Endorphins are stored in biologically active and inactive forms: isolation of α-N-acetyl peptides

No abstract is available for this paper.

• Publication year

  1979

• Venue

  Nature

• Publication date

  1979-05-17

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1038/279252A0
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• Isolation and characterization of endogenous [α]-n-acyl derivatives of the C and C′ of lph

  1979cited by this paper
• Endorphins in Mental Health Research

  1979cited by this paper
• Neuroleptic activity of the neuropeptide β-LPH62–77 ([Des-Tyr1]γ-endorphin; DTγE)

  1978cited by this paper
• Isolation of the C-fragment and C'-fragment of lipotropin from pig pituitary and C-fragment from brain.

  1978cited by this paper
• Hormone—receptor interactions: [4‐Carboranylalanine, 5‐leucine] ‐ enkephalin as a structural probe for the opiate receptor

  1977cited by this paper
• β-Endorphin-Induced Changes in Schizophrenic and Depressed Patients

  1977cited by this paper
• Opiates and endogenous opioid peptides: by H. W. Kosterlitz, published by NorthHolland Publishing Company, Amsterdam/ New York/Oxford,1976. Df.95.- ($36.50) (x+456 pages)

  1977cited by this paper
• Analgesic activity of lipotropin C fragment depends on carboxyl terminal tetrapeptide

  1977cited by this paper
• On the molecular mechanism of alpha-MSH receptor interactions.

  1977cited by this paper
• Characterization of a common precursor to corticotropin and beta-lipotropin: identification of beta-lipotropin peptides and their arrangement relative to corticotropin in the precursor synthesized in a cell-free system.

  1977cited by this paper
• Common precursor to corticotropins and endorphins.

  1977cited by this paper
• Structural requirements for opioid activity of analogues of the enkephalins

  1977cited by this paper
• On the Molecular Mechanism of α-MSH Receptor Interactionsl

  1977cited by this paper
• Endorphins: profound behavioral effects in rats suggest new etiological factors in mental illness.

  1976cited by this paper
• Isolation and structure of an untriakontapeptide with opiate activity from camel pituitary glands.

  1976cited by this paper
• C fragment of lipotropin has a high affinity for brain opiate receptors

  1976cited by this paper
• The C-fragment of beta-lipotropin: an endogenous neuroleptic or antipsychotogen?

  1976cited by this paper
• N-terminal acetylation of the nascent chains of α-crystallin

  1974cited by this paper
• A METHOD FOR DETERMINING LOSS OF PAIN SENSATION

  1941cited by this paper

• αN-Acetyl β-Endorphin Is an Endogenous Ligand of σ1Rs That Regulates Mu-Opioid Receptor Signaling by Exchanging G Proteins for σ2Rs in σ1R Oligomers

  2022cites this paper
• The stress - Reproductive axis in fish: The involvement of functional neuroanatomical systems in the brain.

  2020cites this paper
• Endozepines and their receptors: Structure, functions and pathophysiological significance.

  2020cites this paper
• 60 YEARS OF POMC: Lipotropin and beta-endorphin: a perspective.

  2016cites this paper
• The world of protein acetylation.

  2016cites this paper
• Development of a Novel Strategy to Isolate Lipophilic Allergens (Oleosins) from Peanuts

  2015cites this paper
• Molecular, cellular, and physiological significance of N-terminal acetylation.

  2015cites this paper
• Measurement of nonsulfated cholecystokinins

  2014cites this paper
• Inhibitory effects of β-endorphin on cortisol release from goldfish (Carassius auratus) head kidney: an in vitro study.

  2014cites this paper
• Posttranslational Modifications of Proopiomelanocortin in Vertebrates and Their Biological Significance

  2013cites this paper
• Chapter 234 – Acetylation

  2013cites this paper
• Immunoreactive / 8-Endorphin and Adrenocorticotropin in Human Cerebrospinal Fluid

  2013cites this paper
• Spatial analysis of human lens aquaporin-0 post-translational modifications by MALDI mass spectrometry tissue profiling.

  2011cites this paper
• Posttranslational modifications of the bovine lens beaded filament proteins filensin and CP49.

  2010cites this paper
• Synthesis of chromophoric dehydro analog of leucine enkephalin.

  2009cites this paper
• ISOLATION AND PROPERTIES OF β-ENDORPHIN-(1–27), Nα-ACETYL-β-ENDORPHIN, CORTICOTROPIN, GAMMA-LIPOTROPIN AND NEUROPHYSIN FROM EQUINE PITUITARY GLANDS

  2009cites this paper
• β‐ENDORPHIN: SYNTHESIS AND RADIORECEPTOR BINDING ACTIVITY OF βh‐ENDORPHIN‐(1–27) AND ITS ANALOGS

  2009cites this paper
• Structure-activity relationships of urotensin II and URP.

  2008cites this paper
• CHAPTER 2 – Translation and Posttranslational Processing of Gastrointestinal Peptides

  2006cites this paper
• RAPID COMMUNICATION Absence of Naloxone Sensitivity in Obese Humans

  2005cites this paper
• Detection of functionally active melanocortin receptors and evidence for an immunoregulatory activity of alpha-melanocyte-stimulating hormone in human dermal papilla cells.

  2005cites this paper
• Catabolism of intracellular N-terminal acetylated proteins: involvement of acylpeptide hydrolase and acylase.

  2005cites this paper
• Determination and analyses of the N-termini of oil-body proteins, steroleosin, caleosin and oleosin.

  2005cites this paper
• The rat kidney acylase 1. Evidence for a new cDNA form and comparisons with the porcine intestinal enzyme.

  2004cites this paper
• The role of the N-terminal acetyltransferase NatA in transcriptional silencing in Saccharomyces cerevisiae

  2004cites this paper
• Comparative Aspects of Intracellular Proteolytic Processing of Peptide Hormone Precursors: Studies of Proopiomelanocortin Processing

  2003cites this paper
• An Evolutionarily Conserved N-terminal Acetyltransferase Complex Associated with Neuronal Development*

  2003cites this paper
• Structural Properties of Porcine Intestine Acylpeptide Hydrolase

  2003cites this paper
• Structure–Activity Relationships of Human Urotensin II and Related Analogues on Rat Aortic Ring Contraction

  2003cites this paper
• ACTION OF PROTEOLYTIC ENZYMES ON LIPOTROPINS AND ENDORPHINS: BIOSYNTHESIS, BIOTRANSFORMATION AND FATE

  2002cites this paper
• The diversity of acetylated proteins

  2002cites this paper
• Nα-terminal Acetylation of Eukaryotic Proteins*

  2000cites this paper
• Invertebrate molecular neuroimmune processes.

  2000cites this paper
• Multivariate analysis of associations of 42 genes in ADHD, ODD and conduct disorder

  2000cites this paper
• Hippocampal cholinergic neurostimulating peptides (HCNP).

  2000cites this paper
• Identification of carp proopiomelanocortin-related peptides and their effects on phagocytes.

  2000cites this paper
• Cloning, sequencing and further characterization of acylpeptide hydrolase from porcine intestinal mucosa.

  1999cites this paper
• Identification and specificities of N‐terminal acetyltransferases from Saccharomyces cerevisiae

  1999cites this paper
• Analysis by mass spectrometry of POMC-derived peptides in amphibian melanotrope subpopulations.

  1999cites this paper
• Melanocortin receptors and δ‐opioid receptor mediate opposite signalling actions of POMC‐derived peptides in CATH.a cells

  1998cites this paper
• Pro-opiomelanocortin-derived peptides, cytokines, and nitric oxide in immune responses and stress: an evolutionary approach.

  1997cites this paper
• A Nα-acetyltransferase selectively transfers an acetyl group to NH2-terminal methionine residues: purification and partial characterization

  1997cites this paper
• Background adaptation by Xenopus laevis: a model for studying neuronal information processing in the pituitary pars intermedia.

  1997cites this paper
• The hog intestinal mucosa acylase I: subcellular localization, isolation, kinetic studies and biological function.

  1997cites this paper
• Acetyl salmon endorphin-like immunoreactivity in the ovary of two teleostean species: changes with environmental conditions.

  1997cites this paper
• Chromatographic Methods for Analyzing β-Endorphin and Related Peptides

  1996cites this paper
• Detection and characterization of native β‐endorphin1–31 in bovine pituitary using electrospray ionization, liquid secondary ion and tandem mass spectrometry

  1995cites this paper
• Demonstration of deacetylated hippocampal cholinergic neurostimulating peptide and its precursor protein in rat tissues.

  1995cites this paper
• N-Acetyltransferase mechanism for α-melanocyte stimulating hormone regulation in rat ageing ☆

  1995cites this paper
• N-Acetyl β-endorphin-(1–31) produces a GTP-dependent activation of G transducer proteins in mouse PAG☆

  1994cites this paper
• proopiomelanocortin biosynthesis, processing, and secretion, functional implications

  1993cites this paper
• 20 – Neurotransmitters as Neurotrophic Factors

  1993cites this paper
• N-Terminal Acetylation of Mutationally Altered Form of Iso-1-Cytochromes c in Normal and nat1 - Strains Deficient in the Major N-Terminal Acetyl Transferase of the Yeast Saccharomyces Cerevisiae

  1993cites this paper
• The complete primary structure of rat chaperonin 10 reveals a putative βαβ nucleotide-binding domain with homology to p21ras

  1993cites this paper
• Aging and Analgesic Mechanisms

  1993cites this paper
• Co- and Posttranslational Processes and Mitochondrial Import of Yeast Cytochrome c

  1993cites this paper
• Opioid Peptide Processing Enzymes

  1993cites this paper
• alpha-Melanocyte-stimulating hormone during human perinatal life.

  1993cites this paper
• Beta-endrophin immunoreactivity during human pregnancy.

  1992cites this paper
• A novel opioid structure which accepts protonated as well as non-protonated nitrogen: a family of pure, delta receptor selective antagonists.

  1992cites this paper
• Ovarian opioids and the reproductive cycle of the frog Rana esculenta.

  1992cites this paper
• &bgr;‐Endorphin processing and cellular origins in rat spinal cord

  1992cites this paper
• N-acetylation is required for the lactotrope recruitment activity of alpha-melanocyte-stimulating hormone and beta-endorphin.

  1992cites this paper
• Central changes of &bgr;‐endorphin‐like immunoreactivity during rat tonic pain differ from those of purified &bgr;‐endorphin

  1992cites this paper
• Further characterization of αN-acetyl β-endorphin-(1–31) regulatory activity, I: Effect on opioid- and α2-mediated supraspinal antinociception in mice

  1992cites this paper
• Posttranslational modifications in the amino- terminal region of the large subunit of ribulose- 1,5-bisphosphate carboxylase/oxygenase from several plant species.

  1992cites this paper
• Chapter 11 The peptidergic nervous system of coelenterates

  1992cites this paper
• Neuroimmunology of host-parasite interactions: proopiomelanocortin derived peptides in the infection by Schistosoma mansoni

  1992cites this paper
• Chapter 29 – Endorphins and schizophrenia

  1992cites this paper
• Proopiomelanocortin in the Helminth Schistosoma Mansoni. Synthesis of Beta‐Endorphin, ACTH, and Alpha‐MSH. Existence of POMC‐Related Sequences

  1992cites this paper
• Molecular mechanisms of -endorphin biosynthesis

  1992cites this paper
• αN-acetyl derivatives of β-endorphin-(1–31) and -(1–27) regulate the supraspinal antinociceptive activity of different opioids in mice

  1991cites this paper
• Csf Levels of α-N-Acetylated and Deacetylated ß-Endorphin in Chronic Migraine

  1991cites this paper
• Rat liver polysome N alpha-acetyltransferase: isolation and characterization.

  1991cites this paper
• N-Acetyl-β-endorphin1–31 antagonizes the suppressive effect of β-endorphin1–31 on murine splenocyte proliferation via A naloxone-resistant receptor

  1991cites this paper
• Mass spectrometric quantification of endogenous beta-endorphin.

  1991cites this paper
• Proopiomelanocortin gene and gene products: A comparative study

  1991cites this paper
• Synthesis and secretion of the calcium regulating hormone stanniocalcin in teleost fish

  1991cites this paper
• la proopiomélanocortine et ses fragments : application à l'investigation clinique

  1991cites this paper
• Ionic, neuronal and endocrine influences on the proopiomelanocortin system of the hypothalamus.

  1990cites this paper
• Cotranslational amino-terminal processing.

  1990cites this paper
• Expression of guinea-pig liver transglutaminase cDNA in Escherichia coli. Amino-terminal N alpha-acetyl group is not essential for catalytic function of transglutaminase.

  1990cites this paper
• Characterization of α-melanocyte-stimulating hormone (α-MSH)-like peptides in discrete regions of the rat brain. In vitro release of α-MSH from perifused hypothalamus and amygdala

  1990cites this paper
• Effects of Chronic Treatment of Rats with Dopamine Receptor Drugs on the Post‐Translational Processing of Beta‐Endorphin in the Neurointermediate Lobe of the Pituitary Gland

  1990influential citation
• Isoproterenol-stimulated release of β-endorphin and related peptides from the rat pituitary neurointermediate lobe in vitro: Evidence for preferential release of certain molecular forms of β-endorphin

  1990cites this paper
• Opioid Receptors: Types, Distribution, and Pharmacological Profiles

  1990cites this paper
• Dopaminergic Modulation of Pituitary Alpha-N-Acetyl-Transferase Activity and Adrenarche

  1989cites this paper
• Tolerance develops to the behavioural effects of ACTH-(1-24) during continuous i.c.v. infusion in rats, and is associated with increased hypothalamic levels of beta-endorphin.

  1989cites this paper
• Fetal intermediate lobe is stimulated by parturition.

  1989cites this paper
• Cancer Pain

  1989cites this paper
• The immune-hypothalamic-pituitary-adrenal axis.

  1989cites this paper
• Regulation of pro-opiomelanocortin biosynthesis and processing by transplantation immunity

  1989cites this paper
• Gonadal steroid and chronic morphine treatment do not change the posttranslational processing of beta-endorphin in the rat brain.

  1989cites this paper
• Dopaminergic Regulation of the Intermediate Pituitary

  1989cites this paper
• Characterization of α-MSH-related peptides released from rat hypothalamic neurons in vitro

  1989cites this paper
• Presence of Acetylated and Shortened Endorphins in Human Fetal Pituitary Gland

  1989cites this paper
• Nα‐Acetyl‐Vasopressin‐ and Nα‐Acetyl‐Oxytocin‐Like Substances: Isolation and Characterization in the Rat Neurointermediate Pituitary and Presence in the Brain

  1989cites this paper
• Beta-endorphin in the brainstem and the cerebellum of the human infant: regional levels' profile assessed with immunoaffinity chromatography and solid phase radioimmunoassay.

  1989cites this paper
• Posttranslational Processing of Gut Peptides

  1989cites this paper
• N alpha-acetyl-[Arg8]vasopressin antagonizes the behavioral effect of [Cyt6]vasopressin-(5-9), but not of vasopressin.

  1989cites this paper