Off the beaten pathway: the complex cross talk between Notch and NF-κB

No abstract is available for this paper.

• Publication year

  2008

• Venue

  Laboratory Investigation

• Publication date

  Unknown publication date

• Fields of study

  Biology

• Identifiers
  DOI 10.1038/labinvest.3700700
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• p53 and NF-kappaB crosstalk: IKKalpha tips the balance.

  2007cited by this paper
• Synergism between NF-kappa B1/p50 and Notch2 during the development of marginal zone B lymphocytes.

  2007cited by this paper
• The multifaceted role of Notch in cancer.

  2007cited by this paper
• Structural basis for autoinhibition of Notch

  2007cited by this paper
• Notch signaling in development and cancer.

  2007cited by this paper
• Nuclear IKK activity leads to dysregulated Notch-dependent gene expression in colorectal cancer

  2007influential reference
• IκB Kinase Promotes Tumorigenesis through Inhibition of Forkhead FOXO3a (PII:S0092-8674(04)00302-2)

  2007cited by this paper
• Nuclear Factor-κB in Development, Prevention, and Therapy of Cancer

  2007cited by this paper
• NF-kappaB activation in development and progression of cancer.

  2007cited by this paper
• Coexpression of Notch1 and NF-kappaB signaling pathway components in human cervical cancer progression.

  2007cited by this paper
• NF-κB as a therapeutic target in neurodegenerative diseases

  2007cited by this paper
• NF-κB Signaling and Carcinogenesis

  2007cited by this paper
• NF‐κB activation in development and progression of cancer

  2007cited by this paper
• Integrating cell-signalling pathways with NF-kappaB and IKK function.

  2007influential reference
• Regulation of lymphocyte development by Notch signaling

  2007cited by this paper
• Targeting the NF-κB signaling pathway in Notch1-induced T-cell leukemia

  2007cited by this paper
• p53 and NF-?B Crosstalk: IKKa Tips the Balance

  2007cited by this paper
• NF-kappa B as a therapeutic target in neurodegenerative diseases.

  2007cited by this paper
• NF-kappa B as a target for cancer therapy.

  2007cited by this paper
• NF-kappa B signaling and carcinogenesis.

  2007cited by this paper
• NF-κB as a target for cancer therapy

  2007cited by this paper
• Targeting transcription factors in acute leukemia in children.

  2007cited by this paper
• Nuclear factor-kappaB in development, prevention, and therapy of cancer.

  2007cited by this paper
• Targeting the NF-kappaB signaling pathway in Notch1-induced T-cell leukemia.

  2007cited by this paper
• Notch3 and pre‐TCR interaction unveils distinct NF‐κB pathways in T‐cell development and leukemia

  2006cited by this paper
• Regulation of NF-kappaB function.

  2006cited by this paper
• Retracted: Inhibition of nuclear factor κb activity by genistein is mediated via Notch‐1 signaling pathway in pancreatic cancer cells

  2006cited by this paper
• Myc is a Notch1 transcriptional target and a requisite for Notch1-induced mammary tumorigenesis in mice.

  2006cited by this paper
• IKKalpha stabilizes cytosolic beta-catenin by inhibiting both canonical and non-canonical degradation pathways.

  2006cited by this paper
• Essential role for IκB kinase β in remodeling carma1-bcl10-malt1 complexes upon T cell activation

  2006cited by this paper
• Inhibition of nuclear factor kappab activity by genistein is mediated via Notch-1 signaling pathway in pancreatic cancer cells.

  2006cited by this paper
• IKKα stabilizes cytosolic β-catenin by inhibiting both canonical and non-canonical degradation pathways

  2006cited by this paper
• Notch1 augments NF-kappaB activity by facilitating its nuclear retention.

  2006cited by this paper
• Notch1 augments NF‐κB activity by facilitating its nuclear retention

  2006cited by this paper
• Down-regulation of notch-1 inhibits invasion by inactivation of nuclear factor-kappaB, vascular endothelial growth factor, and matrix metalloproteinase-9 in pancreatic cancer cells.

  2006cited by this paper
• Essential role for IkappaB kinase beta in remodeling Carma1-Bcl10-Malt1 complexes upon T cell activation.

  2006cited by this paper
• c-Myc is an important direct target of Notch1 in T-cell acute lymphoblastic leukemia/lymphoma.

  2006cited by this paper
• Formation of an IKKalpha-dependent transcription complex is required for estrogen receptor-mediated gene activation.

  2005cited by this paper
• IkappaB kinase alpha regulates subcellular distribution and turnover of cyclin D1 by phosphorylation.

  2005cited by this paper
• Control of cell proliferation in the Drosophila eye by Notch signaling.

  2005cited by this paper
• Convergent actions of I kappa B kinase beta and protein kinase C delta modulate mRNA stability through phosphorylation of 14-3-3 beta complexed with tristetraprolin.

  2005cited by this paper
• IκB Kinase α Regulates Subcellular Distribution and Turnover of Cyclin D1 by Phosphorylation*

  2005cited by this paper
• Convergent Actions of IκB Kinase β and Protein Kinase Cδ Modulate mRNA Stability through Phosphorylation of 14-3-3β Complexed with Tristetraprolin

  2005cited by this paper
• Notch1 modulates timing of G1-S progression by inducing SKP2 transcription and p27Kip1 degradation

  2005cited by this paper
• IkappaB kinase is an essential component of the Tpl2 signaling pathway.

  2004cited by this paper
• Recruitment of IκBα to the hes1 promoter is associated with transcriptional repression

  2004cited by this paper
• IκB Kinase Is an Essential Component of the Tpl2 Signaling Pathway

  2004cited by this paper
• Lipopolysaccharide Activation of the TPL-2/MEK/Extracellular Signal-Regulated Kinase Mitogen-Activated Protein Kinase Cascade Is Regulated by I (cid:2) B Kinase-Induced Proteolysis of NF- (cid:2) B1 p105†

  2004cited by this paper
• Notch Subunit Heterodimerization and Prevention of Ligand-Independent Proteolytic Activation Depend, Respectively, on a Novel Domain and the LNR Repeats

  2004cited by this paper
• IkappaB kinase promotes tumorigenesis through inhibition of forkhead FOXO3a.

  2004cited by this paper
• Notch‐1 regulates cell death independently of differentiation in murine erythroleukemia cells through multiple apoptosis and cell cycle pathways

  2004cited by this paper
• Recruitment of IkappaBalpha to the hes1 promoter is associated with transcriptional repression.

  2004cited by this paper
• Drosophila Epsin mediates a select endocytic pathway that DSL ligands must enter to activate Notch

  2004cited by this paper
• Notch signaling: control of cell communication and cell fate

  2004cited by this paper
• Involvement of Notch signaling in hippocampal synaptic plasticity.

  2004cited by this paper
• SMRT derepression by the IkappaB kinase alpha: a prerequisite to NF-kappaB transcription and survival.

  2004cited by this paper
• Histone H3 phosphorylation by IKK-alpha is critical for cytokine-induced gene expression.

  2003cited by this paper
• Histone H3 phosphorylation by IKK-α is critical for cytokine-induced gene expression

  2003cited by this paper
• Tumor necrosis factor-alpha-induced IKK phosphorylation of NF-kappaB p65 on serine 536 is mediated through the TRAF2, TRAF5, and TAK1 signaling pathway.

  2003cited by this paper
• Basal expression of IkappaBalpha is controlled by the mammalian transcriptional repressor RBP-J (CBF1) and its activator Notch1.

  2003cited by this paper
• IKKalpha regulates mitogenic signaling through transcriptional induction of cyclin D1 via Tcf.

  2003cited by this paper
• IKKβ Plays an Essential Role in the Phosphorylation of RelA/p65 on Serine 536 Induced by Lipopolysaccharide1

  2003cited by this paper
• TCR-mediated Notch signaling regulates proliferation and IFN-gamma production in peripheral T cells.

  2003cited by this paper
• Basal Expression of IκBα Is Controlled by the Mammalian Transcriptional Repressor RBP-J (CBF1) and Its Activator Notch1*

  2003cited by this paper
• Tumor Necrosis Factor-α-induced IKK Phosphorylation of NF-κB p65 on Serine 536 Is Mediated through the TRAF2, TRAF5, and TAK1 Signaling Pathway*

  2003cited by this paper
• TCR-Mediated Notch Signaling Regulates Proliferation and IFN-γ Production in Peripheral T Cells 1

  2003cited by this paper
• Jagged-1 mediated activation of notch signaling induces complete maturation of human keratinocytes through NF-κB and PPARγ

  2002cited by this paper
• Regulation of SRC-3 (pCIP/ACTR/AIB-1/RAC-3/TRAM-1) Coactivator Activity by IκB Kinase

  2002cited by this paper
• Regulation of SRC-3 (pCIP/ACTR/AIB-1/RAC-3/TRAM-1) Coactivator activity by I kappa B kinase.

  2002cited by this paper
• Notch Signaling in Cancer

  2002cited by this paper
• Jagged-1 mediated activation of notch signaling induces complete maturation of human keratinocytes through NF-kappaB and PPARgamma.

  2002cited by this paper
• Combined expression of pTalpha and Notch3 in T cell leukemia identifies the requirement of preTCR for leukemogenesis.

  2002cited by this paper
• Combined expression of pTα and Notch3 in T cell leukemia identifies the requirement of preTCR for leukemogenesis

  2002cited by this paper
• Notch-1 regulates NF-kappaB activity in hemopoietic progenitor cells.

  2001cited by this paper
• TAK1 is a ubiquitin-dependent kinase of MKK and IKK

  2001cited by this paper
• Notch-1 Regulates NF-κB Activity in Hemopoietic Progenitor Cells1

  2001cited by this paper
• Human Notch-1 Inhibits NF-κB Activity in the Nucleus Through a Direct Interaction Involving a Novel Domain1

  2001influential reference
• Notch signaling is a direct determinant of keratinocyte growth arrest and entry into differentiation

  2001cited by this paper
• Induction of Cyclin D1 Transcription and CDK2 Activity by Notchic: Implication for Cell Cycle Disruption in Transformation by Notchic

  2001cited by this paper
• Constitutive activation of NF‐κB and T‐cell leukemia/lymphoma in Notch3 transgenic mice

  2000cited by this paper
• Rel/NF‐κB can trigger the Notch signaling pathway by inducing the expression of Jagged1, a ligand for Notch receptors

  1999cited by this paper
• Notch Signaling : Cell Fate Control and Signal Integration in Development

  1999cited by this paper
• NF-κB2 Is a Putative Target Gene of Activated Notch-1 via RBP-Jκ

  1998cited by this paper
• Notch-1 Controls the Expression of Fatty Acid-activated Transcription Factors and Is Required for Adipogenesis*

  1997cited by this paper
• T cell leukemia-associated human Notch/translocation-associated Notch homologue has I kappa B-like activity and physically interacts with nuclear factor-kappa B proteins in T cells

  1996cited by this paper
• The I kappa B proteins: multifunctional regulators of Rel/NF-kappa B transcription factors.

  1993cited by this paper
• Direct association of pp40/I kappa B beta with rel/NF-kappa B transcription factors: role of ankyrin repeats in the inhibition of DNA binding activity.

  1992influential reference
• I kappa B interacts with the nuclear localization sequences of the subunits of NF-kappa B: a mechanism for cytoplasmic retention.

  1992cited by this paper

• Jojoba Oil Protects against Chlorpyrifos-Induced Testicular Toxicity by Modulating Notch1/Jagged1-Inflammatory Axis and Oxidative Stress.

  2026cites this paper
• Molecular insights into chronic glomerulonephritis and dopamine interplay.

  2025cites this paper
• New insights into Notch signaling as a crucial pathway of pancreatic cancer stem cell behavior by chrysin-polylactic acid-based nanocomposite

  2025cites this paper
• Natural bioactive compounds as notch signaling modulators: cutting-edge strategies for cancer therapy

  2025cites this paper
• Common ground on immune infiltration landscape and diagnostic biomarkers in diabetes-complicated atherosclerosis: an integrated bioinformatics analysis

  2024cites this paper
• Adipose-derived stem cell modulate tolerogenic dendritic cell-induced T cell regulation is correlated with activation of Notch-NFκB signaling.

  2024cites this paper
• Amicis Omnia Sunt Communia: NF-κB Inhibition as an Alternative to Overcome Osteosarcoma Heterogeneity

  2024cites this paper
• Melatonin and brain barriers: The protection conferred by melatonin to the blood-brain barrier and blood-cerebrospinal fluid barrier.

  2024cites this paper
• Research Progress on Anti-Inflammatory Effects and Related Mechanisms of Astragalin

  2024cites this paper
• Review: myogenic and muscle toxicity targets of environmental methylmercury exposure

  2024cites this paper
• A novel search engine for proteins involved in Notch crosstalk signaling pathways

  2023cites this paper
• Antibody blockade of Jagged1 attenuates choroidal neovascularization

  2023cites this paper
• The epigenetics orchestra of Notch signaling: a symphony for cancer therapy.

  2023cites this paper
• Notch Signaling in Acute Inflammation and Sepsis

  2023cites this paper
• Cooperative NF-κB and Notch1 signaling promotes macrophage-mediated MenaINV expression in breast cancer

  2023cites this paper
• Resveratrol prevents age‐related heart impairment through inhibiting the Notch/NF‐κB pathway

  2023cites this paper
• SOX4-activated lncRNA MCM3AP-AS1 aggravates osteoarthritis progression by modulating miR-149-5p/Notch1 signaling.

  2022cites this paper
• Modulation of Notch Signaling Pathway by Bioactive Dietary Agents

  2022cites this paper
• Potential effects of fructus aurantii ethanol extracts against colitis-associated carcinogenesis through coordination of Notch/NF-κB/IL-1 signaling pathways.

  2022cites this paper
• Considerations about Hypoxic Changes in Neuraxis Tissue Injuries and Recovery

  2022influential citation
• The Biology of Ocular Adnexal Marginal Zone Lymphomas

  2022cites this paper
• Endometrial Cancer Stem Cells: Where Do We Stand and Where Should We Go?

  2022cites this paper
• Notch Signaling and Cross-Talk in Hypoxia: A Candidate Pathway for High-Altitude Adaptation

  2022cites this paper
• Multi-objective optimization reveals time- and dose-dependent inflammatory cytokine-mediated regulation of human stem cell derived T-cell development

  2022cites this paper
• Jieduquyuziyin Prescription Suppresses the Inflammatory Activity of Macrophages via NOTCH1/NF-κB Pathway

  2022cites this paper
• AGEs-induced MMP-9 activation mediated by Notch1 signaling is involved in impaired wound healing in diabetic rats.

  2022cites this paper
• Signaling cross-talk during development: Context-specific networking of Notch, NF-κB and JNK signaling pathways in Drosophila.

  2021cites this paper
• Notch Signalling in Breast Development and Cancer

  2021cites this paper
• NF-κB and TNF Affect the Astrocytic Differentiation from Neural Stem Cells

  2021cites this paper
• Genes and pathways involved in senescence bypass identified by functional genetic screens.

  2021cites this paper
• Deubiquitinating Enzymes Orchestrate the Cancer Stem Cell-Immunosuppressive Niche Dialogue: New Perspectives and Therapeutic Potential

  2021cites this paper
• A DL-4- and TNFα-based culture system to generate high numbers of nonmodified or genetically modified immunotherapeutic human T-lymphoid progenitors

  2021cites this paper
• Immune modulatory effects of Idelalisib in stromal cells of chronic lymphocytic leukemia

  2021cites this paper
• Inflammatory Cytokines Regulate T-Cell Development from Blood Progenitor Cells in a Stage and Dose-Specifc Manner

  2021cites this paper
• SLX4IP promotes RAP1 SUMOylation by PIAS1 to coordinate telomere maintenance through NF-κB and Notch signaling

  2021cites this paper
• Activation of NOTCH1 by Shear Force Elicits Immediate Cytokine Expression in Human Chondrocytes

  2020cites this paper
• Notch signaling requiem : orchestral role of notch signaling in cancer and developmental disease

  2020cites this paper
• Alterations in Peripheral Lymphocyte Subsets in Early Stage of Novel Coronavirus Pneumonia

  2020cites this paper
• Methylmercury chloride exposure aggravates proinflammatory mediators and Notch-1 signaling in CD14+ and CD40+ cells and is associated with imbalance of neuroimmune function in BTBR T+ Itpr3tf/J mice.

  2020cites this paper
• Tumor microenvironment pathways: Cross regulation in breast cancer metastasis

  2020cites this paper
• p.P476S mutation of RBPJL inhibits the efficacy of anti‐PD‐1 therapy in oesophageal squamous cell carcinoma by blunting T‐cell responses

  2020cites this paper
• Notch signaling: Its essential roles in bone and craniofacial development

  2020cites this paper
• Notch-Inflammation Networks in Regulation of Breast Cancer Progression

  2020cites this paper
• Molecular Regulation of Notch Signaling by Gremlin.

  2020cites this paper
• A systems genomics approach to uncover patient-specific pathogenic pathways and proteins in a complex disease

  2019cites this paper
• The Notch pathway: a novel therapeutic target for cardiovascular diseases?

  2019cites this paper
• Preactivation of Notch1 in remote ischemic preconditioning reduces cerebral ischemia-reperfusion injury through crosstalk with the NF-κB pathway

  2019cites this paper
• Peli1b governs the brain patterning via ERK signaling pathways in zebrafish embryos.

  2019cites this paper
• Personalized and targeted mutational analysis of multiple second primary melanomas under kinase inhibitors.

  2019cites this paper
• The Use of Nutraceuticals to Counteract Atherosclerosis: The Role of the Notch Pathway

  2019cites this paper
• Notch signalling is a potential resistance mechanism of progenitor cells within patient‐derived prostate cultures following ROS‐inducing treatments

  2019cites this paper
• Gastroenteropancreatic neuroendocrine neoplasms and inflammation: A complex cross-talk with relevant clinical implications.

  2019cites this paper
• Folic acid deficiency enhanced microglial immune response via the Notch1/nuclear factor kappa B p65 pathway in hippocampus following rat brain I/R injury and BV2 cells

  2019cites this paper
• Estrogen-mediated protection against coronary heart disease: The role of the Notch pathway.

  2019cites this paper
• GIT1 regulates angiogenic factor secretion in bone marrow mesenchymal stem cells via NF‐κB/Notch signalling to promote angiogenesis

  2019cites this paper
• Could the Notch signaling pathway be a potential therapeutic option in renal diseases?

  2018cites this paper
• Análisis de la vía Notch como una posible diana terapéutica en la patología renal

  2018cites this paper
• Delta-tocotrienol inhibits non-small-cell lung cancer cell invasion via the inhibition of NF-κB, uPA activator, and MMP-9

  2018cites this paper
• Notch and NF-κB: Coach and Players of Regulatory T-Cell Response in Cancer

  2018cites this paper
• NOTCH1 Aberrations in Chronic Lymphocytic Leukemia

  2018cites this paper
• Deregulation of the Notch pathway as a common road in viral carcinogenesis

  2018cites this paper
• Ubiquitin D is Upregulated by Synergy of Notch Signalling and TNF-&agr; in the Inflamed Intestinal Epithelia of IBD Patients

  2018cites this paper
• Notch Signaling in Estrogen-Dependent Cancers

  2018cites this paper
• Noncanonical Notch Signaling

  2018cites this paper
• Acetylation-Dependent Regulation of Notch Signaling in Macrophages by SIRT1 Affects Sepsis Development

  2018cites this paper
• Notch Signaling: A Pivot Regulator of Adaptive and Innate Immunity

  2018cites this paper
• Gremlin activates the Notch pathway linked to renal inflammation.

  2018cites this paper
• Anti-Jagged Immunotherapy Inhibits MDSCs and Overcomes Tumor-Induced Tolerance.

  2017cites this paper
• Interplay between Notch1 and Notch3 promotes EMT and tumor initiation in squamous cell carcinoma

  2017cites this paper
• High-resolution melting analysis for rapid and sensitive NOTCH1 screening in chronic lymphocytic leukemia.

  2017cites this paper
• MiR-182 promotes cancer invasion by linking RET oncogene activated NF-κB to loss of the HES1/Notch1 regulatory circuit

  2017cites this paper
• Interleukin-1beta (IL-1β)-induced Notch ligand Jagged1 suppresses mitogenic action of IL-1β on human dystrophic myogenic cells

  2017cites this paper
• Notch signalling in placental development and gestational diseases.

  2017cites this paper
• Contribution of MAML1 in esophageal squamous cell carcinoma tumorigenesis.

  2017cites this paper
• Neuroprotection of Botch in experimental intracerebral hemorrhage in rats

  2017cites this paper
• The ANK repeats of Notch-4/Int3 activate NF-κB canonical pathway in the absence of Rbpj and causes mammary tumorigenesis

  2017cites this paper
• Hypertonic saline attenuates expression of Notch signaling and proinflammatory mediators in activated microglia in experimentally induced cerebral ischemia and hypoxic BV-2 microglia

  2017cites this paper
• Notch inhibitors and their role in the treatment of triple negative breast cancer: promises and failures

  2017cites this paper
• Notch regulates Th17 differentiation and controls trafficking of IL-17 and metabolic regulators within Th17 cells in a context-dependent manner

  2016cites this paper
• Endothelial Jag1-RBPJ signalling promotes inflammatory leucocyte recruitment and atherosclerosis.

  2016cites this paper
• The emerging role of Notch pathway in ageing: Focus on the related mechanisms in age-related diseases.

  2016cites this paper
• TNF-alpha and Notch signaling regulates the expression of HOXB4 and GATA3 during early T lymphopoiesis

  2016cites this paper
• Notch and its ligands in alloimmunity and rejection

  2016cites this paper
• Osteoclast-Primed Foxp3+ CD8 T Cells Induce T-bet, Eomesodermin, and IFN-γ To Regulate Bone Resorption

  2016cites this paper
• Delta-Like Ligand 4-Notch Signaling in Macrophage Activation.

  2016cites this paper
• Role of Notch signaling in regulating innate immunity and inflammation in health and disease

  2016cites this paper
• CD99 regulates neural differentiation of Ewing sarcoma cells through miR-34a-Notch-mediated control of NF-κB signaling

  2016cites this paper
• Induction of miR-146a by multiple myeloma cells in mesenchymal stromal cells stimulates their pro-tumoral activity.

  2016cites this paper
• Notch Signaling in Neuroendocrine Tumors

  2016cites this paper
• Cortical Structure Alterations and Social Behavior Impairment in p50-Deficient Mice

  2016cites this paper
• Targeting Notch1 and proteasome as an effective strategy to suppress T-cell lymphoproliferative neoplasms

  2015cites this paper
• The role of Notch signaling in muscle progenitor cell depletion and the rapid onset of histopathology in muscular dystrophy.

  2015cites this paper
• Systems approach to the study of brain damage in the very preterm newborn

  2015cites this paper
• Control of peripheral tolerance by regulatory T cell-intrinsic Notch signaling

  2015cites this paper
• Notch pathway is activated in cell culture and mouse models of mutant SOD1-related familial amyotrophic lateral sclerosis, with suppression of its activation as an additional mechanism of neuroprotection for lithium and valproate.

  2015cites this paper
• The Role of Notch in the Cardiovascular System: Potential Adverse Effects of Investigational Notch Inhibitors

  2015cites this paper
• Rac1 contributes to cerebral ischemia reperfusion-induced injury in mice by regulation of Notch2.

  2015cites this paper
• NF‐κB signaling regulates the generation of intermediate progenitors in the developing neocortex

  2015cites this paper
• The Vacuolar ATPase a2-subunit regulates Notch signaling in triple-negative breast cancer cells

  2015cites this paper
• Unraveling novel TF-miRNA regulatory crosstalk in metastasis of Soft Tissue Sarcoma

  2015cites this paper