linked Fab fragments against anthrax toxin in a single mammalian expression vector.

  2007cites this paper
• Self-association of the transmembrane domain of an anthrax toxin receptor.

  2006cites this paper
• Anthrax lethal factor and edema factor act on conserved targets in Drosophila.

  2006cites this paper
• Fighting anthrax with flies.

  2006cites this paper
• Protective Antigen as a Correlative Marker for Anthrax in Animal Models

  2006cites this paper
• Bacillus anthracis: interactions with the host and establishment of inhalational anthrax.

  2006cites this paper
• Peptide inhibitors MAP the way towards fighting anthrax pathogenesis.

  2006cites this paper
• Human Monoclonal Anti-Protective Antigen Antibody Completely Protects Rabbits and Is Synergistic with Ciprofloxacin in Protecting Mice and Guinea Pigs against Inhalation Anthrax

  2006cites this paper
• In vitro binding of anthrax protective antigen on bacteriophage T4 capsid surface through Hoc-capsid interactions: a strategy for efficient display of large full-length proteins.

  2006cites this paper
• Immunological Correlates for Protection against Intranasal Challenge of Bacillus anthracis Spores Conferred by a Protective Antigen-Based Vaccine in Rabbits

  2006cites this paper
• The 2beta2-2beta3 loop of anthrax protective antigen contains a dominant neutralizing epitope.

  2006cites this paper
• Inhibition of mitogen‐activated protein kinase signalling by Bacillus anthracis lethal toxin causes destabilization of interleukin‐8 mRNA

  2006cites this paper
• Anthrax lethal toxin enhances cytokine-induced VCAM-1 expression on human endothelial cells.

  2005cites this paper
• Bacillus anthracis edema toxin causes extensive tissue lesions and rapid lethality in mice.

  2005cites this paper