Dectin‐1 synergizes with TLR2 and TLR4 for cytokine production in human primary monocytes and macrophages

No abstract is available for this paper.

• Publication year

  2008

• Venue

  Cellular Microbiology

• Publication date

  2008-10-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1111/j.1462-5822.2008.01188.xPMID 18549457
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Syk kinase is required for collaborative cytokine production induced through Dectin-1 and Toll-like receptors

  2008influential reference
• C-type lectin receptors in antifungal immunity.

  2008cited by this paper
• Syk‐dependent ERK activation regulates IL‐2 and IL‐10 production by DC stimulated with zymosan

  2007cited by this paper
• Immune Recognition of Candida albicans β-glucan by Dectin-1

  2007cited by this paper
• Signaling pathways downstream of pattern-recognition receptors and their cross talk.

  2007cited by this paper
• Collaboration between the innate immune receptors dectin‐1, TLRs, and Nods

  2007cited by this paper
• Crystal structure of the TLR1-TLR2 heterodimer induced by binding of a tri-acylated lipopeptide.

  2007cited by this paper
• Crosstalk among Jak‐STAT, Toll‐like receptor, and ITAM‐dependent pathways in macrophage activation

  2007cited by this paper
• Epidemiology of Invasive Candidiasis: a Persistent Public Health Problem

  2007cited by this paper
• Dectin-1 is required for beta-glucan recognition and control of fungal infection.

  2007cited by this paper
• Immune recognition of Candida albicans beta-glucan by dectin-1.

  2007cited by this paper
• Syk- and CARD9-dependent coupling of innate immunity to the induction of T helper cells that produce interleukin 17

  2007cited by this paper
• Structure and function of Toll receptors and their ligands.

  2007cited by this paper
• Dectin-1 is required for β-glucan recognition and control of fungal infection

  2007cited by this paper
• Dectin-1 Interaction with Tetraspanin CD37 Inhibits IL-6 Production1

  2007cited by this paper
• Immune sensing of Candida albicans requires cooperative recognition of mannans and glucans by lectin and Toll-like receptors.

  2006influential reference
• Pathogen recognition and innate immunity.

  2006cited by this paper
• Recognition of fungal pathogens by toll-like receptors.

  2006cited by this paper
• Recognition and signaling by toll-like receptors.

  2006cited by this paper
• Toll-like receptor 2 controls expansion and function of regulatory T cells.

  2006cited by this paper
• Card9 controls a non-TLR signalling pathway for innate anti-fungal immunity

  2006cited by this paper
• Ligands for the β-Glucan Receptor, Dectin-1, Assigned Using “Designer” Microarrays of Oligosaccharide Probes (Neoglycolipids) Generated from Glucan Polysaccharides*

  2006cited by this paper
• Dectin-1: a signalling non-TLR pattern-recognition receptor

  2006cited by this paper
• Curdlan and other bacterial (1-->3)-beta-D-glucans.

  2005cited by this paper
• Nucleotide-Binding Oligomerization Domain-2 Modulates Specific TLR Pathways for the Induction of Cytokine Release 1

  2005cited by this paper
• A role for fungal β-glucans and their receptor Dectin-1 in the induction of autoimmune arthritis in genetically susceptible mice

  2005cited by this paper
• Curdlan and other bacterial (1→3)-β-d-glucans

  2005cited by this paper
• Faculty Opinions recommendation of A role for fungal {beta}-glucans and their receptor Dectin-1 in the induction of autoimmune arthritis in genetically susceptible mice.

  2005cited by this paper
• Syk-dependent cytokine induction by Dectin-1 reveals a novel pattern recognition pathway for C type lectins.

  2005cited by this paper
• [Toll-like receptor].

  2005cited by this paper
• The human β‐glucan receptor is widely expressed and functionally equivalent to murine Dectin‐1 on primary cells

  2005cited by this paper
• Dectin‐1 mediates macrophage recognition of Candida albicans yeast but not filaments

  2005cited by this paper
• Development of a sensitive ELISA for the quantification of human tumour necrosis factor-alpha using 4 polyclonal antibodies.

  2005cited by this paper
• Toll-like receptors.

  2005cited by this paper
• How C‐type lectins detect pathogens

  2005cited by this paper
• Toll-Like Receptor 2 Suppresses Immunity against Candida albicans through Induction of IL-10 and Regulatory T Cells

  2004influential reference
• Triggering Receptor Expressed on Myeloid Cells-1 in Neutrophil Inflammatory Responses: Differential Regulation of Activation and Survival

  2004cited by this paper
• Recognition of fungal pathogens by Toll-like receptors

  2004influential reference
• Dectin-1 Mediates the Biological Effects of β-Glucans

  2003influential reference
• Candida albicans phospholipomannan is sensed through toll-like receptors.

  2003cited by this paper
• Toll-like receptors.

  2003cited by this paper
• Faculty Opinions recommendation of Dectin-1 mediates the biological effects of beta-glucans.

  2003influential reference
• The C‐type lectin DC‐SIGN (CD209) is an antigen‐uptake receptor for Candida albicans on dendritic cells

  2003cited by this paper
• Collaborative Induction of Inflammatory Responses by Dectin-1 and Toll-like Receptor 2

  2003cited by this paper
• C-type lectin receptors on dendritic cells and langerhans cells

  2002cited by this paper
• The role of toll-like receptor (TLR) 2 and TLR4 in the host defense against disseminated candidiasis.

  2002influential reference
• Immune recognition. A new receptor for beta-glucans.

  2001cited by this paper
• Characterization of the Human β-Glucan Receptor and Its Alternatively Spliced Isoforms*

  2001cited by this paper
• Regulatory roles for CD14 and phosphatidylinositol in the signaling via toll-like receptor 4-MD-2.

  2000cited by this paper
• Cutting Edge: Repurification of Lipopolysaccharide Eliminates Signaling Through Both Human and Murine Toll-Like Receptor 21

  2000cited by this paper
• Production and function of cytokines in natural and acquired immunity to Candida albicans infection.

  1995cited by this paper
• A method for the solubilization of a (1----3)-beta-D-glucan isolated from Saccharomyces cerevisiae.

  1991cited by this paper
• Regulation of tumor necrosis factor alpha transcription in macrophages: involvement of four kappa B-like motifs and of constitutive and inducible forms of NF-kappa B

  1990influential reference
• Alveolar macrophages differ from blood monocytes in human IL-1 beta release. Quantitation by enzyme-linked immunoassay.

  1989cited by this paper
• Immune Recognition

  1977cited by this paper
• Candida Albicans

  1964cited by this paper

• IL-6 regulates the polarization of Dectin-1 macrophages to weaken immune escape in thyroid cancer

  2026cites this paper
• Spacer-engineered carboxylated curdlan derivatives for dendritic cell activation and cancer immunotherapy

  2026cites this paper
• Dexamethasone induced Dectin-1 activation enhances NLRP3 inflammasome activation

  2025cites this paper
• TNF-α/NF-κB mediated upregulation of Dectin-1 in hyperglycemic obesity: implications for metabolic inflammation and diabetes

  2025cites this paper
• Algal β-glucan: Structure, immunomodulatory effects and application prospects.

  2025cites this paper
• Astragalus polysaccharides: structure-immunomodulation relationships, multi-target pharmacological activities, and cutting-edge applications in immune modulation

  2025cites this paper
• Contribution of CARD9 signaling to wound healing in skin promoted by topical administration of heat-killed Enterococcus faecalis strain KH2 and the involvement of Dectin-2

  2025cites this paper
• Immunometabolic effects of β-glucan-trained immunity in newborn goats.

  2025cites this paper
• Mincle receptor agonist UM-1098 and TLR4 agonist INI-2002 combination adjuvant enhances Th1 responses and provides protection against Mycobacterium tuberculosis challenge in mice

  2025cites this paper
• β-glucans as natural immunostimulants in aquaculture

  2025cites this paper
• Targeting the Dectin‑1 Receptor in Neuroinflammation: Therapeutic Implications for Neuropsychiatric Disorders

  2025cites this paper
• Interferon-gamma production defects characterise immune responses in patients with chronic pulmonary aspergillosis.

  2025cites this paper
• Comprehensive Prevention and Control of Mastitis in Dairy Cows: From Etiology to Prevention

  2025cites this paper
• β-Glucans and their roles in immune and metabolic regulation: A review.

  2025cites this paper
• Fungal β-Glucans Shape Innate Immune Responses in Human Peripheral Blood Mononuclear Cells (PBMCs): An In Vitro Study on PRR Regulation, Cytokine Expression, and Oxidative Balance

  2025cites this paper
• Candida albicans extracellular vesicles trigger type I IFN signalling via cGAS and STING

  2024cites this paper
• Possible role of intestinal fungal dysbiosis in dectin-1 and cytokines expression in patients with ulcerative colitis

  2024cites this paper
• Natural plant-derived polysaccharides targeting macrophage polarization: a promising strategy for cancer immunotherapy

  2024cites this paper
• Epidemiology of Invasive Candidiasis

  2024cites this paper
• Fungal polysaccharides from Inonotus obliquus are agonists for Toll-like receptors and induce macrophage anti-cancer activity

  2024cites this paper
• Exploring the immunomodulatory properties of glucan particles in human primary cells.

  2024cites this paper
• The postbiotic potential of Aspergillus oryzae – a narrative review

  2024cites this paper
• Proteomic alterations associated with the formation of monocyte extracellular trap induced by Candida albicans hyphae.

  2024cites this paper
• β-glucan induced trained immunity enhances antibody levels in a vaccination model in mice

  2024cites this paper
• Investigation of the structural and immunomodulatory properties of alkali-soluble β-glucans from Pleurotus eryngii fruiting bodies.

  2023cites this paper
• Know your neighbors: microbial recognition at the intestinal barrier and its implications for gut homeostasis and inflammatory bowel disease

  2023cites this paper
• C-type lectin receptor Dectin-1 blockade on tumour-associated macrophages improves anti-PD-1 efficacy in gastric cancer

  2023influential citation
• Dectin-1 deficiency alleviates diabetic cardiomyopathy by attenuating macrophage-mediated inflammatory response.

  2023cites this paper
• Succinoglycan riclin relieves UVB-induced skin injury with anti-oxidant and anti-inflammatory properties.

  2023cites this paper
• Intranasal immunization with curdlan induce Th17 responses and enhance protection against enterovirus 71.

  2023cites this paper
• Targeting β-glucans, vital components of the Pneumocystis cell wall

  2023cites this paper
• Antifungal immunity mediated by C-type lectin receptors may be a novel target in immunotherapy for urothelial bladder cancer

  2022cites this paper
• Immobile Ligands Enhance FcγR-TLR2/1 Crosstalk by Promoting Interface Overlap of Receptor Clusters.

  2022cites this paper
• Efficacy of Candida dubliniensis and Fungal β-Glucans in Inducing Trained Innate Immune Protection Against Inducers of Sepsis

  2022cites this paper
• Elevated expression of TLR2 and its correlation with disease activity and clinical manifestations in adult-onset Still’s disease

  2022cites this paper
• Candida Administration in 5/6 Nephrectomized Mice Enhanced Fibrosis in Internal Organs: An Impact of Lipopolysaccharide and (1→3)-β-D-Glucan from Leaky Gut

  2022cites this paper
• Immunostimulatory activity of soybean hull polysaccharide on macrophages

  2022cites this paper
• Targeted delivery of methotrexate by modified yeast β-glucan nanoparticles for rheumatoid arthritis therapy.

  2022cites this paper
• Macrophage depletion alters bacterial gut microbiota partly through fungal overgrowth in feces that worsens cecal ligation and puncture sepsis mice

  2022cites this paper
• Dectin-1 as a Potential Inflammatory Biomarker for Metabolic Inflammation in Adipose Tissue of Individuals with Obesity

  2022cites this paper
• Dectin-1 plays a deleterious role in high fat diet-induced NAFLD of mice through enhancing macrophage activation

  2022cites this paper
• Spatial organization of Dectin-1 and TLR2 during synergistic crosstalk revealed by super-resolution imaging

  2022cites this paper
• Gut Barrier Damage and Gut Translocation of Pathogen Molecules in Lupus, an Impact of Innate Immunity (Macrophages and Neutrophils) in Autoimmune Disease

  2022cites this paper
• Candida Administration in Bilateral Nephrectomy Mice Elevates Serum (1→3)-β-D-glucan That Enhances Systemic Inflammation Through Energy Augmentation in Macrophages

  2021influential citation
• A Synergy Between Endotoxin and (1→3)-Beta-D-Glucan Enhanced Neutrophil Extracellular Traps in Candida Administered Dextran Sulfate Solution Induced Colitis in FcGRIIB-/- Lupus Mice, an Impact of Intestinal Fungi in Lupus

  2021influential citation
• Water-soluble polysaccharides from Pleurotus eryngii fruiting bodies, their activity and affinity for Toll-like receptor 2 and dectin-1.

  2021cites this paper
• Continuous Exposure to Non-Soluble β-Glucans Induces Trained Immunity in M-CSF-Differentiated Macrophages

  2021cites this paper
• Sodium houttuyfonate attenuates dextran sulfate sodium associated colitis precolonized with Candida albicans through inducing β‐glucan exposure

  2021cites this paper
• The role of dectin-1 in health and disease.

  2021cites this paper
• Preparation of Curdlan sulphate - Chitosan nanoparticles as a drug carrier to target Mycobacterium smegmatis infected macrophages.

  2021cites this paper
• Polymeric Materials for Immune Engineering: Molecular Interaction to Biomaterial Design.

  2021cites this paper
• Longitudinal Evaluation of Plasma Cytokine Levels in Patients with Invasive Candidiasis

  2021cites this paper
• Innate immune receptor clustering and its role in immune regulation

  2021cites this paper
• Interaction Between Dendritic Cells and Candida krusei β-Glucan Partially Depends on Dectin-1 and It Promotes High IL-10 Production by T Cells

  2021cites this paper
• Prominent Indomethacin-Induced Enteropathy in Fcgriib Defi-cient lupus Mice: An Impact of Macrophage Responses and Immune Deposition in Gut

  2021cites this paper
• Anisotropic presentation of ligands on cargos modulates degradative function of phagosomes

  2021cites this paper
• Fungal dysbiosis of the gut microbiota is associated with colorectal cancer in Chinese patients

  2021cites this paper
• Pathogenicity Mechanism of Candida albicans

  2021cites this paper
• Bioactivities

  2021cites this paper
• Extracellular Adenosine Triphosphate: A Modulator of Cutaneous Candida albicans Infection.

  2021cites this paper
• Emerging roles of Dectin-1 in noninfectious settings and in the CNS.

  2021cites this paper
• Host cell membrane microdomains and fungal infection

  2021cites this paper
• Oligonucleotide delivery to antigen presenting cells by using schizophyllan.

  2021cites this paper
• Candida Administration Worsens Uremia-Induced Gut Leakage in Bilateral Nephrectomy Mice, an Impact of Gut Fungi and Organismal Molecules in Uremia

  2021cites this paper
• GLUT3 as an Intersection of Glycerophospholipid Metabolism and the Innate Immune Response to Candida albicans

  2021cites this paper
• Structural specificities of cell surface β-glucan polysaccharides determine commensal yeast mediated immuno-modulatory activities

  2021cites this paper
• Candida albicans‐induced leukotriene biosynthesis in neutrophils is restricted to the hyphal morphology

  2021cites this paper
• Beta-d-glucan-based drug delivery system and its potential application in targeting tumor associated macrophages.

  2021cites this paper
• Epiphanies of well-known and newly discovered macromolecular carbohydrates - A review.

  2020cites this paper
• A specific peptide with immunomodulatory activity from Pseudostellaria heterophylla and the action mechanism

  2020cites this paper
• Additional Candida albicans administration enhances the severity of dextran sulfate solution induced colitis mouse model through leaky gut-enhanced systemic inflammation and gut-dysbiosis but attenuated by Lactobacillus rhamnosus L34

  2020cites this paper
• Paeonol alleviates dextran sodium sulfate induced colitis involving Candida albicans-associated dysbiosis.

  2020cites this paper
• Single-nucleotide polymorphisms in CLEC7A, CD209 and TLR4 gene and their association with susceptibility to paratuberculosis in Indian cattle

  2020cites this paper
• Development of Fish Immunity and the Role of β-Glucan in Immune Responses

  2020cites this paper
• Leaky-gut enhanced lupus progression in the Fc gamma receptor-IIb deficient and pristane-induced mouse models of lupus

  2020cites this paper
• Preparation and evaluation of the adjuvant effect of curdlan sulfate in improving the efficacy of dendritic cell-based vaccine for antitumor immunotherapy.

  2020cites this paper
• β‐1,3/1,6‐Glucans and Immunity: State of the Art and Future Directions

  2020cites this paper
• Immunological evaluation in vitro of nanoparticulate impurities isolated from pharmaceutical-grade sucrose.

  2020cites this paper
• Polysaccharides from the fungus Inonotus obliquus activate macrophages into a tumoricidal phenotype via interaction with TLR2, TLR4 and Dectin-1a

  2020cites this paper
• Candida Administration Worsens Cecal Ligation and Puncture-Induced Sepsis in Obese Mice Through Gut Dysbiosis Enhanced Systemic Inflammation, Impact of Pathogen-Associated Molecules From Gut Translocation and Saturated Fatty Acid

  2020cites this paper
• Fungal β-glucans and mannan stimulate peripheral blood mononuclear cells to cytokine production in Syk-dependent manner.

  2020cites this paper
• Association of genetic variability in CD209 gene with bovine paratuberculosis disease: a case–control study in the Indian cattle population

  2020cites this paper
• Pathogen-Associated Molecules from Gut Translocation Enhance Severity of Cecal Ligation and Puncture Sepsis in Iron-Overload β-Thalassemia Mice

  2020cites this paper
• Corrigendum: Candida Administration Worsens Cecal Ligation and Puncture-Induced Sepsis in Obese Mice Through Gut Dysbiosis Enhanced Systemic Inflammation, Impact of Pathogen-Associated Molecules From Gut Translocation and Saturated Fatty Acid

  2020cites this paper
• Barley beta‐Glucan and Zymosan induce Dectin‐1 and Toll‐like receptor 2 co‐localization and anti‐leishmanial immune response in Leishmania donovani‐infected BALB/c mice

  2020cites this paper
• Syk Inhibitor Attenuates Polymicrobial Sepsis in FcgRIIb-Deficient Lupus Mouse Model, the Impact of Lupus Characteristics in Sepsis

  2020cites this paper
• Syk inhibitor attenuates inflammation in lupus mice from FcgRIIb deficiency but not in pristane induction: the influence of lupus pathogenesis on the therapeutic effect

  2020cites this paper
• Nitric Oxide Regulates Macrophage Fungicidal Activity via S-nitrosylation of Dectin-1

  2020cites this paper
• Differences in fungal immune recognition by monocytes and macrophages: N-mannan can be a shield or activator of immune recognition

  2020cites this paper
• Upregulated-gene expression of Pro-inflammatory cytokines (TNF-α, IL-1β and IL-6) via TLRs following NF-κB and MAPKs in bovine mastitis.

  2020cites this paper
• Differences in anti-inflammatory properties of water soluble and insoluble bioactive polysaccharides in lipopolysaccharide-stimulated RAW264.7 macrophages

  2020cites this paper
• β‐glucan as a new tool in vaccine development

  2020cites this paper
• Syk‐dependent glycolytic reprogramming in dendritic cells regulates IL‐1β production to β‐glucan ligands in a TLR‐independent manner

  2019cites this paper
• Signaling pathways associated with macrophage-activating polysaccharides purified from fermented barley.

  2019cites this paper
• Human thioredoxin, a damage-associated molecular pattern and Malassezia-crossreactive autoallergen, modulates immune responses via the C-type lectin receptors Dectin-1 and Dectin-2

  2019cites this paper
• Advanced Detection of Endotoxin and Other PAMPs

  2019cites this paper
• The cooperative induction of macrophage activation by fucoidan derived from Cladosiphon okamuranus and β-glucan derived from Saccharomyces cerevisiae.

  2019cites this paper
• Toll‐like receptor 2 stimulation augments esophageal barrier integrity

  2019cites this paper
• Signaling pathway and structural features of macrophage-activating pectic polysaccharide from Korean citrus, Cheongkyool peels.

  2019cites this paper
• Genetic Association Analysis of the Functional c . 714 T . G Polymorphism and Mucosal Expression of Dectin-1 in Inflammatory Bowel Disease

  2019cites this paper