Expression of human factor IX in rat capillary endothelial cells: toward somatic gene therapy for hemophilia B.

No abstract is available for this paper.

• Publication year

  1991

• Venue

  Proceedings of the National Academy of Sciences of the United States of America

• Publication date

  1991-09-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1073/PNAS.88.18.8101PMID 1896457PMCID PMC52454
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Recombinant antihemophilic factors.

  1991cited by this paper
• Enhancement of the fibrinolytic activity of sheep endothelial cells by retroviral vector-mediated gene transfer.

  1991cited by this paper
• Characterization of a Mouse Factor IX cDNA and Developmental Regulation of the Factor IX Gene Expression in Liver

  1991cited by this paper
• Progress toward human gene therapy.

  1990cited by this paper
• Structural and functional basis of the developmental regulation of human coagulation factor IX gene: factor IX Leyden.

  1990cited by this paper
• Phenotypic correction of factor IX deficiency in skin fibroblasts of hemophilic dogs.

  1990cited by this paper
• Expression of human factor IX in rabbit hepatocytes by retrovirus-mediated gene transfer: potential for gene therapy of hemophilia B.

  1990cited by this paper
• Site-specific gene expression in vivo by direct gene transfer into the arterial wall.

  1990cited by this paper
• Correction of CD18-deficient lymphocytes by retrovirus-mediated gene transfer.

  1990cited by this paper
• The Metabolic basis of inherited disease

  1989cited by this paper
• Production of human factor IX in animals by genetically modified skin fibroblasts: potential therapy for hemophilia B.

  1989cited by this paper
• Progress toward human gene therapy.

  1989cited by this paper
• Human genes for complement components C1r and C1s in a close tail-to-tail arrangement.

  1988cited by this paper
• Safe and efficient generation of recombinant retroviruses with amphotropic and ecotropic host ranges.

  1988cited by this paper
• An alternative approach to somatic cell gene therapy.

  1988cited by this paper
• Correction of the genetic defect in hepatocytes from the Watanabe heritable hyperlipidemic rabbit.

  1988cited by this paper
• Regulation of insulin receptor internalization in vascular endothelial cells by insulin and phorbol ester.

  1987cited by this paper
• Towards gene therapy for hemophilia B.

  1987cited by this paper
• Redesign of retrovirus packaging cell lines to avoid recombination leading to helper virus production

  1986cited by this paper
• Self-inactivating retroviral vectors designed for transfer of whole genes into mammalian cells.

  1986cited by this paper
• Expression of active human factor IX in transfected cells

  1985cited by this paper
• Construction of a retrovirus packaging mutant and its use to produce helper-free defective retrovirus.

  1983cited by this paper

• Enhanced functional recombinant factor IX production by human embryonic kidney cells engineered to overexpress VKORC1

  2020cites this paper
• Improved activity and expression of recombinant human factor IX by propeptide engineering

  2019cites this paper
• Production of recombinant human factor IX by propeptide modification in Drosophila S2 cell line

  2019cites this paper
• Effect of propeptide amino acid substitution in γ‐carboxylation, activity and expression of recombinant human coagulation factor IX

  2018cites this paper
• Functions of the Heterologous Intron-Derived Fragments Intra and Extra Factor IX-cDNA Coding Region on the Human Factor IX Expression in HepG2 and Hek-293T Cells

  2018cites this paper
• Bioengineering of differentiated hepatocytes with human factor IX-expressing plasmids in vitro

  2016cites this paper
• Genetic modification of bone-marrow mesenchymal stem cells and hematopoietic cells with human coagulation factor IX-expressing plasmids.

  2016cites this paper
• Efficient expression of functional human coagulation factor IX in stably-transfected Drosophila melanogaster S2 cells; comparison with the mammalian CHO system

  2016cites this paper
• Megakaryocyte- and megakaryocyte precursor-related gene therapies.

  2016cites this paper
• Functional studies on factor VIII variants containing different lengths of the B-domain AND The construction of a new helper vector for the production of helper-dependent

  2012cites this paper
• Expression of biologically active human clotting factor IX in Drosophila S2 cells: γ‐carboxylation of a human vitamin K‐dependent protein by the insect enzyme

  2012cites this paper
• A Study of the Expression of Functional Human Coagulation Factor IX in Keratinocytes Using a Nonviral Vector Regulated by K14 Promoter

  2010cites this paper
• Heterogeneous Nuclear Ribonucleoprotein A3 Is the Liver Nuclear Protein Binding to Age Related Increase Element RNA of the Factor IX Gene

  2010cites this paper
• Shear-regulated uptake of nanoparticles by endothelial cells and development of endothelial-targeting nanoparticles.

  2009cites this paper
• Biopharmaceuticals: An Industrial Perspective

  2009cites this paper
• Flame synthesis and in vitro biocompatibility assessment of superparamagnetic iron oxide nanoparticles: cellular uptake, toxicity and proliferation studies.

  2009cites this paper
• Drug Delivery Nanoparticles Formulation and Characterization

  2009cites this paper
• AAV-mediated gene transfer for the treatment of hemophilia B: problems and prospects

  2008cites this paper
• Sex hormones affect the production of recombinant Factor IX in CHO and HEK-293 cell lines

  2008cites this paper
• 10 – Artificial cells as a novel approach to gene therapy

  2007cites this paper
• Expression of human coagulation Factor IX in transgenic tomato (Lycopersicon esculentum)

  2007cites this paper
• 10 – Transplants for Hemophilia

  2007cites this paper
• Factor IX variants improve gene therapy efficacy for hemophilia B.

  2005cites this paper
• Adeno‐associated viral vectors for gene therapy

  2005cites this paper
• Gene therapy for cardiovascular applications

  2005cites this paper
• Onco-retroviral and lentiviral vector-based gene therapy for hemophilia: preclinical studies.

  2004cites this paper
• Tumor-selective targeted delivery of genes and antisense oligodeoxyribonucleotides via the folate receptor.

  2004cites this paper
• Onco-Retroviral and Lentiviral Vector-Based Gene Therapy for Hemophilia: Preclinical Studies

  2004cites this paper
• Bone marrow stromal cells as a genetic platformfor systemic delivery of therapeutic proteins in vivo: human factor IX model

  2003cites this paper
• In vitro and in vivo expression of human coagulation factor IX mediated by nonviral transfection of three plasmid vectors coding a factor IX gene

  2003cites this paper
• Adenovirus-mediated regulatable Expression of human Factor IX in vitro and in vivo

  2003cites this paper
• Skeletal muscle as an artificial endocrine tissue.

  2003cites this paper
• Regulation of human factor IX expression using doxycycline-inducible gene expression system

  2003cites this paper
• Theodore E. Woodward Award. AAV-mediated gene transfer for hemophilia.

  2003cites this paper
• Characterization of nanoparticle uptake by endothelial cells.

  2002cites this paper
• RAPID COMMUNICATION kat : A High-Efficiency Retroviral Transduction System for Primary Human T Lymphocytes

  2002cites this paper
• Gene therapy for the hemophilias.

  2002cites this paper
• Hemophilia gene therapy: Update

  2002cites this paper
• Cancer Gene Therapy: Past Achievements and Future Challenges

  2002cites this paper
• Gene therapy for hemophilia

  2002cites this paper
• Effects of a second intron on recombinant MFG retroviral vector

  2001cites this paper
• Gene Therapy for Haemophilia

  2001cites this paper
• Gene transfer into muscle for the treatment of muscular dystrophy and haemophilia Review Article

  2001cites this paper
• Thérapie génique appliquée à l'hémophilie

  2001cites this paper
• Posttranslational modifications of recombinant myotube-synthesized human factor IX.

  2001cites this paper
• Gene Therapy of Hemophilia

  2001cites this paper
• Gene therapy for hemophilia

  2001cites this paper
• Gene therapy for haemophilia

  2001cites this paper
• AAV‐Mediated Gene Transfer for Hemophilia

  2001cites this paper
• Gene therapy: a 2001 perspective

  2001cites this paper
• High-level protein secretion into blood circulation after electric pulse-mediated gene transfer into skeletal muscle.

  2000cites this paper
• The use of skeletal muscle to express genes for the treatment of cancer.

  2000cites this paper
• Gene Therapy for Hemophilia

  2000cites this paper
• Impact of genomics on drug discovery and clinical medicine.

  2000cites this paper
• Therapeutic plasma concentrations of human factor IX in mice after gene delivery into the amniotic cavity: a model for the prenatal treatment of haemophilia B

  1999cites this paper
• Secreted human placental alkaline phosphatase as a reporter gene for in vivo gene transfer.

  1999cites this paper
• Gene therapy for the hemophilias.

  1999cites this paper
• Gene therapy for the hemophilias.

  1999cites this paper
• Using skeletal muscle as an artificial endocrine tissue.

  1999cites this paper
• Production of Recombinant Human Protein C In Vitro and In Vivo by Muscle Cells

  1999cites this paper
• Use of Transgenic Mice in the Study of Thrombosis and Hemostasis

  1999cites this paper
• Recombinant Coagulation Factor IX (BeneFIX

  1999cites this paper
• Endothelial cell transfection with cationic liposomes and herpes simplex-thymidine kinase mediated killing

  1998cites this paper
• Adeno-associated viral vector-mediated gene transfer of human blood coagulation factor IX into mouse liver.

  1998cites this paper
• Construction and expression of inverted configuration of retroviral vector containing intron 1 of hFIX

  1998cites this paper
• Expression of Factor IX cDNA Introduced into Human Marrow Stromal Cells by Electroporation.

  1998cites this paper
• Gene therapy for hemophilia: hopes and hurdles

  1998cites this paper
• Gene therapy for hemophilia: hopes and hurdles.

  1998cites this paper
• Direct intramuscular injection with recombinant AAV vectors results in sustained expression in a dog model of hemophilia

  1998cites this paper
• Sustained Expression of High Levels of Human Factor IX from Human Cells Implanted within an Immunoisolation Device into Athymic Rodents

  1998cites this paper
• Capture and expansion of bone marrow-derived mesenchymal progenitor cells with a transforming growth factor-beta1-von Willebrand's factor fusion protein for retrovirus-mediated delivery of coagulation factor IX.

  1997cites this paper
• An ex vivo keratinocyte model for gene therapy of hemophilia B.

  1997cites this paper
• Gene transfer to cerebral blood vessels after subarachnoid hemorrhage.

  1997cites this paper
• Adenoviral vectors: development and application.

  1997cites this paper
• Characterization of Recombinant Adeno-Associated Virus-2 as a Vehicle for Gene Delivery and Expression into Vascular Cells

  1997cites this paper
• Factors impeding efficient expression of factor VIII complementary DNA minigenes.

  1997cites this paper
• Retroviral mediated gene transduction alters integrin expression on vascular endothelial cells.

  1997cites this paper
• Comparison of Retroviral and Adeno-Associated Viral Vectors Designed to Express Human Clotting Factor IX

  1997cites this paper
• Capture and Expansion of Bone Marrow-Derived Mesenchymal Progenitor Cells with a Transforming Growth Factor-β1–von Willebrand's Factor Fusion Protein for Retrovirus-Mediated Delivery of Coagulation Factor IX

  1997cites this paper
• Endothelial Cell-Specific Expression of Tumor Necrosis Factor-α from the KDR or E-Selectin Promoters Following Retroviral Delivery

  1997cites this paper
• Persistent systemic production of human factor IX in mice by skeletal myoblast-mediated gene transfer: feasibility of repeat application to obtain therapeutic levels.

  1997cites this paper
• Viral Vector-Mediated Gene Therapy for Hemophilia B

  1997cites this paper
• Induction of angiogenesis by lidocaine and basic fibroblast growth factor: a model for in vivo retroviral-mediated gene therapy.

  1997cites this paper
• Gut Epithelial Cells as Targets for Gene Therapy of Hemophilia

  1997cites this paper
• Adenoviral/retroviral vector chimeras: a novel strategy to achieve high‐efficiency stable transduction in vivo

  1997cites this paper
• Genes involved in oncogenesis.

  1997cites this paper
• The carboxyl-terminal region of factor IX is essential for its secretion.

  1997cites this paper
• CELL-BASED VASCULAR GENE DELIVERY: ENDOTHELIAL CELLS AS CARRIERS

  1997cites this paper
• Cell — Based Gene Delivery: Smooth Muscle Cells as Carriers

  1997cites this paper
• Persistent Systemic Production of Human Factor IX in Mice by Skeletal Myoblast-Mediated Gene Transfer: Feasibility of Repeat Application to Obtain Therapeutic Levels

  1997cites this paper
• Construction of Human Factor IX Expression Vectors in Retroviral Vector Frames Optimized for Muscle Cells

  1996cites this paper
• Evaluation of the Effect of Retroviral Gene Transduction on Vascular Endothelial Cell Adhesion

  1996cites this paper
• Age and Sex Dependent Regulation of the Factor IX Gene in Mice

  1996cites this paper
• Loss of expression of a retrovirus-transduced gene in human keratinocytes.

  1996cites this paper
• Evidence for the Systemic Delivery of a Transgene Product from Salivary Glands

  1996cites this paper
• Adenovirus-Mediated Transfer of Human Factor IX Gene in Immunodeficient and Normal Mice: Evidence for Prolonged Stability and Activity of the Transgene in Liver

  1996cites this paper
• Isolation and Characterization of Canine Factor IX

  1996cites this paper
• Towards Gene Therapy for Haemophilia B

  1996cites this paper
• Towards endothelial-cell-directed cancer immunotherapy: in vitro expression of human recombinant cytokine genes by human and mouse primary endothelial cells.

  1996cites this paper
• Non-replicating expression vectors: applications in vaccine development and gene therapy

  1996cites this paper