The influence of tobacco smoking on adhesion molecule profiles

Sequential interactions between several adhesion molecules and their ligands regulate lymphocyte circulation and leukocyte recruitment to inflammatory foci. Adhesion molecules are, therefore, central and critical components of the immune and inflammatory system. We review the evidence that tobacco smoking dysregulates specific components of the adhesion cascade, which may be a common factor in several smoking-induced diseases. Smoking causes inappropriate leukocyte activation, leukocyte-endothelial adhesion, and neutrophil entrapment in the microvasculature, which may help initiate local tissue destruction. Appropriate inflammatory reactions may thus be compromised. In addition to smoke-induced alterations to membrane bound endothelial and leukocyte adhesion molecule expression, which may help explain the above phenomena, smoking has a profound influence on circulating adhesion molecule profiles, most notably sICAM-1 and specific sCD44 variants. Elevated concentrations of soluble adhesion molecules may simply reflect ongoing inflammatory processes. However, increasing evidence suggests that specific soluble adhesion molecules are immunomodulatory, and that alterations to soluble adhesion molecule profiles may represent a significant risk factor for several diverse diseases. This evidence is discussed herein.

• Publication year

  2002

• Venue

  Tobacco Induced Diseases

• Publication date

  2002-01-15

• Fields of study

  Medicine

• Identifiers
  DOI 10.1186/1617-9625-1-1-7PMID 19570245PMCID 2671531
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• Smoking has a strong influence on circulating adhesion molecule profiles, especially soluble intercellular adhesion molecule-1 and specific sCD44 variants, and these alterations may have immunomodulatory and disease-risk consequences.

  Confidence 0.93

  박진우 (dztg5apj7m) extractionB (s683577b42) reviewAnonymous (12632b8b5f) reviewsijun-yang (m6hj47gh7t) review
• Smoking promotes inappropriate leukocyte activation and neutrophil entrapment in the microvasculature, which may help initiate local tissue destruction.

  Confidence 0.94

  박진우 (dztg5apj7m) extractionB (s683577b42) reviewAnonymous (12632b8b5f) reviewsijun-yang (m6hj47gh7t) review
• Tobacco smoking dysregulates adhesion molecule profiles and may be a common factor in several smoking-induced diseases.

  Confidence 0.96

  박진우 (dztg5apj7m) extractionB (s683577b42) reviewAnonymous (12632b8b5f) reviewsijun-yang (m6hj47gh7t) review

• adhesion molecule profiles

  molecular profile

  The distribution and abundance of soluble adhesion-related molecules measured in circulation.

  Aliases: adhesion molecule pattern, circulating adhesion molecule profile

  박진우 (dztg5apj7m) extractionB (s683577b42) reviewAnonymous (12632b8b5f) reviewsijun-yang (m6hj47gh7t) review
• leukocyte activation

  cellular process

  Activation of circulating white blood cells discussed in relation to smoking effects on adhesion.

  박진우 (dztg5apj7m) extractionB (s683577b42) reviewAnonymous (12632b8b5f) reviewsijun-yang (m6hj47gh7t) review
• neutrophil entrapment in the microvasculature

  cellular process, vascular process

  Retention of neutrophils within small blood vessels of the microcirculation.

  박진우 (dztg5apj7m) extractionB (s683577b42) reviewAnonymous (12632b8b5f) reviewsijun-yang (m6hj47gh7t) review
• scd44 variants

  molecule

  Soluble circulating isoforms of the adhesion receptor CD44.

  Aliases: sCD44

  박진우 (dztg5apj7m) extractionB (s683577b42) reviewAnonymous (12632b8b5f) reviewsijun-yang (m6hj47gh7t) review
• soluble intercellular adhesion molecule-1

  molecule

  A soluble circulating form of intercellular adhesion molecule-1.

  Aliases: sICAM-1

  박진우 (dztg5apj7m) extractionB (s683577b42) reviewAnonymous (12632b8b5f) reviewsijun-yang (m6hj47gh7t) review
• tobacco smoking

  exposure

  Exposure to tobacco smoke considered as the environmental factor under review.

  Aliases: cigarette smoking, smoking

  박진우 (dztg5apj7m) extractionB (s683577b42) reviewAnonymous (12632b8b5f) reviewsijun-yang (m6hj47gh7t) review

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