Insulin receptors are widely distributed in the central nervous system of the rat

No abstract is available for this paper.

• Publication year

  1978

• Venue

  Nature

• Publication date

  1978-04-27

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/272827A0PMID 205798
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The insulin receptor of the turkey erythrocyte: similarity to mammalian insulin receptors.

  1977cited by this paper
• The failure of rat hypothalamic tissues to take up labeled insulin in vivo or to respond to insulin in vitro.

  1977cited by this paper
• Insulin Receptors in Cultured Human Fibroblasts

  1976cited by this paper
• Effect of insulin and phenobarbital on uptake of 2‐deoxyglucose by brain slices and hemidiaphragms

  1976cited by this paper
• Influence of the insulin sensitive central nervous system glucoregulator receptor on hepatic glucose metabolism.

  1975cited by this paper
• Neuropharmacological characterization of insulin-sensitive CNS glucoregulator.

  1975cited by this paper
• Effects of insulin injection on responses of olfactory bulb and amygdala single units to odors.

  1975cited by this paper
• Local sites of activity-related glucose metabolism in rat olfactory bulb during olfactory stimulation.

  1975cited by this paper
• Studies on the Nature and Mode of Action of the Insulin-sensitive Glucoregulator Receptor in the Central Nervous System

  1975cited by this paper
• Effect of Intracisternal Insulin on Plasma Glucose and Insulin in the Dog

  1975cited by this paper
• Quantitative aspects of the insulin-receptor interaction in liver plasma membranes.

  1974cited by this paper
• Studies of insulin, growth hormone and prolactin binding: tissue distribution, species variation and characterization.

  1974cited by this paper
• Insulin receptors in human circulating cells and fibroblasts.

  1972cited by this paper
• A direct action of insulin on the hypothalamic satiety center.

  1970cited by this paper
• Rapid effects of insulin on the hypothalamic satiety center.

  1969cited by this paper
• Insulin in the Cerebrospinal Fluid

  1967cited by this paper
• Effect of insulin administered intracisternally on the glucose level of the blood and the cerebrospinal fluid in vagotomized dogs.

  1966cited by this paper
• VISCERAL BRAIN, ITS COMPONENT PARTS AND THEIR CONNECTIONS

  1958cited by this paper

• Antibody Engineering for Receptor-Mediated Transcytosis Across the Blood-Brain Barrier.

  2025cites this paper
• Central cytometabolic functional vascular coupling in health and disease

  2025cites this paper
• Glucose metabolism impairment in major depressive disorder.

  2025cites this paper
• Type 2 Diabetes Mellitus Exacerbates Pathological Processes of Parkinson's Disease: Insights from Signaling Pathways Mediated by Insulin Receptors

  2025cites this paper
• Intranasal insulin enhances postoperative sleep quality and delirium in middle-aged cardiac surgery patients: A randomized controlled trial.

  2025cites this paper
• Understanding glucose metabolism and insulin action at the blood–brain barrier: Implications for brain health and neurodegenerative diseases

  2025cites this paper
• Anle138b improves insulin resistance in mice and its possible signal pathways

  2025cites this paper
• Culprits of Neurodegeneration in Alzheimer’s Diseases: Bench to Bedside Impression

  2025cites this paper
• Sensory Circumventricular Organ Insulin Signaling in Cardiovascular and Metabolic Regulation

  2025cites this paper
• Serum phosphorylated IRS-1 at Ser307 as a potential biomarker of stress-induced depressive-like behavior in rats.

  2025cites this paper
• Potential molecular mechanism of exercise reversing insulin resistance and improving neurodegenerative diseases

  2024cites this paper
• Pharmacological Approaches Using Diabetic Drugs Repurposed for Alzheimer’s Disease

  2024cites this paper
• Metabolic Dysfunction in Parkinson’s Disease: Unraveling the Glucose–Lipid Connection

  2024cites this paper
• The combination treatment of hypothermia and intranasal insulin ameliorates the structural and functional changes in a rat model of traumatic brain injury

  2024cites this paper
• Effect of basal insulin and omega 3 fatty acids on cognitive impairment in dysglycaemia: An exploratory analysis of the ORIGIN trial

  2024cites this paper
• Role of Flavonoids in Mitigating the Pathological Complexities and Treatment Hurdles in Alzheimer's Disease

  2024cites this paper
• İnsülinin Sinaptik Plastisitedeki Rolü: Uzun Dönemli Baskılanma

  2024cites this paper
• Insulin restores retinal ganglion cell functional connectivity and promotes visual recovery in glaucoma

  2024cites this paper
• Insulin-Like Growth Factor Signaling in Alzheimer’s Disease: Pathophysiology and Therapeutic Strategies

  2024cites this paper
• Dysfunction of olfactory structures: A conserved mechanism of neurodegeneration?

  2024cites this paper
• Insulinwirkung im Gehirn als Regulator des Stoffwechsels

  2024cites this paper
• True or False? Alzheimer's disease is Type 3 Diabetes: Evidences from Bench to Bedside.

  2024cites this paper
• Obesogenic diet-induced insulin-resistant rats develop neurobehavioral and memory deficits following bisphenol-A and cadmium co-exposure

  2024cites this paper
• Addressing neurodegeneration in glaucoma: Mechanisms, challenges, and treatments.

  2024cites this paper
• Intranasal insulin increases brain glutathione (GSH) and enhances antioxidant capacity in healthy participants, but not in those with early psychotic disorders.

  2024cites this paper
• Mdm2‐mediated ubiquitination of PKCβII is responsible for insulin‐induced heterologous desensitization of dopamine D3 receptor

  2024cites this paper
• Should We Consider Neurodegeneration by Itself or in a Triangulation with Neuroinflammation and Demyelination? The Example of Multiple Sclerosis and Beyond

  2024cites this paper
• Insulin enhances acid-sensing ion channel currents in rat primary sensory neurons

  2024cites this paper
• The mitochondrial quality control system: a new target for exercise therapeutic intervention in the treatment of brain insulin resistance-induced neurodegeneration in obesity

  2024cites this paper
• The insulin resistant brain: impact on whole-body metabolism and body fat distribution

  2024cites this paper
• The Expression of Insulin in the Central Nervous System: What Have We Learned So Far?

  2023cites this paper
• Hippocampus Insulin Receptors Regulate Episodic and Spatial Memory Through Excitatory/Inhibitory Balance

  2023cites this paper
• Brain Insulin Signaling as A Potential Mediator of Early Life Adversity Effects on Physical and Mental Health.

  2023cites this paper
• Neural Stem Cell-based Regenerative Therapy: A New Approach to Diabetes Treatment.

  2023cites this paper
• Prospects for the Use of Intranasally Administered Insulin and Insulin-Like Growth Factor-1 in Cerebral Ischemia

  2023cites this paper
• Neurotransmitters in Type 2 Diabetes and the Control of Systemic and Central Energy Balance

  2023cites this paper
• Effect of Various Intermittent Fasting Protocols on Hyperglycemia-Induced Cognitive Dysfunction in Rats

  2023cites this paper
• Hot Spots for the Use of Intranasal Insulin: Cerebral Ischemia, Brain Injury, Diabetes Mellitus, Endocrine Disorders and Postoperative Delirium

  2023cites this paper
• Evidence of Disturbed Insulin Signaling in Animal Models of Alzheimer's Disease.

  2023cites this paper
• Metabolic Syndrome as a Risk Factor for Alzheimer’s Disease: A Focus on Insulin Resistance

  2023cites this paper
• Potential Retinal Biomarkers in Alzheimer’s Disease

  2023cites this paper
• Patients with type 1 diabetes and albuminuria have a reduced brain glycolytic capability that is correlated with brain atrophy

  2023cites this paper
• The crucial role and mechanism of insulin resistance in metabolic disease

  2023cites this paper
• Actions and Consequences of Insulin in the Striatum

  2023cites this paper
• Ceramides Mediate Insulin-Induced Impairments in Cerebral Mitochondrial Bioenergetics in ApoE4 Mice

  2023cites this paper
• The complex relationship between obesity and neurodegenerative diseases: an updated review

  2023cites this paper
• Loss of brain energy metabolism control as a driver for memory impairment upon insulin resistance.

  2023cites this paper
• Blockade of endogenous insulin receptor signaling in the nucleus tractus solitarius potentiates exercise pressor reflex function in healthy male rats

  2023cites this paper
• HT22 cell differentiation reduces insulin receptor levels

  2023cites this paper
• AAV5-mediated manipulation of insulin expression in choroid plexus has long-term metabolic and behavioral consequences.

  2023cites this paper
• Metabolic hormones are integral regulators of female reproductive health and function

  2023cites this paper
• Novel Targets and Interventions for Cognitive Complications of Diabetes

  2022cites this paper
• Insulin receptor activation by proinsulin preserves synapses and vision in retinitis pigmentosa

  2022cites this paper
• Insulin replacement prevents the acquisition but not the expression of morphine-induced conditioned place preference in streptozotocin-induced diabetic rats

  2022cites this paper
• Insulin sensitizes neural and vascular TRPV1 receptors in the trigeminovascular system

  2022cites this paper
• Clinical Study of Neurodegenerative Treatment on Glaucoma by Insulin Intravitreal Injection

  2022cites this paper
• Zentralnervöse Prozesse bei der Prävention von Typ-2-Diabetes – Ferdinand-Bertram-Preis 2022 – eine Kurzübersicht der Preisträgerin Stephanie Kullmann

  2022cites this paper
• Prohormone convertase 1/3 deficiency causes obesity due to impaired proinsulin processing

  2022cites this paper
• [The insulin receptor discovery is 50 years old - A review of achieved progress].

  2022cites this paper
• Insulin and Its Key Role for Mitochondrial Function/Dysfunction and Quality Control: A Shared Link between Dysmetabolism and Neurodegeneration

  2022cites this paper
• Intra-NAc insulin reduces the motivation for food and food intake without altering cue-triggered food-seeking

  2022cites this paper
• Systemic and brain delivery of antidiabetic peptides through nasal administration using cell-penetrating peptides

  2022cites this paper
• The ventromedial hypothalamic nucleus: watchdog of whole-body glucose homeostasis

  2022cites this paper
• The PACAP Paradox: Dynamic and Surprisingly Pleiotropic Actions in the Central Regulation of Energy Homeostasis

  2022cites this paper
• Glucose metabolism and AD: evidence for a potential diabetes type 3

  2022cites this paper
• Loss of Microglial Insulin Receptor Leads to Sex-Dependent Metabolic Disorders in Obese Mice

  2022cites this paper
• Vitamin D and rosuvastatin alleviate type-II diabetes-induced cognitive dysfunction by modulating neuroinflammation and canonical/noncanonical Wnt/β-catenin signaling

  2022cites this paper
• Insulin Resistance in the Brain: Evidence Supporting a Role for Inflammation, Reactive Microglia, and the Impact of Biological Sex

  2022cites this paper
• Effects of Nucleus Accumbens Insulin Inactivation on Microstructure of Licking for Glucose and Saccharin in Male and Female Rats.

  2022cites this paper
• Dysmetabolism and Neurodegeneration: Trick or Treat?

  2022cites this paper
• The Effectiveness of Antidiabetic Drugs in Treating Dementia: A Peek into Pharmacological and Pharmacokinetic Properties

  2022cites this paper
• A historical perspective on the interactions of insulin at the blood‐brain barrier

  2021cites this paper
• Expression of glucose transporters in human neurodegenerative diseases.

  2021cites this paper
• Peripheral versus central insulin and leptin resistance: Role in metabolic disorders, cognition, and neuropsychiatric diseases.

  2021cites this paper
• Targeting Insulin Resistance to Treat Cognitive Dysfunction

  2021cites this paper
• Intranasal Insulin for Alzheimer’s Disease

  2021cites this paper
• The crosstalk between brain and periphery: Implications for brain health and disease.

  2021cites this paper
• Central 5-HTR2C in the Control of Metabolic Homeostasis

  2021cites this paper
• Molecular Mechanism of Stimulation of Na-K-ATPase by Leukotriene D4 in Intestinal Epithelial Cells

  2021cites this paper
• Diabetes mellitus and Parkinson’s disease: dangerous liaisons between insulin and dopamine

  2021influential citation
• Central insulin modulates dopamine signaling in the human striatum.

  2021cites this paper
• The infundibular peptidergic neurons and glia cells in overeating, obesity, and diabetes.

  2021cites this paper
• The impact of insulin on the serotonergic system and consequences on diabetes‐associated mood disorders

  2021cites this paper
• Insulin‐degrading enzyme: an ally against metabolic and neurodegenerative diseases

  2021cites this paper
• The Impact of Insulin Resistance on Cardiovascular Control during Exercise in Diabetes.

  2021cites this paper
• Evaluation of Effect of Ninjin'yoeito on Regional Brain Glucose Metabolism by 18F-FDG Autoradiography With Insulin Loading in Aged Mice

  2021cites this paper
• Insulin Signaling as a Therapeutic Target in Glaucomatous Neurodegeneration

  2021cites this paper
• Risk of Alzheimer's disease and environmental bisphenol A exposure

  2021cites this paper
• 食後ホルモンインスリン・GLP-1の求心性迷走神経を介した摂食・糖代謝調節

  2021cites this paper
• Mechanism of Na-K-ATPase Inhibition by PGE2 in Intestinal Epithelial Cells

  2021cites this paper
• Insulin Resistance as a Common Link Between Current Alzheimer’s Disease Hypotheses

  2021cites this paper
• Peptide-Based Strategies for Targeted Tumor Treatment and Imaging

  2021cites this paper
• Central actions of insulin during pregnancy and lactation

  2021cites this paper
• Insulin action on astrocytes: From energy homeostasis to behaviour

  2021cites this paper
• Insulin on the brain: The role of central insulin signalling in energy and glucose homeostasis

  2021cites this paper
• Brain Insulin Resistance: Focus on Insulin Receptor-Mitochondria Interactions

  2021cites this paper
• Insulin differentially modulates GABA signalling in hippocampal neurons and, in an age‐dependent manner, normalizes GABA‐activated currents in the tg‐APPSwe mouse model of Alzheimer’s disease

  2021cites this paper
• Intranasal insulin and orexins to treat age-related cognitive decline.

  2021cites this paper
• Hypothalamic insulin signalling as a nexus regulating mood and metabolism

  2021cites this paper
• Insulin Receptors and Intracellular Ca 2+ Form a Double-Negative Regulatory Feedback Loop Controlling Insulin Sensitivity

  2021cites this paper