Structure of the Uncleaved Human H1 Hemagglutinin from the Extinct 1918 Influenza Virus

No abstract is available for this paper.

• Publication year

  2004

• Venue

  Science

• Publication date

  2004-03-19

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1126/SCIENCE.1093373PMID 14764887
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Membrane Fusion Induced by Vesicular Stomatitis Virus Depends on Histidine Protonation*

  2003cited by this paper
• Het influenzaseizoen 2002/'03 in Nederland en de vaccinsamenstelling voor het seizoen 2003/'04.

  2003cited by this paper
• Are We Ready for Pandemic Influenza?

  2003cited by this paper
• Characterization of the 1918 “Spanish” Influenza Virus Matrix Gene Segment

  2002cited by this paper
• H5 avian and H9 swine influenza virus haemagglutinin structures: possible origin of influenza subtypes

  2002cited by this paper
• Existing antivirals are effective against influenza viruses with genes from the 1918 pandemic virus

  2002cited by this paper
• Regulation of Organelle Acidity

  2001cited by this paper
• X-ray structures of H5 avian and H9 swine influenza virus hemagglutinins bound to avian and human receptor analogs

  2001cited by this paper
• The 1918 Spanish influenza: integrating history and biology.

  2001cited by this paper
• The predicted antigenicity of the haemagglutinin of the 1918 Spanish influenza pandemic suggests an avian origin.

  2001cited by this paper
• Sequence of the 1918 pandemic influenza virus nonstructural gene (NS) segment and characterization of recombinant viruses bearing the 1918 NS genes

  2001cited by this paper
• Characterization of the 1918 "Spanish" influenza virus neuraminidase gene.

  2000cited by this paper
• Receptor binding and membrane fusion in virus entry: the influenza hemagglutinin.

  2000cited by this paper
• Origin and evolution of the 1918 "Spanish" influenza virus hemagglutinin gene.

  1999cited by this paper
• Structure of influenza haemagglutinin at neutral and at fusogenic pH by electron cryo‐microscopy

  1999cited by this paper
• Human infection with influenza H9N2.

  1999cited by this paper
• The 1918 flu and other influenza pandemics: "over there" and back again.

  1999cited by this paper
• Structure of the haemagglutinin-esterase-fusion glycoprotein of influenza C virus

  1998cited by this paper
• Structure of the hemagglutinin precursor cleavage site, a determinant of influenza pathogenicity and the origin of the labile conformation.

  1998cited by this paper
• Characterization of an avian influenza A (H5N1) virus isolated from a child with a fatal respiratory illness.

  1998cited by this paper
• Mechanism of Acidification of the trans-Golgi Network (TGN)

  1998cited by this paper
• SWISS‐MODEL and the Swiss‐Pdb Viewer: An environment for comparative protein modeling

  1997cited by this paper
• VMD: visual molecular dynamics.

  1996cited by this paper
• Reduced surface: an efficient way to compute molecular surfaces.

  1996cited by this paper
• Egg fluids and cells of the chorioallantoic membrane of embryonated chicken eggs can select different variants of influenza A (H3N2) viruses.

  1995cited by this paper
• Structure of influenza haemagglutinin at the pH of membrane fusion

  1994cited by this paper
• Receptor specificity in human, avian, and equine H2 and H3 influenza virus isolates.

  1994cited by this paper
• Pulmonary surfactant is a potential endogenous inhibitor of proteolytic activation of Sendai virus and influenza A virus

  1993cited by this paper
• Receptor binding properties of human and animal H1 influenza virus isolates.

  1989cited by this paper
• The structure and function of the hemagglutinin membrane glycoprotein of influenza virus.

  1987cited by this paper
• The hemagglutinins of the human influenza viruses A and B recognize different receptor microdomains.

  1987cited by this paper
• Receptor determinants of human and animal influenza virus isolates: differences in receptor specificity of the H3 hemagglutinin based on species of origin.

  1983cited by this paper
• Single amino acid substitutions in influenza haemagglutinin change receptor binding specificity

  1983cited by this paper
• Changes in the conformation of influenza virus hemagglutinin at the pH optimum of virus-mediated membrane fusion.

  1982cited by this paper
• Structure of the haemagglutinin membrane glycoprotein of influenza virus at 3 Å resolution

  1981cited by this paper
• THE INCIDENCE OF NEUTRALIZING ANTIBODIES FOR SWINE INFLUENZA VIRUS IN THE SERA OF HUMAN BEINGS OF DIFFERENT AGES

  1936cited by this paper

• High-resolution in situ structures of hantavirus glycoprotein tetramers.

  2026cites this paper
• Isolation and characterization of broadly-neutralizing anti-HCMV-gB antibodies from human donors using a prefusion-stabilized HCMV gB variant

  2026cites this paper
• Bioorthogonal optimized virus immuno-nanomedicine (BOVIN)

  2025cites this paper
• De novo design of D-peptide ligands: Application to influenza virus hemagglutinin

  2025cites this paper
• Distinct components of mRNA vaccines cooperate to instruct efficient germinal center responses

  2025cites this paper
• High-resolution in situ structures of hantavirus glycoprotein tetramers

  2025cites this paper
• Host Switching Mutations in H5N1 Influenza Hemagglutinin Suppress Site-specific Activation Dynamics

  2025influential citation
• Host switching mutations in H5N1 influenza hemagglutinin suppress site-specific activation dynamics

  2025cites this paper
• EASyMap-Guided Stepwise One-Pot Multienzyme (StOPMe) Synthesis and Multiplex Assays Identify Functional Tetraose-Core-Human Milk Oligosaccharides

  2025cites this paper
• Tailoring the adjuvanticity of lipid nanoparticles by PEG lipid ratio and phospholipid modifications

  2025cites this paper
• Transmission of a human isolate of clade 2.3.4.4b A(H5N1) virus in ferrets

  2024cites this paper
• Multivalent interactions between fully glycosylated influenza virus hemagglutinins mediated by glycans at distinct N-glycosylation sites

  2024cites this paper
• Transmembrane domains of H1 and H3 hemagglutinin contribute to membrane fusion in a different manner

  2024cites this paper
• Redirecting antibody responses from egg-adapted epitopes following repeat vaccination with recombinant or cell culture-based versus egg-based influenza vaccines

  2024cites this paper
• Production of Influenza Virus Glycoproteins Using Insect Cells.

  2024cites this paper
• Region-selective and site-specific glycation of influenza proteins surrounding the viral envelope membrane

  2024cites this paper
• A Rapid Virus‐Free Method for Producing Influenza HA Immunogen Needed for Preparation of Influenza Vaccine Potency Antisera Reagents

  2024cites this paper
• A Herpes Simplex Virus Type‐1‐Derived Influenza Vaccine Induces Balanced Adaptive Immune Responses and Protects Mice From Lethal Influenza Virus Challenge

  2024cites this paper
• Advanced Vaccine Design Strategies against SARS-CoV-2 and Emerging Variants

  2023cites this paper
• SARS‐CoV‐2‐related bat virus behavior in human‐relevant models sheds light on the origin of COVID‐19

  2023cites this paper
• Design, synthesis, and evaluation of 4′‐phosphonomethoxy pyrimidine ribonucleosides as potential anti‐influenza agents

  2023cites this paper
• Intradermal Immunization of Soluble Influenza HA Derived from a Lethal Virus Induces High Magnitude and Breadth of Antibody Responses and Provides Complete Protection In Vivo

  2023cites this paper
• Inhibitory effects of Patchouli alcohol on the early lifecycle stages of influenza A virus

  2023cites this paper
• Influenza A virus exploits transferrin receptor recycling to enter host cells

  2023cites this paper
• One HA stalk topping multiple heads as a novel influenza vaccine

  2023cites this paper
• Neutralizing and protective murine monoclonal antibodies to the hemagglutinin of influenza H5 clades 2.3.2.1 and 2.3.4.4

  2023cites this paper
• Design of protein-binding proteins from the target structure alone

  2022cites this paper
• Identification of a cross-neutralizing antibody that targets the receptor binding site of H1N1 and H5N1 influenza viruses

  2022cites this paper
• Genetic Analysis of Influenza A/H1N1pdm Strains Isolated in Bangladesh in Early 2020

  2022cites this paper
• Molecular adaptations during viral epidemics

  2022cites this paper
• Highly pathogenic avian influenza A/Guangdong/17SF003/2016 is immunogenic and induces cross-protection against antigenically divergent H7N9 viruses

  2021cites this paper
• A liposome-displayed hemagglutinin vaccine platform protects mice and ferrets from heterologous influenza virus challenge

  2021cites this paper
• Functional and structural modifications of influenza antibodies during pregnancy

  2021cites this paper
• Weaponized Pathogens and the SARS-CoV-2 Pandemic

  2021cites this paper
• Deciphering transmission dynamics and spillover of avian influenza viruses from avian species to swine populations globally

  2021cites this paper
• Carbohydrate-Based Macromolecular Biomaterials.

  2021cites this paper
• Biological Activities of SP-A and SP-D Against Extracellular and Intracellular Pathogens

  2021cites this paper
• The impact of high-resolution structural data on stemming the COVID-19 pandemic

  2021cites this paper
• Antiviral Peptides with in vivo Activity: Development and Modes of Action.

  2021cites this paper
• Highly pathogenic avian influenza A/Guangdong/17SF003/2016 is immunogenic and induces cross-protection against antigenically divergent H7N9 viruses

  2021cites this paper
• Hemagglutinins of Avian Influenza Viruses Are Proteolytically Activated by TMPRSS2 in Human and Murine Airway Cells

  2021cites this paper
• A Herpes Simplex Virus Type-1-derived influenza vaccine induces balanced adaptive immune responses and protects mice from lethal influenza virus challenge

  2021cites this paper
• Prior infection by seasonal coronaviruses, as assessed by serology, does not prevent SARS-CoV-2 infection and disease in children, France, April to June 2020

  2021cites this paper
• 50 Years of structural immunology

  2021cites this paper
• Predicting Cross-Species Infection of Swine Influenza Virus with Representation Learning of Amino Acid Features

  2021cites this paper
• Targeting influenza at the topologically conserved substructures

  2020cites this paper
• Statistical Binding Matching between Influenza A Virus and Dynamic Glycan Clusters Determines Its Adhesion onto Lipid Membranes.

  2020cites this paper
• Influenza A Viruses: Understanding Human Host Determinants.

  2020cites this paper
• IAV-CNN: a 2D convolutional neural network model to predict antigenic variants of influenza A virus

  2020cites this paper
• Genetically and Antigenically Divergent Influenza A(H9N2) Viruses Exhibit Differential Replication and Transmission Phenotypes in Mammalian Models

  2020cites this paper
• Orally administered recombinant baculovirus vaccine elicits partial protection against avian influenza virus infection in mice.

  2020cites this paper
• Characterizing Receptor Flexibility to Predict Mutations That Lead to Human Adaptation of Influenza Hemagglutinin

  2020cites this paper
• Molecular characterization and three-dimensional structures of avian H8, H11, H14, H15 and swine H4 influenza virus hemagglutinins

  2020cites this paper
• Guanidinothiosialoside-human serum albumin conjugate mimics mucin barrier to restrict influenza infection.

  2020cites this paper
• Hemagglutinin Structure and Activities.

  2020cites this paper
• Tempel: time-series mutation prediction of influenza A viruses via attention-based recurrent neural networks

  2020cites this paper
• Viral Membrane Fusion and the Transmembrane Domain

  2020cites this paper
• Characterization of thermostable Newcastle disease virus recombinants expressing the hemagglutinin of H5N1 avian influenza virus as bivalent vaccine candidates.

  2020cites this paper
• Pre-existing immunity to influenza virus hemagglutinin stalk might drive selection for antibody-escape mutant viruses in a human challenge model

  2020cites this paper
• Comparison of virulence and lethality in mice for two avian influenza A/H5N1 and one A/H3N6 viruses isolated from poultry during 2013 to 2014 in Indonesia.

  2020cites this paper
• Phage capsid nanoparticles with defined ligand arrangement block influenza virus entry

  2020cites this paper
• TMPRSS2 Is the Major Activating Protease of Influenza A Virus in Primary Human Airway Cells and Influenza B Virus in Human Type II Pneumocytes

  2019influential citation
• Capturing the inherent structural dynamics of the HIV-1 envelope glycoprotein fusion peptide

  2019cites this paper
• Activation of Viruses by Host Proteases

  2019influential citation
• Remarkable Structural Diversity of N-Glycan Sulfation on Influenza Vaccines.

  2019cites this paper
• Detection of ON1 and novel genotypes of human respiratory syncytial virus and emergence of palivizumab resistance in Lebanon

  2019cites this paper
• Common characteristics and unique features: A comparison of the fusion machinery of the alphaherpesviruses Pseudorabies virus and Herpes simplex virus.

  2019cites this paper
• New Vaccine Design and Delivery Technologies

  2019cites this paper
• Improving immunogenicity of influenza virus H7N9 recombinant hemagglutinin for vaccine development.

  2019cites this paper
• Evidence for influenza B virus hemagglutinin adaptation to the human host: high cleavability, acid-stability and preference for cool temperature

  2019cites this paper
• A small-molecule fusion inhibitor of influenza virus is orally active in mice

  2019cites this paper
• A conserved histidine in Group-1 influenza subtype hemagglutinin proteins is essential for membrane fusion activity.

  2019cites this paper
• A Numbering Scheme for Influenza A Virus Neuraminidase (NA) Subtypes

  2019cites this paper
• Proteins and Protein Structure

  2019cites this paper
• IgA tetramerization improves target breadth but not peak potency of functionality of anti-influenza virus broadly neutralizing antibody

  2019cites this paper
• Scoring amino acid mutation to predict pandemic risk of avian influenza virus

  2019cites this paper
• The 1918 influenza pandemic: 100 years of questions answered and unanswered

  2019cites this paper
• Intact Glycopeptide Analysis of Influenza A/H1N1/09 Neuraminidase Revealing the Effects of Host and Glycosite Location on Site‐Specific Glycan Structures

  2019cites this paper
• Hemagglutinin Cleavability, Acid Stability, and Temperature Dependence Optimize Influenza B Virus for Replication in Human Airways

  2019cites this paper
• Development of a universal influenza vaccine using hemagglutinin stem protein produced from Pichia pastoris.

  2019cites this paper
• Virus-based SELEX (viro-SELEX) allows development of aptamers targeting knotty proteins.

  2019cites this paper
• The 1918 Influenza Pandemic and Its Legacy.

  2019cites this paper
• Peptide Epitope Hot Spots of CD4 T Cell Recognition Within Influenza Hemagglutinin During the Primary Response to Infection

  2019cites this paper
• The Chimpanzee SIV Envelope Trimer: Structure and Deployment as an HIV Vaccine Template

  2019cites this paper
• Identification of a pH sensor in Influenza hemagglutinin using X-ray crystallography

  2019cites this paper
• The Antiviral Potential of Host Protease Inhibitors

  2018influential citation
• Unanswered questions about the 1918 influenza pandemic: origin, pathology, and the virus itself.

  2018cites this paper
• Structural insights into the design of novel anti-influenza therapies

  2018cites this paper
• Structural Basis for the Broad, Antibody-Mediated Neutralization of H5N1 Influenza Virus

  2018cites this paper
• Kallikrein-related peptidase 5 and seasonal influenza viruses, limitations of the experimental models for activating proteases

  2018cites this paper
• Scoring Amino Acid Mutations to Predict Avian-to-Human Transmission of Avian Influenza Viruses

  2018cites this paper
• Structural and Molecular Characterization of the Hemagglutinin from the Fifth-Epidemic-Wave A(H7N9) Influenza Viruses

  2018cites this paper
• Structural analysis of influenza vaccine virus-like particles reveals a multicomponent organization

  2018cites this paper
• Determinant of receptor-preference switch in influenza hemagglutinin.

  2018cites this paper
• Determinantes de patogenicidad en el virus de influenza pandémico en México: Factores virales asociados con la severidad

  2018cites this paper
• IgA polymerization contributes to efficient virus neutralization on human upper respiratory mucosa after intranasal inactivated influenza vaccine administration

  2018cites this paper
• Activation of the Hemagglutinin of Influenza Viruses

  2018cites this paper
• Towards a universal influenza vaccine: different approaches for one goal

  2018cites this paper
• Pleiotropic effects of hemagglutinin amino acid substitutions of influenza A(H1N1)pdm09 virus escape mutants.

  2018cites this paper
• Structure and Immune Recognition of the HIV Glycan Shield.

  2018cites this paper