Identification and isolation of a membrane protein necessary for leukotriene production

No abstract is available for this paper.

• Publication year

  1990

• Venue

  Nature

• Publication date

  1990-01-18

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1038/343278A0PMID 2300172
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Potential phospholipid source(s) of arachidonate used for the synthesis of leukotrienes by the human neutrophil.

  1989cited by this paper
• L-663,536 (MK-886) (3-[1-(4-chlorobenzyl)-3-t-butyl-thio-5-isopropylindol-2-yl]-2,2 - dimethylpropanoic acid), a novel, orally active leukotriene biosynthesis inhibitor.

  1989cited by this paper
• High-level expression in Escherichia coli of a chemically synthesized gene for [Leu-28]echistatin.

  1989cited by this paper
• Leukotrienes and lipoxygenases

  1989cited by this paper
• Translocation of 5-lipoxygenase to the membrane in human leukocytes challenged with ionophore A23187.

  1988cited by this paper
• Characterization of cloned human leukocyte 5-lipoxygenase expressed in mammalian cells.

  1988cited by this paper
• Leukotrienes and lipoxins: structures, biosynthesis, and biological effects.

  1987cited by this paper
• Characterization of leukotriene A4 synthase from murine mast cells: evidence for its identity to arachidonate 5-lipoxygenase.

  1986cited by this paper
• Single protein from human leukocytes possesses 5-lipoxygenase and leukotriene A4 synthase activities.

  1986cited by this paper
• Advances in Prostaglandin, Thromboxane, and Leukotriene Research

  1985cited by this paper
• Interactions between prostaglandins and leukotrienes.

  1984cited by this paper
• Enzyme with dual lipoxygenase activities catalyzes leukotriene A4 synthesis from arachidonic acid.

  1984cited by this paper
• Inhibition by prostaglandins of leukotriene B4 release from activated neutrophils.

  1983cited by this paper
• Leukotrienes: mediators of immediate hypersensitivity reactions and inflammation.

  1983cited by this paper
• The glomerular permeability determined by dextran clearance using Sephadex gel filtration.

  1968cited by this paper

• Modifications in FLAP's second cytosolic loop influence 5‐LOX interaction, inhibitor binding, and leukotriene formation

  2025cites this paper
• Modulation of Glutathione-S-Transferase by Phytochemicals: To Activate or Inhibit—That Is the Question

  2025cites this paper
• Multifunctional Evaluation of Graphene Oxide–Sulfonamide Nanoconjugates: Antimicrobial, Antibiofilm, Cytocompatibility and Xenobiotic Metabolism Gene Expression Insight

  2025cites this paper
• Control of ALOX5 expression in monocytic cells using a synthetic riboswitch.

  2025cites this paper
• Genetic insights into 5-LOX-activating protein: a narrative review of disease associations

  2025cites this paper
• Glycine tabacina Extract Alleviates Inflammatory Bowel Disease via NF-κB, JNK and Nrf2 Signaling Pathways.

  2025cites this paper
• The role of human 5-Lipoxygenase (5-LO) in carcinogenesis - a question of canonical and non-canonical functions

  2024cites this paper
• Exacerbation of atherosclerosis, hyperlipidemia and inflammation by MK886, an inhibitor of leukotriene biosynthesis, in obese and diabetic mice

  2024cites this paper
• Proteasomal Stimulation by MK886 and Its Derivatives Can Rescue Tau-Induced Neurite Pathology

  2023cites this paper
• Unraveling Mechanisms of Cryptogenic Stroke at the Genetic Level: A Systematic Literature Review

  2023cites this paper
• Structures of Leukotriene Biosynthetic Enzymes and Development of New Therapeutics.

  2022cites this paper
• Toxoplasma gondii Infection Decreases Intestinal 5-Lipoxygenase Expression, while Exogenous LTB4 Controls Parasite Growth

  2022cites this paper
• Helical remodeling augments 5-lipoxygenase activity

  2022cites this paper
• Helical remodeling augments 5-lipoxygenase activity in the synthesis of proinflammatory mediators

  2022influential citation
• The Natural Products Targeting on Allergic Rhinitis: From Traditional Medicine to Modern Drug Discovery

  2021cites this paper
• Two- and three-color STORM analysis reveals higher-order assembly of leukotriene synthetic complexes on the nuclear envelope of murine neutrophils

  2020cites this paper
• Integral membrane enzymes in eicosanoid metabolism: Structures, mechanisms and inhibitor design.

  2020cites this paper
• Discovery of Novel 5-Lipoxygenase-Activating Protein (FLAP) Inhibitors by Exploiting a Multistep Virtual Screening Protocol

  2020cites this paper
• Xenogenization of tumor cells by fusogenic exosomes in tumor microenvironment ignites and propagates antitumor immunity

  2020cites this paper
• Lipoxygenase inhibitors as cancer chemopreventives: discovery, recent developments, and future perspectives.

  2019cites this paper
• Arachidonic Acid Derived Lipid Mediators Influence Kaposi’s Sarcoma-Associated Herpesvirus Infection and Pathogenesis

  2019cites this paper
• Melleolides from Honey Mushroom Inhibit 5-Lipoxygenase via Cys159.

  2019cites this paper
• Biosynthesis, Biological Functions, and Receptors of Leukotriene B4 and 12(S)-Hydroxyheptadecatrienoic Acid

  2019cites this paper
• Remission induction, maintenance, and endoscopic outcome with oral 5‐aminosalicylic acid in intestinal Behçet's disease

  2019cites this paper
• Celecoxib aggravates atherogenesis and upregulates leukotrienes in ApoE-/- mice and lipopolysaccharide-stimulated RAW264.7 macrophages.

  2019cites this paper
• Discovery of the Oral Leukotriene-C4 Synthetase Inhibitor (1S,2S)-2-({5-[(5-Chloro-2,4-difluorophenyl)(2-fluoro-2-methylpropyl)amino]-3-methoxypyrazin-2-yl}carbonyl)cyclopropanecarboxylic acid (AZD9898) as a New Treatment for Asthma.

  2019cites this paper
• Fatty Acid Metabolites as Novel Regulators of Non-shivering Thermogenesis.

  2019cites this paper
• Papel da enzima 5-lipoxigenase na infecção oral por Toxoplasma gondii

  2018cites this paper
• Comparison of exosomes and ferritin protein nanocages for the delivery of membrane protein therapeutics

  2018cites this paper
• Pharmacological profile and efficiency in vivo of diflapolin, the first dual inhibitor of 5-lipoxygenase-activating protein and soluble epoxide hydrolase

  2017cites this paper
• 5-Lipoxygenase-Activating Protein Inhibitors: Promising Drugs for Treating Acute and Chronic Neuroinflammation Following Brain Injury

  2017cites this paper
• Biosynthesis of leukotriene B4.

  2017cites this paper
• Drug discovery approaches targeting 5-lipoxygenase-activating protein (FLAP) for inhibition of cellular leukotriene biosynthesis.

  2017cites this paper
• Role of the Cysteinyl Leukotrienes in the Pathogenesis and Progression of Cardiovascular Diseases

  2017cites this paper
• Novel leukotriene biosynthesis inhibitors (2012-2016) as anti-inflammatory agents

  2017cites this paper
• 5-lipoxygenase pathway is essential for the control of granuloma extension induced by Schistosoma mansoni eggs in lung.

  2016cites this paper
• Polypharmacology of Small-Molecule Modulators of the 5-Lipoxygenase Activating Protein (FLAP) Observed via a High-throughput Lipidomics Platform

  2016cites this paper
• Structural and Functional Analysis of Calcium Ion Mediated Binding of 5-Lipoxygenase to Nanodiscs

  2016cites this paper
• Arachidonate 5-lipoxygenase (ALOX5) gene polymorphism is associated with Alzheimer's disease and body mass index.

  2016cites this paper
• BRP-187: A potent inhibitor of leukotriene biosynthesis that acts through impeding the dynamic 5-lipoxygenase/5-lipoxygenase-activating protein (FLAP) complex assembly.

  2016cites this paper
• Discovery of the Novel Oxadiazole-Containing 5-Lipoxygenase Activating Protein (FLAP) Inhibitor BI 665915

  2016cites this paper
• Development and evaluation of ST-1829 based on 5-benzylidene-2-phenylthiazolones as promising agent for anti-leukotriene therapy.

  2015cites this paper
• Transcellular biosynthesis of eicosanoid lipid mediators.

  2015cites this paper
• Studies of exercise-induced bronchoconstriction to define protective mechanisms in asthma

  2015cites this paper
• Synthesis, SAR, and series evolution of novel oxadiazole-containing 5-lipoxygenase activating protein inhibitors: discovery of 2-[4-(3-{(r)-1-[4-(2-amino-pyrimidin-5-yl)-phenyl]-1-cyclopropyl-ethyl}-[1,2,4]oxadiazol-5-yl)-pyrazol-1-yl]-N,N-dimethyl-acetamide (BI 665915).

  2015cites this paper
• Lipoxygenase regulation in vivo and in vitro by lipid compounds

  2015cites this paper
• Medical Therapy for Inflammatory Bowel Disease.

  2015cites this paper
• Microsomal prostaglandin E synthase 1 and microsomal glutathione transferase 1: inhibition and mechanism

  2014influential citation
• Identification, characterization and evaluation of novel leukotriene biosynthesis inhibitors

  2014cites this paper
• From THE INSTITUTE OF ENVIRONMENTAL MEDICINE

  2014cites this paper
• The Kaposi's Sarcoma-Associated Herpesvirus (KSHV)-Induced 5-Lipoxygenase-Leukotriene B4 Cascade Plays Key Roles in KSHV Latency, Monocyte Recruitment, and Lipogenesis

  2014cites this paper
• Metalloproteinase dependent reduction of cell surface cluster determinants upon the induction of apoptosis

  2014cites this paper
• Multi-dimensional target profiling of N,4-diaryl-1,3-thiazole-2-amines as potent inhibitors of eicosanoid metabolism.

  2014cites this paper
• Chronic Hypoxia Promotes Pulmonary Artery Endothelial Cell Proliferation through H2O2-Induced 5-Lipoxygenase

  2014cites this paper
• The novel benzimidazole derivative BRP‐7 inhibits leukotriene biosynthesis in vitro and in vivo by targeting 5‐lipoxygenase‐activating protein (FLAP)

  2014cites this paper
• Pharmacodynamics, pharmacokinetics and safety of GSK2190915, a novel oral anti-inflammatory 5-lipoxygenase-activating protein inhibitor.

  2013cites this paper
• FLAP pharmacological blockade modulates metabolism of endogenous tau in vivo

  2013cites this paper
• macrophage phagocytosis of IgG-coated targets but not apoptotic cells regulated event involved in - Syk activation is a leukotriene B4

  2013cites this paper
• A review on leukotrienes and their receptors with reference to asthma

  2013cites this paper
• The Kaposi's Sarcoma-Associated Herpesvirus (KSHV)-Induced 5-Lipoxygenase-Leukotriene B4 Cascade Plays Key Roles in KSHV Latency, Monocyte Recruitment, and Lipogenesis

  2013cites this paper
• Structure-based drug design on membrane protein targets: human integral membrane protein 5-lipoxygenase-activating protein.

  2012cites this paper
• Evaluation of endo- and exo-aryl-substitutions and central scaffold modifications on diphenyl substituted alkanes as 5-lipoxygenase activating protein inhibitors.

  2012cites this paper
• The nuclear membrane leukotriene synthetic complex is a signal integrator and transducer

  2012cites this paper
• Inhibition of 5-lipoxygenase by U73122 is due to covalent binding to cysteine 416.

  2012cites this paper
• Discovery and Development of Montelukast (Singulair

  2012cites this paper
• Synthesis and biological evaluation of a class of 5-benzylidene-2-phenyl-thiazolinones as potent 5-lipoxygenase inhibitors.

  2012cites this paper
• SAR-study on a new class of imidazo[1,2-a]pyridine-based inhibitors of 5-lipoxygenase.

  2012cites this paper
• Contrôle physiologique et pharmacologique de la biosynthèse des leucotriènes

  2012cites this paper
• Effect of COX and LOX inhibitors on melanoma

  2012cites this paper
• The Potential Role of Tocopherol in Asthma and Allergies

  2012cites this paper
• Systematic approaches to toxicology in the zebrafish.

  2012cites this paper
• Lipoxygenase and Cyclooxygenase Pathways and Colorectal Cancer Prevention

  2012cites this paper
• The Development of Cysteinyl Leukotriene Receptor Antagonists

  2012cites this paper
• Synthesis and evaluation of indole-based chalcones as inducers of methuosis, a novel type of nonapoptotic cell death.

  2012cites this paper
• Involvement of 5-lipoxygenase activating protein in the amyloidotic phenotype of an Alzheimer’s disease mouse model

  2012cites this paper
• Anti-inflammatory, Antipyretic, and Safety Assessment of Aqueous and Ethanolic Leaf Extracts of Pistia stratiotes Linn (Araceae)

  2012cites this paper
• COX-2-dependent and -independent biosynthesis of dihydroxy-arachidonic acids in activated human leukocytes

  2012cites this paper
• How chemoproteomics can enable drug discovery and development.

  2012cites this paper
• Structural and functional insights of human 5-lipoxygenase

  2011cites this paper
• Lipoxygenase and leukotriene pathways: biochemistry, biology, and roles in disease.

  2011cites this paper
• Mechanisms of induction of cytosolic and microsomal glutathione transferase (GST) genes by xenobiotics and pro-inflammatory agents

  2011cites this paper
• Genetic Variants in the Promoter Region of the ALOX5AP Gene and Susceptibility of Ischemic Stroke

  2011cites this paper
• Ligation of CD40 receptor in human B lymphocytes triggers the 5-lipoxygenase pathway to produce reactive oxygen species and activate p38 MAPK

  2011cites this paper
• Designing zebrafish chemical screens.

  2011cites this paper
• Evaluation of the Anti-Inflammatory Effects of Novel Pirinixic Acid Derivatives

  2011cites this paper
• Leukotriene receptors.

  2011cites this paper
• Joint Tissues Amplify Inflammation and Alter Their Invasive Behavior via Leukotriene B4 in Experimental Inflammatory Arthritis

  2010cites this paper
• This information is current as Inflammatory Arthritis in Experimental 4 Leukotriene B Alter Their Invasive Behavior via Joint Tissues Amplify Inflammation and

  2010cites this paper
• Studies on arachidonic acid metabolism in normal and malignant hematopoietic cells

  2010cites this paper
• The relationship between the polymorphism of SG13S114 A/T in ALOX5AP gene and the vulnerability of carotid atherosclerosis in Chinese Han population.

  2010cites this paper
• Structure and Function of Microsomal Prostaglandin E Synthase-1

  2010cites this paper
• The activity of medicinal plants and secondary metabolites on eosinophilic inflammation.

  2010cites this paper
• Cysteinyl Leukotrienes and Their Receptors: Molecular and Functional Characteristics

  2010cites this paper
• Studies on leukotriene B4 and alarmins in inflammatory responses

  2010cites this paper
• FLAP inhibitors for the treatment of inflammatory diseases.

  2009cites this paper
• Pharmacological Characterization of 3-[3-tert-Butylsulfanyl-1-[4-(6-methoxy-pyridin-3-yl)-benzyl]-5-(pyridin-2-ylmethoxy)-1H-indol-2-yl]-2,2-dimethyl-propionic Acid (AM103), a Novel Selective 5-Lipoxygenase-Activating Protein Inhibitor That Reduces Acute and Chronic Inflammation

  2009cites this paper
• Efeito de um inibidor de leucotrienos no processo inflamatório decorrente da infecção por Paracoccidioides brasiliensis em camundongos geneticamente selecionados

  2009cites this paper
• Inhibitors of 5-lipoxygenase activating protein: WO 2008/030369

  2009cites this paper
• Inhibitors of the 5-lipoxygenase pathway in atherosclerosis.

  2009cites this paper
• Anti-inflammatory agents as cancer therapeutics.

  2009cites this paper