Compromised respiratory adaptation and thermoregulation in aging and age-related diseases.

No abstract is available for this paper.

• Publication year

  2010

• Venue

  Ageing Research Reviews

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.1016/j.arr.2009.09.006PMID 19800420
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Special Review Series - Biogenesis and Physiological Adaptation of Mitochondria The 'novel' 'uncoupling' proteins UCP2 and UCP3: what do they really do? Pros and cons for suggested functions

  2011cited by this paper
• The Brain Uncoupling Protein UCP4 Attenuates Mitochondrial Toxin-Induced Cell Death: Role of Extracellular Signal-Regulated Kinases in Bioenergetics Adaptation and Cell Survival

  2009cited by this paper
• Muscle Mitochondrial Uncoupling Dismantles Neuromuscular Junction and Triggers Distal Degeneration of Motor Neurons

  2009cited by this paper
• UCP2 mediates ghrelin’s action on NPY/AgRP neurons by lowering free radicals

  2008cited by this paper
• Mitochondria in neuroplasticity and neurological disorders.

  2008cited by this paper
• Mitochondrial Uncoupling Protein-2 Mediates Steatotic Liver Injury following Ischemia/Reperfusion*

  2008cited by this paper
• Cerebral Mitochondrial Metabolism in Early Parkinson's Disease

  2008cited by this paper
• The ADP and ATP transport in mitochondria and its carrier.

  2008cited by this paper
• Preventing β-amyloid fibrillization and deposition: β-sheet breakers and pathological chaperone inhibitors

  2008cited by this paper
• Mild mitochondrial uncoupling in mice affects energy metabolism, redox balance and longevity

  2008cited by this paper
• The mitochondrial uncoupling protein-2 promotes chemoresistance in cancer cells.

  2008cited by this paper
• Effect of aging, caloric restriction, and uncoupling protein 3 (UCP3) on mitochondrial proton leak in mice.

  2008cited by this paper
• UCP-2 and UCP-3 Proteins Are Differentially Regulated in Pancreatic Beta-Cells

  2008cited by this paper
• Overexpression of UCP2 Protects Thalamic Neurons following Global Ischemia in the Mouse

  2008cited by this paper
• Mitochondria--a nexus for aging, calorie restriction, and sirtuins?

  2008cited by this paper
• Reduced TOR signaling extends chronological life span via increased respiration and upregulation of mitochondrial gene expression.

  2007cited by this paper
• Mitochondrial UCP4 mediates an adaptive shift in energy metabolism and increases the resistance of neurons to metabolic and oxidative stress

  2007cited by this paper
• Mitochondrial Dysfunction: Impact on Exercise Performance and Cellular Aging

  2007cited by this paper
• Uncoupling is without an effect on the production of reactive oxygen species by in situ synaptic mitochondria

  2007cited by this paper
• Respiratory uncoupling in skeletal muscle delays death and diminishes age-related disease.

  2007cited by this paper
• Partial uncoupling of oxidative phosphorylation induces premature senescence in human fibroblasts and yeast mother cells.

  2007cited by this paper
• Aging-Associated Reductions in AMP-Activated Protein Kinase Activity and Mitochondrial Biogenesis

  2007cited by this paper
• ‘Mild Uncoupling’ does not decrease mitochondrial superoxide levels in cultured cerebellar granule neurons but decreases spare respiratory capacity and increases toxicity to glutamate and oxidative stress

  2007cited by this paper
• Calorie Restriction Improves Cardiovascular Risk Factors via Reduction of Mitochondrial Reactive Oxygen Species in Type II Diabetic Rats

  2007cited by this paper
• Bioenergetics in aging: mitochondrial proton leak in aging rat liver, kidney and heart

  2007cited by this paper
• Mild mitochondrial uncoupling impacts cellular aging in human muscles in vivo

  2007cited by this paper
• Role of protein aggregation in mitochondrial dysfunction and neurodegeneration in Alzheimer’s and Parkinson’s diseases

  2007cited by this paper
• PGC-1alpha over-expression promotes recovery from mitochondrial dysfunction and cell injury.

  2007cited by this paper
• A fundamental system of cellular energy homeostasis regulated by PGC-1α

  2007cited by this paper
• Amplified expression of uncoupling proteins in human brain ischemic lesions

  2007cited by this paper
• Mitochondrial uncoupling proteins--what is their physiological role?

  2007cited by this paper
• Genetic links between diet and lifespan: shared mechanisms from yeast to humans

  2007cited by this paper
• Expanding insights of mitochondrial dysfunction in Parkinson's disease

  2006cited by this paper
• Molecular biology of amyotrophic lateral sclerosis: insights from genetics

  2006cited by this paper
• Genipin inhibits UCP2-mediated proton leak and acutely reverses obesity- and high glucose-induced beta cell dysfunction in isolated pancreatic islets.

  2006cited by this paper
• Protein oxidation and aging

  2006cited by this paper
• Antioxidants as a potential therapy against age-related neurodegenerative diseases: amyloid Beta toxicity and Alzheimer's disease.

  2006cited by this paper
• Transcriptional Repression of PGC-1a by Mutant Huntingtin Leads to Mitochondrial Dysfunction and Neurodegeneration

  2006cited by this paper
• Uncoupling protein‐2 promotes nigrostriatal dopamine neuronal function

  2006cited by this paper
• Uncoupling proteins: a role in protection against reactive oxygen species--or not?

  2006cited by this paper
• ALS: a disease of motor neurons and their nonneuronal neighbors.

  2006cited by this paper
• Cytotoxicity of a mutant huntingtin fragment in yeast involves early alterations in mitochondrial OXPHOS complexes II and III.

  2006cited by this paper
• Enhanced sensitivity of DJ-1-deficient dopaminergic neurons to energy metabolism impairment: role of Na+/K+ ATPase.

  2006cited by this paper
• Review ALS: A Disease of Motor Neurons and Their Nonneuronal Neighbors

  2006cited by this paper
• Putative function and physiological relevance of the mitochondrial uncoupling protein-3: involvement in fatty acid metabolism?

  2006cited by this paper
• Thermoregulatory and metabolic defects in Huntington's disease transgenic mice implicate PGC-1alpha in Huntington's disease neurodegeneration.

  2006cited by this paper
• Molecular indices of oxidative stress and mitochondrial dysfunction occur early and often progress with severity of Alzheimer's disease

  2006cited by this paper
• Mitochondrial Uncoupling Protein-4 Regulates Calcium Homeostasis and Sensitivity to Store Depletion-induced Apoptosis in Neural Cells*

  2006cited by this paper
• Dinitrophenol-induced mitochondrial uncoupling in vivo triggers respiratory adaptation in HepG2 cells.

  2006cited by this paper
• Mitochondrial DNA mutations, energy metabolism and apoptosis in aging muscle.

  2006cited by this paper
• Involvement of Oxidative Stress in Alzheimer Disease

  2006cited by this paper
• Calorie restriction induces mitochondrial biogenesis and bioenergetic efficiency.

  2006cited by this paper
• Variation in the UCP2-UCP3 Gene Cluster Predicts the Development of Type 2 Diabetes in Healthy Middle-Aged Men

  2006cited by this paper
• Calorie restriction mimetics: an emerging research field

  2006cited by this paper
• Mitochondrial Respiration and ATP Production Are Significantly Impaired in Striatal Cells Expressing Mutant Huntingtin*

  2005cited by this paper
• Uncoupler of Oxidative Phosphorylation Prolongs the Lifespan of Drosophila

  2005cited by this paper
• Mitochondria, oxidants, and aging.

  2005cited by this paper
• Sirt1 Regulates Insulin Secretion by Repressing UCP2 in Pancreatic β Cells

  2005cited by this paper
• Calorie restriction--the SIR2 connection.

  2005cited by this paper
• Nuclear and mitochondrial DNA repair: similar pathways?

  2005cited by this paper
• Mitochondrial ATP-Sensitive K+ Channels Prevent Oxidative Stress, Permeability Transition and Cell Death

  2005cited by this paper
• Mitochondrial uncoupling proteins in the cns: in support of function and survival

  2005cited by this paper
• Mitochondria take center stage in aging and neurodegeneration

  2005cited by this paper
• Mitochondrial H(+) leak and ROS generation: an odd couple.

  2005cited by this paper
• Extension of Murine Life Span by Overexpression of Catalase Targeted to Mitochondria

  2005cited by this paper
• The basal proton conductance of mitochondria depends on adenine nucleotide translocase content.

  2005cited by this paper
• Global prevalence of dementia: a Delphi consensus study

  2005cited by this paper
• Lack of effect of caloric restriction on bioenergetics and reactive oxygen species production in intact rat hepatocytes.

  2005cited by this paper
• Physiological functions of the mitochondrial uncoupling proteins UCP2 and UCP3.

  2005cited by this paper
• Uncoupling protein 2 protects dopaminergic neurons from acute 1,2,3,6‐methyl‐phenyl‐tetrahydropyridine toxicity

  2005cited by this paper
• No evidence of mitochondrial respiratory dysfunction in OGG1-null mice deficient in removal of 8-oxodeoxyguanine from mitochondrial DNA.

  2005cited by this paper
• The orphan nuclear receptor SHP regulates PGC-1alpha expression and energy production in brown adipocytes.

  2005cited by this paper
• K-ATP channels promote the differential degeneration of dopaminergic midbrain neurons

  2005cited by this paper
• Molecular pathophysiology of Parkinson's disease.

  2005cited by this paper
• Functional and morphological alterations of mitochondria in pancreatic beta cells from type 2 diabetic patients

  2005cited by this paper
• Long-term caloric restriction increases UCP3 content but decreases proton leak and reactive oxygen species production in rat skeletal muscle mitochondria.

  2005cited by this paper
• Enhanced catabolism of mitochondrial superoxide/hydrogen peroxide and aging in transgenic Drosophila.

  2005cited by this paper
• 3‐Nitropropionic acid: a mitochondrial toxin to uncover physiopathological mechanisms underlying striatal degeneration in Huntington's disease

  2005cited by this paper
• Physiological increases in uncoupling protein 3 augment fatty acid oxidation and decrease reactive oxygen species production without uncoupling respiration in muscle cells.

  2005cited by this paper
• Targeted expression of the human uncoupling protein 2 (hUCP2) to adult neurons extends life span in the fly.

  2005cited by this paper
• Mitochondrial Uncoupling Proteins in the Central Nervous System

  2005cited by this paper
• Reactive Oxygen and Nitrogen Species: Weapons of Neuronal Destruction in Models of Parkinson's Disease

  2005cited by this paper
• The reactions catalysed by the mitochondrial uncoupling proteins UCP2 and UCP3.

  2005cited by this paper
• The mitochondrial uncoupler 2,4‐dinitrophenol attenuates tissue damage and improves mitochondrial homeostasis following transient focal cerebral ischemia

  2005cited by this paper
• Long-term calorie restriction reduces proton leak and hydrogen peroxide production in liver mitochondria.

  2005cited by this paper
• Reduced mitochondrial coupling in vivo alters cellular energetics in aged mouse skeletal muscle

  2005cited by this paper
• Adipose tissue energy metabolism: altered gene expression profile of mice subjected to long‐term caloric restriction

  2004cited by this paper
• Expression of Lung Uncoupling Protein-2 mRNA is Modulated Developmentally and by Caloric Intake

  2004cited by this paper
• Huntington’s disease: pathomechanism and therapeutic perspectives

  2004cited by this paper
• Supramolecular Organization of Cytochrome c Oxidase- and Alternative Oxidase-dependent Respiratory Chains in the Filamentous Fungus Podospora anserina*

  2004cited by this paper
• Rat brain and liver mitochondria develop oxidative stress and lose enzymatic activities on aging.

  2004cited by this paper
• Higher Respiratory Activity Decreases Mitochondrial Reactive Oxygen Release and Increases Life Span in Saccharomyces cerevisiae*

  2004cited by this paper
• Effects of short- and medium-term calorie restriction on muscle mitochondrial proton leak and reactive oxygen species production.

  2004cited by this paper
• Targeting the neurotoxic species in Alzheimer's disease: inhibitors of Aβ oligomerization

  2004cited by this paper
• Expression of Uncoupling Protein-2 in Human Colon Cancer

  2004cited by this paper
• Proton leak and hydrogen peroxide production in liver mitochondria from energy-restricted rats.

  2004cited by this paper
• Exogenous insulin can reverse the effects of caloric restriction on mitochondria.

  2004cited by this paper
• The Mitochondrial Uncoupling Agent 2,4-Dinitrophenol Improves Mitochondrial Function, Attenuates Oxidative Damage, and Increases White Matter Sparing in the Contused Spinal Cord

  2004cited by this paper
• The Energetics of Huntington's Disease

  2004cited by this paper
• Uncoupling protein‐2 deficiency promotes oxidant stress and delays liver regeneration in mice

  2004cited by this paper

• Synergistic Anti-Inflammatory Effects and Efficient Weight Loss through the Combination of Chinese Herbs and Photothermal Therapy in Obesity Treatment.

  2026cites this paper
• Multiscale Average Absolute Difference (MSAAD): A Computationally Efficient and Nonparametric Adaptation of Line Length for Noisy, Uncontrolled Wearables Time Series

  2025cites this paper
• Unveiling the Longevity Potential of Natural Phytochemicals: A Comprehensive Review of Active Ingredients in Dietary Plants and Herbs

  2024cites this paper
• Local hyperthermia therapy induces browning of white fat and treats obesity.

  2022cites this paper
• Antioxidant properties of lactic acid bacteria isolated from traditional fermented yak milk and their probiotic effects on the oxidative senescence of Caenorhabditis elegans.

  2022cites this paper
• Mito-nuclear interactions modify Drosophila exercise performance.

  2019cites this paper
• Spatiotemporal and demographic variation in the association between temperature variability and hospitalizations in Brazil during 2000-2015: A nationwide time-series study.

  2018cites this paper
• Study of respiratory chain dysfunction in heart disease

  2018cites this paper
• Perspectives on mitochondrial uncoupling proteins-mediated neuroprotection

  2015influential citation
• The breathing heart - mitochondrial respiratory chain dysfunction in cardiac disease.

  2014cites this paper
• Cistanches Herba reduces the weight gain in high fat diet-induced obese mice possibly through mitochondrial uncoupling

  2014cites this paper
• Does Parkinson's disease and type-2 diabetes mellitus present common pathophysiological mechanisms and treatments?

  2014cites this paper
• UCP2 and ANT differently modulate proton-leak in brain mitochondria of long-term hyperglycemic and recurrent hypoglycemic rats

  2013cites this paper
• Hyperglycemia, hypoglycemia and dementia: role of mitochondria and uncoupling proteins.

  2013cites this paper
• Synthesis of deuterium-labeled analogs of the lipid hydroperoxide-derived bifunctional electrophile 4-oxo-2(E)-nonenal.

  2011cites this paper
• cAMP/PKA signaling balances respiratory activity with mitochondria dependent apoptosis via transcriptional regulation

  2010cites this paper