In‐vitro mutagenic potential and effect on permeability of co‐administered drugs across Caco‐2 cell monolayers of Rubus idaeus and its fortified fractions

No abstract is available for this paper.

• Publication year

  2006

• Venue

  The Journal of pharmacy and pharmacology

• Publication date

  2006-11-01

• Fields of study

  Agricultural and Food Sciences, Medicine, Chemistry, Environmental Science

• Identifiers
  DOI 10.1211/jpp.58.11.0016PMID 17132218
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Current industrial practices of assessing permeability and P-glycoprotein interaction

  2006influential reference
• Genotoxicity and antigenotoxicity of Origanum oil and carvacrol evaluated by Ames Salmonella/microsomal test

  2005cited by this paper
• Drug Bioactivation Covalent Binding to Target Proteins and Toxicity Relevance

  2005cited by this paper
• Preclinical evaluation of rapeseed, raspberry, and pine bark phenolics for health related effects.

  2005cited by this paper
• Catechins and procyanidins in berries of vaccinium species and their antioxidant activity.

  2005cited by this paper
• Molecular mechanisms of toxicity of important food-borne phytotoxins.

  2005cited by this paper
• Nutraceuticals and functional foods: I. Current trend in phytochemical antioxidant research

  2005cited by this paper
• Role of monocarboxylic acid transporters in the cellular uptake of NSAIDs

  2005cited by this paper
• Polyphenols: food sources and bioavailability.

  2004cited by this paper
• Natural products in the process of finding new drug candidates.

  2004cited by this paper
• Rapid induction of P-glycoprotein expression by high permeability compounds in colonic cells in vitro: a possible source of transporter mediated drug interactions?

  2004cited by this paper
• Permeability characteristics and membrane affinity of flavonoids and alkyl gallates in Caco-2 cells and in phospholipid vesicles.

  2004cited by this paper
• Study of antioxidant and mutagenic activity of different orange juices

  2004cited by this paper
• Inhibition of protein and lipid oxidation in liposomes by berry phenolics.

  2004cited by this paper
• Effects of Extracts of Commonly Consumed Food Supplements and Food Fractions on the Permeability of Drugs Across Caco-2 Cell Monolayers

  2004influential reference
• Berry anthocyanins: isolation, identification and antioxidant activities

  2003cited by this paper
• Antimutagenic activity of extracts of natural substances in the Salmonella/microsome assay.

  2003cited by this paper
• In vitro assessment of inhibition by natural polyphenols of metabolic activation of procarcinogens by human CYP1A1.

  2003cited by this paper
• N-in-One Permeability Studies of Heterogeneous Sets of Compounds Across Caco-2 Cell Monolayers

  2003cited by this paper
• Antioxidant activity of anthocyanins and their aglycons.

  2003cited by this paper
• Antioxidant and antimutagenic activities of pomegranate peel extracts

  2003cited by this paper
• Ellagitannins, flavonoids, and other phenolics in red raspberries and their contribution to antioxidant capacity and vasorelaxation properties.

  2002cited by this paper
• Herbal medication: potential for adverse interactions with analgesic drugs

  2002cited by this paper
• Is It Really OK to Take This with Food? Old Interactions with a New Twist

  2002cited by this paper
• Absorption and metabolism of polyphenols in the gut and impact on health.

  2002cited by this paper
• Plants as source of drugs.

  2001cited by this paper
• Evaluation of the cytotoxicity, mutagenicity and antimutagenicity of emerging edible plants.

  2001cited by this paper
• Caco-2 monolayers in experimental and theoretical predictions of drug transport.

  2001cited by this paper
• Berry phenolics and their antioxidant activity.

  2001influential reference
• Mini mutagenicity test: a miniaturized version of the Ames test used in a prescreening assay for point mutagenesis assessment.

  2001influential reference
• Ellagitannins : nature, occurrence and dietary burden

  2000cited by this paper
• Quercetin intake and the incidence of cerebrovascular disease

  2000cited by this paper
• Optimized conditions for prediction of intestinal drug permeability using Caco-2 cells.

  2000cited by this paper
• The Ames Salmonella/microsome mutagenicity assay.

  2000cited by this paper
• Differences between coumaric and cinnamic acids in membrane permeation as evidenced by time-dependent calorimetry.

  1999cited by this paper
• Dietary flavonoids: intake, health effects and bioavailability.

  1999cited by this paper
• Screening of selected flavonoids and phenolic acids in 19 berries

  1999cited by this paper
• Scientific Concepts of Functional Foods in Europe Consensus Document

  1999cited by this paper
• Role of P-glycoprotein-mediated secretion in absorptive drug permeability: An approach using passive membrane permeability and affinity to P-glycoprotein.

  1999cited by this paper
• Antioxidant flavonols and coronary heart disease risk.

  1997cited by this paper
• Dietary flavonoids and the risk of lung cancer and other malignant neoplasms.

  1997cited by this paper
• Effect of menthol and related terpenes on the percutaneous absorption of propranolol across excised hairless mouse skin.

  1997cited by this paper
• Applications of the Caco-2 model in the design and development of orally active drugs: elucidation of biochemical and physical barriers posed by the intestinal epithelium

  1997cited by this paper
• Effects of steroids and verapamil on P-glycoprotein ATPase activity: progesterone, desoxycorticosterone, corticosterone and verapamil are mutually non-exclusive modulators.

  1996cited by this paper
• Activity profiles of antimutagens: in vitro and in vivo data.

  1996cited by this paper
• Flavonoid intake and coronary mortality in Finland: a cohort study

  1996cited by this paper
• A Theoretical Basis for a Biopharmaceutic Drug Classification: The Correlation of in Vitro Drug Product Dissolution and in Vivo Bioavailability

  1995cited by this paper
• Participation of a proton-cotransporter, MCT1, in the intestinal transport of monocarboxylic acids.

  1995cited by this paper
• Absence of cooperativity for MgATP and verapamil effects on the ATPase activity of P-glycoprotein containing membrane vesicles.

  1993influential reference
• Tannins and related compounds. CXXII. New dimeric, trimeric and tetrameric ellagitannins, lambertianins A-D, from Rubus lambertianus Seringe.

  1993cited by this paper
• Dietary antioxidant flavonoids and risk of coronary heart disease: the Zutphen Elderly Study.

  1993cited by this paper
• Antimutagenic effects of flavonoids, chalcones and structurally related compounds on the activity of 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) and other heterocyclic amine mutagens from cooked food.

  1993cited by this paper
• Inter- and intrasubject variations of multiple saliva peaks of acetaminophen after oral administration of tablets

  1992cited by this paper
• Optimum associations of tester strains for maximum detection of mutagenic compounds in the Ames test.

  1991cited by this paper
• Epithelial transport of drugs in cell culture. I: A model for studying the passive diffusion of drugs over intestinal absorptive (Caco-2) cells.

  1990cited by this paper
• Plant Polyphenols: Vegetable Tannins Revisited

  1989influential reference
• Rapid high-performance liquid chromatographic assay for the simultaneous analysis of non-steroidal anti-inflammatory drugs in plasma.

  1987cited by this paper
• The Salmonella typhimurium/mammalian microsomal assay. A report of the U.S. Environmental Protection Agency Gene-Tox Program.

  1986cited by this paper
• Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays.

  1983cited by this paper
• Revised methods for the Salmonella mutagenicity test.

  1983cited by this paper
• The metabolism of gallic acid and hexahydroxydiphenic acid in plants: Biogenetic and molecular taxonomic considerations

  1982cited by this paper
• Overcoming of vincristine resistance in P388 leukemia in vivo and in vitro through enhanced cytotoxicity of vincristine and vinblastine by verapamil.

  1981influential reference
• Methods for detecting carcinogens and mutagens with the Salmonella/mammalian-microsome mutagenicity test.

  1975cited by this paper
• Carcinogens are mutagens: a simple test system combining liver homogenates for activation and bacteria for detection.

  1973cited by this paper

• Cytogenotoxic screening of the natural compound niga‐ichigoside F1 from Rubus imperialis (Rosaceae)

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  2023cites this paper
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  2023cites this paper
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  2020cites this paper
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  2020cites this paper
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  2019cites this paper
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  2018cites this paper
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  2017cites this paper
• In vivo evaluation of the genetic toxicity of Rubus niveus Thunb. (Rosaceae) extract and initial screening of its potential chemoprevention against doxorubicin-induced DNA damage.

  2015cites this paper
• Genotoxic assessment of Rubus imperialis (Rosaceae) extract in vivo and its potential chemoprevention against cyclophosphamide-induced DNA damage.

  2014cites this paper
• International Evaluation of Research and Doctoral Training at the University of Helsinki 2005-2010: RC-Specific Evaluation of DePoNa - Drug Delivery and Polymer Based Nanotechnology

  2012cites this paper
• Natural Occurring Polyphenols as Template for Drug Design. Focus on Serine Proteases

  2009cites this paper
• Therapeutic Potential and Chemical Composition of Plants from the Genus Rubus: A Mini Review of the Last 10 Years

  2008cites this paper
• Development of an automated 7-day 96-well Caco-2 cell culture model.

  2008cites this paper
• Antioxidant activity and antimicrobial effect of berry phenolics--a Finnish perspective.

  2007cites this paper