Protein kinase C regulation of the receptor-coupled calcium signal in histamine-secreting rat basophilic leukaemia cells

No abstract is available for this paper.

• Publication year

  1985

• Venue

  Nature

• Publication date

  1985-01-03

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/313059A0PMID 2578217
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Purification to homogeneity of protein kinase C from bovine brain–identity with the phorbol ester receptor.

  1984cited by this paper
• Protein kinase C, a coupling element between stimulus and secretion of basophils.

  1984cited by this paper
• Resolution of cellular compartments involved in membrane potential changes accompanying IgE‐mediated degranulation of rat basophilic leukemia cells.

  1984cited by this paper
• The mechanism of the calcium signal and correlation with histamine release in 2H3 cells.

  1984cited by this paper
• Phorbol esters inhibit LH stimulated steroidogenesis by mouse Leydig cells in vitro.

  1984cited by this paper
• Phorbol esters inhibit alpha 1 adrenergic stimulation of glycogenolysis in isolated rat hepatocytes.

  1984cited by this paper
• The cromolyn binding protein constitutes the Ca2+ channel of basophils opening upon immunological stimulus.

  1984cited by this paper
• Synergistic action of protein kinase C and calcium for histamine release from rat peritoneal mast cells.

  1984cited by this paper
• Aldosterone secretion: effect of phorbol ester and A23187.

  1983cited by this paper
• A role of calcium-activated phospholipid-dependent protein kinase in human platelet activation. Comparison of thrombin and collagen actions.

  1983cited by this paper
• Phospholipid-sensitive Ca2+-dependent protein kinase and its substrates in human neutrophils.

  1983cited by this paper
• The phorbol ester TPA increases the affinity of exocytosis for calcium in ‘leaky’ adrenal medullary cells

  1983cited by this paper
• The role of the protector in attenuation

  1983cited by this paper
• New calcium indicators and buffers with high selectivity against magnesium and protons: design, synthesis, and properties of prototype structures.

  1980cited by this paper
• Dimeric immunoglobulin E serves as a unit signal for mast cell degranulation.

  1977cited by this paper

• Design of an ultrabright biosensor for dynamic imaging of kinase activity in cells

  2025cites this paper
• KIRA6 is an Effective and Versatile Mast Cell Inhibitor of IgE‐mediated Activation

  2024cites this paper
• Role of epithelial Na+ channels in endothelial function

  2016cites this paper
• Immunopharmacological modulation of mast cells.

  2014cites this paper
• Interplay Of Protein Kinase C, The Marcks Protein, And Phosphoinositides In Regulating Mast Cell Signaling

  2012cites this paper
• Inhibitory Effects of Water-Soluble Low-Molecular-Weight β-(1,3-1,6) D-Glucan Isolated from Aureobasidium pullulans 1A1 Strain Black Yeast on Mast Cell Degranulation and Passive Cutaneous Anaphylaxis

  2012cites this paper
• Effects of Proatherogenic and Probiotic Bacteria on Mast Cells and Inflammation

  2012cites this paper
• Sequestration of phosphoinositides by mutated MARCKS effector domain inhibits stimulated Ca2+ mobilization and degranulation in mast cells

  2011cites this paper
• Regulatory mechanisms of epithelial sodium channel

  2010cites this paper
• Silver nanoparticle-induced degranulation observed with quantitative phase microscopy

  2010cites this paper
• C3a-derived peptide binds to the type I FcepsilonR and inhibits proximal-coupling signal processes and cytokine secretion by mast cells.

  2008cites this paper
• Compartmentalization of the Type I Fcε receptor and MAFA on mast cell membranes

  2007cites this paper
• Regulation of the mast cell response to the type 1 Fc epsilon receptor.

  2007cites this paper
• Inhibition of ciliary activity by phorbol esters in rabbit tracheal epithelial cells

  2007cites this paper
• Compartmentalization of the Type I Fc epsilon receptor and MAFA on mast cell membranes.

  2007cites this paper
• Regulation of the mast cell response to the type 1 Fcε receptor

  2007cites this paper
• A redundant role for PKC-epsilon in mast cell signaling and effector function.

  2006cites this paper
• A redundant role for PKC-e in mast cell signaling and effector function

  2006cites this paper
• Regulation of Immunoreceptor Activities: The Paradigm of the Type I Fcε Receptor

  2005cites this paper
• Flavonols inhibit proinflammatory mediator release, intracellular calcium ion levels and protein kinase C theta phosphorylation in human mast cells

  2005cites this paper
• A molecular understanding of mast cell activation and the promise of anti-allergic therapeutics.

  2004cites this paper
• Reduced IgE Receptor-Dependent Secretion

  2004cites this paper
• The mast cell function-associated antigen and its interactions with the type I Fcepsilon receptor.

  2002cites this paper
• Suppression of Synaptotagmin II restrains phorbolester-induced downregulation of protein kinase Calpha by diverting the kinase from a degradative pathway to the recycling endocytic compartment.

  2002cites this paper
• The molecular mechanisms of allergic diseases: immunoglobulin E dependent and independent signaling pathways converge in eliciting the release of arachidonic acid metabolites.

  2002cites this paper
• Protein kinase C theta is expressed in mast cells and is functionally involved in Fcepsilon receptor I signaling.

  2001cites this paper
• Protein kinase C θ is expressed in mast cells and is functionally involved in Fcɛ receptor I signaling

  2001cites this paper
• Cdc42 and Rac Stimulate Exocytosis of Secretory Granules by Activating the Ip3/Calcium Pathway in Rbl-2h3 Mast Cells

  2000influential citation
• Calcium-dependent Threonine Phosphorylation of Nonmuscle Myosin in Stimulated RBL-2H3 Mast Cells*

  2000cites this paper
• Cdc 42 and Rac Stimulate Exocytosis of Secretory Granules by Activating the IP 3 / Calcium Pathway in RBL-2 H 3 Mast Cells

  2000cites this paper
• Involvement of hrs binding protein in IgE receptor-triggered exocytosis in RBL-2H3 mast cells.

  2000cites this paper
• Pharmacology of IgE-mediated desensitization of human basophils: effects of protein kinase C and src-family kinase inhibitors.

  2000cites this paper
• Gi-mediated activation of mitogen-activated protein kinase (MAPK) pathway by receptor mimetic basic secretagogues of connective tissue-type mast cells: bifurcation of arachidonic acid-induced release upstream of MAPK.

  1999cites this paper
• Protein kinase C activator PMA reduces the Ca2+ response to antigen stimulation of adherent RBL‐2H3 mucosal mast cells by inhibiting depletion of intracellular Ca2+ stores

  1999cites this paper
• Protein kinase C activator PMA reduces the Ca(2+) response to antigen stimulation of adherent RBL-2H3 mucosal mast cells by inhibiting depletion of intracellular Ca(2+) stores.

  1999cites this paper
• Activation of Heterotrimeric GTP-Binding Proteins

  1999cites this paper
• Regulation of Secretion in Human Basophils

  1999cites this paper
• Phospholipase C Signaling Pathway GTP-Binding Proteins Linked toiExpression of G Mast Cell Secretagogues Through Increased Quercetin Sensitizes RBL-2 H 3 Cells to Polybasic

  1998influential citation
• Purification and preliminary characterization of an Fc epsilon-receptor-activated protein-tyrosine phosphatase from mast cells.

  1998cites this paper
• Quercetin sensitizes RBL-2H3 cells to polybasic mast cell secretagogues through increased expression of Gi GTP-binding proteins linked to a phospholipase C signaling pathway.

  1998cites this paper
• SIGNAL TRANSDUCTION BY PROTEIN KINASE C IN MAMMALIAN CELLS

  1998cites this paper
• Expression of protein kinase C isozymes in human basophils: regulation by physiological and nonphysiological stimuli.

  1998cites this paper
• Thapsigargin-induced secretion is dependent on activation of a cholera toxin-sensitive and phosphatidylinositol-3-kinase-regulated phospholipase D in a mast cell line.

  1998cites this paper
• Signaling in Mast Cells

  1998cites this paper
• Desensitization of IgE‐mediated IL‐4 release from human basophils

  1998cites this paper
• Signal Transduction Issues in Studies of Human Basophils and Mast Cells

  1997cites this paper
• Dual regulation of the Na+/H+‐exchange in rat peritoneal mast cells: role of protein kinase C and calcium on pHi regulation and histamine release

  1996cites this paper
• Role of calcium, protein kinase C and MAP kinase in the activation of mast cells

  1996cites this paper
• Differential Effects of the Protein Kinase C Activator Phorbol 12-Myristate 13-Acetate on Calcium Responses and Secretion in Adherent and Suspended RBL-2H3 Mucosal Mast Cells (*)

  1996cites this paper
• Roles for Ca2+ stores release and two Ca2+ influx pathways in the Fc epsilon R1-activated Ca2+ responses of RBL-2H3 mast cells.

  1995cites this paper
• Characterization of a method for the detection of drugs with free radical scavenging activity using porcine leukocytes.

  1994cites this paper
• New hexahydroxybiphenyl derivatives as inhibitors of protein kinase C.

  1994cites this paper
• Studies with transfected and permeabilized RBL-2H3 cells reveal unique inhibitory properties of protein kinase C gamma.

  1994cites this paper
• Possible role of protein kinase C in regulation of flagellar motility and intracellular free Ca2+ concentration of fowl spermatozoa.

  1994cites this paper
• FcϵRI and the T cell receptor for antigen activate similar signalling pathways in T cell-RBL cell hybrids

  1993cites this paper
• Ca2+ ionophore A23187-dependent stabilization of granulocyte-macrophage colony-stimulating factor messenger RNA in murine thymoma EL-4 cells is mediated through two distinct regions in the 3'-untranslated region.

  1993cites this paper
• Ca(2+)-dependent and Ca(2+)-independent isozymes of protein kinase C mediate exocytosis in antigen-stimulated rat basophilic RBL-2H3 cells. Reconstitution of secretory responses with Ca2+ and purified isozymes in washed permeabilized cells.

  1993cites this paper
• Fc epsilon RI and the T cell receptor for antigen activate similar signalling pathways in T cell-RBL cell hybrids.

  1993cites this paper
• 5 – Signal Transduction during Exocytosis in Mast Cells

  1993cites this paper
• CGP 41251, a novel protein kinase inhibitor with in vitro selectivity for protein kinase C, strongly inhibits immunological activation of human skin mast cells and human basophils.

  1993cites this paper
• Lead inhibits 1,25-dihydroxyvitamin D-3 regulation of calcium metabolism in osteoblastic osteosarcoma cells (ROS 17/2.8).

  1992cites this paper
• Protein kinase C initially inhibits the induction of meiotic cell division in Xenopus oocytes.

  1992cites this paper
• Synergistic effects of 12-O-tetradecanoylphorbol-13-acetate and dexamethasone on de novo synthesis of histidine decarboxylase in mouse mastocytoma P-815 cells.

  1992cites this paper
• The Epithelial Phenotype of Human Neuroblastoma Cells Expresses Bradykinin, Endothelin, and Angiotensin II Receptors That Stimulate Phosphoinositide Hydrolysis

  1992cites this paper
• Murine FcγRII and III in Mast Cell Activation

  1992cites this paper
• Murine Fc gamma RII and III in mast cell activation.

  1992cites this paper
• Pharmacological studies on the role of protein kinase C in signal transduction of human basophils.

  1992cites this paper
• Dual effects of a phorbol ester on calcium-dependent chloride secretion by T84 epithelial cells.

  1992cites this paper
• Rat basophilic leukemia cells: protein kinase C and secretion.

  1991cites this paper
• Arachidonic acid release by basophilic leukemia cells and macrophages stimulated by Ca2+ ionophores, antigen and diacylglycerol: essential role for protein kinase C and prevention by glucocorticosteroids.

  1991cites this paper
• The role of external and internal free Ca2+ concentration on ionomycin induced leukotriene C4 formation in rat basophilic leukemia cells.

  1991cites this paper
• Antigen- and ionophore-induced signal transduction in rat basophilic leukemia cells involves protein tyrosine phosphorylation.

  1991cites this paper
• The high affinity receptor for IgE on mast cells

  1991cites this paper
• Calcium influx in a rat mast cell (RBL-2H3) line. Use of multivalent metal ions to define its characteristics and role in exocytosis.

  1991cites this paper
• The effects of phorbol myristate acetate on the intracellular degradation of bovine parathyroid hormone.

  1991cites this paper
• Membrane Receptor Clustering as a Cellular Stimulus — The Mast Cell Case

  1991cites this paper
• The effect of staurosporine on Ca2+ signals in rat basophilic leukemia (RBL-2H3) cells.

  1991cites this paper
• A novel cell-permeable cromoglycate derivative inhibits type I Fc epsilon receptor mediated Ca2+ influx and mediator secretion in rat mucosal mast cells.

  1991cites this paper
• Ca antagonist verapamil and tumor promoter 12-O-tetradecanoylphorbol-13- acetate (TPA) induce chromosomal aberrations in human lymphocytes.

  1990cites this paper
• Effect of 12-O-tetradecanoylphorbol-13-acetate (TPA) on substance P-induced histamine release from rat peritoneal mast cells

  1990cites this paper
• Tyrosine phosphorylation coupled to IgE receptor-mediated signal transduction and histamine release.

  1990cites this paper
• on Rat Granulosa Cell Steroidogenesis In Vitro1

  1990cites this paper
• Desensitization of muscarinic M1 receptors of murine neuroblastoma cells (clone N1E-115) without receptor down-regulation and protein kinase C activity.

  1990cites this paper
• Differential down-regulation of protein kinase C selectively affects IgE-dependent exocytosis and inositol trisphosphate formation.

  1990cites this paper
• The modulatory effects of phorbol esters on histamine release from mast cells induced by a polyethylenimine and a polyallylamine.

  1990cites this paper
• Substances with an Antiallergic Effect

  1990cites this paper
• Calcium Is Required for PMA Induced Superoxide Release From Human Neutrophils

  1990cites this paper
• Evaluation of the role of inositol trisphosphate in IgE-dependent exocytosis.

  1990cites this paper
• Structure and Function of the High-Affinity Receptor for Immunoglobulin E

  1990cites this paper
• CHAPTER 25 – GTP-Binding Proteins and Exocytotic Secretion

  1990cites this paper
• Exocytosis in mast cells by basic secretagogues: evidence for direct activation of GTP-binding proteins

  1990cites this paper
• Antigen‐Dependent transition of IgE to a detergent‐insoluble form is associated with reduced IgE receptor‐dependent secretion from RBL‐2H3 mast cells

  1990cites this paper
• Signal transduction events in human basophils. A comparative study of the role of protein kinase C in basophils activated by anti-IgE antibody and formyl-methionyl-leucyl-phenylalanine.

  1990cites this paper
• The role of protein kinase C in histamine secretion from mast cells.

  1990cites this paper
• Divergent effects of 1-oleoyl-2-acetylglycerol and tumor-promoting phorbol ester on rat granulosa cell steroidogenesis in vitro.

  1990cites this paper
• Heterogeneity of the regulation of phospholipase C by phorbol esters in T lymphocytes.

  1990cites this paper
• Down-regulation of protein kinase C potentiates angiotensin II-stimulated polyphosphoinositide hydrolysis in vascular smooth-muscle cells.

  1989cites this paper
• Bidirectional effects of protein kinase C activators. Studies with human neutrophils and platelet-activating factor.

  1989cites this paper
• The rise in concentration of free Ca2+ and of pH provides sequential, synergistic signals for secretion in antigen-stimulated rat basophilic leukemia (RBL-2H3) cells.

  1989cites this paper
• Studies of protein kinase C in the rat basophilic leukemia (RBL-2H3) cell reveal that antigen-induced signals are not mimicked by the actions of phorbol myristate acetate and Ca2+ ionophore.

  1989cites this paper