The inositol tris/tetrakisphosphate pathway—demonstration of Ins(l,4,5)P3 3-kinase activity in animal tissues

No abstract is available for this paper.

• Publication year

  1986

• Venue

  Nature

• Publication date

  1986-04-17

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/320631A0PMID 3010126
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Isolation and characterization of the inositol cyclic phosphate products of phosphoinositide cleavage by phospholipase C. Metabolism in cell-free extracts.

  1986cited by this paper
• Molecular mechanisms of transmembrane signalling

  1985cited by this paper
• Metabolism of inositol 1,4,5-trisphosphate and inositol 1,3,4-trisphosphate in rat parotid glands.

  1985cited by this paper
• Rapid formation of inositol 1,3,4,5-tetrakisphosphate following muscarinic receptor stimulation of rat cerebral cortical slices.

  1985cited by this paper
• Inositol tetrakis- and pentakisphosphates in GH4 cells.

  1985cited by this paper
• Interleukin 2 induces a rapid increase in intracellular pH through activation of a Na+/H+ antiport. Cytoplasmic alkalinization is not required for lymphocyte proliferation.

  1985cited by this paper
• Mass changes in myoinositol trisphosphate in human platelets stimulated by thrombin. Inhibitory effects of phorbol ester.

  1985cited by this paper
• Isolation and characterization of the inositol cyclic phosphate products of polyphosphoinositide cleavage by phospholipase C. Physiological effects in permeabilized platelets and Limulus photoreceptor cells.

  1985cited by this paper
• Inositol cyclic phosphates are produced by cleavage of phosphatidylphosphoinositols (polyphosphoinositides) with purified sheep seminal vesicle phospholipase C enzymes.

  1985cited by this paper
• Inositol 1,4,5-trisphosphate and inositol 1,3,4-trisphosphate formation in Ca2+-mobilizing-hormone-activated cells.

  1985cited by this paper
• Isolation of a phosphomonoesterase from human platelets that specifically hydrolyzes the 5-phosphate of inositol 1,4,5-trisphosphate.

  1985cited by this paper
• Phosphatidylinositol-4,5-bisphosphate phosphodiesterase and phosphomonoesterase activities of rat brain. Some properties and possible control mechanisms.

  1984cited by this paper
• Inositol trisphosphates in carbachol-stimulated rat parotid glands.

  1984cited by this paper
• Stepwise enzymatic dephosphorylation of inositol 1,4,5-trisphosphate to inositol in liver

  1984cited by this paper
• The role of protein kinase C in cell surface signal transduction and tumour promotion

  1984cited by this paper
• Inositol trisphosphate, a novel second messenger in cellular signal transduction

  1984cited by this paper
• Inositol trisphosphate and diacylglycerol as second messengers.

  1984cited by this paper
• The inositol trisphosphate phosphomonoesterase of the human erythrocyte membrane.

  1982cited by this paper
• The control by Ca2+ of the polyphosphoinositide phosphodiesterase and the Ca2+-pump ATPase in human erythrocytes.

  1982cited by this paper
• THE DISTRIBUTION OF CALCIUM‐DEPENDENT PHOSPHATIDYLINOSITOL‐SPECIFIC PHOSPHODIESTERASE IN RAT BRAIN

  1978cited by this paper
• Phosphatidylinositol-degrading enzymes in liver lysosomes.

  1977cited by this paper
• The enzymic formation of myoinositol 1:2-cyclic phosphate from phosphatidylinositol.

  1971cited by this paper

• Inositol Phosphate Kinase Architecture: Practical Approaches and Lessons Learned.

  2025cites this paper
• Analytical methods and tools for studying inositol phosphates.

  2025cites this paper
• Phosphatidylinositol 4-phosphate; A minor lipid with multiple personalities.

  2025cites this paper
• Substrate promiscuity of inositol 1,4,5-trisphosphate kinase driven by structurally-modified ligands and active site plasticity

  2024cites this paper
• Evidence that inositol 1,4,5-trisphosphate 3-kinase and inositol 1,3,4,5-tetrakisphosphate are negative regulators of platelet function

  2024cites this paper
• Sir Michael John Berridge. 22 October 1938 — 13 February 2020

  2024cites this paper
• INPP5A phosphatase is a synthetic lethal target in GNAQ and GNA11-mutant melanomas

  2024cites this paper
• Origin, evolution, and diversification of inositol 1,4,5-trisphosphate 3-kinases in plants and animals

  2024cites this paper
• The actin bundling activity of ITPKA mainly accounts for its migration-promoting effect in lung cancer cells

  2023cites this paper
• The Role of Inositols in the Hyperandrogenic Phenotypes of PCOS: A Re-Reading of Larner’s Results

  2023cites this paper
• Myo-Inositol and D-Chiro-Inositol as Modulators of Ovary Steroidogenesis: A Narrative Review

  2023cites this paper
• New Advances in SHR Research –

  2020cites this paper
• A Short Historical Perspective of Methods in Inositol Phosphate Research.

  2020cites this paper
• Inositol Phosphates: Methods and Protocols

  2020cites this paper
• Structural analyses of inositol phosphate second messengers bound to signaling effector proteins.

  2020cites this paper
• G Protein-Coupled Receptor-Mediated Calcium Signaling in Astrocytes

  2018cites this paper
• The crystal structure of mammalian inositol 1,3,4,5,6-pentakisphosphate 2-kinase reveals a new zinc-binding site and key features for protein function

  2017cites this paper
• Inositol‐1,4,5‐trisphosphate 3‐kinase‐A (ITPKA) is frequently over‐expressed and functions as an oncogene in several tumor types

  2017cites this paper
• Inositol(1,4,5)P3 3-kinase isoenzymes: Catalytic properties and importance of targeting to F-actin to understand function.

  2016cites this paper
• Pharmacodynamics and pharmacokinetics of inositol(s) in health and disease

  2016influential citation
• Inositol polyphosphate multikinase (IPMK) in transcriptional regulation and nuclear inositide metabolism.

  2016cites this paper
• A tale of two inositol trisphosphates.

  2016cites this paper
• Synthesis and in vitro anticancer activity evaluation of novel bioreversible phosphate inositol derivatives.

  2015cites this paper
• Signal Transduction, a Step Forward in Medicine Regarding Regulators of Cellular Process

  2015cites this paper
• Principles Driving the Spatial Organization of Rho GTPase Signaling at Synapses

  2014influential citation
• Chemical Approach to Signal Transduction by Inositol Triphosphate

  2014cites this paper
• 2-Aminoethyl diphenylborinate (2-APB) analogues: part 2. regulators of Ca2+ release and consequent cellular processes

  2014cites this paper
• 2-Aminoethyl Diphenylborinate (2-APB) Analogues: Part 3 - Regulators of Huntington Aggregation and Transglutaminase

  2014cites this paper
• Signaling crosstalk between the mTOR complexes

  2014cites this paper
• Structure-function studies of multiple inositol polyphosphate phosphatases from gut commensal bacteria

  2014cites this paper
• 2-Aminoethyl Diphenylborinate (2-APB) Analogues: Part 4 - Poly-Boron Compounds: Regulators of Ca2+ Release and Consequent Cellular Processes

  2014cites this paper
• Papel do IP3 na transdução de sinal e função da heme oxigenase em Plasmodium falciparum.

  2013cites this paper
• The role of intracellular calcium stores in synaptic plasticity and memory consolidation.

  2013cites this paper
• Phosphoinositides: tiny lipids with giant impact on cell regulation.

  2013cites this paper
• P 2-Purinergic Receptor Agonists Inhibit the Growth of Androgen-independent Prostate Carcinoma Cells

  2013cites this paper
• Biochemical Evidence for a Putative Inositol 1,3,4,5-Tetrakisphosphate Receptor in the Olfactory System of Atlantic Salmon (Salmo salar)

  2013cites this paper
• Mechanisms of Egg Activation

  2013cites this paper
• An Investigation on the Role and Regulation of Signal Transduction Pathways during Embryonic Wound Healing

  2013cites this paper
• 2-Aminoethyl diphenylborinate (2-APB) analogues: regulation of Ca2+ signaling.

  2013cites this paper
• Defining signal transduction by inositol phosphates.

  2012cites this paper
• Inositol 1,4,5-Trisphosphate 3-Kinase A Is a Novel Microtubule-associated Protein

  2012cites this paper
• The Regulation of Mammalian Target of Rapamycin

  2012cites this paper
• Monitoring Gq-coupled receptor response through inositol phosphate quantification with the IP-One assay

  2011cites this paper
• Inositol Pyrophosphates as Mammalian Cell Signals

  2011influential citation
• Intrazelluläre Zielsteuerung der humanen Inositol-1,4,5-trisphosphat 3-Kinase Isoform B

  2011cites this paper
• Inositol phosphate synthesis and the nuclear processes they affect.

  2010cites this paper
• The Genetic Landscape of a Cell

  2010cites this paper
• Calcium Signals Driven by Single Channel Noise

  2010cites this paper
• Nonlinear Gap Junctions Enable Long-Distance Propagation of Pulsating Calcium Waves in Astrocyte Networks

  2010cites this paper
• A screen for phosphatidylinositol 3,4-bisphosphate and other 3-phosphoinositide effector proteins

  2010cites this paper
• Total synthesis of optically active myo-inositol 1,4,5-trisphosphate and myo-inositol 1,3,4,5-tetrakisphosphate

  2010cites this paper
• Molecular manipulation and analysis of inositol phosphate and pyrophosphate levels in Mammalian cells.

  2010cites this paper
• The cellular forms and functions of the inositol phospholipids and their metabolic derivatives.

  2009cites this paper
• Natural products and their derivatives in cancer prevention and therapy: inositol phosphates and Illudin.

  2009cites this paper
• Glutamate regulation of calcium and IP3 oscillating and pulsating dynamics in astrocytes

  2009influential citation
• Inositol 1,4,5-Trisphosphate 3-Kinase A Functions As a Scaffold for Synaptic Rac Signaling

  2009influential citation
• Phosphoinositide and Inositol Phosphate Analysis in Lymphocyte Activation

  2009influential citation
• Inositol polyphosphate multikinase: metabolic architect of nuclear inositides.

  2008cites this paper
• Mechanistic Role of Calpains in Postischemic Neurodegeneration

  2008cites this paper
• Deoxygenated phosphorothioate inositol phosphate analogs: synthesis, phosphatase stability, and binding affinity.

  2008cites this paper
• Regulation of Inositol 1,4,5-Trisphosphate 3-Kinases by Calcium and Localization in Cells*

  2007cites this paper
• PLC‐β3 signals upstream of PKC&egr; in acute and chronic inflammatory hyperalgesia

  2007cites this paper
• Alterations in an inositol phosphate code through synergistic activation of a G protein and inositol phosphate kinases

  2007cites this paper
• PLC-beta 3 signals upstream of PKC epsilon in acute and chronic inflammatory hyperalgesia.

  2007cites this paper
• D-myo-inositol 1-phosphate as a surrogate of D-myo-inositol 1,4,5-tris phosphate to monitor G protein-coupled receptor activation.

  2006cites this paper
• The regulation and function of inositol 1,4,5-trisphosphate 3-kinases

  2006cites this paper
• Alzheimer's disease: mRNA expression profiles of multiple patients show alterations of genes involved with calcium signaling

  2006cites this paper
• CHAPTER 53 – Stimulus-Secretion Coupling in Pancreatic Acinar Cells

  2006cites this paper
• Interaction of the Catalytic Domain of Inositol 1,4,5‐Trisphosphate 3‐Kinase A with Inositol Phosphate Analogues

  2005cites this paper
• To my daughter Wilma Original publications

  2005influential citation
• Antiproliferative Plant and Synthetic Polyphenolics Are Specific Inhibitors of Vertebrate Inositol-1,4,5-trisphosphate 3-Kinases and Inositol Polyphosphate Multikinase*

  2005cites this paper
• Regulation of the localization and activity of inositol 1,4,5-trisphosphate 3-kinase B in intact cells by proteolysis.

  2005cites this paper
• Hypertrophic Rat Heart

  2005cites this paper
• Crystal structure of the catalytic core of inositol 1,4,5-trisphosphate 3-kinase.

  2004cites this paper
• Control of aldosterone secretion: a model for convergence in cellular signaling pathways.

  2004cites this paper
• Pharmacological Modulation of Sarcoplasmic Reticulum Function in Smooth Muscle

  2004cites this paper
• How versatile are inositol phosphate kinases?

  2004cites this paper
• Structure of a human inositol 1,4,5-trisphosphate 3-kinase: substrate binding reveals why it is not a phosphoinositide 3-kinase.

  2004cites this paper
• Spatial learning enhances the expression of inositol 1,4,5-trisphosphate 3-kinase A in the hippocampal formation of rat.

  2004cites this paper
• Intrinsic inhibitor of inositol 1,4,5-trisphosphate binding

  2004cites this paper
• Cell signaling by a physiologically reversible inositol phosphate kinase/phosphatase.

  2004cites this paper
• Ins(1,4,5)P3 metabolism and the family of IP3-3Kinases.

  2004cites this paper
• Regulatory pathways in lacrimal gland epithelium.

  2003cites this paper
• The three isoenzymes of human inositol-1,4,5-trisphosphate 3-kinase show specific intracellular localization but comparable Ca2+ responses on transfection in COS-7 cells.

  2003cites this paper
• Calpain cleavage of the B isoform of Ins(1,4,5)P3 3-kinase separates the catalytic domain from the membrane anchoring domain.

  2003cites this paper
• Inositol 1,4,5-trisphosphate 3-kinase and 5-phosphatase

  2003cites this paper
• Divergent syntheses of all possible optically active regioisomers of myo-inositol tris- and tetrakisphosphates.

  2002cites this paper
• Caenorhabditis elegans inositol 5-phosphatase homolog negatively regulates inositol 1,4,5-triphosphate signaling in ovulation.

  2002cites this paper
• elegans Inositol 5-Phosphatase Homologue Negatively Regulates Inositol 1 , 4 , 5-triphosphate Signaling in Ovulation

  2002cites this paper
• Biochemical and Functional Responses Stimulated by Platelet-activating Factor in Murine Peritoneal Macrophages

  2002cites this paper
• A straightforward method for analysis of highly phosphorylated inositols in blood cells by high-performance liquid chromatography.

  2002cites this paper
• InsP, and Ins(I,3,4,5)P, act in synergy to stimulate influx of extracellular Ca2+ in Xenopus oocytes

  2002cites this paper
• Purine‐Based Inhibitors of Inositol‐1,4,5‐trisphosphate‐3‐kinase

  2002cites this paper
• Wirkung von Inositolphosphatkinase-Inhibitoren auf den Inositolphosphatstoffwechsel und das Wachstum von chinese-hamster-ovary-cells (CHO)

  2001cites this paper
• Analysis of inositol phospholipid turnover during lymphocyte activation.

  2001cites this paper
• Inositol 1,4,5 trisphosphate is inactivated by a 5-phosphatase in stamen hair cells of Tradescantia

  2001cites this paper
• Pharmacology of phosphoinositides, regulators of multiple cellular functions.

  2001cites this paper
• Back in the water: the return of the inositol phosphates

  2001cites this paper
• Calcium signalling in endothelial cells.

  2000cites this paper
• The Second Messenger Binding Site of Inositol 1,4,5-Trisphosphate 3-Kinase Is Centered in the Catalytic Domain and Related to the Inositol Trisphosphate Receptor Site*

  2000cites this paper