Targeting memory Th2 cells for the treatment of allergic asthma.

No abstract is available for this paper.

• Publication year

  2006

• Venue

  Pharmacology and Therapeutics

• Publication date

  Unknown publication date

• Fields of study

  Medicine

• Identifiers
  DOI 10.1016/J.PHARMTHERA.2005.06.006PMID 16081161
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• References Subscriptions Permissions Email Alerts A Broad-Spectrum Caspase Inhibitor Attenuates Allergic Airway Inflammation in Murine Asthma Model

  2013cited by this paper
• Reduced expression of transforming growth factor β1 exacerbates pathology in an experimental asthma model

  2005cited by this paper
• Inhaled p38alpha mitogen-activated protein kinase antisense oligonucleotide attenuates asthma in mice.

  2005cited by this paper
• Inhibitors of mitogen-activated protein kinases differentially regulate costimulated T cell cytokine production and mouse airway eosinophilia

  2005cited by this paper
• Chemokine‐receptor expression on T cells in lung compartments of challenged asthmatic patients

  2005cited by this paper
• A novel benzoimidazole derivative, M50367, modulates helper T type I/II responses in atopic dermatitis mice and intradermal melanoma-bearing mice.

  2005cited by this paper
• Mice Deficient in OX40 and CD30 Signals Lack Memory Antibody Responses because of Deficient CD4 T Cell Memory1

  2005cited by this paper
• Modulation of Memory CD4 T Cell Function and Survival Potential by Altering the Strength of the Recall Stimulus1

  2005cited by this paper
• Impact of Sublingual Immunotherapy on Specific Antibody Levels in Asthmatic Children Allergic to House Dust Mites

  2005cited by this paper
• Phosphodiesterase-4 inhibitors for asthma and chronic obstructive pulmonary disease.

  2005cited by this paper
• Viral-Induced T Helper Type 1 Responses Enhance Allergic Disease by Effects on Lung Dendritic Cells

  2005cited by this paper
• IL-7: maintaining T-cell memory and achieving homeostasis.

  2005cited by this paper
• Lipoprotein I, a TLR2/4 Ligand Modulates Th2-Driven Allergic Immune Responses

  2005cited by this paper
• The anti-inflammatory effects of omalizumab confirm the central role of IgE in allergic inflammation.

  2005cited by this paper
• Treatment of cockroach allergen asthma model with imatinib attenuates airway responses.

  2005cited by this paper
• A Role for Caspases in Controlling IL-4 Expression in T Cells1

  2005cited by this paper
• A protective role for the A1 adenosine receptor in adenosine-dependent pulmonary injury.

  2005cited by this paper
• Regulation of T helper type 2 cell differentiation by murine Schnurri-2

  2005cited by this paper
• Fel d 1‐derived T cell peptide therapy induces recruitment of CD4+CD25+; CD4+ interferon‐γ+ T helper type 1 cells to sites of allergen‐induced late‐phase skin reactions in cat‐allergic subjects

  2005cited by this paper
• Blocking IL-15 Prevents the Induction of Allergen-Specific T Cells and Allergic Inflammation In Vivo

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• Prostaglandin D2-Induced Eosinophilic Airway Inflammation Is Mediated by CRTH2 Receptor

  2005cited by this paper
• Sublingual immunotherapy: from proven prevention to putative rapid relief of allergic symptoms

  2005cited by this paper
• Toll-like receptor 4 or 2 agonists decrease allergic inflammation.

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• A coherent framework for multiresolution analysis of biological networks with "memory": Ras pathway, cell cycle, and immune system.

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• Peptide-based therapeutic vaccines for allergic and autoimmune diseases

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• Trichostatin A attenuates airway inflammation in mouse asthma model

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• Functional Heterogeneity of Memory CD4 T Cell Responses in Different Conditions of Antigen Exposure and Persistence1

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• T Cell Epitope Immunotherapy Induces a CD4+ T Cell Population with Regulatory Activity

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• Activation of the Prostaglandin D2 Receptor DP2/CRTH2 Increases Allergic Inflammation in Mouse 1

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• CCR4 ligands are up-regulated in the airways of atopic asthmatics after segmental allergen challenge

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• Anti-IL-13 monoclonal antibody inhibits airway hyperresponsiveness, inflammation and airway remodeling.

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• A novel anionic dendrimer for improved cellular delivery of antisense oligonucleotides.

  2004cited by this paper
• The alveolar macrophage: the forgotten cell in asthma.

  2004cited by this paper
• Arginine in asthma and lung inflammation.

  2004cited by this paper
• Peptide therapy and asthma.

  2004cited by this paper
• The effect of selective phosphodiesterase inhibitors, alone and in combination, on a murine model of allergic asthma

  2004cited by this paper
• Inhibition of airway remodeling in IL-5-deficient mice.

  2004cited by this paper
• Flt-3 Ligand Reverses Late Allergic Response and Airway Hyper-Responsiveness in a Mouse Model of Allergic Inflammation1

  2004cited by this paper
• CD16+ human monocyte-derived dendritic cells matured with different and unrelated stimuli promote similar allogeneic Th2 responses: regulation by pro- and anti-inflammatory cytokines.

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• Stimulation of allergen-loaded macrophages by TLR9-ligand potentiates IL-10-mediated suppression of allergic airway inflammation in mice

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• Naturally-occurring CD4+CD25+ immunoregulatory T cells: central players in the arena of peripheral tolerance.

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  2004cited by this paper
• T-cell-mediated inflammation does not contribute to the maintenance of airway dysfunction in mice.

  2004cited by this paper
• Type 2 cytokines in the pathogenesis of sustained airway dysfunction and airway remodeling in mice.

  2004cited by this paper
• Effects of anticytokine therapy in a mouse model of chronic asthma.

  2004cited by this paper
• Blockade of Allergic Airway Inflammation Following Systemic Treatment with a B7-Dendritic Cell (PD-L2) Cross-Linking Human Antibody1

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• Grass Pollen Immunotherapy Induces Mucosal and Peripheral IL-10 Responses and Blocking IgG Activity1

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• Higher prostaglandin e2 production by dendritic cells from subjects with asthma compared with normal subjects.

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• Adenovirus expressing Fas ligand gene decreases airway hyper-responsiveness and eosinophilia in a murine model of asthma

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• Signaling control of memory T cell generation and function.

  2004cited by this paper
• Mechanisms of immunotherapy.

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• Allergen immunotherapy with cat allergen peptides

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• Runx3 regulates mouse TGF‐β‐mediated dendritic cell function and its absence results in airway inflammation

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• Tregs and allergic disease.

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