Phosphoinositide metabolism and insulin secretion from isolated rat pancreatic islets.

No abstract is available for this paper.

• Publication year

  1976

• Venue

  Journal of Clinical Investigation

• Publication date

  1976-03-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1172/JCI108325PMID 175090PMCID PMC436702
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Inositol phospholipids and cell surface receptor function.

  1975cited by this paper
• Electrical and Secretory Manifestations of Glucose and Amino Acid Interactions in Rat Pancreatic Islets

  1975cited by this paper
• The regulated catabolism of endogenous and exogenous phosphatidylinositol by Saccharomyces cerevisiae leading to extracellular glycerophosphorylinositol and inositol.

  1975cited by this paper
• Relationship between enhanced turnover of phosphatidylinositol and lymphocyte activation by mitogens.

  1975cited by this paper
• Effects of insulin secretagogues on phospholipid metabolism in pancreatic beta-cells.

  1975cited by this paper
• Acetylcholine causes a net decrease in phosphatidylinositol and a net increase in phosphatidic acid in mouse pancreas.

  1974cited by this paper
• Isolation of cyclic inositol-1,2-phosphate from mammalian cells and a probable function of phosphatidylinositol turnover.

  1974cited by this paper
• Breakdown of phosphatidylinositol provoked by muscarinic cholinergic stimulation of rat parotid-gland fragments.

  1974cited by this paper
• Rapid transient efflux of phosphate ions from pancreatic islets as an early action of insulin secretagogues.

  1974cited by this paper
• Stimulation of the incorporation of 32Pi and myo-(2-3H)inositol into the phosphoinositides in polymorphonuclear leukocytes during phagocytosis.

  1974cited by this paper
• Phosphatidylinositol cleavage catalysed by the soluble fraction from lymphocytes. Activity at pH5.5 and pH7.0.

  1974cited by this paper
• Exocytosis-Endocytosis Coupling in the Pancreatic Beta Cell

  1973cited by this paper
• The association between phosphatidylinositol phosphodiesterase activity and a specific subunit of microtubular protein in rat brain.

  1973cited by this paper
• Insulin secretion: Multifactorial regulation for a single process of release

  1973cited by this paper
• Role of Inositol Cyclic Phosphate in Stimulated Tissues

  1973cited by this paper
• Effect of D‐glucose on the incorporation of 32P into phospholipids of mouse pancreatic islets

  1972cited by this paper
• Production of cyclic inositol phosphate in stimulated tissues.

  1972cited by this paper
• Perifusion of Isolated Rat Islets in Vitro: Participation of the Microtubular System in the Biphasic Release of Insulin

  1972cited by this paper
• Phosphoinositide interconversion: a model for control of Na + and K + permeability in the nerve axon membrane.

  1971cited by this paper
• The enzymic formation of myoinositol 1:2-cyclic phosphate from phosphatidylinositol.

  1971cited by this paper
• The metabolism of phosphatidylinositol in the thyroid gland of the pig.

  1971cited by this paper
• Glucose‐induced electrical activity in pancreatic islet cells

  1970cited by this paper
• Incorporation of [32P]orthophosphate into brain-slice phospholipids and their precursors. Effects of electrical stimulation.

  1969cited by this paper
• Dynamic aspects of phospholipids during protein secretion.

  1968cited by this paper
• The Phosphoinositide Inositolphosphohydrolase of Guinea-Pig Intestinal Mucosa

  1968cited by this paper
• Thin-layer chromatography of the phosphoinositides.

  1968cited by this paper
• Monophosphatidyl inositol inositolphosphohydrolase in guinea-pig brain.

  1967cited by this paper
• The phosphoinositide inositolphosphohydrolase of guinea-pig intestinal mucosa.

  1966cited by this paper
• ION EXCHANGE CHROMATOGRAPHY OF INTACT BRAIN PHOSPHOINOSITIDES ON DIETHYLAMINOETHYL CELLULOSE BY GRADIENT SALT ELUTION IN A MIXED SOLVENT SYSTEM.

  1964cited by this paper
• STATISTICAL METHODS

  1962cited by this paper
• Electron microscopy of the beta cell of the pancreas.

  1961cited by this paper
• The presence of phosphatidic acid in animal tissues.

  1958cited by this paper
• Phospholipides and adrenaline secretion in guinea pig adrenal medulla.

  1958cited by this paper
• Pathways of thyroidal phosphorus metabolism: the effect of pituitary thyrotropin upon the phospholipids of the sheep thyroid gland.

  1957cited by this paper

• Synthesis of unsaturated phosphatidylinositol 4-phosphates and the effects of substrate unsaturation on SopB phosphatase activity.

  2015cites this paper
• New Horizons in Cellular Regulation by Inositol Polyphosphates: Insights from the Pancreatic β-Cell

  2013cites this paper
• Role of Ca 2 + in Secretagogue-stimulated Breakdown of Phosphatidylinositol in Rat Pancreatic Islets

  2013influential citation
• Rapid Turnover of Phosphatidylinositol-4,5-Bisphosphate in Insulin-Secreting Cells Mediated by Ca2+ and the ATP-to-ADP Ratio

  2007cites this paper
• Cytoanalysis of Pancreatic B-cells: Using an Avian Model, Mammalian Tissue Culture and Implications of Antisense Oligonucleotides Transfection

  2004cites this paper
• ADP-ribosylation factor 6 regulates insulin secretion through plasma membrane phosphatidylinositol 4,5-bisphosphate

  2003cites this paper
• Intracellular calcium ion response to glucose in β-cells of calbindin-D28k nullmutant mice and in βHC13 cells overexpressing calbindin-D28k

  2002cites this paper
• Intracellular calcium ion response to glucose in beta-cells of calbindin-D28k nullmutant mice and in betaHC13 cells overexpressing calbindin-D28k.

  2002cites this paper
• Roles of GTP and phospholipase C in the potentiation of Ca(2+)-induced insulin secretion by glucose in rat pancreatic islets.

  1997cites this paper
• Phosphoinositide Hydrolysis and Insulin Release in Fetal Rat Islets

  1994cites this paper
• Essential fatty acids (EFA): Role in pancreatic hormone release and concomitant metabolic effect

  1993cites this paper
• Inositol cycling and phosphoinositide metabolism in rat pancreatic islets.

  1991cites this paper
• Vanadate stimulation of insulin release in normal mouse islets.

  1991cites this paper
• CCKA receptor antagonism inhibits mechanisms underlying CCK-8-stimulated insulin release in isolated rat islets.

  1991cites this paper
• Chronic in vivo hyperglycemia impairs phosphoinositide hydrolysis and insulin release in isolated perifused rat islets.

  1990cites this paper
• Gastric inhibitory polypeptide mechanisms of augmenting insulin secretion.

  1990cites this paper
• Phospholipases in biology and medicine.

  1990cites this paper
• Dual mechanism involved in the hydrolysis of polyphosphoinositides in rat pancreatic islets.

  1989cites this paper
• Insulin Release in RINm5F Cells and Glyceraldehyde Activation of Protein Kinase C

  1989influential citation
• Phasic Effects of Glucose, p-Hydroxymercuribenzoate, and Lysophosphatidylcholine on Insulin Secretion from HIT Cells

  1989cites this paper
• Interactions between lithium, inositol and mono-oleoylglycerol in the regulation of insulin secretion from isolated perifused rat islets.

  1989cites this paper
• The conditions under which rat islets are labelled with [3H]inositol alter the subsequent responses of these islets to a high glucose concentration.

  1989cites this paper
• Muscarinic control of pancreatic B cell function involves sodium-dependent depolarization and calcium influx.

  1988cites this paper
• Induction of Memory in Rat Pancreatic Islets by Tolbutamide: Dependence on Ambient Glucose Level, Calcium, and Phosphoinositide Hydrolysis

  1988cites this paper
• GTP- and inositol 1,4,5-trisphosphate-induced release of 45Ca2+ from a membrane store co-localized with pancreatic-islet-cell plasma membrane.

  1988cites this paper
• Time-dependent potentiation of insulin release induced by alpha-ketoisocaproate and leucine in rats: possible involvement of phosphoinositide hydrolysis

  1988cites this paper
• Role of phosphoinositide metabolism in induction of memory in isolated perifused rat islets.

  1988cites this paper
• Membrane phospholipid turnover as an intermediary step in insulin secretion. Putative roles of phospholipases in cell signaling.

  1988cites this paper
• Glucose-, calcium- and concentration-dependence of acetylcholine stimulation of insulin release and ionic fluxes in mouse islets.

  1988cites this paper
• Studies of the Ca2+ requirements for glucose- and carbachol-induced augmentation of inositol trisphosphate and inositol tetrakisphosphate accumulation in digitonin-permeabilized islets. Evidence for a glucose recognition site in insulin secretion.

  1988cites this paper
• Influence of cAMP and Calcium on [3H]Inositol Efflux, Inositol Phosphate Accumulation, and Insulin Release From Isolated Rat Islets

  1988cites this paper
• Possible involvement of diacylglycerol-activated, Ca2+-dependent protein kinase in glucose memory of the rat pancreatic B-cell.

  1988cites this paper
• Phosphoinositide Hydrolysis and Insulin Release From Isolated Perifused Rat Islets: Studies With Glucose

  1988influential citation
• Phasic effects of glucose, phospholipase A2, and lysophospholipids on insulin secretion.

  1987cites this paper
• Phospholipases, lysophospholipases, and lipases and their involvement in various diseases.

  1987cites this paper
• Phosphoinositides turnover and insulin secretion in pancreatic islets.

  1987cites this paper
• Interactions of Cholecystokinin and Glucose in Rat Pancreatic Islets

  1987cites this paper
• Cholecystokinin-lnduced Alterations in β-Cell Sensitivity: Duration, Specificity, and Involvement of Phosphoinositide Metabolism

  1987cites this paper
• The role of phospholipid-derived mediators including arachidonic acid, its metabolites, and inositoltrisphosphate and of intracellular Ca2+ in glucose-induced insulin secretion by pancreatic islets.

  1987cites this paper
• Ca2+-mediated generation of inositol 1,4,5-triphosphate and inositol 1,3,4,5-tetrakisphosphate in pancreatic islets. Studies with K+, glucose, and carbamylcholine.

  1987cites this paper
• Intracellular Ca2+ mobilization by arachidonic acid. Comparison with myo-inositol 1,4,5-trisphosphate in isolated pancreatic islets.

  1986cites this paper
• Glucose-induced phospholipid hydrolysis in isolated pancreatic islets: quantitative effects on the phospholipid content of arachidonate and other fatty acids.

  1986cites this paper
• Glucose stimulation of insulin secretion in islets of fed and starved rats and its dependence on lipid metabolism.

  1986cites this paper
• Signal transduction in insulin secretion: comparison between fuel stimuli and receptor agonists.

  1986cites this paper
• Chapter 8 – Calcium and the Control of Insulin Secretion

  1986cites this paper
• Active transport of myo-inositol in rat pancreatic islets.

  1986cites this paper
• The Third Phase of In Vitro Insulin Secretion: Evidence For Glucose Insensitivity

  1986cites this paper
• Dissociation of phosphatidylinositol hydrolysis and insulin secretion of cultured mouse pancreatic islets.

  1986cites this paper
• Glucose-stimulated sequestration of Ca2+ in clonal insulin-releasing cells. Evidence for an opposing effect of muscarinic-receptor activation.

  1986cites this paper
• In vitro exhaustion of pancreatic beta-cells.

  1986cites this paper
• Signal Transduction in Insulin Secretion:

  1986cites this paper
• Effect of Exogenous Phospholipase A2 on Insulin Secretion from Perifused Rat Islets

  1985cites this paper
• Effect of glucose on polyphosphoinositide metabolism in isolated rat islets of Langerhans.

  1985cites this paper
• Role of phospholipase and calmodulin inhibitors on insulin, arachidonic acid and prostaglandin E2 release.

  1985cites this paper
• Eicosanoids as regulators of pancreatic islet hormone secretion.

  1985cites this paper
• The digitonin-permeabilized pancreatic islet model. Effect of myo-inositol 1,4,5-trisphosphate on Ca2+ mobilization.

  1985cites this paper
• Perifusion of a Clonal Cell Line of Simian Virus 40-Transformed Beta Cells: Insulin Secretory Dynamics in Response to Glucose, 3-Isobutyl-1-Methylxanthine, and Potassium

  1985cites this paper
• Calcium-mobilizing receptors, polyphosphoinositides, and the generation of second messengers.

  1985cites this paper
• Receptors and phosphoinositide-generated second messengers.

  1985cites this paper
• Phospholipids as intermediates in hormone action.

  1984cites this paper
• Prostaglandin synthesis linked to phosphatidylinositol turnover in isolated rat glomeruli.

  1984cites this paper
• Phospholipid metabolism in pancreatic islets

  1984cites this paper
• Role of arachidonate lipoxygenase and cyclooxygenase products in insulin and glucagon secretion from rat pancreatic islets.

  1984cites this paper
• Oxygenation products of arachidonic acid: third messengers for insulin release.

  1984cites this paper
• Is phospholipase A2 a "glucose sensor" responsible for the phasic pattern of insulin release?

  1984cites this paper
• Nutrient and hormone-neurotransmitter stimuli induce hydrolysis of polyphosphoinositides in rat pancreatic islets.

  1984cites this paper
• Identification and characterization of Ca2+-phospholipid-dependent protein kinase in rat islets and hamster beta-cells.

  1984cites this paper
• Inositol as a lipotropic agent in dairy cattle diets.

  1984cites this paper
• Distinct effects of acetylcholine and glucose on 45calcium and 86rubidium efflux from mouse pancreatic islets

  1984cites this paper
• [Multifactorial regulation of insulin secretion].

  1984cites this paper
• Endogenous Prostaglandin Synthesis and Glucose-induced Insulin Secretion from the Adult Rat Pancreatic Islet

  1983cites this paper
• The phosphatidate-phosphoinositide cycle: an intracellular messenger system in the action of hormones and neurotransmitters.

  1983cites this paper
• Role of Ca2+ in secretagogue-stimulated breakdown of phosphatidylinositol in rat pancreatic islets.

  1983influential citation
• Phosphoinositide metabolism and hormone action.

  1983cites this paper
• Phosphatidylinositol hydrolysis in isolated guinea-pig islets of Langerhans.

  1983cites this paper
• Stimulation of phosphoinositide breakdown in rat pancreatic islets by glucose and carbamylcholine.

  1983cites this paper
• Lipoxygenase pathway in islet endocrine cells. Oxidative metabolism of arachidonic acid promotes insulin release.

  1983cites this paper
• Phosphatidylinositol and phosphatidic acid metabolism in rat pancreatic islets in response to neurotransmitter and hormonal stimuli.

  1983cites this paper
• Fatty Acid Incorporation into Phospholipids of Isolated Pancreatic Islets of the Rat: Relationship to Insulin Release

  1983cites this paper
• A role for the lipoxygenase pathway of arachidonic acid metabolism in glucose- and glucagon-induced insulin secretion.

  1983cites this paper
• Effects of nutrient secretagogues upon phospholipid metabolism in rat pancreatic islets.

  1983cites this paper
• Differential effects of microtubule-altering agents on beta-cells during development.

  1983cites this paper
• Identification and metabolism of polyphosphoinositides in isolated islets of Langerhans.

  1983cites this paper
• Phospholipids and islet function

  1983influential citation
• Biosynthesis of a proinsulin-like molecule in the pancreas of a lizard.

  1983cites this paper
• Molecular events following activation of muscarinic receptors: the role of inositol phospholipids.

  1982cites this paper
• Calcium‐activated, phospholipid‐dependent protein kinase in rat pancreas islets of langerhans

  1982cites this paper
• The nutritional significance, metabolism, and function of myo-inositol and phosphatidylinositol in health and disease.

  1982cites this paper
• Continuous‐Perifusion tissue culture of fetal and adult pancreas of the lizard Anolis carolinensis

  1982cites this paper
• Contemporary Metabolism

  1982cites this paper
• Myoinositol decreases N-nitroso-N-methylurethane induced lung surfactant deficiency.

  1982cites this paper
• Lipoxygenation of arachidonic acid: a pivotal step in stimulus-secretion coupling in the pancreatic beta cell.

  1982cites this paper
• Calcium-activated, phospholipid-dependent protein kinase in rat pancreas islets of langerhans. Its possible role in glucose-induced insulin release.

  1982cites this paper
• Kinetics of protein-mediated transfer of rat pancreatic microsomal phosphatidylinositol to liposomes.

  1982cites this paper
• Stimulated Phosphatidylinositol Turnover A Brief Appraisal

  1982cites this paper
• Chapter 12 – Regulation of Insulin Release and Protein Phosphorylation by Calcium and Cyclic AMP: Possible Role for Calmodulin*

  1982cites this paper
• 3 – Roles of Phospholipid Metabolism in Secretory Cells

  1982cites this paper
• Feedback modulation of glucose-induced insulin secretion by arachidonic acid metabolites: possible molecular mechanisms and relevance to diabetes mellitus.

  1981cites this paper
• Myo-inositol and the maintenance of beta-cell function in cultured rat pancreatic islets.

  1981cites this paper
• Myo-lnositol and the Maintenance of β-Cell Function in Cultured Rat Pancreatic Islets

  1981cites this paper