Accumulation of Acrolein–Protein Adducts after Traumatic Spinal Cord Injury

No abstract is available for this paper.

• Publication year

  2005

• Venue

  Neurochemical Research

• Publication date

  2005-03-01

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1007/s11064-005-2602-7PMID 16018572
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The dynamics of axolemmal disruption in guinea pig spinal cord following compression

  2004cited by this paper
• Acrolein induces axolemmal disruption, oxidative stress, and mitochondrial impairment in spinal cord tissue.

  2004cited by this paper
• Ischemic insult exacerbates acrolein-induced conduction loss and axonal membrane disruption in guinea pig spinal cord white matter.

  2003cited by this paper
• 4-Hydroxy-2-nonenal: a product and mediator of oxidative stress.

  2003cited by this paper
• Acrolein inflicts axonal membrane disruption and conduction loss in isolated guinea-pig spinal cord.

  2002cited by this paper
• Behavioral recovery from spinal cord injury following delayed application of polyethylene glycol.

  2002cited by this paper
• Acrolein is increased in Alzheimer's disease brain and is toxic to primary hippocampal cultures.

  2001cited by this paper
• Immediate recovery from spinal cord injury through molecular repair of nerve membranes with polyethylene glycol

  2000cited by this paper
• Quantitation of 4-hydroxynonenal protein adducts.

  2000cited by this paper
• The molecular effects of acrolein.

  2000cited by this paper
• Free Radical Pathways in CNS Injury

  2000cited by this paper
• Protein‐Bound Acrolein

  1999cited by this paper
• Protein-bound acrolein: potential markers for oxidative stress.

  1998cited by this paper
• Acrolein Is a Product of Lipid Peroxidation Reaction

  1998cited by this paper
• Four-hydroxynonenal, a product of lipid peroxidation, is increased in the brain in Alzheimer's disease.

  1998cited by this paper
• The presence of 4-hydroxynonenal/protein complex as an indicator of oxidative stress after experimental spinal cord contusion in a rat model.

  1998influential reference
• 4‐Hydroxynonenal, a Lipid Peroxidation Product, Rapidly Accumulates Following Traumatic Spinal Cord Injury and Inhibits Glutamate Uptake

  1997influential reference
• Fate and effects of acrolein.

  1995cited by this paper
• Lipid antioxidants in acute central nervous system injury.

  1993cited by this paper
• The role of oxygen radicals in the pathobiology of traumatic brain injury.

  1992cited by this paper
• The role of oxygen radicals in the pathobiology of traumatic brain injury.

  1992cited by this paper
• Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes.

  1991influential reference
• The biology of oxygen radicals.

  1978cited by this paper

• Acrolein-Induced Alterations in Morphology and Stress Resilience in hiPSC-Derived Cortical Neurons.

  2025cites this paper
• An analog of phenelzine demonstrates effective acrolein scavenging and neuroprotection without monoamine oxidase inhibition in a rat SCI model.

  2025cites this paper
• Concussive injuries induce neuronal stress-dependent tau mislocalization to dendritic spines with acrolein and functional network alteration in TBI-on-a-chip

  2025cites this paper
• Impact Induces Phagocytic Defect in Reactive Microglia

  2025cites this paper
• The Role of Vitamins in Spinal Cord Injury: Mechanisms and Benefits

  2024cites this paper
• Temporal differential effects of post-injury alcohol consumption in a mouse model of blast-induced traumatic brain injury.

  2024cites this paper
• Original research manuscript intended for publication in Journal of Agriculture and Food Research Evaluation of acrolein content in food products from South Korea using LC-MS/MS

  2024cites this paper
• SMOX Inhibition Preserved Visual Acuity, Contrast Sensitivity, and Retinal Function and Reduced Neuro-Glial Injury in Mice During Prolonged Diabetes

  2024cites this paper
• Acute Transcriptomic and Epigenetic Alterations at T12 After Rat T10 Spinal Cord Contusive Injury

  2023cites this paper
• Toxic aldehyde-scavenging polypeptides mitigate secondary injury after spinal cord injury

  2023cites this paper
• The contribution of initial concussive forces and resulting acrolein surge to β-amyloid accumulation and functional alterations in neuronal networks using a TBI-on-a-chip model.

  2023cites this paper
• Electrophile versus oxidant modification of cysteine residues: Kinetics as a key driver of protein modification.

  2022cites this paper
• The Role of Acrolein in Neurodegenerative Diseases and Its Protective Strategy

  2022cites this paper
• Utilizing novel TBI-on-a-chip device to link physical impacts to neurodegeneration and decipher primary and secondary injury mechanisms

  2022cites this paper
• Regulatory significance of CULLIN2 in neuronal differentiation and regeneration.

  2022cites this paper
• Acrolein, an endogenous aldehyde induces Alzheimer's disease-like pathologies in mice: A new sporadic AD animal model.

  2021cites this paper
• Application of Acrolein Imines to Organic Synthesis, Biofunctional Studies, and Clinical Practice

  2021cites this paper
• Ischemic spinal cord injury - experimental evidence and evolution of protective measures.

  2021cites this paper
• Acrolein: A Potential Mediator of Oxidative Damage in Diabetic Retinopathy

  2020cites this paper
• Deferoxamine Ameliorates Compressed Spinal Cord Injury by Promoting Neovascularization in Rats

  2020influential citation
• Acute Cellular and Functional Changes With a Combinatorial Treatment of Ion Channel Inhibitors Following Spinal Cord Injury

  2020cites this paper
• Neuroprotection in Spinal Cord Injury

  2019cites this paper
• Biological effect of protein modifications by lipid peroxidation products.

  2019cites this paper
• Chemical Sensing of Acrolein-Amine Conjugates for Food Quality Control: A Case Study of Milk Products

  2019cites this paper
• Determination of Acrolein-Associated T1 and T2 Relaxation Times and Noninvasive Detection Using Nuclear Magnetic Resonance and Magnetic Resonance Spectroscopy

  2019cites this paper
• The research progress of miRNA/lncRNA associated with spinal cord injury

  2019cites this paper
• The Importance of Natural Antioxidants in the Treatment of Spinal Cord Injury in Animal Models: An Overview

  2019cites this paper
• Systemic Acrolein Elevations in Mice With Experimental Autoimmune Encephalomyelitis and Patients With Multiple Sclerosis

  2018cites this paper
• 13.25 – Aldehydes and Cardiovascular Disease☆

  2018cites this paper
• Carbonyl scavengers as pharmacotherapies in degenerative disease: Hydralazine repurposing and challenges in clinical translation.

  2018cites this paper
• Acrolein‐mediated neuronal cell death and alpha‐synuclein aggregation: Implications for Parkinson's disease

  2018cites this paper
• Carbonyl Scavenging as an Antioxidant Neuroprotective Strategy for Acute Traumatic Brain Injury

  2017cites this paper
• Exogenous Acrolein intensifies sensory hypersensitivity after spinal cord injury in rat.

  2017cites this paper
• Pathological correlations between traumatic brain injury and chronic neurodegenerative diseases

  2017influential citation
• Contribution of the HNE-immunohistochemistry to modern pathological concepts of major human diseases.

  2017cites this paper
• Acrolein and Human Disease: Untangling the Knotty Exposure Scenarios Accompanying Several Diverse Disorders.

  2017cites this paper
• Dimercaprol is an acrolein scavenger that mitigates acrolein‐mediated PC‐12 cells toxicity and reduces acrolein in rat following spinal cord injury

  2017influential citation
• Structural and biochemical abnormalities in the absence of acute deficits in mild primary blast-induced head trauma.

  2016cites this paper
• Inflammogenesis of Secondary Spinal Cord Injury

  2016cites this paper
• Mitigation of sensory and motor deficits by acrolein scavenger phenelzine in a rat model of spinal cord contusive injury

  2016cites this paper
• Membrane lipid peroxidation in neurodegeneration: Role of thrombin and proteinase-activated receptor-1.

  2016cites this paper
• A Reduction-Based Sensor for Acrolein Conjugates with the Inexpensive Nitrobenzene as an Alternative to Monoclonal Antibody

  2016cites this paper
• Unilateral microinjection of acrolein into thoracic spinal cord produces acute and chronic injury and functional deficits.

  2016cites this paper
• Tropomyosins in the healthy and diseased nervous system.

  2016cites this paper
• Molecular mechanisms of acrolein-mediated myelin destruction in CNS trauma and disease

  2015cites this paper
• Acrolein contributes to TRPA1 up‐regulation in peripheral and central sensory hypersensitivity following spinal cord injury

  2015influential citation
• Nanomedicine strategies for treatment of secondary spinal cord injury

  2015cites this paper
• Macrophage activation and its role in repair and pathology after spinal cord injury.

  2015cites this paper
• Hydrogen peroxide administered into the rat spinal cord at the level elevated by contusion spinal cord injury oxidizes proteins, DNA and membrane phospholipids, and induces cell death: attenuation by a metalloporphyrin.

  2015cites this paper
• Interactions of silica nanoparticles with therapeutics for oxidative stress attenuation in neurons

  2015cites this paper
• The pathological role of acrolein in experimental autoimmune encephalomyelitis and multiple sclerosis

  2015cites this paper
• Exclusive formation of imino[4 + 4]cycloaddition products with biologically relevant amines: plausible candidates for acrolein biomarkers and biofunctional modulators

  2015cites this paper
• Acrolein as a novel therapeutic target for motor and sensory deficits in spinal cord injury

  2014cites this paper
• Review of the pathogenesis and treatment of acute spinal cord injury and investigation into the use of urine 3-HPMA as a novel biomarker of secondary injury after acute spinal cord injury in the dog

  2014cites this paper
• Acrolein involvement in sensory and behavioral hypersensitivity following spinal cord injury in the rat

  2014cites this paper
• Susceptibility of parkinson's disease following mild blast traumatic brain injury

  2014cites this paper
• Acrolein detection: potential theranostic utility in multiple sclerosis and spinal cord injury

  2014influential citation
• Silica nanoparticles as vehicles for therapy delivery in neurological injury

  2014cites this paper
• Injectable hydrogels for the improved delivery of treatments in spinal cord injury

  2014cites this paper
• Acute systemic accumulation of acrolein in mice by inhalation at a concentration similar to that in cigarette smoke

  2014cites this paper
• Imino [4+4] cycloaddition products as exclusive and biologically relevant acrolein-amine conjugates are intermediates of 3-formyl-3,4-dehydropiperidine (FDP), an acrolein biomarker.

  2014cites this paper
• Mediating the potent ROS toxicity of acrolein in neurons with silica nanoparticles and a natural product approach

  2014cites this paper
• Neuroprotective role of hydralazine in rat spinal cord injury‐attenuation of acrolein‐mediated damage

  2014cites this paper
• Polyamine modification by acrolein exclusively produces 1,5-diazacyclooctanes: a previously unrecognized mechanism for acrolein-mediated oxidative stress.

  2014cites this paper
• Ethanol-Induced Lipid Peroxidation and Apoptosis in Embryopathy

  2013cites this paper
• Mn (III) tetrakis (4-benzoic acid) porphyrin scavenges reactive species, reduces oxidative stress, and improves functional recovery after experimental spinal cord injury in rats: comparison with methylprednisolone

  2013cites this paper
• Determination of Urine 3-HPMA, a Stable Acrolein Metabolite in a Rat Model of Spinal Cord Injury

  2013cites this paper
• Mesoporous silica nanoparticles for treating spinal cord injury

  2013cites this paper
• VDAC1: from structure to cancer therapy

  2012cites this paper
• Antioxidant therapies in traumatic brain and spinal cord injury.

  2012cites this paper
• Mn (III) tetrakis (4-benzoic acid) porphyrin protects against neuronal and glial oxidative stress and death after spinal cord injury.

  2012cites this paper
• Attenuation of mouse somatic and emotional inflammatory pain by hydralazine through scavenging acrolein and inhibiting neuronal activation.

  2012influential citation
• Assessments of Oxidative Damage and Lipid Peroxidation After Traumatic Brain Injury and Spinal Cord Injury

  2012cites this paper
• Mitochondrial VDAC1: function in cell life and death and a target for cancer therapy.

  2012cites this paper
• Endothelial dysfunction and claudin 5 regulation during acrolein-induced lung injury.

  2011cites this paper
• Anti-acrolein treatment improves behavioral outcome and alleviates myelin damage in experimental autoimmune encephalomyelitis mouse.

  2011cites this paper
• Antioxidant Therapies for Acute Spinal Cord Injury

  2011cites this paper
• Expressions of lipid oxidation markers, N(ε)-hexanoyl lysine and acrolein in cisplatin-induced nephrotoxicity in rats.

  2011cites this paper
• Acrolein-mediated injury in nervous system trauma and diseases.

  2011influential citation
• Oxidative stress in spinal cord injury and antioxidant-based intervention

  2011cites this paper
• Protein modification by acrolein: relevance to pathological conditions and inhibition by aldehyde sequestering agents.

  2011cites this paper
• Acrolein induces myelin damage in mammalian spinal cord

  2011cites this paper
• REACTIVE γ -KETOALDEHYDES FORMED VIA THE ISOPROSTANE PATHWAY DISRUPT MITOCHONDRIAL RESPIRATION AND CALCIUM HOMEOSTASIS

  2011cites this paper
• Lipid Peroxidation-Derived Reactive Aldehydes Directly and Differentially Impair Spinal Cord and Brain Mitochondrial Function

  2010cites this paper
• NTI-ACROLEIN TREATMENT IMPROVES BEHAVIORAL OUTCOME ND ALLEVIATES MYELIN DAMAGE IN EXPERIMENTAL UTOIMMUNE ENCHEPHALOMYELITIS MOUSE

  2010cites this paper
• Reactive gamma-ketoaldehydes formed via the isoprostane pathway disrupt mitochondrial respiration and calcium homeostasis.

  2010cites this paper
• VDAC, a multi-functional mitochondrial protein regulating cell life and death.

  2010cites this paper
• Evidence supporting a role for Nε-(3-formyl-3,4-dehydropiperidino)lysine accumulation in Müller glia dysfunction and death in diabetic retinopathy

  2010cites this paper
• Aldehydes and Cardiovascular Disease

  2010cites this paper
• Acrolein scavenging: a potential novel mechanism of attenuating oxidative stress following spinal cord injury

  2009influential citation
• Matrix metalloproteinase-14 mediates a phenotypic shift in the airways to increase mucin production.

  2009cites this paper
• Critical role of acrolein in secondary injury following ex vivo spinal cord trauma

  2008influential citation
• ROLE OF REACTIVE OXYGEN SPECIES PEROXYNITRITE IN TRAUMATIC SPINAL CORD INJURY

  2008cites this paper
• Carbonyl-scavenging drugs & protection against carbonyl stress-associated cell injury.

  2008cites this paper
• Acrylamide-induced nerve terminal damage: relevance to neurotoxic and neurodegenerative mechanisms.

  2008cites this paper
• Potentialities and pitfalls accompanying chemico-pharmacological strategies against endogenous electrophiles and carbonyl stress.

  2008cites this paper
• Protein alkylation, transcriptional responses and cytochrome c release during acrolein toxicity in A549 cells: influence of nucleophilic culture media constituents.

  2008cites this paper
• Potential Therapeutic Targets for PPARγ after Spinal Cord Injury

  2008cites this paper
• Differential Effects of High Glucose and Methylglyoxal on Viability and Polyol Metabolism in Immortalized Adult Mouse Schwann Cells

  2008cites this paper
• Hydralazine inhibits compression and acrolein‐mediated injuries in ex vivo spinal cord

  2007influential citation