SIR2 and SIR4 interactions differ in core and extended telomeric heterochromatin in yeast.

No abstract is available for this paper.

• Publication year

  1997

• Venue

  Genes & Development

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1101/GAD.11.1.83PMID 9000052
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Genetic analysis of Rap1p/Sir3p interactions in telomeric and HML silencing in Saccharomyces cerevisiae.

  1996cited by this paper
• Spreading of transcriptional represser SIR3 from telomeric heterochromatin

  1996cited by this paper
• A deubiquitinating enzyme interacts with SIR4 and regulates silencing in S. cerevisiae.

  1996cited by this paper
• Evidence for silencing compartments within the yeast nucleus: a role for telomere proximity and Sir protein concentration in silencer-mediated repression.

  1996cited by this paper
• The clustering of telomeres and colocalization with Rap1, Sir3, and Sir4 proteins in wild-type Saccharomyces cerevisiae

  1996cited by this paper
• Heterochromatin and gene expression in Drosophila.

  1995cited by this paper
• The SIR2 gene family, conserved from bacteria to humans, functions in silencing, cell cycle progression, and chromosome stability.

  1995cited by this paper
• Action of a RAP1 carboxy-terminal silencing domain reveals an underlying competition between HMR and telomeres in yeast.

  1995cited by this paper
• Histone H3 and H4 N-termini interact with SIR3 and SIR4 proteins: a molecular model for the formation of heterochromatin in yeast.

  1995cited by this paper
• The carboxy termini of Sir4 and Rap1 affect Sir3 localization: evidence for a multicomponent complex required for yeast telomeric silencing

  1995cited by this paper
• Specific repression of the yeast silent mating locus HMR by an adjacent telomere

  1994cited by this paper
• Mutational analysis defines a C-terminal tail domain of RAP1 essential for Telomeric silencing in Saccharomyces cerevisiae.

  1994cited by this paper
• Histone H3 amino terminus is required for telomeric and silent mating locus repression in yeast

  1994cited by this paper
• Position effect variegation at fission yeast centromeres.

  1994cited by this paper
• Evidence that a complex of SIR proteins interacts with the silencer and telomere-binding protein RAP1.

  1994cited by this paper
• Mapping Polycomb-repressed domains in the bithorax complex using in vivo formaldehyde cross-linked chromatin.

  1993cited by this paper
• Histones and the regulation of heterochromatin in yeast.

  1993cited by this paper
• Transcriptional silencing in yeast is associated with reduced nucleosome acetylation.

  1993cited by this paper
• RAP1 and telomere structure regulate telomere position effects in Saccharomyces cerevisiae.

  1993cited by this paper
• SIR3 and SIR4 proteins are required for the positioning and integrity of yeast telomeres.

  1993cited by this paper
• Silent domains are assembled continuously from the telomere and are defined by promoter distance and strength, and by SIR3 dosage.

  1993influential reference
• Saccharomyces telomeres assume a non-nucleosomal chromatin structure.

  1992cited by this paper
• Improved method for high efficiency transformation of intact yeast cells.

  1992cited by this paper
• Multifunctional yeast high-copy-number shuttle vectors.

  1992cited by this paper
• Silencers, silencing, and heritable transcriptional states.

  1992cited by this paper
• A RAP1-interacting protein involved in transcriptional silencing and telomere length regulation.

  1992cited by this paper
• RAP1 protein activates and silences transcription of mating-type genes in yeast

  1991cited by this paper
• Modifiers of position effect are shared between telomeric and silent mating-type loci in S. cerevisiae.

  1991cited by this paper
• RAP1 protein activates and silences transcription of mating-type genes in yeast.

  1991cited by this paper
• The two-hybrid system: a method to identify and clone genes for proteins that interact with a protein of interest.

  1991cited by this paper
• 1 Genome Structure and Organization in Saccharomyces cerevisiae

  1991cited by this paper
• Position-effect variegation after 60 years.

  1990cited by this paper
• Position effect at S. cerevisiae telomeres: reversible repression of Pol II transcription.

  1990cited by this paper
• Genetic evidence for an interaction between SIR3 and histone H4 in the repression of the silent mating loci in Saccharomyces cerevisiae.

  1990cited by this paper
• Transcriptional silencing and lamins

  1989cited by this paper
• A new role for a yeast transcriptional silencer gene, SIR2, in regulation of recombination in ribosomal DNA.

  1989cited by this paper
• Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase.

  1988cited by this paper
• Dosage-dependent modifiers of position effect variegation in Drosophila and a mass action model that explains their effect.

  1988cited by this paper
• Two DNA-binding factors recognize specific sequences at silencers, upstream activating sequences, autonomously replicating sequences, and telomeres in Saccharomyces cerevisiae

  1988cited by this paper
• Functional domains of SIR4, a gene required for position effect regulation in Saccharomyces cerevisiae

  1987cited by this paper
• Purification and cloning of a DNA binding protein from yeast that binds to both silencer and activator elements.

  1987cited by this paper
• The structure of an antigenic determinant in a protein.

  1984cited by this paper
• Affinity purification of antibodies from diazotized paper blots of heterogeneous protein samples.

  1981cited by this paper

• Cohesin sumoylation is required for repression of subtelomeric gene expression in Saccharomyces cerevisiae

  2025cites this paper
• ERC accumulation depletes Sir2 from rDNA and induces cellular senescence by rDNA destabilization

  2025cites this paper
• Protocol for development and use of spike-in control for chromatin immunoprecipitation of chromatin-binding proteins in Schizosaccharomyces pombe

  2025cites this paper
• Protocol for the development and use of spike-in control for chromatin immunoprecipitation (ChIP) of chromatin-binding proteins

  2025cites this paper
• Mapping the Telomeric 3D Interactome with Telomere-C Reveals Repetitive Element Hubs Associated with Telomere Maintenance

  2025cites this paper
• A large C-terminal Rad52 segment acts as a chaperone to Form and Stabilize Rad51 Filaments

  2025cites this paper
• Spt5 orchestrates cryptic transcript suppression and transcriptional directionality

  2024cites this paper
• Unwrap RAP1’s Mystery at Kinetoplastid Telomeres

  2024cites this paper
• RNA quality control factors nucleate Clr4/SUV39H and trigger constitutive heterochromatin assembly.

  2024cites this paper
• Abf1 negatively regulates the expression of EPA1 and affects adhesion in Candida glabrata.

  2024cites this paper
• Transcriptional silencing in Saccharomyces cerevisiae: known unknowns

  2024cites this paper
• The functional significance of the RPA- and PCNA-dependent recruitment of Pif1 to DNA

  2024influential citation
• The regional sequestration of heterochromatin structural proteins is critical to form and maintain silent chromatin

  2022influential citation
• SESAME-catalyzed H3T11 phosphorylation inhibits Dot1-catalyzed H3K79me3 to regulate autophagy and telomere silencing

  2022cites this paper
• A proteomic screen of Ty1 integrase partners identifies the protein kinase CK2 as a regulator of Ty1 retrotransposition

  2022cites this paper
• Substrates of the MAPK Slt2: Shaping Yeast Cell Integrity

  2022cites this paper
• Sir2 and Reb1 antagonistically regulate nucleosome occupancy in subtelomeric X-elements and repress TERRAs by distinct mechanisms

  2022cites this paper
• Measuring the buffering capacity of gene silencing in Saccharomyces cerevisiae

  2021cites this paper
• Metabolic regulation of telomere silencing by SESAME complex-catalyzed H3T11 phosphorylation

  2021cites this paper
• Sir3 heterochromatin protein promotes non‐homologous end joining by direct inhibition of Sae2

  2021cites this paper
• Insights into Transcriptional Regulation by Individual H3K4 Methylation Marks in S. Cerevisiae

  2021cites this paper
• Sir3 Heterochromatin Protein Promotes NHEJ by Direct Inhibition of Sae2

  2021cites this paper
• Distinguishing between recruitment and spread of silent chromatin structures in Saccharomyces cerevisiae

  2021cites this paper
• H3K36 methylation and DNA-binding both promote Ioc4 recruitment and Isw1b remodeler function

  2021cites this paper
• Humanizing the yeast origin recognition complex

  2021cites this paper
• RNA surveillance controls 3D genome structure via stable cohesin-chromosome interaction

  2021cites this paper
• Rad52 Oligomeric N-Terminal Domain Stabilizes Rad51 Nucleoprotein Filaments and Contributes to Their Protection against Srs2

  2021cites this paper
• The chromatin immunoprecipitation (ChIP) assay and ChIP-qPCR

  2020cites this paper
• Chromatin Immunoprecipitation

  2020cites this paper
• Lithium directs embryonic stem cell differentiation versus hemogenic endothelium

  2020cites this paper
• Subtelomeres as Specialized Chromatin Domains

  2020cites this paper
• In vivo chromatin organization on native yeast telomeric regions is independent of a cis-telomere loopback conformation

  2020cites this paper
• A Prion Epigenetic Switch Establishes an Active Chromatin State.

  2020influential citation
• NAD+ Metabolism and Regulation: Lessons From Yeast

  2020cites this paper
• Chromatin modifiers and recombination factors promote a telomere fold-back structure, that is lost during replicative senescence

  2020cites this paper
• Stabilization of Sir3 interactions by an epigenetic metabolic small molecule, O-acetyl-ADP-ribose, on yeast SIR-nucleosome silent heterochromatin.

  2019cites this paper
• The Capability of O-Acetyl-ADP-Ribose, an Epigenetic Metabolic Small Molecule, on Promoting the Further Spreading of Sir3 along the Telomeric Chromatin

  2019cites this paper
• Genes to Cells

  2019cites this paper
• Fine chromatin-driven mechanism of transcription interference by antisense noncoding transcription

  2019cites this paper
• Nuclear aconitase antagonizes heterochromatic silencing by interfering with Chp1 binding to DNA.

  2019cites this paper
• Rap1-Mediated Chromatin And Gene Expression Changes At Senescence

  2019influential citation
• Characterizing the Role of SUMO in Transcriptional Repression in S. cerevisiae

  2019cites this paper
• Rap1‐mediated nucleosome displacement can regulate gene expression in senescent cells without impacting the pace of senescence

  2019cites this paper
• Localization and function of budding yeast CENP-A depends upon kinetochore protein interactions and is independent of canonical centromere DNA sequence

  2019influential citation
• The Sir4 H‐BRCT domain interacts with phospho‐proteins to sequester and repress yeast heterochromatin

  2019cites this paper
• The BAH domain of Rsc 2 is a histone H 3 binding domain

  2019cites this paper
• At the Beginning of the End and in the Middle of the Beginning: Structure and Maintenance of Telomeric DNA Repeats and Interstitial Telomeric Sequences

  2019cites this paper
• SIR proteins create compact heterochromatin fibers

  2018cites this paper
• Characterization of Candida glabrata cis-acting elements that negatively regulate transcription of EPA genes through silencing proteins

  2018cites this paper
• Transcriptional Regulation of Telomeric Expression Sites and Antigenic Variation in Trypanosomes

  2018cites this paper
• Elevated dosage of Ulp1 disrupts telomeric silencing in Saccharomyces cerevisiae

  2018cites this paper
• Rad52-Rad51 association is essential to protect Rad51 filaments against Srs2, but facultative for filament formation

  2018cites this paper
• Shepherding DNA ends: Rif1 protects telomeres and chromosome breaks

  2018cites this paper
• Chd1p recognizes H3K36Ac to maintain nucleosome positioning near the transcription start site.

  2018cites this paper
• An interplay between multiple sirtuins promotes completion of DNA replication in cells with short telomeres

  2018cites this paper
• Scalable longitudinal statistical models for genomics data

  2018cites this paper
• Regulated acetylation and deacetylation of H4 K16 is essential for efficient NER in Saccharomyces cerevisiae.

  2018cites this paper
• Kinetochore inactivation by expression of a repressive mRNA

  2017cites this paper
• Yeast genome-wide telomere screens and insights into cancer

  2017influential citation
• Quantitative Genome-Wide Measurements of Meiotic DNA Double-Strand Breaks and Protein Binding in S. pombe.

  2017cites this paper
• Recombination at subtelomeres is regulated by physical distance, double‐strand break resection and chromatin status

  2017cites this paper
• Spatio-Temporal Control of Cellular and Organismal Physiology by Sirtuins

  2017cites this paper
• Expanding heterochromatin reveals discrete subtelomeric domains delimited by chromatin landscape transitions

  2017cites this paper
• Modulations of SIR-nucleosome interactions of reconstructed yeast silent pre-heterochromatin by O-acetyl-ADP-ribose and magnesium

  2017cites this paper
• The role of Tbf1 in telomere homeostasis in Saccharomyces cerevisiae

  2017cites this paper
• Repair of UV-induced DNA lesions in natural Saccharomyces cerevisiae telomeres is moderated by Sir2 and Sir3, and inhibited by yKu–Sir4 interaction

  2017cites this paper
• Role of Nhp6 and Hmo1 in SWI/SNF occupancy and nucleosome landscape at gene regulatory regions.

  2017cites this paper
• Dose-dependency of heterochromatin domains reveals subtelomeric structuration in budding yeast

  2017cites this paper
• New Insights into the Regulation of Heterochromatin.

  2016cites this paper
• Erratum to: Transitions between the Arabidopsis-type and the human-type telomere sequence in green algae (clade Caudivolvoxa, Chlamydomonadales)

  2016cites this paper
• Title Impact of Childcare and Eldercare on Off-farm Activities in Rural China Permalink

  2016cites this paper
• Histone H3K36 methylation regulates pre-mRNA splicing in Saccharomyces cerevisiae

  2016cites this paper
• Molecular dynamics of de novo telomere heterochromatin formation in budding yeast.

  2016cites this paper
• The Nuts and Bolts of Transcriptionally Silent Chromatin in Saccharomyces cerevisiae

  2016cites this paper
• Smc5/6 Is a Telomere-Associated Complex that Regulates Sir4 Binding and TPE

  2016cites this paper
• Local chromosome context is a major determinant of crossover pathway biochemistry during budding yeast meiosis

  2016cites this paper
• Mte1 interacts with Mph1 and promotes crossover recombination and telomere maintenance

  2016cites this paper
• Local chromosome context is a major determinant of crossover pathway biochemistry during budding yeast meiosis

  2016cites this paper
• The Role of Sirtuin 6 in Maintaining Vascular Integrity

  2016cites this paper
• The proper connection between shelterin components is required for telomeric heterochromatin assembly

  2016cites this paper
• Heterochromatin assembly by interrupted Sir3 bridges across neighboring nucleosomes

  2016cites this paper
• Mte1 interacts with Mph1 and promotes crossover recombination and telomere maintenance

  2016cites this paper
• A beginning of the end: new insights into the functional organization of telomeres

  2015cites this paper
• Constitutive heterochromatin formation and transcription in mammals

  2015influential citation
• Genome-wide chromatin footprinting reveals changes in replication origin architecture induced by pre-RC assembly

  2015cites this paper
• Transitions between the Arabidopsis-type and the human-type telomere sequence in green algae (clade Caudivolvoxa, Chlamydomonadales)

  2015cites this paper
• Molecular modelling studies of sirtuin 2 inhibitors using three-dimensional structure-activity relationship analysis and molecular dynamics simulations.

  2015cites this paper
• Sir2 is involved in the transcriptional modulation of NHP6A in Saccharomyces cerevisiae.

  2015cites this paper
• Less is more: Nutrient limitation induces cross-talk of nutrient sensing pathways with NAD+ homeostasis and contributes to longevity

  2015cites this paper
• Chromatin immunoprecipitation assays: analyzing transcription factor binding and histone modifications in vivo.

  2015cites this paper
• Epigenetic Regulation of Silent Chromatin in Saccharomyces cerevisiae

  2015cites this paper
• The Shape of Silence: The Solution-State Conformation of Sir Heterochromatin: A Dissertation

  2015cites this paper
• Retrotransposon profiling of RNA polymerase III initiation sites Material Supplemental

  2015cites this paper
• Studies on the Evolution of Silencing in Budding Yeasts Using Comparative Genomics

  2015cites this paper
• Coordinated activities of chromatin modifying complexes in DNA regulation in Saccharomyces cerevisiae

  2015cites this paper
• Aging Mechanisms

  2015cites this paper
• Cellular Longevity of Budding Yeast During Replicative and Chronological Aging

  2015cites this paper
• ATP-Dependent Heterochromatin Remodeling: A Dissertation

  2015influential citation
• Elg1, a central player in genome stability.

  2015cites this paper
• The Interaction Between Sir3 and Sir4 is Dispensable for Silent Chromatin Spreading in Budding Yeast

  2015influential citation