Cooperative interaction between c-myc and bcl-2 proto-oncogenes

No abstract is available for this paper.

• Publication year

  1992

• Venue

  Nature

• Publication date

  1992-10-08

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/359554A0PMID 1406976
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Induction of apoptosis in fibroblasts by c-myc protein.

  1992cited by this paper
• Control of c-myc regulation in normal and neoplastic cells.

  1991cited by this paper
• Progression from lymphoid hyperplasia to high-grade malignant lymphoma in mice transgenic for the t(14;18)

  1991cited by this paper
• The MYC protein activates transcription of the alpha‐prothymosin gene.

  1991cited by this paper
• bcl-2 transgene inhibits T cell death and perturbs thymic self-censorship.

  1991cited by this paper
• bcl-2 inhibits multiple forms of apoptosis but not negative selection in thymocytes.

  1991cited by this paper
• Genetic mechanisms of drug resistance. A review.

  1991cited by this paper
• Constitutive c-myc expression in an IL-3-dependent myeloid cell line suppresses cell cycle arrest and accelerates apoptosis.

  1991cited by this paper
• Structure and polymorphism of human telomere-associated DNA.

  1990cited by this paper
• Induction of apoptosis (programmed cell death) in tumour cell lines by widely diverging stimuli.

  1990cited by this paper
• Novel primitive lymphoid tumours induced in transgenic mice by cooperation between myc and bcl-2

  1990cited by this paper
• Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death

  1990cited by this paper
• Complementation by BCL2 and C-HA-RAS oncogenes in malignant transformation of rat embryo fibroblasts

  1990cited by this paper
• Expression of the bcl-2 oncogene protein is not specific for the 14;18 chromosomal translocation.

  1990cited by this paper
• Advanced mammalian gene transfer: high titre retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line.

  1990cited by this paper
• The biochemistry of cell death by apoptosis.

  1990cited by this paper
• DNA topoisomerase poisons as antitumor drugs.

  1989cited by this paper
• Chimaeras of Myc oncoprotein and steroid receptors cause hormone-dependent transformation of cells

  1989cited by this paper
• Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells

  1988cited by this paper
• Apoptosis: Cell death in tissue regulation

  1987cited by this paper
• Studies on the interaction of the human c-myc protein with cell nuclei: p62c-myc as a member of a discrete subset of nuclear proteins.

  1985cited by this paper
• Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes

  1983cited by this paper

• What does BCL-2 do? From new molecular insights to the clinical implications.

  2026cites this paper
• A novel 5’tRNA-derived fragment tRF-Tyr inhibits tumor progression by targeting hnRNPD in gastric cancer

  2025cites this paper
• The BCL-2 protein family: from discovery to drug development

  2025cites this paper
• Acute Myeloid Leukemia with MYC Amplification on a Ring Chromosome 8

  2025cites this paper
• Design, synthesis and evaluation of styrylquinolinium derivatives targeting c-MYC /BCL2 G-quadruplexes against breast cancer.

  2025cites this paper
• MYC Induces Oncogenic Stress through RNA Decay and Ribonucleotide Catabolism in Breast Cancer

  2024cites this paper
• Combination Targeted Therapy in Relapsed Diffuse Large B-Cell Lymphoma

  2024cites this paper
• Increased c-MYC Expression Associated with Active IGH Locus Rearrangement: An Emerging Role for c-MYC in Chronic Lymphocytic Leukemia

  2024cites this paper
• Ubiquitin-proteasome system-mediated ubiquitination modification patterns and characterization of tumor microenvironment infiltration, stemness and cellular senescence in low-grade glioma

  2023cites this paper
• Targeting BCL2 overcomes resistance and augments response to aurora kinase B inhibition by AZD2811 in small cell lung cancer.

  2023cites this paper
• Mechanism of co-operation of mutant IL-7Rα and mutant NRAS in acute lymphoblastic leukemia: role of MYC

  2023cites this paper
• MYC sensitises cells to apoptosis by driving energetic demand

  2022cites this paper
• Human herpesvirus 8-negative effusion-based large B-cell lymphoma: a distinct entity with unique clinicopathologic characteristics

  2022cites this paper
• O envolvimento de genes e proteínas na regulação da apoptose – Carcinogênese

  2022cites this paper
• Targeting Bcl-2 for cancer therapy.

  2021cites this paper
• Co-Operativity between MYC and BCL-2 Pro-Survival Proteins in Cancer

  2021cites this paper
• Dual targeting of the DNA damage response pathway and BCL-2 in diffuse large B-cell lymphoma

  2021cites this paper
• Targeting mitochondrial respiration and the BCL2 family in high‐grade MYC‐associated B‐cell lymphoma

  2021cites this paper
• Emerging connectivity of programmed cell death pathways and its physiological implications

  2020cites this paper
• SUN-308 The Combinatory Effects of Estradiol and Tumor Derived Factors on Myeloid Cell Differentiation in Lymphangioleiomyomatosis (LAM)

  2020cites this paper
• Targeting mitochondrial respiration and the BCL2 family in MYC-associated B-cell lymphoma

  2020cites this paper
• Single and dual target inhibitors based on Bcl-2: Promising anti-tumor agents for cancer therapy.

  2020cites this paper
• Antiproliferative and proapoptotic effects of Inula viscosa extract on Burkitt lymphoma cell line

  2020cites this paper
• Inhibiting the inhibitors: Targeting anti-apoptotic proteins in cancer and therapy resistance.

  2020cites this paper
• Pro-survival Bcl-2 Proteins are Modifiers of MYC-VX-680 Synthetic Lethality

  2020cites this paper
• Cell Death in the Origin and Treatment of Cancer.

  2020cites this paper
• Emerging approaches to target mitochondrial apoptosis in cancer cells

  2019cites this paper
• Recent advances in apoptosis: The role of hydrazones.

  2019cites this paper
• Regulation and Function of theMYCOncogene

  2019cites this paper
• Regulation and Function of the MYC Oncogene

  2019cites this paper
• Current perspectives on the treatment of double hit lymphoma

  2019cites this paper
• Targeting the Oncogenic MYC Pathway by Miniproteins: Understanding Mechanism of Action

  2019influential citation
• Therapeutic synergy between tigecycline and venetoclax in a preclinical model of MYC/BCL2 double-hit B cell lymphoma

  2018cites this paper
• The Intrinsic Pathway of Apoptosis and Carcinogenesis : An Update

  2018cites this paper
• Molecular therapy using siRNA: Recent trends and advances of multi target inhibition of cancer growth.

  2018cites this paper
• Elucidating the Mechanism by which KRI-1/CCM1 Regulates Apoptosis Cell Non-Autonomously in Caenorhabditis elegans

  2018cites this paper
• Targeting BCL-2 regulated apoptosis in cancer

  2018cites this paper
• Bcl-2 Overexpression Improves Survival and Efficacy of Neural Stem Cell-Mediated Enzyme Prodrug Therapy

  2018cites this paper
• BCL-2 as therapeutic target for hematological malignancies

  2018influential citation
• Therapeutic nanosystems co-deliver anticancer drugs and oncogene SiRNA to achieve synergetic precise cancer chemo-gene therapy.

  2018cites this paper
• Dihydroartemisinin triggers c-Myc proteolysis and inhibits protein kinase B/glycogen synthase kinase 3β pathway in T-cell lymphoma cells.

  2018cites this paper
• Regulation and Function of the MYC Oncogene

  2018cites this paper
• Overall Downregulation of mRNAs and Enrichment of H3K4me3 Change Near Genome-Wide Association Study Signals in Systemic Lupus Erythematosus: Cell-Specific Effects

  2018cites this paper
• Reactive Oxygen Species and Oncoprotein Signaling-A Dangerous Liaison

  2018cites this paper
• Modulation of let-7 miRNAs controls the differentiation of effector CD8 T cells

  2017influential citation
• Dysregulation of BCL-2 family proteins by leukemia fusion genes

  2017cites this paper
• Tissue-specific tumorigenesis: context matters

  2017cites this paper
• Effects of Overexpression of C-Myc and Bcl-2 on Viability, Apoptosis and Differentiation of Dental Pulp Stem Cells

  2017cites this paper
• Found in Translation: How Preclinical Research Is Guiding the Clinical Development of the BCL2-Selective Inhibitor Venetoclax.

  2017influential citation
• The Role of c-MYC in B-Cell Lymphomas: Diagnostic and Molecular Aspects

  2017cites this paper
• Apoptosis and Cancer

  2017cites this paper
• BCL2 expression in DLBCL: reappraisal of immunohistochemistry with new criteria for therapeutic biomarker evaluation.

  2017cites this paper
• of immunohistochemistry with new criteria for therapeutic biomarker evaluation Short title : Prognostic impact of BCL 2 IHC scoring in

  2017cites this paper
• Leukaemia fusions and apoptosis 1 Dysregulation of BCL-2 family proteins by leukaemia fusion genes

  2017cites this paper
• High Energy Particle Radiation-associated Oncogenic Transformation in Normal Mice: Insight into the Connection between Activation of Oncotargets and Oncogene Addiction

  2016cites this paper
• Thirty years of BCL-2: translating cell death discoveries into novel cancer therapies

  2016cites this paper
• Current challenges and novel treatment strategies in double hit lymphomas

  2016cites this paper
• Опыт цитогенетических исследований при неходжкинских лимфомах у детей

  2016cites this paper
• The cell's dilemma, or the story of cell death: an entertainment in three acts

  2016cites this paper
• A fate worse than death: apoptosis as an oncogenic process

  2016cites this paper
• A Comparative Docking Strategy to Identify Polyphenolic Derivatives as Promising Antineoplastic Binders of G‐quadruplex DNA c‐myc and bcl‐2 Sequences

  2016cites this paper
• c-Myc Signalling in the Genetic Mechanism of Polycystic Kidney Disease

  2015cites this paper
• Marine Drugs Regulating Apoptosis Induced by Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL)

  2015cites this paper
• Origins, genetic landscape, and emerging therapies of small cell lung cancer

  2015cites this paper
• Emerging understanding of Bcl-2 biology: Implications for neoplastic progression and treatment.

  2015cites this paper
• Role of c-MYC, BCL2, and BCL6 Expression in Pathogenesis of Diffuse Large B-Cell Lymphoma

  2015cites this paper
• Understanding the mechanism of MYC induced vulnerabilities

  2015cites this paper
• Caspase-3 promotes genetic instability and carcinogenesis.

  2015cites this paper
• BCL2 inhibition in double hit lymphoma

  2015cites this paper
• Novel targeted therapies in diffuse large B-cell lymphoma.

  2015cites this paper
• How cell death shapes cancer

  2015cites this paper
• Apoptosis in Polycystic Kidney Disease: From Pathogenesis to Treatment

  2015cites this paper
• Bcl 2 Family Functions as Signaling Target in Nicotine-/ NNK-Induced Survival of Human Lung Cancer Cells

  2015cites this paper
• Cancer Bioinformatics

  2014cites this paper
• Multiple Routes for Survival: Understanding How Cancer Evades Apoptosis

  2014cites this paper
• AN INSIGHT TO VIRTUAL LIGAND SCREENING METHODS FOR STRUCTURE-BASED DRUG DESIGN AND METHODS TO PREDICT PROTEIN STRUCTURE AND FUNCTION IN LUNG CANCER: APPROACHES AND PROGRESS

  2014cites this paper
• Significant improvements in CO₂ capture by pyridine-containing anion-functionalized ionic liquids through multiple-site cooperative interactions.

  2014cites this paper
• Pre-Clinical Analysis of Changes in Intra-cellular Biochemistry of Glioblastoma Multiforme (GBM) Cells Due to c-Myc Silencing

  2014cites this paper
• [Successful treatment of a patient with two hematologic tumors: double-hit lymphoma and acute myelomonoblastic leukemia].

  2014cites this paper
• Expresión de oncogenes, receptores hormonales esteroideos y marcadores de proliferación en el carcinoma endometrial

  2014cites this paper
• Precision therapy for lymphoma—current state and future directions

  2014cites this paper
• ALA-Dependent Cancericides

  2014cites this paper
• BIM is the primary mediator of MYC-induced apoptosis in multiple solid tissues.

  2014cites this paper
• Bcl2 Family Functions as Signaling Target in Nicotine-/NNK-Induced Survival of Human Lung Cancer Cells

  2014cites this paper
• MYC and MNT in transcriptional regulation and chromatin dynamics

  2014cites this paper
• Роль экспрессии c-MYC, BCL2 и BCL6 в патогенезе диффузной В-крупноклеточной лимфомы

  2014cites this paper
• Ketamine used as an acesodyne in human breast cancer therapy causes an undesirable side effect, upregulating anti-apoptosis protein Bcl-2 expression.

  2013cites this paper
• The mutant p53 mouse as a pre-clinical model

  2013cites this paper
• Identifying and modeling perturbed networks in cancer through statistical and constraint-based analysis

  2013cites this paper
• The toxicogenomic study on Persistent Organic Pollutants (POPs) in human hepatoma cell line

  2013cites this paper
• Chlorophyll Biosynthesis and Technological Applications

  2013cites this paper
• Disruption of the CREBBP gene and decreased expression of CREB, NFκB p65, c-JUN, c-FOS, BCL2 and c-MYC suggest immune dysregulation.

  2013cites this paper
• Radioprotective effect of adenine on irradiation-induced apoptosis.

  2013cites this paper
• Therapy of Smac mimetic SM-164 in combination with gemcitabine for pancreatic cancer.

  2013cites this paper
• Activated ALK collaborates with MYCN in neuroblastoma pathogenesis.

  2012cites this paper
• Neither loss of Bik alone, nor combined loss of Bik and Noxa, accelerate murine lymphoma development or render lymphoma cells resistant to DNA damaging drugs

  2012cites this paper
• The interplay between MYCN and the DNA damage response : modulation of MYCN expression, its interactions with components of the DNA damage response and cellular responses to N-myc following genotoxic stress

  2012cites this paper
• A role for Epstein-Barr viral BALF1 in facilitating tumor formation and metastasis potential.

  2012cites this paper
• Characterization of N-terminal Myc Ubiquitylation and the Novel Oncogene CUL7

  2012influential citation
• Taspase1 is a Non-oncogene Mediator of Tumorigenesis and Maintenance

  2012cites this paper