Rosiglitazone reverses memory decline and hippocampal glucocorticoid receptor down-regulation in an Alzheimer's disease mouse model.

No abstract is available for this paper.

• Publication year

  2009

• Venue

  Biochemical and Biophysical Research Communications - BBRC

• Publication date

  2009-02-06

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.bbrc.2008.12.071PMID 19109927
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The Role of Peroxisome Proliferator-Activated Receptor-γ PPARγ) in Alzheimer’s Disease

  2012cited by this paper
• The Amyloid Hypothesis of Alzheimer ’ s Disease : Progress and Problems on the Road to Therapeutics

  2009cited by this paper
• Thiazolidinediones are partial agonists for the glucocorticoid receptor.

  2009cited by this paper
• Glucocorticoids trigger Alzheimer disease‐like pathobiochemistry in rat neuronal cells expressing human tau

  2008cited by this paper
• The role of peroxisome proliferator-activated receptor-gamma (PPARgamma) in Alzheimer's disease: therapeutic implications.

  2008cited by this paper
• Complete Rescue of Cerebrovascular Function in Aged Alzheimer's Disease Transgenic Mice by Antioxidants and Pioglitazone, a Peroxisome Proliferator-Activated Receptor γ Agonist

  2008cited by this paper
• Rosiglitazone Induces Mitochondrial Biogenesis in Mouse Brain

  2007cited by this paper
• Chronic stress accelerates learning and memory impairments and increases amyloid deposition in APPV717I‐CT100 transgenic mice, an Alzheimer's disease model

  2006cited by this paper
• Efficacy of rosiglitazone in a genetically defined population with mild-to-moderate Alzheimer's disease

  2006cited by this paper
• Rosiglitazone attenuates learning and memory deficits in Tg2576 Alzheimer mice.

  2006cited by this paper
• AbstractPoster presentation: Sunday posterP1-035: Chronic stress accelerates learning and memory impairments and increases amyloid deposition in APPV717I-CT100 transgenic mice, an Alzheimer’s disease model

  2006cited by this paper
• Opposing effects of AMPA and 5-HT1A receptor blockade on passive avoidance and object recognition performance: correlation with AMPA receptor subunit expression in rat hippocampus.

  2006cited by this paper
• Glucocorticoids Increase Amyloid-β and Tau Pathology in a Mouse Model of Alzheimer’s Disease

  2006cited by this paper
• Cognitive dysfunction, hippocampal atrophy and glucocorticoid feedback in Alzheimer's disease.

  2006cited by this paper
• Nonsteroidal anti-inflammatory drugs repress beta-secretase gene promoter activity by the activation of PPARgamma.

  2006cited by this paper
• Nonsteroidal anti-inflammatory drugs repress (cid:1) -secretase gene promoter activity by the activation of PPAR (cid:2)

  2005cited by this paper
• Mechanism of the Anti-Inflammatory Effect of Thiazolidinediones: Relationship with the Glucocorticoid Pathway

  2005cited by this paper
• Acute treatment with the PPARgamma agonist pioglitazone and ibuprofen reduces glial inflammation and Abeta1-42 levels in APPV717I transgenic mice.

  2005cited by this paper
• Preserved Cognition in Patients With Early Alzheimer Disease and Amnestic Mild Cognitive Impairment During Treatment With Rosiglitazone: A Preliminary Study

  2005cited by this paper
• Increased risk of Alzheimer's disease in Type II diabetes: insulin resistance of the brain or insulin-induced amyloid pathology?

  2005cited by this paper
• Acute treatment with the PPARγ agonist pioglitazone and ibuprofen reduces glial inflammation and Aβ1–42 levels in APPV717I transgenic mice

  2005cited by this paper
• Preserved cognition in patients with early Alzheimer disease and amnestic mild cognitive impairment during treatment with rosiglitazone: a preliminary study.

  2005cited by this paper
• Role of peroxisome proliferator-activated receptor gamma in amyloid precursor protein processing and amyloid beta-mediated cell death.

  2005cited by this paper
• Deciphering the molecular basis of memory failure in Alzheimer's disease.

  2004cited by this paper
• Peroxisome Proliferator-Activated Receptor γ Induces a Clearance Mechanism for the Amyloid-β Peptide

  2004cited by this paper
• Nonsteroidal anti-inflammatory drugs and peroxisome proliferator-activated receptor-gamma agonists modulate immunostimulated processing of amyloid precursor protein through regulation of beta-secretase.

  2003cited by this paper
• Nonsteroidal Anti-Inflammatory Drugs and Peroxisome Proliferator-Activated Receptor-γ Agonists Modulate Immunostimulated Processing of Amyloid Precursor Protein through Regulation of β-Secretase

  2003cited by this paper
• Decrements in nuclear glucocorticoid receptor (GR) protein levels and DNA binding in aged rat hippocampus.

  2002cited by this paper
• Reduction of Neuronal Intranuclear Rodlets Immunoreactive for Tubulin and Glucocorticoid Receptor in Alzheimer's Disease

  2002cited by this paper
• The Amyloid Hypothesis of Alzheimer's Disease: Progress and Problems on the Road to Therapeutics

  2002cited by this paper
• Do glucocorticoids contribute to brain aging?

  2001cited by this paper
• High-Level Neuronal Expression of Aβ1–42 in Wild-Type Human Amyloid Protein Precursor Transgenic Mice: Synaptotoxicity without Plaque Formation

  2000cited by this paper
• Cortisol secretion and Alzheimer's disease progression.

  1997cited by this paper
• Spatial Learning Deficits in Mice with a Targeted Glucocorticoid Receptor Gene Disruption

  1997cited by this paper
• An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor gamma (PPAR gamma).

  1995cited by this paper
• An Antidiabetic Thiazolidinedione Is a High Affinity Ligand for Peroxisome Proliferator-activated Receptor γ (PPARγ) (*)

  1995cited by this paper
• Inhibition of glucocorticoid secretion by the hippocampal formation in the primate

  1991cited by this paper
• Antiglucocorticoid RU 38486 attenuates retention of a behaviour and disinhibits the hypothalamic-pituitary adrenal axis at different brain sites.

  1988cited by this paper

• Postbiotics as natural antimicrobials: a novel biocontrol strategy for food safety

  2026cites this paper
• Role of FK506 binding protein 51 in central nervous system diseases

  2026cites this paper
• Effect of antidiabetic drugs in Alzheimer´s disease: a systematic review of preclinical and clinical studies

  2025cites this paper
• Pioglitazone attenuates complement-mediated microglial synaptic engulfment in an Alzheimer's disease model.

  2025cites this paper
• The Lemon Flavonoid Eriomin® Suppresses Pituitary–Adrenal Axis Activity in Aged Rats

  2025cites this paper
• Glucocorticoid receptor signaling in the brain and its involvement in cognitive function

  2024cites this paper
• Conquering Insulin Network Dysfunctions in Alzheimer’s Disease: Where Are We Today?

  2024cites this paper
• Pharmacological Approaches Using Diabetic Drugs Repurposed for Alzheimer’s Disease

  2024cites this paper
• Exploring the molecular mechanisms of PPARγ agonists in modulating memory impairment in neurodegenerative disorders

  2024cites this paper
• Alzheimer’s Disease: a Search for the Best Experimental Models to Decode Cellular and Molecular Mechanisms of Its Development

  2023cites this paper
• Selective neurodegeneration of the hippocampus caused by chronic cerebral hypoperfusion: F-18 FDG PET study in rats

  2022cites this paper
• Therapeutic Strategies for Tauopathies and Drug Repurposing as a Potential Approach.

  2022cites this paper
• Synthesize heterogeneous biological knowledge via representation learning for Alzheimer’s disease drug repurposing

  2022cites this paper
• Behavioral and Proteomic Studies Reveal Methylglyoxal Activate Pathways Associated with Alzheimer's Disease.

  2022cites this paper
• A Mechanistic approach of Peroxisome Proliferator-Activated Receptors and its subtypes on Clinical and preclinical model of Neurodegenerative disorders

  2021cites this paper
• Advances in PPARs Molecular Dynamics and Glitazones as a Repurposing Therapeutic Strategy through Mitochondrial Redox Dynamics against Neurodegeneration

  2021cites this paper
• Deep Learning for Alzheimer's Disease Drug Repurposing using Knowledge Graph and Multi-level Evidence

  2021cites this paper
• Hypoglycemia, Vascular Disease and Cognitive Dysfunction in Diabetes: Insights from Text Mining-Based Reconstruction and Bioinformatics Analysis of the Gene Networks

  2021cites this paper
• Analysis of Shared Genetic Regulatory Networks for Alzheimer's Disease and Epilepsy

  2021cites this paper
• RGS14414-Mediated Activation of the 14-3-3ζ in Rodent Perirhinal Cortex Induces Dendritic Arborization, an Increase in Spine Number, Long-Lasting Memory Enhancement, and the Prevention of Memory Deficits.

  2021cites this paper
• Reassessment of Pioglitazone for Alzheimer’s Disease

  2021cites this paper
• The role of peroxisome proliferator-activated receptors in healthy and diseased eyes.

  2021cites this paper
• Rodent Models of Amyloid-Beta Feature of Alzheimer’s Disease: Development and Potential Treatment Implications

  2020cites this paper
• Type 2 Diabetes Mellitus Drugs for Alzheimer's Disease: Current Evidence and Therapeutic Opportunities.

  2020cites this paper
• Reversal of object recognition memory deficit in perirhinal cortex-lesioned rats and primates and in rodent models of aging and alzheimeŕs diseases.

  2020cites this paper
• The impact of acute rosiglitazone on insulin pharmacokinetics at the blood‐brain barrier

  2020cites this paper
• Coexistence of amyloid-β and Tau hyperphosphorylation rescues cognitive and electrophysiological deficiencies in a mouse model of Alzheimer's disease

  2020cites this paper
• Drug repurposing for Alzheimer’s disease: in silico and in vitro investigation of FDA-approved drugs as acetylcholinesterase inhibitors

  2020cites this paper
• Mitochondria as a promising target for developing novel agents for treating Alzheimer's disease

  2020cites this paper
• The impact of single and combined PPAR-α and PPAR-γ activation on the neurological outcomes following cerebral ischemia reperfusion.

  2020cites this paper
• RGS14414 treatment induces memory enhancement and rescues episodic memory deficits

  2019cites this paper
• Pioglitazone Improves Mitochondrial Organization and Bioenergetics in Down Syndrome Cells

  2019cites this paper
• Iso-α-Acids, Bitter Components in Beer, Suppress Inflammatory Responses and Attenuate Neural Hyperactivation in the Hippocampus

  2019cites this paper
• Tau, Diabetes and Insulin.

  2019cites this paper
• Tissue engineering scaffolds in the treatment of brain disorders in geriatric patients.

  2019cites this paper
• Anxiolytic impact of Apelin-13 in a rat model of Alzheimer's disease: Involvement of glucocorticoid receptor and FKBP5.

  2019cites this paper
• PU-91 drug rescues human age-related macular degeneration RPE cells; implications for AMD therapeutics

  2019cites this paper
• Divergent Mechanisms for PPARγ Agonism in Ameliorating Aging-Related Versus Cranial Irradiation-Induced Context Discrimination Deficits

  2019cites this paper
• Mitochondrial Dysfunction in Alzheimer’s Disease and Progress in Mitochondria-Targeted Therapeutics

  2019cites this paper
• The Time Course of Recognition Memory Impairment and Glial Pathology in the hAPP-J20 Mouse Model of Alzheimer’s Disease

  2018cites this paper
• Mitochondrial Abnormalities in Down Syndrome: Pathogenesis, Effects and Therapeutic Approaches

  2018cites this paper
• Targeting Insulin for Alzheimer’s Disease: Mechanisms, Status and Potential Directions

  2018cites this paper
• Chapter 7 Mitochondrial Abnormalities in Down Syndrome : Pathogenesis , Effects and Therapeutic Approaches

  2018cites this paper
• Insulin Resistance in Alzheimer ’ s Disease 1 MedDocs eBooks

  2018cites this paper
• Membrane-Associated Effects of Glucocorticoid on BACE1 Upregulation and Aβ Generation: Involvement of Lipid Raft-Mediated CREB Activation

  2017cites this paper
• NUCLEAR RECEPTORS AS THERAPEUTIC TARGETS FOR ALZHEIMER’S DISEASE

  2017cites this paper
• PPARgamma agonists rescue increased phosphorylation of FGF14 at S226 in the Tg2576 mouse model of Alzheimer's disease

  2017cites this paper
• Preclinical to phase II amyloid beta (Aβ) peptide modulators under investigation for Alzheimer’s disease

  2017cites this paper
• Peroxisome proliferator-activated receptors (PPARs) as therapeutic target in neurodegenerative disorders.

  2017cites this paper
• Review: Neuropathology and behavioural features of transgenic murine models of Alzheimer's disease

  2017cites this paper
• Combination treatment with leptin and pioglitazone in a mouse model of Alzheimer's disease

  2016cites this paper
• Alterations in Glucose Metabolism on Cognition: A Possible Link Between Diabetes and Dementia.

  2016cites this paper
• Insulin resistance and Parkinson's disease: A new target for disease modification?

  2016cites this paper
• Effects of curcumin on synapses in APPswe/PS1dE9 mice

  2016cites this paper
• The glucocorticoid receptor in the limbic system of the human brain

  2016cites this paper
• Effects of Curcumin on Oxidative Stress in Animal Models and Patients with Alzheimer Disease

  2016cites this paper
• Evaluating 2B3, a novel immunotherapy in PDAPP model of amyloid pathology

  2016cites this paper
• Therapeutic Potentials of Curcumin for Alzheimer Disease

  2016cites this paper
• Tackling Alzheimer’s Disease by Targeting Oxidative Stress and Mitochondria

  2016cites this paper
• Rosiglitazone ameliorates astrocyte over-activation and inflammatory cytokine release induced by global cerebral ischemia/reperfusion.

  2016cites this paper
• Transcription Modulation of Mitochondrial Function and Related Pathways as a Therapeutic Opportunity in Parkinson’s Disease

  2016cites this paper
• Early life inflammatory pain induces long-lasting deficits in hippocampal-dependent spatial memory in male and female rats.

  2015cites this paper
• Role of anti-diabetic drugs as therapeutic agents in Alzheimer's disease

  2015cites this paper
• Rosiglitazone Attenuates Memory Impairment in Aged Rat with Diabetes by Inhibiting NF-kappa B Signal Pathway Activation

  2015cites this paper
• Role of extracellular matrix and mitochondria related genes in determining cardiac defects in Down syndrome

  2015cites this paper
• Influence of drug transporters and stereoselectivity on the brain penetration of pioglitazone as a potential medicine against Alzheimer's disease

  2015cites this paper
• Role of Peroxisome Proliferator-Activated Receptor γ in Ocular Diseases

  2015cites this paper
• Pioglitazone in adult rats reverses immediate postnatal overfeeding-induced metabolic, hormonal, and inflammatory alterations

  2015cites this paper
• Object recognition test for studying cognitive impairments in animal models of Alzheimer's disease.

  2015cites this paper
• Insulin sensitizers improve learning and attenuate tau hyperphosphorylation and neuroinflammation in 3xTg-AD mice

  2015cites this paper
• To Eat or Not To Eat: Contributions of Dorsal Hippocampal Neurons and Memory to Meal Onset

  2015cites this paper
• The emerging role of peptidyl‐prolyl isomerase chaperones in tau oligomerization, amyloid processing, and Alzheimer's disease

  2015cites this paper
• Sitagliptin, a dipeptidyl peptidase‐4 inhibitor, improves recognition memory, oxidative stress and hippocampal neurogenesis and upregulates key genes involved in cognitive decline

  2015cites this paper
• Metabolic roles of PGC-1α and its implications for type 2 diabetes.

  2015cites this paper
• PPARγ Agonists Improve Survival and Neurocognitive Outcomes in Experimental Cerebral Malaria and Induce Neuroprotective Pathways in Human Malaria

  2014cites this paper
• MicroRNA-137 regulates a glucocorticoid receptor-dependent signalling network: implications for the etiology of schizophrenia.

  2014cites this paper
• Replicative association analysis of genetic markers of cognitive traits with Alzheimer’s disease in the Russian population

  2014cites this paper
• Reduced phosphorylation of brain insulin receptor substrate and Akt proteins in apolipoprotein-E4 targeted replacement mice

  2014cites this paper
• Elevated risk of type 2 diabetes for development of Alzheimer disease: a key role for oxidative stress in brain.

  2014cites this paper
• NRIP1/RIP140 siRNA-mediated attenuation counteracts mitochondrial dysfunction in Down syndrome.

  2014cites this paper
• Impaired insulin signaling and mechanisms of memory loss.

  2014cites this paper
• Cognitive Enhancing Treatment with a PPARγ Agonist Normalizes Dentate Granule Cell Presynaptic Function in Tg2576 APP Mice

  2014cites this paper
• Using mice to model Alzheimer's dementia: an overview of the clinical disease and the preclinical behavioral changes in 10 mouse models

  2014cites this paper
• Targeting the Prodromal Stage of Alzheimer’s Disease: Bioenergetic and Mitochondrial Opportunities

  2014influential citation
• Rosiglitazone Synergizes the Neuroprotective Effects of Valproic Acid Against Quinolinic Acid-Induced Neurotoxicity in Rats: Targeting PPARγ and HDAC Pathways

  2014cites this paper
• The role of neuronal insulin/insulin-like growth factor-1 signaling for the pathogenesis of Alzheimer's disease: possible therapeutic implications.

  2014cites this paper
• Current challenges to overcome in the management of type 2 diabetes mellitus and associated neurological disorders.

  2014cites this paper
• Retracted: Mechanisms and effects of curcumin on spatial learning and memory improvement in APPswe/PS1dE9 mice

  2014cites this paper
• Lycopene attenuates insulin signaling deficits, oxidative stress, neuroinflammation, and cognitive impairment in fructose-drinking insulin resistant rats.

  2014cites this paper
• PPARγ Recruitment to Active ERK during Memory Consolidation Is Required for Alzheimer's Disease-Related Cognitive Enhancement

  2014cites this paper
• Nuclear receptors in neurodegenerative diseases.

  2014cites this paper
• IUGR disrupts the PPARγ‐Setd8‐H4K20me1 and Wnt signaling pathways in the juvenile rat hippocampus

  2014cites this paper
• METAPLASTICITY IN A MOUSE MODEL OF ALZHEIMER’S DISEASE AND POSSIBLE THERAPEUTIC INTERVENTIONS

  2014cites this paper
• Insulin resistance in Alzheimer's disease.

  2014cites this paper
• Spatial memory impairments in a prediabetic rat model.

  2013cites this paper
• Association between reduced expression of hippocampal glucocorticoid receptors and cognitive dysfunction in a rat model of traumatic brain injury due to lateral head acceleration.

  2013cites this paper
• Comprehensive behavioral characterization of an APP/PS-1 double knock-in mouse model of Alzheimer's disease

  2013cites this paper
• Vascular oxidative stress and mitochondrial failure in the pathobiology of Alzheimer's disease: a new approach to therapy.

  2013cites this paper
• The Role of Peroxisome Proliferator-Activated Receptor and Effects of Its Agonist, Pioglitazone, on a Rat Model of Optic Nerve Crush: PPARγ in Retinal Neuroprotection

  2013cites this paper
• Stress oxydant et maladie d’Alzheimer

  2013cites this paper