Suppression of c-ras transformation by GTPase-activating protein

No abstract is available for this paper.

• Publication year

  1990

• Venue

  Nature

• Publication date

  1990-08-23

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1038/346754A0PMID 2201922
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• S. cerevisiae genes IRA1 and IRA2 encode proteins that may be functionally equivalent to mammalian ras GTPase activating protein.

  1990cited by this paper
• Phosphorylation of GAP and GAP-associated proteins by transforming and mitogenic tyrosine kinases

  1990cited by this paper
• Genetic analysis of mammalian GAP expressed in yeast.

  1989cited by this paper
• A C‐terminal domain of GAP is sufficient to stimulate ras p21 GTPase activity.

  1989cited by this paper
• ras GTPase activating protein: signal transmitter and signal terminator.

  1989cited by this paper
• A highly efficient retroviral vector allows detection of the transforming activity of the human c-fps/fes proto-oncogene

  1989cited by this paper
• PDGF induction of tyrosine phosphorylation of GTPase activating protein

  1989cited by this paper
• The ras oncogene--an important regulatory element in lower eucaryotic organisms

  1989cited by this paper
• Harvey murine sarcoma virus: influences of coding and noncoding sequences on cell transformation in vitro and oncogenicity in vivo

  1989cited by this paper
• Purification of a RAS-responsive adenylyl cyclase complex from Saccharomyces cerevisiae by use of an epitope addition method

  1988cited by this paper
• p21-ras effector domain mutants constructed by "cassette" mutagenesis

  1988cited by this paper
• Cloning of bovine GAP and its interaction with oncogenic ras p21

  1988cited by this paper
• The cytoplasmic protein GAP is implicated as the target for regulation by the ras gene product

  1988cited by this paper
• Characterization of a factor that stimulates hydrolysis of GTP bound to ras gene product p21 (GTPase-activating protein) and correlation of its activity to cell density

  1988cited by this paper
• Guanosine triphosphatase activating protein (GAP) interacts with the p21 ras effector binding domain.

  1988cited by this paper
• Two dominant-acting selectable markers for gene transfer studies in mammalian cells.

  1988cited by this paper
• Molecular cloning of two types of GAP complementary DNA from human placenta.

  1988cited by this paper
• Induction of neurite formation in PC12 cells by microinjection of proto-oncogenic Ha-ras protein preincubated with guanosine-5'-O-(3-thiotriphosphate)

  1987cited by this paper
• Guanine nucleotide activation of, and competition between, RAS proteins from Saccharomyces cerevisiae

  1987cited by this paper
• A cytoplasmic protein stimulates normal N-ras p21 GTPase, but does not affect oncogenic mutants.

  1987cited by this paper
• ras genes.

  1987cited by this paper
• Adenylate cyclase activity of NIH 3T3 cells morphologically transformed by ras genes

  1986cited by this paper
• Transduction of host cellular sequences by a retroviral shuttle vector

  1986cited by this paper
• Mutational analysis of a ras catalytic domain

  1986cited by this paper
• Requirement for c-ras proteins during viral oncogene transformation

  1986cited by this paper
• Identification of effector residues and a neutralizing epitope of Ha-ras-encoded p21.

  1986cited by this paper
• The ras oncogene product p21 is not a regulatory component of adenylate cyclase

  1985cited by this paper
• Requirement for ras proto-oncogene function during serum-stimulated growth of NIH 3T3 cells

  1985cited by this paper
• Measurement of protein using bicinchoninic acid.

  1985cited by this paper
• Monoclonal antibodies to the p21 products of the transforming gene of Harvey murine sarcoma virus and of the cellular ras gene family

  1982cited by this paper
• Biological activity of cloned Moloney sarcoma virus DNA: Terminally redundant sequences may enhance transformation efficiency.

  1980cited by this paper
• Integration in vivo into simian virus 40 DNA of a sequence that resembles a certain family of genomic interspersed repeated sequences.

  1980cited by this paper

• Cisplatin and Pemetrexed Have Distinctive Growth-inhibitory Effects in Monotherapy and Combination Therapy on KRAS-dependent A549 Lung Cancer Cells

  2021cites this paper
• The sensitivity to Hsp90 inhibitors of both normal and oncogenically transformed cells is determined by the equilibrium between cellular quiescence and activity

  2018cites this paper
• Investigation of the mechanisms terminating growth factor induced Ras activation

  2016cites this paper
• Tyrosine phosphorylation of RAS by ABL allosterically enhances effector binding

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  2012cites this paper
• Rasd1 Modulates the Coactivator Function of NonO in the Cyclic AMP Pathway

  2011cites this paper
• Regulation of Ras proteins by reactive nitrogen species.

  2011cites this paper
• p120Ras-GAP binds the DLC1 Rho-GAP tumor suppressor protein and inhibits its RhoA GTPase and growth-suppressing activities

  2009cites this paper
• Annexin A6 inhibits Ras signalling in breast cancer cells

  2009cites this paper
• Analysis of Multiprotein Complexes in the Mammalian REtina

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• Transcriptional Signature of Epidermal Keratinocytes Subjected to in Vitro Scratch Wounding Reveals Selective Roles for ERK1/2, p38, and Phosphatidylinositol 3-Kinase Signaling Pathways*

  2007cites this paper
• High resolution crystal structures of the p120 RasGAP SH3 domain.

  2007cites this paper
• Developmental Signaling Disorders in Craniofacial Anomalies and Cancers

  2006cites this paper
• Inhibition of T-Cell Antigen Receptor Signaling by Overexpression of p 1 2 OGAP 1

  2005cites this paper
• Platelet-derived Growth Factor-induced p 21 ras-mediated Signaling Is Independent of Platelet-derived Growth Factor Receptor Interaction with GTPase-activating Protein or Phosphatidylinositol-3-Kinase 1

  2005cites this paper
• Epidermal Growth Factor Increases Protein and Messenger RNA Expression Levels of Ras GTPase Activating Protein 1

  2005cites this paper
• Human RAS Superfamily Proteins and Related GTPases

  2004cites this paper
• Genetic analysis of the catalytic domain of the GAP gene in human lung cancer cell lines

  2004cites this paper
• Ectopic expression of murine diphosphoinositol polyphosphate phosphohydrolase 1 attenuates signaling through the ERK1/2 pathway.

  2004cites this paper
• Positive and negative regulators of Ras in T cells

  2004cites this paper
• CAMP activates Rap1 in differentiating mouse male germ cells: a new signaling pathway mediated by the cAMP-activated exchange factor Epac?

  2003cites this paper
• Sari , a gene from Schizosaccharomyces pombe encoding a protein that regulates rasl

  2003cites this paper
• Genetic requirement for Ras in the transformation of fibroblasts and hematopoietic cells by the oncogene.

  2003cites this paper
• Paracrine and autocrine functions of PDGF in malignant disease.

  2002cites this paper
• RACK1, a protein kinase C scaffolding protein, interacts with the PH domain of p120GAP.

  2001cites this paper
• Specific Signaling Through Heteromeric PDGF Receptor Complexes

  2000cites this paper
• Cellular compartmentation effects in receptor-mediated signal transduction

  1999cites this paper
• Inhibition of RhoGAP activity is sufficient for the induction of Rho-mediated actin reorganization.

  1999cites this paper
• Platelet-derived growth factor-dependent association of the GTPase-activating protein of Ras and Src.

  1999cites this paper
• Ras-GAP Controls Rho-Mediated Cytoskeletal Reorganization through Its SH3 Domain

  1998cites this paper
• RAS pathways to cell cycle control and cell transformation.

  1998cites this paper
• Ein photochemischer Schalter zur Kontrolle von Protein-Protein-Wechselwirkungen

  1998cites this paper
• An Effector-like Function of Ras GTPase-activating Protein Predominates in Cardiac Muscle Cells*

  1997cites this paper
• The Role of Low Molecular Weight GTP-Binding Proteins in Human Platelets

  1997cites this paper
• Expression of Ras GTPase-activating protein (GAP) in human normal chorionic villi and hydatidiform mole.

  1997cites this paper
• Ras-GTPase activating protein (GAP): a putative effector for Ras.

  1997cites this paper
• The neurotrophic action and signalling of epidermal growth factor.

  1997cites this paper
• Association of p120 ras GAP with endocytic components and colocalization with epidermal growth factor (EGF) receptor in response to EGF stimulation.

  1996cites this paper
• The Ras GTPase-activating-protein-related human protein IQGAP2 harbors a potential actin binding domain and interacts with calmodulin and Rho family GTPases

  1996cites this paper
• Compensatory modulation of GAP activity in response to oncogenic stimulation.

  1996cites this paper
• Case of acute monocytic leukemia with 47,XY,+X,t(2;10)(q21.1;q26.1) and basophilia.

  1996cites this paper
• N-terminal Sequences Contained in the Src Homology 2 and 3 Domains of p120 GTPase-activating Protein Are Required for Full Catalytic Activity Toward Ras (*)

  1996cites this paper
• Ras inhibitors.

  1996cites this paper
• Differential activation of phospholipase C-gamma 1 and mitogen-activated protein kinase in naive and antigen-primed CD4 T cells by the peptide/MHC ligand.

  1996cites this paper
• [The role of p21ras oncoprotein in signal transduction mediated through B cell antigen receptor (BCR)].

  1996cites this paper
• Multiple changes in oncogenes and tumor suppressor genes in human retinoblastoma.

  1996cites this paper
• ras effector loop mutations that dissociate p120GAP and neurofibromin interactions

  1996cites this paper
• Induction of a complex between rasGAP and a novel 110 kD protein is required for immortalization of primary epithelial cells by the E1A 12S oncoprotein of adenovirus.

  1996cites this paper
• Requirement of phospholipase C gamma, the tyrosine phosphatase Syp and the adaptor proteins Shc and Nck for PDGF‐induced DNA synthesis: evidence for the existence of Ras‐dependent and Ras‐independent pathways.

  1996cites this paper
• Genetic requirement for Ras in the transformation of fibroblasts and hematopoietic cells by the Bcr-Abl oncogene

  1995cites this paper
• Effects of epidermal growth factor and phorbol ester on thyroid epithelial integrity.

  1995cites this paper
• Suppression and restoration of v-SRC expression in rsv transformed-cells after transfection with N-ras and its antagonist.

  1995cites this paper
• Overexpression of genes in health and sickness. A bird's eye view.

  1995cites this paper
• Raf-1 N-terminal sequences necessary for Ras-Raf interaction and signal transduction

  1995cites this paper
• Transformation reversion induced in JB6 RT101 cells by AP-1 inhibitors.

  1995cites this paper
• Ras target proteins in eukaryotic cells

  1995cites this paper
• The role of ras GTPase activating protein in human tumorigenesis.

  1995cites this paper
• Neurofibromatosis type 1 and Ras-mediated signaling: filling in the GAPs.

  1995cites this paper
• Both v-Ha-Ras and v-Raf Stimulate Expression of the Vascular Endothelial Growth Factor in NIH 3T3 Cells (*)

  1995cites this paper
• Ras signaling and NF1.

  1995cites this paper
• Two regions with differential growth-modulating activity in the N-terminal domain of ras GTPase-activating protein (p120GAP) src homology and Gly-Ala-Pro-rich regions.

  1995cites this paper
• CaLB: a 43 amino acid calcium-dependent membrane/phospholipid binding domain in p120 Ras GTPase-activating protein.

  1995cites this paper
• Decreased expression of Ras GTPase activating protein in human trophoblastic tumors.

  1995cites this paper
• Regulation of the Ras signaling pathway by GTPase-activating protein in PC12 cells.

  1995cites this paper
• A Novel GTPase-activating Protein for R-Ras (*)

  1995cites this paper
• Expression of α1‐chimaerin (rac‐1 GAP) alters the cytoskeletal and adhesive properties of fibroblasts

  1994cites this paper
• Characterization of a 78-residue fragment of c-Raf-1 that comprises a minimal binding domain for the interaction with Ras-GTP.

  1994cites this paper
• Increased p21ras-specific Guanine-nucleotide exchange causes tumor-formation in nude-mice.

  1994cites this paper
• Signal transduction pathways involving RAS

  1994cites this paper
• Inhibition of T-cell antigen receptor signaling by overexpression of p120GAP.

  1994cites this paper
• p190 RhoGAP, the major RasGAP-associated protein, binds GTP directly

  1994cites this paper
• Proteines gap associees aux ras

  1994cites this paper
• Cellular alterations in pituitary tumors.

  1994cites this paper
• The Ras signal transduction pathway

  1994cites this paper
• Epidermal growth factor increases protein and messenger RNA expression levels of Ras GTPase activating protein.

  1994cites this paper
• Expression of two different products of CDC25Mm, a mammalian Ras activator, during development of mouse brain.

  1994cites this paper
• Low molecular weight GTP-binding proteins: molecular switches regulating diverse cellular functions.

  1994cites this paper
• Subtraction cloning of H-rev107, a gene specifically expressed in H-ras resistant fibroblasts.

  1994cites this paper
• Identification of a human rasGAP-related protein containing calmodulin-binding motifs.

  1994cites this paper
• Aspects of growth factor signal transduction in the cell cytoplasm.

  1994cites this paper
• Platelet-derived growth factor-induced p21ras-mediated signaling is independent of platelet-derived growth factor receptor interaction with GTPase-activating protein or phosphatidylinositol-3-kinase.

  1994cites this paper
• Signal transduction pathways involving the raf proto-oncogene

  1994cites this paper
• The PDGF receptor alpha subunit activates p21ras and triggers DNA synthesis without interacting with rasGAP.

  1994cites this paper
• Signal transduction by the PDGF receptors.

  1994cites this paper
• Signal transduction pathways involving Ras. Mini review.

  1994cites this paper
• The role of p21ras in receptor tyrosine kinase signalling.

  1994cites this paper
• Chapter 3 – Colonic Carcinoma: A Common Tumor with Multiple Genomic Abnormalities

  1994cites this paper
• Receptor protein-tyrosine kinases and their signal transduction pathways.

  1994cites this paper
• Differential antagonism of Ras biological activity by catalytic and Src homology domains of Ras GTPase activation protein.

  1993cites this paper
• Suppression of oncogenic Ras by mutant neurofibromatosis type 1 genes with single amino acid substitutions.

  1993cites this paper
• Growth factors and malignant transformation.

  1993cites this paper
• Oncogenes and protein kinases in neuronal growth-factor action.

  1993cites this paper
• Effector domain mutations dissociate p21ras effector function and GTPase-activating protein interaction

  1993cites this paper
• Regulated and constitutive activity by CDC25Mm (GRF), a Ras-specific exchange factor

  1993cites this paper
• Differential contribution of M r 120 kDa rasGTPase‐activating protein and neurofibromatosis type 1 gene product during the transition from growth phase to arrested state in human fibroblasts accompanied by a unique rasGTPase‐activating active

  1993cites this paper
• Biological actions of oncogenes.

  1993cites this paper
• Complex formation between the p21ras GTPase-activating protein and phosphoproteins p62 and p190 is independent of p21ras signalling.

  1993cites this paper
• Analysis of multistage mouse skin carcinogenesis by retroviral mediated gene transfer

  1993cites this paper
• Differential regulation of cellular activities by GTPase-activating protein and NF1

  1993cites this paper