Specific binding of antitumour drug cis-Pt(NH3)2Cl2 to DNA rich in guanine and cytosine

No abstract is available for this paper.

• Publication year

  1974

• Venue

  Nature

• Publication date

  1974-10-25

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1038/251736A0PMID 4427676
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Binding of cis- and trans-dichlorodiammineplatinum(II) to nucleosides. I. Location of the binding sites.

  1973cited by this paper
• Cross-linking of Complementary Strands of DNA in Mammalian Cells by Antitumour Platinum Compounds

  1972cited by this paper
• Changes in the hydrodynamic properties of DNA induced by interaction with platinum (II) compounds.

  1972cited by this paper
• Interaction of cis-dichlorodiammineplatinum (II) with DNA.

  1971cited by this paper
• Inhibitory effects of anti‐tumor platinum compounds on DNA, RNA and protein syntheses in mammalian cells in vitro

  1970cited by this paper
• Procedures in nucleic acid research

  1966cited by this paper

• New Au(III)- and Fe(III)-based complexes of bio-pharmacological interest: DFT and in silico studies

  2022cites this paper
• Interference between copper transport systems and platinum drugs.

  2021cites this paper
• Synthesis and Characterization of New Guanine Complexes of Pt(IV) and Pd(II) by X-ray Diffraction and Hirshfeld Surface Analysis

  2021cites this paper
• Platinum drugs, copper transporters and copper chelators

  2018cites this paper
• Structures and Electrical Properties of Some Biologically Active Nucleic Acid Constituents

  2018cites this paper
• The use of Resonant X-ray Emission Spectroscopy (RXES) for the electronic analysis of metal complexes and their interactions with biomolecules.

  2015cites this paper
• DNA binding mode of transition metal complexes, a relationship to tumor cell toxicity.

  2014cites this paper
• Novel in situ methodology to observe the interactions of chemotherapeutical Pt drugs with DNA under physiological conditions.

  2014cites this paper
• Binding of a ruthenium complex to a thioether ligand embedded in a negatively charged lipid bilayer: a two-step mechanism.

  2014cites this paper
• Binding of platinum compounds to nucleic acids with respect to the anti-tumor activity of cis-diamminedichloroplatinum(II) and derivatives†

  2010cites this paper
• Catalytic nanomedicine: a new field in antitumor treatment using supported platinum nanoparticles. In vitro DNA degradation and in vivo tests with C6 animal model on Wistar rats.

  2010cites this paper
• The role of electronic delocalization in transition metal complexes from the electron localization function and the quantum theory of atoms in molecules viewpoints

  2009cites this paper
• Potentiometric studies of ternary complexes involving ethylenediamine N,N′-diacetic acid (EDDA) palladium(II) and some bioligands

  2009cites this paper
• High-performance collection of palladium ions in acidic media using nucleic-acid-base-immobilized porous hollow-fiber membranes

  2008cites this paper
• Amifostine Protective Effect on Cisplatin‐Treated Rat Testis

  2008cites this paper
• Cholesteryl moiety terminated amphiphilic polymethacrylates containing nucleic acid bases for drug delivery

  2007cites this paper
• Metal‐Ion Interactions with Nucleic Acids and Nucleic Acid Derivatives

  2007cites this paper
• Cisplatin Stabilizes a Multimeric Complex of the Human Ctr1 Copper Transporter

  2004cites this paper
• New drugs under clinical evaluation in the United States

  2004cites this paper
• Multiplicity of metal ion binding patterns to nucleobases

  2000cites this paper
• Effects of Disopyramide and Verapamil on Renal Disposition and Nephrotoxicity of Cisplatin in Rats

  1999cites this paper
• APPLICATIONS OF AN ELECTROCHEMICAL DNA-BIOSENSOR TO ENVIRONMENTAL PROBLEMS

  1998cites this paper
• Electrochemical determination of carboplatin in serum using a DNA‐modified glassy carbon electrode

  1996cites this paper
• Mixed-ligand complexes of palladium(II) involving propane 1,2,3-triamine as primary ligand and amino acids, peptides, or DNA units as secondary ligands

  1996cites this paper
• Effects of temperature on the interaction of cisplatin and carboplatin with cellular DNA.

  1993cites this paper
• Sensitization of Resistant Human Tumor Cells to Cisplatin or Carboplatin by Inhibitors of DNA Excision Repair

  1991cites this paper
• Curing of pBR322 and pBR329 plasmids in Escherichia coli by cis-dichlorodiamine platinum(II) chloride (Cis-DDP).

  1991cites this paper
• Treatment of Advanced Refractory Lymphomas with a Combination of Carmustine, Bleomycin, Teniposide, Dexamethasone, and Cisplatin (The BBVDD Regimen)

  1991cites this paper
• Platinum Nucleobase Chemistry

  1991cites this paper
• Inhibition of nucleic acid synthesis in P388 lymphocytic leukemia cells in culture by cis-platinum derivatives.

  1990cites this paper
• Mechanisms of Neurotoxicity and Experimental Models

  1990cites this paper
• Interaction of Metal Complexes with DNA

  1989cites this paper
• Enhancement of UV-induced mutagenesis and sister-chromatid exchanges by nickel ions in V79 cells: evidence for inhibition of DNA repair.

  1989cites this paper
• Formation and structure of reaction products of cis-PtCl2(NH3)2 with d(ApG) and/or d(GpA) in di-, tri- and penta-nucleotides. Preference for GpA chelation over ApG chelation.

  1989cites this paper
• Ultraviolet irradiation produces cytotoxic synergy and increased DNA interstrand crosslinking with cis- and trans-diamminedichloroplatinum(II).

  1989cites this paper
• The chemical and biochemical consequences of the binding of the antitumour drug cisplatin and other platinum group metal complexes to DNA

  1989cites this paper
• Importance of DNA Sequence in the Reaction of d(ApG) and d(GpA) with Cis-Diamminedichloroplatinum (II)

  1988cites this paper
• Chemical reactions occurring between metal-containing antineoplastic drugs and biological molecules.

  1988cites this paper
• Reactions of [PtCl(dien)]Cl with glutathione, oxidized glutathione and S-methyl glutathione. Formation of an S-bridged dinuclear unit

  1988cites this paper
• Effect of the R46 and PKM101 plasmids on the repair of DNA.

  1988cites this paper
• A study on configuration-activity relationship of diamminedichloroplatinum (II) by the pseudopotential valence electron-only ab initio calculation method.

  1987cites this paper
• The formation, isolation and characterization of DNA adducts produced by anticancer platinum complexes.

  1987cites this paper
• trans-Diamminedichloroplatinum(II), a reversible RNA-protein cross-linking agent. Application to the ribosome and to an aminoacyl-tRNA synthetase/tRNA complex.

  1987cites this paper
• Sugar interaction with biologically active cis-PtCl2(NH3)2 (anticancer) and its inactive trans isomer.

  1987cites this paper
• Characterization of the ternary complexes formed in the reaction of cis-diamminedichloroplatinum (II), ethidium bromide and nucleic acids.

  1987cites this paper
• Quantitative estimation of cisplatin-induced DNA interstrand cross-links and their repair in mammalian cells: relationship to toxicity.

  1987cites this paper
• Palladium and platinum guanine complexes

  1986cites this paper
• Binding of cis- and trans-diamminedichloroplatinum(II) to deoxyribonucleic acid exposes nucleosides as measured immunochemically with anti-nucleoside antibodies.

  1986cites this paper
• Reaction of nucleic acids and cis-diamminedichloroplatinum(II) in the presence of intercalating agents.

  1986cites this paper
• Mono- and bis(1-methylcytosine) complexes of cisplatin: the crystal structures of cis-[(NH3)2Pt(1-MeC)Cl]2[Pt(CN)4] and cis-[(NH3)2Pt(1-MeC)2][Pt(CN)4]·2H2O

  1986cites this paper
• A model study on mode of bonding of cisplatin with DNA.

  1986cites this paper
• cis-diamminedichloroplatinum(II) induced distortion of a single and double stranded deoxydecanucleosidenonaphosphate studied by nuclear magnetic resonance.

  1985cites this paper
• The synthesis and characterisation of some xanthine complexes: Evidence for the existence of oxygen involvement using O(6) and O(2)

  1985cites this paper
• Fast atom Bombardment Mass Spectrometry of Nucleosides, Nucleotides and Oligonucleotides

  1985cites this paper
• Simple Coordination Complexes: Drugs and Probes for DNA Structure

  1985cites this paper
• Role of ligand exchange processes in the reaction kinetics of the antitumor drug cis-diamminedichloroplatinum(II) with its targets.

  1985cites this paper
• Roleof LigandExchangeProcessesin the ReactionKineticsof the Antitumor Drugc/s-Diamminedichloroplatinum(ll) withItsTargets1

  1985influential citation
• Fundamental studies with cisplatin.

  1985cites this paper
• A 1H and 31P NMR study of cis-Pt(NH3)2[d(CpGpG)-N7(2),N7(3)]. The influence of a 5'-terminal cytosine, on the structure of the cis-Pt(NH3)2[d(GpG)-N7,N7] intrastrand cross-link.

  1985cites this paper
• Charles F. Kettring prize. Fundamental studies with cisplatin

  1985cites this paper
• Binding study of the drug cis-dichlorodiammineplatinum(II) to Gp5′ and dGp5′ by high resolution proton and carbon-13 NMR spectroscopy

  1985cites this paper
• Comparison between poly(dG-dC).poly(dG-dC) and DNA modified by cis-diamminedichloroplatinum (II): immunological and spectroscopic studies.

  1985cites this paper
• Binding of the antitumor drug cis-diamminedichloroplatinum(II) (cisplatin) to DNA.

  1985cites this paper
• Sequence-dependent termination of in vitro DNA synthesis by cis- and trans-diamminedichloroplatinum (II).

  1985cites this paper
• Reactions of the UVRABC excision nuclease with DNA damaged by diamminedichloroplatinum(II).

  1985cites this paper
• Proton‐NMR study of the interaction of trans‐dichloro‐diamine‐platinum(II) with poly(I) and poly(I)·poly(C)

  1984cites this paper
• Interaction of poly(I)·poly(C) with trans‐dichloro‐diammine‐platinum (II)

  1984cites this paper
• Suppressive effect of cupric acetate on DNA alkylation, DNA synthesis and tumorigenesis in the liver of dimethylnitrosamine-treated rats.

  1984cites this paper
• cis-Diamminedichloroplatinum(II): effects of a representative metal coordination complex on mammalian cells.

  1984cites this paper
• Relationships between functionality and genetic toxicology of selected DNA-damaging agents.

  1984cites this paper
• Studies of enzyme inhibition: the interaction of some platinum(II) complexes with fumarase and malate dehydrogenase

  1984cites this paper
• In vivo properties of some new cis-platinum complexes containing 7-azaindole ligands

  1984cites this paper
• Platinum(II) Complex involving 9-methylxanthine: evidence for N(7), O(6) interaction

  1984cites this paper
• Studies on the inhibition of fumarase and malate dehydrogenase by second generation platinum antitumor drugs

  1984cites this paper
• Mechanisms of cisplatin (cis-diamminodichloroplatinum II)-induced cytotoxicity and genotoxicity in yeast.

  1984cites this paper
• A CNDO/2 study on bonding mechanism of cis‐dichlorodiammine platinum (II) with DNA

  1983cites this paper
• Recognition of chemically damaged DNA by the gene 32 protein from bacteriophage T4.

  1983cites this paper
• Plasmid R46 fails to protect Escherichia coli against double-strand DNA-binding agents but increases their mutagenic activities.

  1983cites this paper
• Similar binding of the carcinostatic drugs cis-[Pt(NH3)2Cl2] and [Ru(NH3)5Cl] Cl2 to tRNAphe and a comparison with the binding of the inactive trans-[Pt(NH3)2Cl2] complex - reluctance in binding to Watson-Crick base pairs within double helix.

  1983cites this paper
• Interaction of platinum(II) amino acid complexes with nucleosides

  1983cites this paper
• The Binding of the Carcinostatic Drugs Cis-[Pt(NH3)2Cl2] and [Ru(NH3)5Cl]Cl2 with Yeast Transfer RNAPhe. Absence or Binding to Watson-Crick Base Pairs

  1983cites this paper
• Action of Platinum Antitumour Drugs

  1983cites this paper
• Some observations blocking of nuclear on the mechanisms of staining by cisplatin

  1982cites this paper
• Interaction of poly C with cis‐ and trans‐diamminedichloroplatinum (II): Secondary structure effects

  1982cites this paper
• New chemistry of an old molecule: cis-[Pt(NH3)2Cl2].

  1982cites this paper
• Some observations on the mechanisms of blocking of nuclear staining by cisplatin

  1982cites this paper
• Cis- and trans-diamminedichloroplatinum(II) binding products different tertiary structural changes on SV40 DNA.

  1982cites this paper
• Fast atom bombardment mass spectra of the bis-guanosine adduct with cisplatin

  1982cites this paper
• Mixed nucleobase complexes cis-Pt(NH3)2TX with T = 1-methylthymine anion and X = 1-methylcytosine, 9-ethylguanine, 9-methyladenine and 9-methyladeninium cation

  1982cites this paper
• Reduction of cis-diamminedichloroplatinum nephrotoxicity in rats by optimal circadian drug timing.

  1982cites this paper
• Cis-diamminedichloroplatinum (II) modification of SV40 DNA occurs preferentially in (G+C) rich regions: implications into the mechanism of action.

  1982cites this paper
• Genetic effects of some platinum co-ordination complexes on E.coli DNA as revealed by transformation studies.

  1982cites this paper
• Ethidium bromide changes the nuclease-sensitive DNA binding sites of the antitumor drug cis-diamminedichloroplatinum(II).

  1982cites this paper
• Coordination chemistry of 7,9-disubstituted 6-oxopurine metal compounds. 4. Platinum(II) coordination at N(1). Molecular and crystal structure of [(ethylenediamine)bis(7,9-dimethylhypoxanthine)platinum(II)] hexafluorophosphate ☆

  1982cites this paper
• The B goes to Z transition of poly(dG-dC) . poly(dG-dC) modified by some platinum derivatives.

  1981cites this paper
• Immunochemical studies of DNA modified by cis-dichlorodiammineplatinum(II) in vivo and in vitro.

  1981cites this paper
• Use of exonuclease III to determine the site of stable lesions in defined sequences of DNA: the cyclobutane pyrimidine dimer and cis and trans dichlorodiammine platinum II examples.

  1981cites this paper
• Binding of the anticancer drug cis-dichlorodiammineplatinum to 3'(2')-guanosine monophosphate and nucleic acids.

  1981cites this paper
• Base-pair substitution hotspots in GAG and GCG nucleotide sequences in Escherichia coli K-12 induced by cis-diamminedichloroplatinum (II).

  1981cites this paper
• The Adsorption of Nucleic Acid Bases by Raney-nickel, -cobalt, and -copper

  1981cites this paper