Intrathecal serotonin in mice: analgesia and inhibition of a spinal action of substance P.

No abstract is available for this paper.

• Publication year

  1983

• Venue

  Life Science

• Publication date

  1983-08-22

• Fields of study

  Medicine

• Identifiers
  DOI 10.1016/0024-3205(83)90785-3PMID 6193388
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Intrathecal opioids block a spinal action of substance P in mice: functional importance of both mu- and delta-receptors.

  1982cited by this paper
• Intrathecal opioids block a spinal action of substance P in mice: Functional importance of both μ- and δ-receptors

  1982cited by this paper
• Immunocytochemical analysis of serotonergic axons in laminae I and II of the lumbar spinal cord of the cat

  1982cited by this paper
• Substance P: evidence for spinal mediation of some behavioural effects.

  1981cited by this paper
• Functional aspects of bulbospinal monoaminergic projections in modulating processing of somatosensory information.

  1981cited by this paper
• Neonatal rat spinal cord slice preparation: postsynaptic effects of neuropeptides on dorsal horn neurons.

  1981cited by this paper
• Behavioral evidence that substance P may be a spinal cord sensory neurotransmitter.

  1981cited by this paper
• Ultrastructure of descending serotoninergic axonal endings in layers I and II of the dorsal horn.

  1981cited by this paper
• 5-Hydroxytryptamine reduces substabce P responses on dorsal horn interneurones: a possible interaction of neurotransmitters

  1981cited by this paper
• Intrathecal substance P elicits a caudally-directed biting and scratching behavior in mice.

  1981cited by this paper
• Postsynaptic inhibition of primate spinothalamic neurons by stimulation in nucleus raphe magnus.

  1981cited by this paper
• Intrathecal morphine inhibits substance P release from mammalian spinal cord in vivo

  1980cited by this paper
• Ultrastructural characterization of axonal endings in the substantia gelatinosa which take up [3H]serotonin.

  1980cited by this paper
• Intrathecal morphine in mice: a new technique.

  1980cited by this paper
• Direct evidence that spinal serotonin and noradrenaline terminals mediate the spinal antinociceptive effects of morphine in the periaqueductal gray.

  1979cited by this paper
• Spinal serotonin terminal system mediates antinociception.

  1979cited by this paper
• Depression of primate spinothalamic tract neurons by iontophoretic application of 5‐hydroxytryptamine

  1978cited by this paper
• Serotonin‐containing neurons: their possible role in pain and analgesia

  1977cited by this paper
• Effect of substance P in cat dorsal horn neurones activated by noxious stimuli.

  1977cited by this paper
• Antinociceptive Effect of Intrathecally Administered Serotonin

  1977cited by this paper
• Effects of substance P on functionally identified units in cat spinal cord.

  1976cited by this paper
• Substance p: localization in the central nervous system and in some primary sensory neurons

  1975cited by this paper
• Enhancement by morphine of the central descending inhibitory influence on spinal sensory transmission.

  1971cited by this paper
• Analgesia from Electrical Stimulation in the Brainstem of the Rat

  1971cited by this paper
• Surgery in the Rat during Electrical Analgesia Induced by Focal Brain Stimulation

  1969cited by this paper
• The effect of analgesics on the spinal reflex activity of the cat.

  1955cited by this paper

• The development of descending serotonergic modulation of the spinal nociceptive network: a life span perspective

  2021cites this paper
• Adjunctive effect of the serotonin 5-HT2C receptor agonist lorcaserin on opioid-induced antinociception in mice.

  2020influential citation
• Ethyl pyruvate protects against sepsis-associated encephalopathy through inhibiting the NLRP3 inflammasome

  2020cites this paper
• Role of Tissue Inhibitor of Matrix Metalloproteinase-1 in the Development of Hypersensitivity Using an Animal Model of Cutaneous Inflammation

  2019cites this paper
• TIMP-1 Attenuates the Development of Inflammatory Pain Through MMP-Dependent and Receptor-Mediated Cell Signaling Mechanisms

  2019cites this paper
• TIMP-1 attenuates the development of cutaneous inflammation-induced hypersensitivity

  2019cites this paper
• Serotonergic Modulation of Nociceptive Circuits in Spinal Cord Dorsal Horn

  2019cites this paper
• The developmental emergence of differential brainstem serotonergic control of the sensory spinal cord

  2017cites this paper
• Cholinergic receptor subtypes functional regulation in spinal cord injured monoplegic rats

  2012cites this paper
• Distribution of Glycine/GABA Neurons in the Ventromedial Medulla with Descending Spinal Projections and Evidence for an Ascending Glycine/GABA Projection

  2012cites this paper
• Spinal 5‐HT receptors that contribute to the pain‐relieving effects of spinal cord stimulation in a rat model of neuropathy

  2011cites this paper
• Mu Opioid Receptor Mediated Analgesia and Reward

  2011cites this paper
• Antinociceptive Interactions between Mu-Opioid Receptor Agonists and the Serotonin Uptake Inhibitor Clomipramine in Rhesus Monkeys: Role of Mu Agonist Efficacy

  2010cites this paper
• Antinociceptive interactions between mu-opioid receptor agonists and the serotonin uptake inhibitor clomipramine in rhesus monkeys: role of mu agonist efficacy

  2010cites this paper
• Caracterização do efeito anti-inflamatório e anti-hemorrágico dos extratos e frações enriquecidas de espécies do projeto temático BIOTA/FAPESP

  2010cites this paper
• Advances in perioperative pain management: use of medications with dual analgesic mechanisms, tramadol & tapentadol.

  2010cites this paper
• Descending Modulation of Pain

  2009cites this paper
• Interaction between midazolam and epibatidine in spinally mediated antinociception in rats

  2009cites this paper
• Interaction between midazolam and serotonin in spinally mediated antinociception in rats

  2009cites this paper
• Evidence for a role of 5-HT(1A) receptor on antinociceptive action from Geissospermum vellosii.

  2009cites this paper
• Preclinical and early clinical investigations related to monoaminergic pain modulation

  2009cites this paper
• AVALIAÇÃO DA ATIVIDADE ANTINOCICEPTIVA DO EXTRATO BRUTO, DAS FRAÇÕES E DOS COMPOSTOS OBTIDOS DE Geissospermum vellosii

  2008cites this paper
• Mechanisms of pain in nonmalignant disease

  2008cites this paper
• Neuropathic pain: multiple mechanisms at multiple sites

  2007cites this paper
• Effects of peripheral inflammation on activation of p38 mitogen-activated protein kinase in the rostral ventromedial medulla.

  2007cites this paper
• Central nervous system mechanisms of pain modulation

  2006cites this paper
• Mecanismos de modulación del dolor del sistema nervioso central

  2006cites this paper
• Antinociceptive properties of the ethanolic extract and of the triterpene 3beta,6beta,16beta-trihidroxilup-20(29)-ene obtained from the flowers of Combretum leprosum in mice.

  2006cites this paper
• Stress-induced hyperalgesia: animal models and putative mechanisms.

  2006cites this paper
• Effect of intrathecal serotonin on nociception in rats: influence of the pain test used

  2006cites this paper
• Subsensitivity of serotonin and substance P receptors involved in nociception after repeated administration of a serotonin receptor agonist

  2005cites this paper
• Cardiovascular effects of intrathecal administration of substance P in the rat: interactions with serotonergic mechanisms

  2005cites this paper
• Effects of peripheral inflammation on activation of ERK in the rostral ventromedial medulla.

  2005cites this paper
• Evidence for a spinal serotonergic control of the peripheral inflammation in the rat.

  2005cites this paper
• Central and peripheral serotonergic influences on viscerovisceral inhibitory reflex during duodenal distension in sheep

  2005cites this paper
• Involvement of 5-HT2 receptors in the antinociceptive effect of Uncaria tomentosa.

  2005cites this paper
• Effects of a 5-HT2A receptor antagonist, sarpogrelate on thermal or inflammatory pain.

  2005cites this paper
• The effects of acute and chronic restraint stress on activation of ERK in the rostral ventromedial medulla and locus coeruleus

  2004cites this paper
• Pathophysiology of the Blood–Spinal Cord Barrier in Traumatic Injury

  2004cites this paper
• Attenuation of metabolic heat production and cold‐escape/warm‐seeking behaviour during a cold exposure following systemic salt loading in rats

  2003cites this paper
• Antinociceptive Effects of Methysergide in Various Pain Models

  2003cites this paper
• Anti-analgesic activity of enterostatin (VPDPR) is mediated by corticosterone.

  2003cites this paper
• Intrathecal transplantation of neuroblastoma cells decreases heat hyperalgesia and cold allodynia in a rat model of neuropathic pain.

  2002cites this paper
• The role of 5‐hydroxytryptamine1A and 5‐hydroxytryptamine1B receptors in modulating spinal nociceptive transmission in normal and carrageenan‐injected rats

  2001cites this paper
• The Role of L-Arginine/Nitric Oxide Pathway in the Antinociceptive Activity of Pyridoxine in Mouse

  2001cites this paper
• Antiallodynic effect of intrathecally administered 5‐HT2 agonists in rats with nerve ligation

  2001cites this paper
• Neurotransmitters and receptors in the dorsal horn of the spinal cord

  2000cites this paper
• Modulation of Nociception by Descending Serotoninergic Projections

  2000cites this paper
• High intensity social conflict in the Swiss albino mouse induces analgesia modulated by 5-HT1A receptors.

  1997cites this paper
• Mediators and pharmacology of visceral sensitivity: from basic to clinical investigations.

  1997cites this paper
• Spinal morphine/clonidine antinociceptive synergism: involvement of G proteins and N-type voltage-dependent calcium channels.

  1996cites this paper
• Dual effect of serotonin on formalin-induced nociception in the rat spinal cord.

  1996cites this paper
• The analgesic effect of clonixine is not mediated by 5-HT3 subtype receptors.

  1995cites this paper
• Effect of 5-HT on pain modulation of substance P in spinal cord of rats.

  1995cites this paper
• Meta‐chlorophenylpiperazine attenuates formalin‐induced nociceptive responses through 5‐HT1/2 receptors in both normal and diabetic mice

  1995cites this paper
• Subarachnoid Bupivacaine Increases Human Cerebrospinal Fluid Concentration of Serotonin

  1995cites this paper
• Tiapride attenuates pain transmission through an indirect activation of central serotonergic mechanism.

  1995cites this paper
• Decreased spinal morphine/clonidine antinociceptive synergism in morphine-tolerant mice.

  1994cites this paper
• Raphe magnus stimulation-induced antinociception in the cat is associated with release of amino acids as well as serotonin in the lumbar dorsal horn.

  1993cites this paper
• Endogenous dynorphin modulates calcium-mediated antinociception in mice.

  1993cites this paper
• Intrathecal 5-methoxy-N,N-dimethyltryptamine in mice modulates 5-HT1 and 5-HT3 receptors.

  1993cites this paper
• Differential roles of 5-hydroxytryptamine1A and 5-hydroxytryptamine1B receptor subtypes in modulating spinal nociceptive transmission in mice.

  1993cites this paper
• Autoradiographic localization of 5-hydroxytryptamine1A, 5-hydroxytryptamine1B and 5-hydroxytryptamine1C/2 binding sites in the rat spinal cord.

  1993cites this paper
• Intrathecal coadministration of serotonin and morphine differentially modulates the tail-flick reflex of intact and spinal rats.

  1993cites this paper
• Central and peripheral serotonergic influences on viscerovisceral inhibitory reflex during duodenal distension in sheep

  1993cites this paper
• Regional distribution of serotonin and substance P co-existing in nerve fibers and terminals in the brainstem of the rat.

  1993cites this paper
• Stimulation of 5-HT1 receptors in the spinal cord changes substance P-induced behaviour.

  1992cites this paper
• Evidence that endogenous opioids mediate the antinociceptive effects of intrathecally administered calcium in mice.

  1992cites this paper
• Spinal interactions between opioid and noradrenergic agonists in mice: multiplicativity involves delta and alpha-2 receptors.

  1992cites this paper
• Imipramine inhibits intrathecal substance P-induced behavior and blocks spinal cord substance P receptors in mice.

  1992cites this paper
• 術後針刺對人工膝關節置換術後疼痛緩解效應的評估; Assessment of the effect of postoperative acupuncture stimulation on pain relief after total knee replacement

  1992cites this paper
• Mechanisms of L-NG-nitro arginine methyl ester-induced antinociception in mice: a role for serotonergic and adrenergic neurons.

  1992cites this paper
• Further evidence for enigmas in adaptation mechanisms for the DOI-induced behaviors.

  1992cites this paper
• Spinal 5-HT3 receptor-mediated antinociception: possible release of GABA

  1991cites this paper
• Noradrenergic and purinergic involvement in spinal antinociception by 5-hydroxytryptamine and 2-methyl-5-hydroxytryptamine.

  1991cites this paper
• Different role of 5-HT1A and 5-HT2 receptors in spinal cord in the control of nociceptive responsiveness.

  1991cites this paper
• Antinociceptive effect of ketanserin in mice: involvement of supraspinal 5-HT2 receptors in nociceptive transmission.

  1991cites this paper
• Characterization of the 5‐HT receptor subtypes involved in the motor behaviours produced by intrathecal administration of 5‐HT agonists in rats

  1991cites this paper
• Evidence for co-existence of thyrotropin-releasing hormone, substance P and serotonin in ventral medullary neurons that project to the intermediolateral cell column in the rat.

  1990cites this paper
• Alteration of substance P after trauma to the spinal cord: an experimental study in the rat.

  1990cites this paper
• Differential contribution of descending serotonergic and noradrenergic systems to central Tyr-D-Ala2-Gly-NMePhe4-Gly-ol5 (DAMGO) and morphine-induced antinociception in mice.

  1990cites this paper
• 5-hydroxytryptamine (HT)1A receptors and the tail-flick response. II. High efficacy 5-HT1A agonists attenuate morphine-induced antinociception in mice in a competitive-like manner.

  1990cites this paper
• Morphine (intracerebroventricular) activates spinal systems to inhibit behavior induced by putative pain neurotransmitters.

  1989cites this paper
• Involvement of 5‐HT2 receptors in the behaviours produced by intrathecal administration of selected 5‐HT agonists and the TRH analogue (CG 3509) to rats

  1989cites this paper
• Is substance P a primary afferent neurotransmitter for nociceptive input? III. Valproic acid and chlordiazepoxide decrease behaviors elicited by intrathecal injection of substance P and excitatory compounds.

  1988cites this paper
• Intrathecal substance P modulates the depressant effect of 5-methoxy-N,N-dimethyltryptamine on a reflex response to radiant heat in mice.

  1988cites this paper
• Is substance P a primary afferent neurotransmitter for nociceptive input? I. Analysis of pain-related behaviors resulting from intrathecal administration of substance P and 6 excitatory compounds.

  1988cites this paper
• Increased behavioural response to intrathecal serotonin after lesion of serotonergic pathways with 5,7-dihydroxytryptamine seems not to be due to depletion of serotonin.

  1988cites this paper
• Pharmacological Studies of Grooming and Scratching Behavior Elicited by Spinal Substance P and Excitatory Amino Acids a

  1988cites this paper
• Desensitization to intrathecal substance P in mice: possible involvement of opioids

  1988cites this paper
• Serotonergic mediation of spinal analgesia and its interaction with noradrenergic systems.

  1988cites this paper
• Interaction of morphine with intrathecally administered calcium and calcium antagonists: evidence for supraspinal endogenous opioid mediation of intrathecal calcium-induced antinociception in mice.

  1988cites this paper
• Is substance P a primary afferent neurotransmitter for nociceptive input? II. Spinalization does not reduce and intrathecal morphine potentiates behavioral responses to substance P.

  1988cites this paper
• Mechanisms of effects of intrathecal serotonin on nociception and blood pressure in rats.

  1988cites this paper
• Interactions of substance P antagonists with serotonin in the mouse spinal cord.

  1988cites this paper
• 5-Hydroxytryptamine releases adenosine from primary afferent nerve terminals in the spinal cord.

  1988cites this paper
• Changes in nociception after acute and chronic administration of zimelidine: different effects in the formalin test and the substance P behavioural assay.

  1987cites this paper
• Senktide, a selective neurokinin B-like agonist, elicits serotonin-mediated behaviour following intracisternal administration in the mouse.

  1987cites this paper
• Central and systemic morphine-induced antinociception in mice: contribution of descending serotonergic and noradrenergic pathways.

  1987cites this paper
• Analgesic properties of intrathecally administered heterocyclic antidepressants

  1987cites this paper