Rhesus Macaques Are More Susceptible to Progressive Tuberculosis than Cynomolgus Macaques: a Quantitative Comparison

No abstract is available for this paper.

• Publication year

  2017

• Venue

  Infection and Immunity

• Publication date

  2017-09-25

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.1128/IAI.00505-17PMID 28947646PMCID PMC5778369
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• An aerosol challenge model of tuberculosis in Mauritian cynomolgus macaques

  2017cited by this paper
• Experimental Animal Models of Tuberculosis

  2017cited by this paper
• Analysis of 18FDG PET/CT Imaging as a Tool for Studying Mycobacterium tuberculosis Infection and Treatment in Non-human Primates.

  2017cited by this paper
• Variable BCG efficacy in rhesus populations: Pulmonary BCG provides protection where standard intra-dermal vaccination fails.

  2017cited by this paper
• Heterogeneity in tuberculosis

  2017cited by this paper
• Digitally Barcoding Mycobacterium tuberculosis Reveals In Vivo Infection Dynamics in the Macaque Model of Tuberculosis

  2017cited by this paper
• Route of delivery to the airway influences the distribution of pulmonary disease but not the outcome of Mycobacterium tuberculosis infection in rhesus macaques.

  2016cited by this paper
• PET CT Identifies Reactivation Risk in Cynomolgus Macaques with Latent M. tuberculosis

  2016cited by this paper
• Effects of B Cell Depletion on Early Mycobacterium tuberculosis Infection in Cynomolgus Macaques

  2016cited by this paper
• CD4+ T-cell–independent mechanisms suppress reactivation of latent tuberculosis in a macaque model of HIV coinfection

  2016cited by this paper
• Ultra low dose aerosol challenge with Mycobacterium tuberculosis leads to divergent outcomes in rhesus and cynomolgus macaques.

  2016cited by this paper
• Temporal Expression of Peripheral Blood Leukocyte Biomarkers in a Macaca fascicularis Infection Model of Tuberculosis; Comparison with Human Datasets and Analysis with Parametric/Non-parametric Tools for Improved Diagnostic Biomarker Identification

  2016cited by this paper
• The TB-specific CD4(+) T cell immune repertoire in both cynomolgus and rhesus macaques largely overlap with humans.

  2015cited by this paper
• Protection of monkeys against airborne tuberculosis by aerosol vaccination with bacillus Calmette-Guerin.

  2015cited by this paper
• PET/CT imaging reveals a therapeutic response to oxazolidinones in macaques and humans with tuberculosis

  2014influential reference
• Modeling tuberculosis in nonhuman primates.

  2014cited by this paper
• A review of preclinical animal models utilised for TB vaccine evaluation in the context of recent human efficacy data

  2014cited by this paper
• Early Changes by 18Fluorodeoxyglucose Positron Emission Tomography Coregistered with Computed Tomography Predict Outcome after Mycobacterium tuberculosis Infection in Cynomolgus Macaques

  2014influential reference
• Radiologic Responses in Cynomolgus Macaques for Assessing Tuberculosis Chemotherapy Regimens

  2013cited by this paper
• The genetic composition of populations of cynomolgus macaques (Macaca fascicularis) used in biomedical research

  2013cited by this paper
• Sterilization of granulomas is common in both active and latent tuberculosis despite extensive within-host variability in bacterial killing

  2013cited by this paper
• CD4 T Cell Depletion Exacerbates Acute Mycobacterium tuberculosis While Reactivation of Latent Infection Is Dependent on Severity of Tissue Depletion in Cynomolgus Macaques

  2012cited by this paper
• Use of whole genome sequencing to estimate the mutation rate of Mycobacterium tuberculosis during latent infection

  2011cited by this paper
• Conditional CD8+ T Cell Escape during Acute Simian Immunodeficiency Virus Infection

  2011cited by this paper
• Genome sequencing and comparison of two nonhuman primate animal models, the cynomolgus and Chinese rhesus macaques

  2011cited by this paper
• Tumor necrosis factor neutralization results in disseminated disease in acute and latent Mycobacterium tuberculosis infection with normal granuloma structure in a cynomolgus macaque model.

  2010cited by this paper
• Selective functional inhibition of JAK-3 is sufficient for efficacy in collagen-induced arthritis in mice.

  2010cited by this paper
• Reactivation of Latent Tuberculosis in Cynomolgus Macaques Infected with SIV Is Associated with Early Peripheral T Cell Depletion and Not Virus Load

  2010cited by this paper
• Pulmonary Tuberculosis in Monkeys

  2010cited by this paper
• A Color Atlas of Comparative Pathology of Pulmonary Tuberculosis

  2010cited by this paper
• MHC Heterozygote Advantage in Simian Immunodeficiency Virus–Infected Mauritian Cynomolgus Macaques

  2010cited by this paper
• Quantitative Comparison of Active and Latent Tuberculosis in the Cynomolgus Macaque Model

  2009influential reference
• MVA.85A Boosting of BCG and an Attenuated, phoP Deficient M. tuberculosis Vaccine Both Show Protective Efficacy Against Tuberculosis in Rhesus Macaques

  2009cited by this paper
• Determination of lesion volume by MRI and stereology in a macaque model of tuberculosis.

  2009cited by this paper
• Major histocompatibility complex genotyping with massively parallel pyrosequencing

  2009cited by this paper
• The role of cytokines in the initiation, expansion, and control of cellular immunity to tuberculosis

  2008cited by this paper
• Comprehensive characterization of MHC class II haplotypes in Mauritian cynomolgus macaques

  2007cited by this paper
• Simian Immunodeficiency Virus SIVmac239 Infection of Major Histocompatibility Complex-Identical Cynomolgus Macaques from Mauritius

  2006cited by this paper
• High resolution radiographic and fine immunologic definition of TB disease progression in the rhesus macaque.

  2006cited by this paper
• Evidence for a rhesus monkey model of asymptomatic tuberculosis

  2004cited by this paper
• Experimental Mycobacterium tuberculosis Infection of Cynomolgus Macaques Closely Resembles the Various Manifestations of Human M. tuberculosis Infection

  2003influential reference
• Divergent effect of bacillus Calmette–Guérin (BCG) vaccination on Mycobacterium tuberculosis infection in highly related macaque species: Implications for primate models in tuberculosis vaccine research

  2001cited by this paper
• Erythrocyte sedimentation rate in childhood tuberculosis: is it still worthwhile?

  2000influential reference
• Yield of gastric lavage and bronchial wash in pulmonary tuberculosis.

  2000cited by this paper
• The Philippine cynomolgus monkey (Macaca fasicularis) provides a new nonhuman primate model of tuberculosis that resembles human disease

  1996cited by this paper
• Efficacy of BCG vaccine in the prevention of tuberculosis. Meta-analysis of the published literature.

  1994cited by this paper
• Aerosol-Induced Tuberculosis in Subhuman Primates and the Course of the Disease After Intravenous BCG Vaccination

  1970cited by this paper

• DNA Barcoding Supports Mitochondrial Lineage Structure in the Genus Macaca With Implications for Biomedical Research and Laboratory Colony Management

  2026cites this paper
• Controlled human infection with Mycobacterium tuberculosis: practical considerations for clinical trials.

  2026cites this paper
• Distinct mechanisms drive post-antibiotic Tuberculosis relapse post-cure versus post-treatment-failure

  2026cites this paper
• Mycobacterium tuberculosis preferentially infects specific macrophage subsets in primate granulomas during the early stages of tuberculosis.

  2026cites this paper
• Antiretroviral treatment does not prevent extrapulmonary tuberculosis during SIV/Mtb co-infection in macaques

  2025cites this paper
• GEODE: an in silico tool that translates in vitro to in vivo predictions of tuberculosis antibiotic combination efficacy

  2025cites this paper
• Chimeric hemagglutinin-based universal influenza mRNA vaccine induces protective immunity and bone marrow plasma cells in rhesus macaques

  2025cites this paper
• Protection against reinfection with Mycobacterium tuberculosis extends across heterologous Mtb lineages

  2025cites this paper
• The Impact of Animal Models and Strain Standardization on the Evaluation of Tuberculosis Vaccine Efficacy

  2025cites this paper
• Characterizing PET CT patterns and bacterial dissemination features of tuberculosis relapse in the macaque model

  2025influential citation
• Spatially-distinct programming of macrophage diversity within the granulomas of Mycobacterium tuberculosis infected nonhuman primates

  2025cites this paper
• PET imaging of mycobacterial infection: transforming the pipeline for tuberculosis drug development

  2025cites this paper
• Model systems to study Mycobacterium tuberculosis infections: an overview of scientific potential and impediments

  2025cites this paper
• Characterizing PET CT patterns and bacterial dissemination features of tuberculosis relapse in the macaque model

  2025cites this paper
• NK cell-macrophage interactions in granulomas correlate with limited tuberculosis pathology

  2025cites this paper
• A BCG kill switch strain protects against Mycobacterium tuberculosis in mice and non-human primates with improved safety and immunogenicity

  2025influential citation
• Intravenous BCG-mediated protection against tuberculosis requires CD4+ T cells and CD8α+ lymphocytes

  2025influential citation
• High-dose intravenous BCG vaccination induces enhanced immune signaling in the airways

  2025cites this paper
• Viral control is required for intravenous BCG-mediated protection against tuberculosis in simian immunodeficiency virus-infected macaques

  2025cites this paper
• A Systemic Approach to Chest Radiographic Assessment in Mycobacterium tuberculosis-Infected Cynomolgus Macaques (Macaca fascicularis).

  2025cites this paper
• Natural outbreak of Mycobacterium caprae infection in imported laboratory cynomolgus macaques (Macaca fascicularis): diagnostic pitfalls and management of safety precautions

  2024cites this paper
• Transiently boosting Vγ9+Vδ2+ γδ T cells early in Mtb coinfection of SIV-infected juvenile macaques does not improve Mtb host resistance

  2024influential citation
• Understanding the development of tuberculous granulomas: insights into host protection and pathogenesis, a review in humans and animals

  2024cites this paper
• PET-CT outcomes from a randomised controlled trial of rosuvastatin as an adjunct to standard tuberculosis treatment

  2024cites this paper
• Markov field network model of multi-modal data predicts effects of immune system perturbations on intravenous BCG vaccination in macaques.

  2024cites this paper
• Intravenous Bacillus Calmette-Guérin (BCG) Induces a More Potent Airway and Lung Immune Response than Intradermal BCG in Simian Immunodeficiency Virus-infected Macaques.

  2024cites this paper
• Transiently boosting Vγ9+Vδ2+ γδ T cells early in Mtb coinfection of SIV-infected juvenile macaques does not improve Mtb host resistance

  2024cites this paper
• Intravenous BCG induces a more potent airway and lung immune response than intradermal BCG in SIV-infected macaques

  2024cites this paper
• Metabolically active neutrophils represent a permissive niche for Mycobacterium tuberculosis

  2024cites this paper
• CD4 T cells and CD8α+ lymphocytes are necessary for intravenous BCG-induced protection against tuberculosis in macaques

  2024cites this paper
• Markov Field network model of multi-modal data predicts effects of immune system perturbations on intravenous BCG vaccination in macaques

  2024influential citation
• Advances in understanding immune homeostasis in latent tuberculosis infection.

  2024cites this paper
• Surveillance of Daughter Micronodule Formation Is a Key Factor for Vaccine Evaluation Using Experimental Infection Models of Tuberculosis in Macaques

  2023influential citation
• A “suicide” BCG strain provides enhanced immunogenicity and robust protection against Mycobacterium tuberculosis in macaques

  2023cites this paper
• Antibody glycosylation correlates with disease progression in SIV‐ Mycobacterium tuberculosis coinfected cynomolgus macaques

  2023cites this paper
• CD8+ lymphocytes are critical for early control of tuberculosis in macaques

  2023cites this paper
• Intravenous Bacille Calmette–Guérin vaccination protects simian immunodeficiency virus-infected macaques from tuberculosis

  2023influential citation
• Does PET-CT Have a Role in the Evaluation of Tuberculosis Treatment in Phase 2 Clinical Trials?

  2023cites this paper
• Advances in protein subunit vaccines against tuberculosis

  2023cites this paper
• Animal models for COVID-19 and tuberculosis

  2023cites this paper
• Protective intravenous BCG vaccination induces enhanced immune signaling in the airways

  2023cites this paper
• Airway T cells are a correlate of i.v. Bacille Calmette-Guerin-mediated protection against tuberculosis in rhesus macaques.

  2023cites this paper
• Characterizing the spectrum of latent Mtb infection in the cynomolgus macaque model: Clinical, immunologic, and PET CT features of evolution.

  2023cites this paper
• Vaccination with intravenous BCG protects macaques with pre-existing SIV infection from tuberculosis

  2023cites this paper
• Mycobacterium tuberculosis-Specific CD4 T Cells Expressing Transcription Factors T-Bet or RORγT Associate with Bacterial Control in Granulomas

  2023cites this paper
• Prevalence of Mycobacterium tuberculosis Complex among Wild Rhesus Macaques and 2 Subspecies of Long-Tailed Macaques, Thailand, 2018–2022

  2023cites this paper
• Dynamics of Macrophage, T and B Cell Infiltration Within Pulmonary Granulomas Induced by Mycobacterium tuberculosis in Two Non-Human Primate Models of Aerosol Infection

  2022cites this paper
• Human M1 macrophages express unique innate immune response genes after mycobacterial infection to defend against tuberculosis

  2022cites this paper
• Induction of Functional Specific Antibodies, IgG-Secreting Plasmablasts and Memory B Cells Following BCG Vaccination

  2022cites this paper
• Dynamic Control Balancing Cell Proliferation and Inflammation is Crucial for an Effective Immune Response to Malaria

  2022cites this paper
• Multimodal profiling of lung granulomas in macaques reveals cellular correlates of tuberculosis control

  2022cites this paper
• T cell transcription factor expression evolves over time in granulomas from Mycobacterium tuberculosis-infected cynomolgus macaques

  2022cites this paper
• Characterization of natural killer cells in the blood and airways of cynomolgus macaques during Mycobacterium tuberculosis infection

  2022cites this paper
• Pulmonary Granuloma Is Not Always the Tuberculosis Hallmark: Pathology of Tuberculosis Stages in New World and Old World Monkeys Naturally Infected with the Mycobacterium tuberculosis Complex.

  2022cites this paper
• Mycobacterium tuberculosis-specific CD4 T cells expressing transcription factors associate with bacterial control in granulomas

  2022cites this paper
• Host Immunity to Mycobacterium tuberculosis Infection Is Similar in Simian Immunodeficiency Virus (SIV)-Infected, Antiretroviral Therapy-Treated and SIV-Naïve Juvenile Macaques

  2022influential citation
• Primary infection with Zika virus provides one-way heterologous protection against Spondweni virus infection in rhesus macaques

  2022cites this paper
• Monkeying around with MAIT Cells: Studying the Role of MAIT Cells in SIV and Mtb Co-Infection

  2021influential citation
• Quantitative Rapid Test for Detection and Monitoring of Active Pulmonary Tuberculosis in Nonhuman Primates

  2021cites this paper
• Neutrophil Dynamics Affect Mycobacterium tuberculosis Granuloma Outcomes and Dissemination

  2021cites this paper
• High dose aerosol challenge with Mycobacterium tuberculosis fails to overcome BCG vaccination-induced protection in cynomolgus macaques of Chinese origin: implications of natural resistance for TB vaccine evaluation.

  2021cites this paper
• A virtual host model of Mycobacterium tuberculosis infection identifies early immune events as predictive of infection outcomes

  2021cites this paper
• Spontaneous Control of SIV Replication Does Not Prevent T Cell Dysregulation and Bacterial Dissemination in Animals Co-Infected with M. tuberculosis

  2021influential citation
• Differences in host immune populations between rhesus macaques and cynomolgus macaque subspecies in relation to susceptibility to Mycobacterium tuberculosis infection

  2021cites this paper
• Non-human primate models of human respiratory infections

  2021cites this paper
• One Size Fits All? Not in In Vivo Modeling of Tuberculosis Chemotherapeutics

  2021cites this paper
• Functional inactivation of pulmonary MAIT cells following 5-OP-RU treatment of non-human primates

  2021cites this paper
• T Cells Specific for a Mycobacterial Glycolipid Expand after Intravenous Bacillus Calmette–Guérin Vaccination

  2021cites this paper
• The knowns and unknowns of latent Mycobacterium tuberculosis infection.

  2021cites this paper
• Pre-existing Simian Immunodeficiency Virus Infection Increases Expression of T Cell Markers Associated with Activation during Early Mycobacterium tuberculosis Coinfection and Impairs TNF Responses in Granulomas

  2021cites this paper
• Multimodal profiling of lung granulomas reveals cellular correlates of tuberculosis control

  2021cites this paper
• High-dose Mycobacterium tuberculosis aerosol challenge cannot overcome BCG-induced protection in Chinese origin cynomolgus macaques; implications of natural resistance for vaccine evaluation

  2021cites this paper
• Systemic and pulmonary C1q as biomarker of progressive disease in experimental non-human primate tuberculosis

  2020cites this paper
• The Mtb-HIV syndemic interaction: why treating M. tuberculosis infection may be crucial for HIV-1 eradication

  2020cites this paper
• SARS-CoV-2 infection of African green monkeys results in mild respiratory disease discernible by PET/CT imaging and shedding of infectious virus from both respiratory and gastrointestinal tracts

  2020cites this paper
• MAIT cells are minimally responsive to Mycobacterium tuberculosis within granulomas, but are functionally impaired by SIV in a macaque model of SIV and Mtb co-infection

  2020cites this paper
• SIV and Mycobacterium tuberculosis synergy within the granuloma accelerates the reactivation pattern of latent tuberculosis

  2020cites this paper
• At the Interface of Microbiology and Immunology

  2020cites this paper
• Prevention of tuberculosis in macaques after intravenous BCG immunization

  2020cites this paper
• The status of tuberculosis vaccine development.

  2020cites this paper
• Biomarkers and immunological tests. Experimental and clinical parallels of latent tuberculosis infection

  2020cites this paper
• Mycobacterial Infections in Monkeys

  2020cites this paper
• Title: SARS-CoV-2 infection of African green monkeys results in mild respiratory disease discernible by PET/CT imaging and prolonged shedding of infectious virus from both respiratory and gastrointestinal tracts

  2020cites this paper
• Pre-existing SIV infection increases expression of T cell markers associated with activation during early Mycobacterium tuberculosis co-infection and impairs TNF responses in granulomas

  2020cites this paper
• Addressing Latent Tuberculosis: New Advances in Mimicking the Disease, Discovering Key Targets, and Designing Hit Compounds

  2020cites this paper
• Single-cell profiling of tuberculosis lung granulomas reveals functional lymphocyte signatures of bacterial control

  2020cites this paper
• Биомаркеры и иммунологические тесты. Экспериментально-клинические параллели латентной туберкулезной инфекции

  2020cites this paper
• Detection of tuberculosis in cynomolgus macaques (Macaca fascicularis) using a supplementary Monkey Interferon Gamma Releasing Assay (mIGRA)

  2020cites this paper
• Lymph nodes—The neglected battlefield in tuberculosis

  2020cites this paper
• SARS-CoV-2 infection of African green monkeys results in mild respiratory disease discernible by PET/CT imaging and prolonged shedding of infectious virus from both respiratory and gastrointestinal tracts

  2020cites this paper
• Pulmonary Mycobacterium tuberculosis control associates with CXCR3- and CCR6-expressing antigen-specific Th1 and Th17 cell recruitment.

  2020cites this paper
• MAIT cells are functionally impaired in a Mauritian cynomolgus macaque model of SIV and Mtb co-infection

  2020cites this paper
• Chronic Immune Activation in TB/HIV Co-infection.

  2020cites this paper
• Evaluation of IL-1 Blockade as an Adjunct to Linezolid Therapy for Tuberculosis in Mice and Macaques

  2020cites this paper
• Ratio of the Bronchial Lumen to Pulmonary Artery Diameter in Rhesus Macaques (Macaca mulatta) without Clinical Pulmonary Disease.

  2019cites this paper
• IL-10 Impairs Local Immune Response in Lung Granulomas and Lymph Nodes during Early Mycobacterium tuberculosis Infection

  2019cites this paper
• Evaluation of IL-1 blockade as a host-directed therapy for tuberculosis in mice and macaques

  2019cites this paper
• Disparate Tuberculosis Disease Development in Macaque Species Is Associated With Innate Immunity

  2019cites this paper
• Comparing Fan Beam and Cone Beam CT for Non-Clinical Imaging of Tuberculosis

  2019cites this paper
• A computational model tracks whole-lung Mycobacterium tuberculosis infection and predicts factors that inhibit dissemination

  2019cites this paper