Enzyme-catalyzed detoxication reactions: mechanisms and stereochemistry.

No abstract is available for this paper.

• Publication year

  1987

• Venue

  CRC Critical Reviews in Biochemistry

• Publication date

  Unknown publication date

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.3109/10409238709082547PMID 3115676
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Binding energy, specificity, and enzymic catalysis: the circe effect.

  2006cited by this paper
• The isoenzymes of glutathione transferase.

  2006cited by this paper
• Genes for cytochrome P-450 and their regulation.

  1986cited by this paper
• The mechanism of olefin epoxidation by oxo-iron porphyrins. Direct observation of an intermediate.

  1986cited by this paper
• Rat liver UDP-glucuronosyltransferase. Sequence and expression of a cDNA encoding a phenobarbital-inducible form.

  1986cited by this paper
• Microsomal epoxide hydrolase of rat liver. Purification and characterization of enzyme fractions with different chromatographic characteristics.

  1986cited by this paper
• Horseradish peroxidase catalyzed hydroxylations: mechanistic studies.

  1986cited by this paper
• Catalytic properties and inhibition of hepatic cholesterol-epoxide hydrolase.

  1986cited by this paper
• Multiplicity of glutathione S-transferase genes in the rat and association with a type 2 Alu repetitive element.

  1986cited by this paper
• N4-(Malonyl-D-cysteinyl)-L-2,4-diaminobutyrate: the end-group-modified retro-inverso isomer of glutathione

  1986cited by this paper
• Formation and transport of xenobiotic glutathione-S-conjugates in red cells.

  1986cited by this paper
• S-[2-(N7-guanyl)ethyl]glutathione, the major DNA adduct formed from 1,2-dibromoethane.

  1986cited by this paper
• A subclass of glutathione S-transferases as intracellular high-capacity and high-affinity steroid-binding proteins.

  1986cited by this paper
• Kinetic independence of the subunits of cytosolic glutathione transferase from the rat.

  1985cited by this paper
• Enzymatic reaction of chlorotrifluoroethene with glutathione: 19F NMR evidence for stereochemical control of the reaction.

  1985cited by this paper
• Branchpoint for heme alkylation and metabolite formation in the oxidation of arylacetylenes by cytochrome P-450.

  1985cited by this paper
• Enzymatic hydration of leukotriene A4. Purification and characterization of a novel epoxide hydrolase from human erythrocytes.

  1985cited by this paper
• Glutathione S-transferases catalyzed conjugation of 1,4-disubstituted butanes with glutathione in vitro.

  1985cited by this paper
• The structure of phenobarbital-inducible rat liver cytochrome P-450 isoenzyme PB-4. Production and characterization of site-specific antibodies.

  1985cited by this paper
• Differential activities of rat and human lung glutathione S-transferase isoenzymes towards benzo(a)pyrene epoxides.

  1985cited by this paper
• Trialkyl phosphorothioates and glutathione S-transferases.

  1985cited by this paper
• Absolute configuration of the 5,6-oxide formed from 7,12-dimethylbenz[a]anthracene by cytochrome P450c.

  1985cited by this paper
• Leukotriene C4 formation catalyzed by three distinct forms of human cytosolic glutathione transferase.

  1985cited by this paper
• Pseudorotation barriers in cis-4,5-dimethyl- and cis-3,4,5,6-tetramethyl-9,10-dihydroxy-9,10-dihydrophenanthrene: measurement of the buttressing effect

  1985cited by this paper
• A reactive hydroxymethyl sulfate ester formed regioselectively from the carcinogen, 7,12-dihydroxymethylbenz[alpha]anthracene, by rat liver sulfotransferase.

  1985cited by this paper
• Heterogeneity of hepatic microsomal UDP-glucuronosyltransferase activities. Conjugations of phenolic and monoterpenoid aglycones in control and induced rats and guinea pigs.

  1985cited by this paper
• Rat liver glutathione S-transferases. Construction of a cDNA clone complementary to a Yc mRNA and prediction of the complete amino acid sequence of a Yc subunit.

  1985cited by this paper
• Identification of Yb-glutathione-S-transferase as a major rat liver protein labeled with dexamethasone 21-methanesulfonate.

  1985cited by this paper
• Inhibition of epoxide metabolism by α,β-epoxyketones and isosteric analogs

  1985cited by this paper
• Inhibition of epoxide metabolism by alpha,beta-epoxyketones and isosteric analogs.

  1985cited by this paper
• Synthesis and characterization of the oxygen and desthio analogues of glutathione as dead-end inhibitors of glutathione S-transferase.

  1985cited by this paper
• The carcinogen, 7-hydroxymethyl-12-methylbenz[a]anthracene, is activated and covalently binds to DNA via a sulphate ester.

  1985cited by this paper
• Protection against toxic redox cycles between benzo(a)pyrene-3,6-quinone and its quinol by 3-methylcholanthrene-inducible formation of the quinol mono- and diglucuronide.

  1985cited by this paper
• Purification and characterization of cytosolic liver protein facilitating heme transport into apocytochrome b5 from mitochondria. Evidence for identifying the heme transfer protein as belonging to a group of glutathione S-transferases.

  1985cited by this paper
• Formation of benzo[a]pyrene-3,6-quinol mono- and diglucuronides in rat liver microsomes.

  1985cited by this paper
• 4‐Hydroxyalk‐2‐enals are substrates for glutathione transferase

  1985cited by this paper
• Enantioselectivity in glutathione conjugation of 1,2-epoxy-1,2,3,4-tetrahydronaphthalene by hepatic glutathione S-transferase.

  1985cited by this paper
• Gamma-glutamylcysteine: a substrate for glutathione S-transferases.

  1985cited by this paper
• Stereoselectivity of microsomal epoxide hydrolase toward diol epoxides and tetrahydroepoxides derived from benz[a]anthracene.

  1985cited by this paper
• Enantioselectivity of the microsomal epoxide hydrolase-catalyzed hydrolysis of trans-4,5-dimethyl-1,2-epoxycyclohexane

  1985cited by this paper
• The carcinogen, 7-hydroxymethyl-12-methylbenz[a]anthracene, is activated and covalently binds to DNA via a sulphate ester.

  1985cited by this paper
• Properties of cytosolic epoxide hydrolase purified from the liver of untreated and clofibrate-treated mice. Purification procedure and physiochemical characterization of the pure enzymes.

  1985cited by this paper
• Cyclopropyl oxiranes: reversible inhibitors of cytosolic and microsomal epoxide hydrolases.

  1985cited by this paper
• Identification of heterogeneous and microheterogeneous subunits of glutathione S-transferase in rat liver cytosol.

  1985cited by this paper
• The isolation, characterisation and kinetics of glutathione-S-transferase from human platelets.

  1985cited by this paper
• Rat liver glutathione S-transferases. Nucleotide sequence analysis of a Yb1 cDNA clone and prediction of the complete amino acid sequence of the Yb1 subunit.

  1985cited by this paper
• On the multiplicity of rat liver glutathione S-transferases.

  1985cited by this paper
• Differential stereoselectivity of cytochromes P-450b and P-450c in the formation of naphthalene and anthracene 1,2-oxides. The role of epoxide hydrolase in determining the enantiomer composition of the 1,2-dihydrodiols formed.

  1985cited by this paper
• The 2.6-A crystal structure of Pseudomonas putida cytochrome P-450.

  1985cited by this paper
• Microsomal glutathione transferase. Primary structure.

  1985cited by this paper
• Epoxidation of styrene by hemoglobin and myoglobin. Transfer of oxidizing equivalents to the protein surface.

  1985cited by this paper
• Isolation and characterization of the multiple glutathione S-transferases from human liver. Evidence for unique heme-binding sites.

  1985cited by this paper
• KINETICALLY STABLE CONFORMERS OF 3,4,5,6-TETRAMETHYL-9,10-DIHYDROXY-9,10-DIHYDROPHENANTHRENE AS PROBES OF THE CONFORMER SPECIFICITY OF UDPGLUCURONOSYLTRANSFERASE

  1985cited by this paper
• Cloning and characterization of DNA complementary to rat liver UDP-glucuronosyltransferase mRNA.

  1984cited by this paper
• Characterization of nine monoclonal antibodies against rat hepatic cytochrome P-450c. Delineation of at least five spatially distinct epitopes.

  1984cited by this paper
• Substrate specificity of the monooxygenase activity of hemoglobin.

  1984cited by this paper
• Kinetic studies of latent microsomal UDP-glucuronyltransferases. Kinetics of glucuronidation in intact and perturbant-treated membranes.

  1984cited by this paper
• The molecular weights of UDP-glucuronyltransferase determined with radiation-inactivation analysis. A molecular model of bilirubin UDP-glucuronyltransferase.

  1984cited by this paper
• Mechanism and subcellular site of bilirubin diglucuronide formation in rat liver.

  1984cited by this paper
• Chemical mechanisms of catalysis by cytochromes P-450: a unified view

  1984cited by this paper
• Hepatic microsomal glucuronidation of bilirubin in unilamellar liposomal membranes. Implications for intracellular transport of lipophilic substrates.

  1984cited by this paper
• Coding nucleotide sequence of 3-methylcholanthrene-inducible cytochrome P-450d cDNA from rat liver.

  1984cited by this paper
• Regiospecific and diastereoselective inactivation of mutagenic 9,10-dihydrobenzo[a]-pyrene 7,8-oxide by hepatic cytosolic glutathione S-transferase.

  1984cited by this paper
• Immunohistochemical localization of carcinogen-metabolizing enzymes within the rat and hamster exocrine pancreas.

  1984cited by this paper
• Studies of the catalytic mechanism of microsomal UDP-glucuronyltransferase. Alpha-glucuronidase activity and its stimulation by phospholipids.

  1984cited by this paper
• The Yc and Ya subunits of rat liver glutathione S-transferases are the products of separate genes.

  1984cited by this paper
• Microsomal hydroxylation of specifically deuterated monosubstituted benzenes. Evidence for direct aromatic hydroxylation.

  1984cited by this paper
• Kinetic isotope effects on cytochrome P-450-catalyzed oxidation reactions. The oxidative O-dealkylation of 7-ethoxycoumarin.

  1984cited by this paper
• The nucleotide sequence of a rat liver glutathione S-transferase subunit cDNA clone.

  1984cited by this paper
• Demethylation of N,N-dimethylaniline and p-cyano-N,N-dimethylaniline and their N-oxides by cytochromes P450LM2 and P450CAM

  1984cited by this paper
• Rat liver glutathione S-transferases. Complete nucleotide sequence of a glutathione S-transferase mRNA and the regulation of the Ya, Yb, and Yc mRNAs by 3-methylcholanthrene and phenobarbital.

  1984cited by this paper
• Kinetic properties of UDP-glucuronosyltransferase(S) in different membranes of rat liver cells.

  1984cited by this paper
• Kinetic studies and active site-binding properties of glutathione S-transferase using spin-labeled glutathione, a product analogue.

  1984cited by this paper
• Investigation of the kinetic and stereochemical recognition of arene and azaarene oxides by isozymes A2 and C2 of glutathione S-transferase.

  1984cited by this paper
• 2-Propylthiouracil does not replace glutathione for the glutathione transferases.

  1984cited by this paper
• Cell-free translation of mouse liver mRNA coding for two forms of UDP glucuronosyltransferase.

  1984cited by this paper
• Solubilization and characterization of the leukotriene C4 synthetase of rat basophil leukemia cells: a novel, particulate glutathione S-transferase.

  1984cited by this paper
• The direct mutagenic activity of alpha, omega-dihalogenoalkanes in Salmonella typhimurium. Strong correlation between chemical properties and mutagenic activity.

  1984cited by this paper
• Structural analysis of the cysteine-containing peptides from the major 3-methylcholanthrene-induced isozyme of cytochrome P-450 (P-450c) in rat liver microsomes.

  1984cited by this paper
• The covalent structure of hepatic microsomal epoxide hydrolase. I. Isolation and characterization of the cyanogen bromide fragments.

  1984cited by this paper
• The covalent structure of hepatic microsomal epoxide hydrolase. II. The complete amino acid sequence.

  1984cited by this paper
• Glucuronidation of bile acids by rat liver 3-OH androgen UDP-glucuronyltransferase.

  1984cited by this paper
• Regioselectivity in the cytochromes P-450: control by protein constraints and by chemical reactivities.

  1984cited by this paper
• Stereoselectivity of cytochrome P-450c in the formation of naphthalene and anthracene 1,2-oxides.

  1984cited by this paper
• Heterogeneity of hepatic microsomal UDP-glucuronosyltransferase(s) activities: comparison between human and mammalian species activities.

  1984cited by this paper
• Glutathione transferases: nomenclature.

  1984cited by this paper
• Studies of the relationship between the catalytic activity and binding of non-substrate ligands by the glutathione S-transferases.

  1984cited by this paper
• Kinetic isotope effects on cytochrome P-450-catalyzed oxidation reactions. Evidence for the irreversible formation of an activated oxygen intermediate of cytochrome P-448.

  1984cited by this paper
• Regiospecific glutathione conjugation of alkylarylethylene oxides by hepatic glutathione S-transferase.

  1984cited by this paper
• The direct mutagenic activity of α,ω-dihalogenoalkanes in Salmonella typhimurium: Strong correlation between chemical properties and mutagenic activity

  1984cited by this paper
• Regiospecific and diastereoselective inactivation of mutagenic 9,10-dihydrobenzo[a]- pyrene 7,8-oxide by hepatic cytosolic glutathione S-transferase

  1984cited by this paper
• Regio- and stereoselective metabolism of two C19 steroids by five highly purified and reconstituted rat hepatic cytochrome P-450 isozymes.

  1983cited by this paper
• Studies on the subunit composition of rat liver glutathione S-transferases.

  1983cited by this paper
• Do the soluble glutathione S-transferases have direct access to membrane-bound substrates?

  1983cited by this paper
• The catalytic mechanism of glutathione reductase as derived from x-ray diffraction analyses of reaction intermediates.

  1983cited by this paper
• Purification and characterization of corn glutathione S-transferase.

  1983cited by this paper
• Stereoselectivity of isozyme C of glutathione S-transferase toward arene and azaarene oxides.

  1983cited by this paper
• Evidence for an active site arginine in UDP-glucuronyltransferase.

  1983cited by this paper
• Distinct rat hepatic microsomal epoxide hydrolases catalyze the hydration of cholesterol 5,6 alpha-oxide and certain xenobiotic alkene and arene oxides.

  1983cited by this paper
• The refined structure of the selenoenzyme glutathione peroxidase at 0.2-nm resolution.

  1983cited by this paper

• Glutathione S-Transferase Mediated Epoxide Conversion: Functional and Structural Properties of an Enantioselective Catalyst

  2025cites this paper
• Mind your tyres: The ecotoxicological impact of urban sediments on an aquatic organism.

  2024cites this paper
• Review on Bortezomib Resistance in Multiple Myeloma and Potential Role of Emerging Technologies

  2023cites this paper
• DeepGATGO: A Hierarchical Pretraining-Based Graph-Attention Model for Automatic Protein Function Prediction

  2023cites this paper
• Detoxification Enzyme-Catalyzed Conjugation Reactions

  2020cites this paper
• DESIGN OF SULFONAMIDOBENZOTHIAZOLE DERIVATIVES AS hGSTP1-1 INHIBITORS

  2020cites this paper
• Association of Activity Altering Genotypes - Tyr113His and His139Arg in Microsomal Epoxide Hydrolase Enzyme with Esophageal Squamous Cell Carcinoma

  2019cites this paper
• Enzymatic Carbon-Sulfur Bond Formation in Natural Product Biosynthesis.

  2017cites this paper
• Is Promiscuous CALB a Good Scaffold for Designing New Epoxidases?

  2015cites this paper
• Long-term exposure of the isopod Porcellionides pruinosus to nickel: Costs in the energy budget and detoxification enzymes.

  2015cites this paper
• The role of epoxide hydrolases in health and disease

  2014cites this paper
• Endokrine Substanzen in der aquatischen Umwelt

  2014cites this paper
• CONSTITUTIVE EXPRESSION OF XENOBIOTIC-METABOLIZING ENZYMES IN RAT TESTIS: IMMUNOCHEMICAL CHARACTERIZATION AND REGULATION BY 17-BETA-ESTRADIOL BENZOATE AND BISPHENOL A

  2013cites this paper
• Determinants of Reactivity and Selectivity in Soluble Epoxide Hydrolase from Quantum Mechanics/Molecular Mechanics Modeling

  2012cites this paper
• Catalytic Reactions of Phase II Enzymes

  2012cites this paper
• Utility of Genetically Modified Animal Models for Drug Metabolism and Drug Transporters

  2012cites this paper
• Modeling Chemical Interaction Profiles: I. Spectral Data-Activity Relationship and Structure-Activity Relationship Models for Inhibitors and Non-inhibitors of Cytochrome P450 CYP3A4 and CYP2D6 Isozymes

  2012cites this paper
• Activation and Detoxification Enzymes

  2011cites this paper
• Exploring new structural and functional space in the glutathione transferase superfamily from Escherichia coli K-12

  2011influential citation
• Carcinogenic Polycyclic Aromatic Hydrocarbons

  2010cites this paper
• Structural basis for featuring of steroid isomerase activity in alpha class glutathione transferases.

  2010cites this paper
• 4.16 – Glutathione Transferases

  2010cites this paper
• Corrigendum to: ''The FEMA GRAS assessment of a,b-unsaturated aldehydes and related substances used as flavor ingredients" [Food and Chemical Toxicology 46 (2008) 2935-2967] (DOI:10.1016/j.fct.2008.06.082)

  2009cites this paper
• Mammalian epoxide hydrolases in xenobiotic metabolism and signalling

  2009cites this paper
• Étude de l'impact des récepteurs non stéroïdiens sur l'activité androgénique dans les cellules cancéreuses de la prostate

  2008cites this paper
• The FEMA GRAS assessment of alpha,beta-unsaturated aldehydes and related substances used as flavor ingredients.

  2008cites this paper
• Mechanisms of Toxification and Detoxification which Challenge Drug Candidates and Drugs

  2007cites this paper
• Molecular engineering of epoxide hydrolase and its application to asymmetric and enantioconvergent hydrolysis

  2007cites this paper
• Maternal Smoking during Early Pregnancy, GSTP1 and EPHX1 Variants, and Risk of Isolated Orofacial Clefts

  2007cites this paper
• Development and characterization of recombinant whole-cell biocatalysts expressing epoxide hydrolase from Rhodotorula glutinis for enantioselective resolution of racemic epoxides

  2006cites this paper
• Two glutathione S-transferase isoenzymes purified from Bulinus truncatus (Gastropoda: Planorbidae).

  2006cites this paper
• Stereochemische Uniformität bei marinen Polyetherleitern: Folgerungen für Biosynthese und Struktur des Maitotoxins

  2006cites this paper
• ANALYSIS OF PROTEIN ADDUCTION KINETICS AND THE EFFECTS OF PROTEIN ADDUCTION ON C-JUN N-TERMINAL KINASE SIGNALING

  2006cites this paper
• Stereochemical uniformity in marine polyether ladders--implications for the biosynthesis and structure of maitotoxin.

  2006cites this paper
• The importance of local chemical structure for chemical metabolism by human uridine 5'-diphosphate-glucuronosyltransferase.

  2006cites this paper
• EHPred: an SVM-based method for epoxide hydrolases recognition and classification

  2006cites this paper
• Soybean Epoxide Hydrolase

  2005cites this paper
• Effects of 3-chlorobiphenyl on photosynthetic oxygen production, glutathione content and detoxication enzymes in the aquatic macrophyte Ceratophyllum demersum.

  2005cites this paper
• Sequence and structure of epoxide hydrolases: A systematic analysis

  2004cites this paper
• Structure of Rhodococcus erythropolis limonene‐1,2‐epoxide hydrolase reveals a novel active site

  2003cites this paper
• Protection of DNA during early development: adaptations and evolutionary consequences

  2003cites this paper
• Effects of bisphenol A and phytosterols on the European polecat (Mustela putorius) and the field vole (Microtus agrestis)

  2002cites this paper
• Opinion of the SCF on pulegone and menthofuran

  2002cites this paper
• IN VIVO EFFECTS OF BISPHENOL A ON THE POLECAT ( MUSTELA PUTORIUS )

  2002cites this paper
• Bisphenol A affects endocrine physiology and biotransformation enzyme activities of the field vole (Microtus agrestis).

  2002cites this paper
• Physiological and biochemical factors affecting carotenoid utilization in salmonid fish

  2001cites this paper
• Formation and detoxification of reactive intermediates in the metabolism of chlorinated ethenes.

  2001cites this paper
• Preparation of enantiopure epoxides by biocatalytic kinetic resolution

  2001cites this paper
• NEW STRUCTURAL AND CHEMICAL INSIGHT INTO THE CATALYTIC MECHANISM OF EPOXIDE HYDROLASES*

  2000cites this paper
• Tyrosine residues serve as proton donor in the catalytic mechanism of epoxide hydrolase from Agrobacterium radiobacter.

  2000cites this paper
• Epoxide hydrolases: biochemistry and molecular biology.

  2000cites this paper
• Chapter 4 – Xenobiotic Metabolism

  1999cites this paper
• Substrate specificity and stereospecificity of limonene-1,2-epoxide hydrolase from Rhodococcus erythropolis DCL14; an enzyme showing sequential and enantioconvergent substrate conversion

  1999cites this paper
• 5.04 – Nucleophilic Epoxide Openings

  1999cites this paper
• Kinetic and chemical mechanism of epoxide hydrolase.

  1999cites this paper
• Solution structure of the carboxyl terminus of a human class Mu glutathione S-transferase: NMR assignment strategies in large proteins.

  1999cites this paper
• Photoaffinity labeling of rat liver glutathione S-transferase, 4-4, by glutathionyl S-[4-(succinimidyl)-benzophenone].

  1998cites this paper
• Microbial transformation of epoxides

  1998cites this paper
• [Free radicals and antioxidants: physiology, human pathology and therapeutic aspects (part II)].

  1998cites this paper
• Molecular orbital study of porphyrin-substrate interactions in cytochrome P450 catalysed aromatic hydroxylation of substituted anilines.

  1998cites this paper
• Phytooxylipins and plant defense reactions.

  1998cites this paper
• Mechanism of microsomal epoxide hydrolase. Semifunctional site-specific mutants affecting the alkylation half-reaction.

  1998cites this paper
• Limonene-1,2-Epoxide Hydrolase fromRhodococcus erythropolis DCL14 Belongs to a Novel Class of Epoxide Hydrolases

  1998cites this paper
• Endogenous glutathione conjugates: occurrence and biological functions.

  1998cites this paper
• Stereochemical aspects of 1,3-butadiene metabolism and toxicity in rat and mouse liver microsomes and freshly isolated rat hepatocytes.

  1997cites this paper
• CYP4T1--a cytochrome P450 expressed in rainbow trout (Oncorhynchus mykiss) liver.

  1997cites this paper
• Visualization of a covalent intermediate between microsomal epoxide hydrolase, but not cholesterol epoxide hydrolase, and their substrates.

  1997cites this paper
• Biotransformation of the fungicide chlorthalonil by glutathione conjugation.

  1996cites this paper
• Tyrosine 8 contributes to catalysis but is not required for activity of rat liver glutathione S‐transferase, 1–1

  1996cites this paper
• Comparative MO-QSAR studies in various species including man.

  1996cites this paper
• In vitro inhibition of rat and human glutathione S-transferase isoenzymes by disulfiram and diethyldithiocarbamate.

  1996cites this paper
• The FEMA GRAS assessment of alicyclic substances used as flavour ingredients.

  1996cites this paper
• Stereoselective and regioselective hydration of 7-methylbenz[c]acridine-5,6-oxide enantiomers by rodent and human microsomal epoxide hydrolases.

  1996cites this paper
• Transformation of presumptive precursors to frontalin and exo-brevicomin by bark beetles and west Indian sugarcane weevil (Coleoptera).

  1996cites this paper
• Glutathione S-transferases.

  1996cites this paper
• 1.03 – Oxiranes and Oxirenes: Monocyclic

  1996cites this paper
• Mammalian glutathione S-transferase: regulation of an enzyme system to achieve chemotherapeutic efficacy.

  1995cites this paper
• Stereocontrolled hydrolysis of the linoleic acid monoepoxide regioisomers catalyzed by soybean epoxide hydrolase.

  1995cites this paper
• Monobromobimane as an Affinity Label of the Xenobiotic Binding Site of Rat Glutathione S-Transferase 3-3 (*)

  1995cites this paper
• Microsomal and soluble epoxide hydrolases are members of the same family of C-X bond hydrolase enzymes.

  1994cites this paper
• Molecular orbital-based quantitative structure-activity relationship for the cytochrome P450-catalyzed 4-hydroxylation of halogenated anilines.

  1994cites this paper
• Pesticide Metabolism in Aquatic Organisms

  1994cites this paper
• X-ray crystal structures of cytosolic glutathione S-transferases. Implications for protein architecture, substrate recognition and catalytic function.

  1994cites this paper
• Detoxication of the 2',3'-epoxide metabolites of allylbenzene and estragole. Conjugation with glutathione.

  1994cites this paper
• Cytosylglucuronic acid synthase (cytosine: UDP-glucuronosyltransferase) from Streptomyces griseochromogenes, the first prokaryotic UDP-glucuronosyltransferase

  1994cites this paper
• Qualitative and quantitative influences of ortho chlorine substituents on the microsomal metabolism of 4-toluidines.

  1993cites this paper
• Inhibition of epoxide hydrolase from human, monkey, bovine, rabbit and murine liver by trans-3-phenylglycidols.

  1993cites this paper
• Glutathione S-transferases: biomedical applications.

  1993cites this paper
• Role of cytochromes P-450 and flavin-containing monooxygenase in the biotransformation of 4-fluoro-N-methylaniline.

  1993cites this paper
• Stereoselective glucuronidation of (R)- and (S)-naproxen by recombinant rat phenol UDP-glucuronosyltransferase (UGT1A1) and its human orthologue.

  1993cites this paper
• Identification of ionizable groups essential for the enzyme catalysis on glutathione S-transferase P.

  1993cites this paper
• Affinity labeling of glutathione S-transferase, isozyme 4-4, by 4-(fluorosulfonyl)benzoic acid reveals Tyr115 to be an important determinant of xenobiotic substrate specificity.

  1993cites this paper
• Regio- and enantiofacial selectivity of epoxyeicosatrienoic acid hydration by cytosolic epoxide hydrolase.

  1993cites this paper
• Interaction of hepatic microsomal epoxide hydrolase derived from a recombinant baculovirus expression system with an azarene oxide and an aziridine substrate analogue.

  1993cites this paper
• Identification of Tyr115 labeled by S-(4-bromo-2,3-dioxobutyl)glutathione in the hydrophobic substrate binding site of glutathione S-transferase, isoenzyme 3-3.

  1992cites this paper
• Evidence for the involvement of tryptophan 38 in the active site of glutathione S-transferase P.

  1992cites this paper
• Affinity labeling of Cys111 of glutathione S-transferase, isoenzyme 1-1, by S-(4-bromo-2,3-dioxobutyl)glutathione.

  1992cites this paper
• Steroid UDP glucuronosyltransferases.

  1992cites this paper
• Chiral inversion and stereoselective glutathione conjugation of the four 2-bromo-3-methylvaleric acid stereoisomers in the rat in vivo and in vitro.

  1992cites this paper
• Structural studies on human glutathione S-transferase pi. Family of native-specific monoclonal antibodies used to block catalysis.

  1992cites this paper