Striatal-enriched Tyrosine Protein Phosphatase (STEP) in the Mechanisms of Depressive Disorders.

No abstract is available for this paper.

• Publication year

  2017

• Venue

  Current protein and peptide science

• Publication date

  2017-08-30

• Fields of study

  Medicine, Chemistry, Psychology

• Identifiers
  DOI 10.2174/1389203718666170710121532PMID 28699511
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The serotonergic system in the neurobiology of depression: Relevance for novel antidepressants

  2016cited by this paper
• Stress-based animal models of depression: Do we actually know what we are doing?

  2016cited by this paper
• Neuropathology of mood disorders: do we see the stigmata of inflammation?

  2016cited by this paper
• Protective effect of liquiritigenin on depressive-like behavior in mice after lipopolysaccharide administration.

  2016cited by this paper
• PSD-95 stabilizes NMDA receptors by inducing the degradation of STEP61

  2016cited by this paper
• Agmatine ameliorates lipopolysaccharide induced depressive-like behaviour in mice by targeting the underlying inflammatory and oxido-nitrosative mediators.

  2016cited by this paper
• Esculetin attenuates lipopolysaccharide (LPS)-induced neuroinflammatory processes and depressive-like behavior in mice.

  2016cited by this paper
• Down‐regulation of BDNF in cell and animal models increases striatal‐enriched protein tyrosine phosphatase 61 (STEP61) levels

  2016cited by this paper
• BDNF Induces Striatal-Enriched Protein Tyrosine Phosphatase 61 Degradation Through the Proteasome

  2016cited by this paper
• Brain-derived Neurotrophic Factor (BDNF)-TrkB Signaling in Inflammation-related Depression and Potential Therapeutic Targets

  2016cited by this paper
• Paeonol attenuates lipopolysaccharide-induced depressive-like behavior in mice.

  2016cited by this paper
• STEP activation by Gαq coupled GPCRs opposes Src regulation of NMDA receptors containing the GluN2A subunit

  2016cited by this paper
• Resveratrol abrogates lipopolysaccharide-induced depressive-like behavior, neuroinflammatory response, and CREB/BDNF signaling in mice.

  2015cited by this paper
• Catatonia vis-à-vis delirium: the significance of recognizing catatonia in altered mental status.

  2015cited by this paper
• Integrating the monoamine, neurotrophin and cytokine hypotheses of depression--a central role for the serotonin transporter?

  2015cited by this paper
• Striatal‐enriched protein tyrosine phosphatase regulates the PTPα/Fyn signaling pathway

  2015cited by this paper
• STEP Levels Are Unchanged in Pre-Frontal Cortex and Associative Striatum in Post-Mortem Human Brain Samples from Subjects with Schizophrenia, Bipolar Disorder and Major Depressive Disorder

  2015cited by this paper
• The serotonin transporter in psychiatric disorders: insights from PET imaging.

  2015cited by this paper
• Tryptophan hydroxylase 2 in seasonal affective disorder: underestimated perspectives?

  2015cited by this paper
• Recent advances in the neuropsychopharmacology of serotonergic hallucinogens.

  2015cited by this paper
• Inhibition of the tyrosine phosphatase STEP61 restores BDNF expression and reverses motor and cognitive deficits in phencyclidine-treated mice

  2015cited by this paper
• Depression: from psychopathology to pathophysiology

  2015cited by this paper
• The role of serotonin 5-HT2A receptors in memory and cognition

  2015cited by this paper
• Central serotonin-2A (5-HT2A) receptor dysfunction in depression and epilepsy: the missing link?

  2015cited by this paper
• Serotonin: a never-ending story.

  2015cited by this paper
• The current state of the neurogenic theory of depression and anxiety.

  2015cited by this paper
• [Comparison of behavioral effects of fluoxetine, imipramine and new psychotropic drug TC-2153 on mice with hereditary predisposition to catalepsy].

  2015cited by this paper
• Network beyond IDO in psychiatric disorders: revisiting neurodegeneration hypothesis.

  2014cited by this paper
• Revisiting the concept of late catatonia.

  2014cited by this paper
• Brain‐derived neurotrophic factor Val66Met polymorphism association with antidepressant efficacy: A systematic review and meta‐analysis

  2014cited by this paper
• Molecular mechanism of ERK dephosphorylation by striatal‐enriched protein tyrosine phosphatase

  2014cited by this paper
• Inhibitor of the Tyrosine Phosphatase STEP Reverses Cognitive Deficits in a Mouse Model of Alzheimer's Disease

  2014cited by this paper
• Antidepressant-like effect of nitric oxide synthase inhibitors and sildenafil against lipopolysaccharide-induced depressive-like behavior in mice.

  2014cited by this paper
• Immuno-neuroendocrino-neurochemical interaction in psychiatric disorders.

  2014cited by this paper
• Behavioral characterization of striatal‐enriched protein tyrosine phosphatase (STEP) knockout mice

  2014cited by this paper
• Stress, serotonin, and hippocampal neurogenesis in relation to depression and antidepressant effects.

  2014cited by this paper
• Disruption of striatal-enriched protein tyrosine phosphatase (STEP) function in neuropsychiatric disorders.

  2014cited by this paper
• Serotonin receptors involved in antidepressant effects.

  2013cited by this paper
• NMDA Receptor Blockade by Ketamine Abrogates Lipopolysaccharide-Induced Depressive-Like Behavior in C57BL/6J Mice

  2013cited by this paper
• The neurobiology of depression and antidepressant action.

  2013cited by this paper
• Time course of the effects of lipopolysaccharide on prepulse inhibition and brain nitrite content in mice.

  2013cited by this paper
• Tryptophan metabolism: entering the field of aging and age-related pathologies.

  2013cited by this paper
• 5-Hydroxytryptamine 2A receptor antagonists as potential treatment for psychiatric disorders

  2013cited by this paper
• Serotonin and beyond: therapeutics for major depression

  2013cited by this paper
• Effects of antidepressants on alternations in serum cytokines and depressive-like behavior in mice after lipopolysaccharide administration.

  2013cited by this paper
• Integrative physiology of depression and antidepressant drug action: implications for serotonergic mechanisms of action and novel therapeutic strategies for treatment of depression.

  2013cited by this paper
• Effects of doxycycline on depressive-like behavior in mice after lipopolysaccharide (LPS) administration.

  2013cited by this paper
• Animal models of serotonergic psychedelics.

  2013cited by this paper
• The epidemiology of depression across cultures.

  2013cited by this paper
• Monoamine neurocircuitry in depression and strategies for new treatments.

  2013cited by this paper
• A critical review of the mechanism of action for the selective serotonin reuptake inhibitors: do these drugs possess anti-inflammatory properties and how relevant is this in the treatment of depression?

  2013cited by this paper
• The Epidemiological Modelling of Major Depressive Disorder: Application for the Global Burden of Disease Study 2010

  2013cited by this paper
• A new synthetic varacin analogue, 8-(trifluoromethyl)-1,2,3,4,5-benzopentathiepin-6-amine hydrochloride (TC-2153), decreased hereditary catalepsy and increased the BDNF gene expression in the hippocampus in mice

  2012cited by this paper
• A neurotrophic hypothesis of depression: role of synaptogenesis in the actions of NMDA receptor antagonists

  2012cited by this paper
• Probing the diversity of serotonin neurons

  2012cited by this paper
• A pharmacological evidence of positive association between mouse intermale aggression and brain serotonin metabolism.

  2012cited by this paper
• Exaggerated aggression and decreased anxiety in mice deficient in brain serotonin

  2012cited by this paper
• Head-twitch response in rodents induced by the hallucinogen 2,5-dimethoxy-4-iodoamphetamine: a comprehensive history, a re-evaluation of mechanisms, and its utility as a model.

  2012cited by this paper
• Effect of brain-derived neurotrophic factor on behavior and key members of the brain serotonin system in genetically predisposed to behavioral disorders mouse strains.

  2012cited by this paper
• Signaling pathways underlying the pathophysiology and treatment of depression: novel mechanisms for rapid-acting agents.

  2012cited by this paper
• Antidepressant-Like Effects of Central BDNF Administration in Mice of Antidepressant Sensitive Catalepsy (ASC) Strain.

  2012cited by this paper
• Comorbid anxiety in bipolar spectrum disorders: a neglected research and treatment issue?

  2012cited by this paper
• Therapeutic Implications for Striatal-Enriched Protein Tyrosine Phosphatase (STEP) in Neuropsychiatric Disorders

  2012cited by this paper
• Serotonin receptors - from molecular biology to clinical applications.

  2011cited by this paper
• Measuring catatonia: a systematic review of rating scales.

  2011cited by this paper
• Striatal‐enriched protein tyrosine phosphatase (STEP) knockout mice have enhanced hippocampal memory

  2011cited by this paper
• Cross-national epidemiology of DSM-IV major depressive episode

  2011cited by this paper
• Transcriptional regulation and multiple functions of MAO genes

  2011cited by this paper
• The new '5-HT' hypothesis of depression: cell-mediated immune activation induces indoleamine 2,3-dioxygenase, which leads to lower plasma tryptophan and an increased synthesis of detrimental tryptophan catabolites (TRYCATs), both of which contribute to the onset of depression.

  2011cited by this paper
• The Role of Striatal-Enriched Protein Tyrosine Phosphatase (STEP) in Cognition

  2011cited by this paper
• Psychotherapies for comorbid anxiety in bipolar spectrum disorders.

  2011cited by this paper
• NR2B‐NMDA receptor mediated modulation of the tyrosine phosphatase STEP regulates glutamate induced neuronal cell death

  2010cited by this paper
• Metabolic syndrome, age‐associated neuroendocrine disorders, and dysregulation of tryptophan—kynurenine metabolism

  2010cited by this paper
• Behavioral Indices in Antipsychotic Drug Discovery

  2010cited by this paper
• Genetic reduction of striatal-enriched tyrosine phosphatase (STEP) reverses cognitive and cellular deficits in an Alzheimer’s disease mouse model

  2010cited by this paper
• Targeting tryptophan hydroxylase 2 in affective disorder

  2010cited by this paper
• Tyrosine dephosphorylation regulates AMPAR internalisation in mGluR-LTD.

  2009cited by this paper
• Functional properties of missense variants of human tryptophan hydroxylase 2

  2009cited by this paper
• Association of Brain-Derived Neurotrophic Factor Genetic Val66Met Polymorphism with Severity of Depression, Efficacy of Fluoxetine and Its Side Effects in Chinese Major Depressive Patients

  2009cited by this paper
• Novel sequence variations in the brain-derived neurotrophic factor gene and association with major depression and antidepressant treatment response.

  2009cited by this paper
• Deficit in BDNF does not increase vulnerability to stress but dampens antidepressant-like effects in the unpredictable chronic mild stress.

  2009cited by this paper
• Genetic Disruption of Both Tryptophan Hydroxylase Genes Dramatically Reduces Serotonin and Affects Behavior in Models Sensitive to Antidepressants

  2008cited by this paper
• Behavioral and serotonergic consequences of decreasing or increasing hippocampus brain-derived neurotrophic factor protein levels in mice.

  2008cited by this paper
• Genetic structure of hereditary catalepsy in mice

  2008cited by this paper
• Role of GSK3β in behavioral abnormalities induced by serotonin deficiency

  2008cited by this paper
• The Tyrosine Phosphatase STEP Mediates AMPA Receptor Endocytosis after Metabotropic Glutamate Receptor Stimulation

  2008cited by this paper
• Dietary Amino Acids and Brain Serotonin Function; Implications for Stress-Related Affective Changes

  2008cited by this paper
• Serotonin(4) (5-HT(4)) receptor agonists are putative antidepressants with a rapid onset of action.

  2007cited by this paper
• Selective breeding for catalepsy changes the distribution of microsatellite D13Mit76 alleles linked to the 5‐HT1A serotonin receptor gene in mice

  2006cited by this paper
• Reduced NMDA receptor tyrosine phosphorylation in PTPα‐deficient mouse synaptosomes is accompanied by inhibition of four src family kinases and Pyk2: an upstream role for PTPα in NMDA receptor regulation

  2006cited by this paper
• Regulation of NMDA receptor trafficking and function by striatal‐enriched tyrosine phosphatase (STEP)

  2006cited by this paper
• A neurotrophic model for stress-related mood disorders.

  2006cited by this paper
• Effect of imipramine on the behavior and cerebral 5-HT1A serotonin receptors in mice genetically predisposed to catalepsy

  2006cited by this paper
• Brain-derived neurotrophic factor gene polymorphism (Val66Met) and citalopram response in major depressive disorder.

  2006cited by this paper
• Tyrosine Phosphatases Regulate AMPA Receptor Trafficking during Metabotropic Glutamate Receptor-Mediated Long-Term Depression

  2006cited by this paper
• Acute effects of selective serotonin reuptake inhibitors on neuroleptic-induced catalepsy in mice.

  2005cited by this paper
• Loss-of-function mutation in tryptophan hydroxylase-2 identified in unipolar major depression.

  2005cited by this paper
• Increased phosphorylation and redistribution of NMDA receptors between synaptic lipid rafts and post‐synaptic densities following transient global ischemia in the rat brain

  2005cited by this paper
• Regulation of NMDA receptor trafficking by amyloid-beta.

  2005cited by this paper
• Mice with reduced brain-derived neurotrophic factor expression show decreased choline acetyltransferase activity, but regular brain monoamine levels and unaltered emotional behavior.

  2004cited by this paper

• BDNF and miRNAs in acupuncture-regulated neuroplasticity: Emerging mechanisms and therapeutic strategies

  2026cites this paper
• Restraint stress effects on glutamate signaling protein levels in the rats’ frontal cortex: Does β1 adrenoceptor activity matter?

  2025cites this paper
• Current Concepts of the Role of the STEP Striatal-Enriched Protein Tyrosine Phosphatase in the Pathological and Neurodegenerative Processes in the Brain

  2024cites this paper
• The pathobiology of depression in Huntington’s disease: an unresolved puzzle

  2024cites this paper
• Current Concepts of the Role of Striatal-Enriched Protein Tyrosine Phosphatase STEP in the Pathological and Neurodegenerative Processes in the Brain

  2024cites this paper
• On Associations between Fear-Induced Aggression, Bdnf Transcripts, and Serotonin Receptors in the Brains of Norway Rats: An Influence of Antiaggressive Drug TC-2153

  2023cites this paper
• On an association between fear-induced aggression and striatal-enriched protein tyrosine phosphatase (STEP) in the brain of Norway rats.

  2022cites this paper
• Transcriptomic Studies of Antidepressant Action in Rodent Models of Depression: A First Meta-Analysis

  2022cites this paper
• Fbxo45‐mediated NP‐STEP46 degradation via K6‐linked ubiquitination sustains ERK activity in lung cancer

  2022cites this paper
• Roles of non-receptor tyrosine kinases in pathogenesis and treatment of depression

  2022cites this paper
• The Implication of STEP in Synaptic Plasticity and Cognitive Impairments in Alzheimer’s Disease and Other Neurological Disorders

  2021cites this paper
• Acute Administration of Imipramine and Citalopram Increases Activity of Striatal-Enriched Tyrosine Protein Phosphatase (STEP) in Brain of Zebrafish Danio rerio

  2021cites this paper
• Effect of Aging on the Behavior and Brain Expression of Genes Encoding Kaiso, BDNF, CREB, and STEP Proteins in Mice

  2021cites this paper
• Insight into the Role of the STriatal-Enriched Protein Tyrosine Phosphatase (STEP) in A2A Receptor-Mediated Effects in the Central Nervous System

  2021cites this paper
• Genetic underpinnings of affective temperaments: a pilot GWAS investigation identifies a new genome-wide significant SNP for anxious temperament in ADGRB3 gene

  2021cites this paper
• Long noncoding RNA expression profiles of rat extrasynaptic and synaptic neurons expressing the N-methyl-D-aspartate receptor revealed by microarray analysis.

  2021cites this paper
• PTPN5 promotes follicle‐stimulating hormone secretion through regulating intracellular calcium homeostasis

  2021cites this paper
• Ambiguous Effects of Prolonged Dietary Supplementation with a Striatal-Enriched Protein Tyrosine Phosphatase Inhibitor, TC-2153, on a Rat Model of Sporadic Alzheimer’s Disease

  2021cites this paper
• Pargyline and р-Chlorophenylalanine Decrease Expression of Ptpn5 Encoding Striatal-Enriched Protein Tyrosine Phosphatase (STEP) in the Mouse Striatum

  2020cites this paper
• Aging-related modifications to G protein-coupled receptor signaling diversity.

  2020cites this paper
• Alterations of STEP46 and STEP61 Expression in the Rat Retina with Age and AMD-Like Retinopathy Development

  2020cites this paper
• Distinguishing and phenotype monitoring of traumatic brain injury and post-concussion syndrome including chronic migraine in serum of Iraq and Afghanistan war veterans

  2019cites this paper
• Effects of Acute and Chronic Treatment of Novel Psychotropic Drug, 8- (Trifluoromethyl)-1, 2, 3, 4, 5-benzopentathiepin-6-amine Hydrochloride (TC-2153), on the Behavior of Zebrafish (Danio Rerio): A Comparison with Fluoxetine

  2019cites this paper
• Alterations in the expression and activity of STEP in the mouse brain induced by genetically defined obesity and lipopolysaccharide (LPS) administration

  2019cites this paper
• The susceptibility to chronic social defeat stress is related to low hippocampal extrasynaptic NMDA receptor function

  2019cites this paper
• Signal Transduction Pathways of Acupuncture for Treating Some Nervous System Diseases

  2019cites this paper
• On association of the lethal yellow (AY) mutation in the agouti gene with the alterations in mouse brain and behavior

  2019cites this paper
• Inhibitor of Striatal-Enriched Protein Tyrosine Phosphatase, 8-(Trifluoromethyl)-1,2,3,4,5-Benzopentathiepin-6-Amine hydrochloride (TC-2153), Produces Antidepressant-Like Effect and Decreases Functional Activity and Protein Level of 5-HT2A Receptor in the Brain.

  2018cites this paper