Regulation of c-jun expression during hypoxic and low-glucose stress

No abstract is available for this paper.

• Publication year

  1994

• Venue

  Molecular and Cellular Biology

• Publication date

  1994-08-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1128/mcb.14.8.5032-5042.1994PMID 8035787PMCID PMC359022
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  1993cited by this paper
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  1993cited by this paper
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  1992cited by this paper
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  1992cited by this paper
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  1992cited by this paper
• Gadd45 and Gadd153 messenger RNA levels are increased during hypoxia and after exposure of cells to agents which elevate the levels of the glucose-regulated proteins.

  1992cited by this paper
• Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis

  1992cited by this paper
• Induction of c-jun protooncogene expression and transcription factor AP-1 activity by the polyoma virus middle-sized tumor antigen.

  1992cited by this paper
• The mammalian ultraviolet response is triggered by activation of Src tyrosine kinases.

  1992influential reference
• Phorbol ester-induced amino-terminal phosphorylation of human JUN but not JUNB regulates transcriptional activation.

  1992cited by this paper
• Protein synthesis inhibitors differentially superinduce c‐fos and c‐jun by three distinct mechanisms: lack of evidence for labile repressors.

  1992cited by this paper
• Identification and characterization of Ref‐1, a nuclear protein that facilitates AP‐1 DNA‐binding activity.

  1992cited by this paper
• Activation of the heat shock transcription factor by hypoxia in normal and tumor cell lines in vivo and in vitro.

  1992cited by this paper
• Determination of coexisting nuclear transcription rates and cytoplasmic mRNA levels for gonadotropin subunit genes in rat anterior pituitary.

  1992cited by this paper
• ULTRAVIOLET‐RADIATION INDUCED c‐jun GENE TRANSCRIPTION: TWO AP‐1 LIKE BINDING SITES MEDIATE THE RESPONSE

  1992cited by this paper
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  1992cited by this paper
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  1992cited by this paper
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  1992cited by this paper
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  1992cited by this paper
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  1992cited by this paper
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  1991cited by this paper
• Ha-Ras augments c-Jun activity and stimulates phosphorylation of its activation domain

  1991cited by this paper
• Hypoxia-induced drug resistance: comparison to P-glycoprotein-associated drug resistance.

  1991cited by this paper
• A rapid micropreparation technique for extraction of DNA-binding proteins from limiting numbers of mammalian cells.

  1991cited by this paper
• Cross-family dimerization of transcription factors Fos/Jun and ATF/CREB alters DNA binding specificity.

  1991cited by this paper
• Oxygen regulated 80 kDa protein and glucose regulated 78 kDa protein are identical

  1991cited by this paper
• Activation of protein kinase C decreases phosphorylation of c-Jun at sites that negatively regulate its DNA-binding activity.

  1991cited by this paper
• Phosphorylation of c-jun mediated by MAP kinases

  1991cited by this paper
• Rapid and preferential activation of the c-jun gene during the mammalian UV response

  1991cited by this paper
• Glutathione deficiency produced by inhibition of its synthesis, and its reversal; applications in research and therapy.

  1991cited by this paper
• Redox regulation of fos and jun DNA-binding activity in vitro.

  1990cited by this paper
• Selective Activation of Drugs by Redox Processes

  1990cited by this paper
• Transactivation by the hepatitis B virus X protein depends on AP-2 and other transcription factors

  1990cited by this paper
• jun: oncogene and transcription factor.

  1990cited by this paper
• A ubiquitous nuclear protein stimulates the DNA-binding activity of fos and jun indirectly.

  1990cited by this paper
• Enhanced synthesis of stress proteins caused by hypoxia and relation to altered cell growth and metabolism.

  1990cited by this paper
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  1990cited by this paper
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  1990cited by this paper
• Retrotransposon-like VL30 elements are efficiently induced in anoxic rat fibroblasts.

  1989cited by this paper
• Normal fibroblasts responding to anoxia exhibit features of the malignant phenotype.

  1989cited by this paper
• Parallel association of Fos and Jun leucine zippers juxtaposes DNA binding domains.

  1989cited by this paper
• Deregulated expression of human c-jun transforms primary rat embryo cells in cooperation with an activated c-Ha-ras gene and transforms rat-1a cells as a single gene.

  1989cited by this paper
• Prolonged activation of jun and collagenase genes by tumour necrosis factor-α

  1989cited by this paper
• The protein kinase C family: heterogeneity and its implications.

  1989cited by this paper
• Leucine repeats and an adjacent DNA binding domain mediate the formation of functional cFos-cJun heterodimers.

  1989cited by this paper
• Induction of proto-oncogene JUN/AP-1 by serum and TPA

  1988cited by this paper
• The jun proto-oncogene is positively autoregulated by its product, Jun/AP-1.

  1988cited by this paper
• Activation of the transforming potential of the human fos proto-oncogene requires message stabilization and results in increased amounts of partially modified fos protein

  1988cited by this paper
• Hypoxia induces DNA overreplication and enhances metastatic potential of murine tumor cells.

  1988cited by this paper
• Epidermal growth factor stimulates transcription of the c-jun proto-oncogene in rat fibroblasts

  1988cited by this paper
• Heme oxygenase: function, multiplicity, regulatory mechanisms, and clinical applications

  1988cited by this paper
• Human heme oxygenase cDNA and induction of its mRNA by hemin.

  1988cited by this paper
• Human proto-oncogene c-jun encodes a DNA binding protein with structural and functional properties of transcription factor AP-1.

  1987cited by this paper
• Modification of fos proteins: phosphorylation of c-fos, but not v-fos, is stimulated by 12-tetradecanoyl-phorbol-13-acetate and serum

  1987cited by this paper
• Avian sarcoma virus 17 carries the jun oncogene.

  1987cited by this paper
• Frequencies of independent and simultaneous selection of Chinese hamster cells for methotrexate and doxorubicin (adriamycin) resistance.

  1987cited by this paper
• Induction characteristics of oxygen regulated proteins.

  1986cited by this paper
• Negative regulation of the Saccharomyces cerevisiae ANB1 gene by heme, as mediated by the ROX1 gene product

  1986cited by this paper
• Transient hypoxia enhances the frequency of dihydrofolate reductase gene amplification in Chinese hamster ovary cells.

  1986cited by this paper
• Induction of glucose-regulated proteins during anaerobic exposure and of heat-shock proteins after reoxygenation.

  1984cited by this paper

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  2024cites this paper
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  2024cites this paper
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  2023cites this paper
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  2022cites this paper
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  2021cites this paper
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  2020cites this paper
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  2020cites this paper
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  2018cites this paper
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  2017cites this paper
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  2017cites this paper
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  2016cites this paper
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  2015cites this paper
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  2015cites this paper
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  2015influential citation
• Contribution of Transcription Factors and Genes in the Induction of Oxidative Stress

  2014cites this paper
• [Involvement of transcriptional factor induced by hypoxia in the neuronal mechanisms of adaptation to psychoemotional and hypoxic stress].

  2014cites this paper
• Inflammation and Oxidative Stress in Neurological Disorders

  2014cites this paper
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  2014cites this paper
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  2013cites this paper
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  2011cites this paper
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  2010cites this paper
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  2010cites this paper
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  2010cites this paper
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  2009cites this paper
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  2009cites this paper
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  2009cites this paper
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  2008cites this paper
• Tumor hypoxia and therapeutic resistance

  2008cites this paper
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  2007cites this paper
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  2007cites this paper
• Critical role for NF‐κB‐induced JunB in VEGF regulation and tumor angiogenesis

  2007cites this paper
• Involvement of single- and double-strand break repair processes in beta-lapachone-induced cell death.

  2007cites this paper
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  2007cites this paper
• Comparison of Molecular Markers of Hypoxia and Imaging with 60Cu-ATSM in Cancer of the Uterine Cervix

  2007cites this paper
• New tricks for old drugs: the anticarcinogenic potential of DNA repair inhibitors

  2006cites this paper
• The interaction between HIF-1 and AP-1 transcription factors in response to low oxygen.

  2005cites this paper
• Cellular redox state and activating protein-1 are involved in ascorbate effect on calcitriol-induced differentiation

  2005cites this paper
• Cellular reaction to hypoxia: sensing and responding to an adverse environment.

  2005cites this paper
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  2004cites this paper
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  2004cites this paper
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  2004cites this paper
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  2003cites this paper
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  2003cites this paper
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  2002cites this paper
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  2002cites this paper
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  2002cites this paper
• Hypoxia as a target for combined modality treatments.

  2002cites this paper
• Heme Oxygenase-1: Molecular Mechanisms of Gene Expression in Oxygen-Related Stress

  2002cites this paper
• [Tissue hypoxia, tumor angiogenesis and radiotherapy].

  2001cites this paper
• Tumor hypoxia: definitions and current clinical, biologic, and molecular aspects.

  2001cites this paper
• Hypoxia‐induced upregulation of eNOS gene expression is redox‐sensitive: A comparison between hypoxia and inhibitors of cell metabolism

  2001influential citation
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  2001cites this paper
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  2001cites this paper
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  2001cites this paper
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  2000cites this paper
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  2000cites this paper
• Candidate Genes for the Hypoxic Tumor Phenotype 1

  2000cites this paper
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  2000cites this paper
• Multicellular resistance: a paradigm for clinical resistance?

  2000cites this paper
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  2000cites this paper
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  2000cites this paper
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  2000cites this paper
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  1999cites this paper
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  1999cites this paper
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  1999cites this paper
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  1998cites this paper
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  1998influential citation