Divergent skeletal muscle respiratory capacities in rats artificially selected for high and low running ability: a role for Nor1?

No abstract is available for this paper.

• Publication year

  2012

• Venue

  Journal of applied physiology

• Publication date

  2012-11-01

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.1152/japplphysiol.00788.2012PMID 22936731PMCID PMC3524666
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Measurement of mitochondrial DNA copy number.

  2012cited by this paper
• Utility of array CGH in molecular diagnosis of mitochondrial disorders.

  2012cited by this paper
• Assay to measure oxidized and reduced forms of CoQ by LC-MS/MS.

  2012cited by this paper
• Skeletal muscle respiratory capacity is enhanced in rats consuming an obesogenic Western diet.

  2012cited by this paper
• A PGC1–α–dependent myokine that drives brown–fat–like development of white fat and thermogenesis

  2012influential reference
• The nuclear receptor, Nor-1, markedly increases type II oxidative muscle fibers and resistance to fatigue.

  2012cited by this paper
• High-resolution respirometry: OXPHOS protocols for human cells and permeabilized fibers from small biopsies of human muscle.

  2012cited by this paper
• The nuclear orphan receptor Nur77 is a lipotoxicity sensor regulating glucose-induced insulin secretion in pancreatic β-cells.

  2012influential reference
• A PGC1α-dependent myokine that drives browning of white fat and thermogenesis

  2012cited by this paper
• Intrinsic Aerobic Capacity Sets a Divide for Aging and Longevity

  2011cited by this paper
• Lower oxidative DNA damage despite greater ROS production in muscles from rats selectively bred for high running capacity.

  2011influential reference
• Low intrinsic running capacity is associated with reduced skeletal muscle substrate oxidation and lower mitochondrial content in white skeletal muscle.

  2011influential reference
• Exercise training reverses impaired skeletal muscle metabolism induced by artificial selection for low aerobic capacity.

  2011influential reference
• Spontaneous activity, economy of activity, and resistance to diet-induced obesity in rats bred for high intrinsic aerobic capacity.

  2010cited by this paper
• Skeletal muscle mitochondrial and metabolic responses to a high-fat diet in female rats bred for high and low aerobic capacity.

  2010influential reference
• Minireview: Nuclear hormone receptor 4A signaling: implications for metabolic disease.

  2010influential reference
• Phenotypic and evolutionary plasticity of body composition in rats selectively bred for high endurance capacity.

  2010cited by this paper
• Rats selectively bred for low aerobic capacity have reduced hepatic mitochondrial oxidative capacity and susceptibility to hepatic steatosis and injury

  2009cited by this paper
• Impaired skeletal muscle beta-adrenergic activation and lipolysis are associated with whole-body insulin resistance in rats bred for low intrinsic exercise capacity.

  2009influential reference
• Endurance Capacity, Not Body Size, Determines Physical Activity Levels: Role of Skeletal Muscle PEPCK

  2009cited by this paper
• Aerobic interval training vs. continuous moderate exercise in the metabolic syndrome of rats artificially selected for low aerobic capacity.

  2008cited by this paper
• Differences in Daily Energy Expenditure in Lean and Obese Women: The Role of Posture Allocation

  2008cited by this paper
• The orphan nuclear receptor, NOR-1, a target of beta-adrenergic signaling, regulates gene expression that controls oxidative metabolism in skeletal muscle.

  2008cited by this paper
• The energy expenditure of using a “walk-and-work” desk for office workers with obesity

  2007cited by this paper
• Role of Low Energy Expenditure and Sitting in Obesity, Metabolic Syndrome, Type 2 Diabetes, and Cardiovascular Disease

  2007cited by this paper
• Tissue-Specific Effects of Rosiglitazone and Exercise in the Treatment of Lipid-Induced Insulin Resistance

  2007cited by this paper
• Artificial selection for high-capacity endurance running is protective against high-fat diet-induced insulin resistance.

  2007influential reference
• Enhanced mitochondrial sensitivity to creatine in rats bred for high aerobic capacity.

  2006cited by this paper
• Central orexin sensitivity, physical activity, and obesity in diet-induced obese and diet-resistant rats.

  2006cited by this paper
• NR4A orphan nuclear receptors are transcriptional regulators of hepatic glucose metabolism

  2006cited by this paper
• Divergent Selection for Aerobic Capacity in Rats as a Model for Complex Disease1

  2005cited by this paper
• Interindividual Variation in Posture Allocation: Possible Role in Human Obesity

  2005cited by this paper
• Cardiovascular Risk Factors Emerge After Artificial Selection for Low Aerobic Capacity

  2005influential reference
• The AMP-activated protein kinase α2 catalytic subunit controls whole-body insulin sensitivity

  2003cited by this paper
• Muscle oxidative capacity is a better predictor of insulin sensitivity than lipid status.

  2003cited by this paper
• Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1

  2003cited by this paper
• PGC-1α-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes

  2003cited by this paper
• Time- and exercise-dependent gene regulation in human skeletal muscle

  2003cited by this paper
• Selected contribution: skeletal muscle capillarity and enzyme activity in rats selectively bred for running endurance.

  2003influential reference
• Exercise capacity and mortality among men referred for exercise testing.

  2002cited by this paper
• Artificial selection for intrinsic aerobic endurance running capacity in rats.

  2001cited by this paper
• Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method.

  2001cited by this paper
• Relationship between low cardiorespiratory fitness and mortality in normal-weight, overweight, and obese men.

  1999cited by this paper
• Suitability of 2-deoxyglucose for in vitro measurement of glucose transport activity in skeletal muscle.

  1994cited by this paper
• Mitochondrial respiratory parameters in cardiac tissue: a novel method of assessment by using saponin-skinned fibers.

  1987cited by this paper
• Activation of glucose transport in muscle by prolonged exposure to insulin. Effects of glucose and insulin concentrations.

  1986cited by this paper
• Blood flows within and among rat muscles as a function of time during high speed treadmill exercise.

  1983cited by this paper
• [1] Citrate synthase. [EC 4.1.3.7. Citrate oxaloacetate-lyase (CoA-acetylating)]

  1969cited by this paper
• The FASEB Journal express article 10.1096/fj.04-3149fje. Published online June 28, 2005. Analysis of global mRNA expression in human skeletal muscle during recovery from endurance exercise

  year unknowncited by this paper
• Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2 2 DD C T Method

  year unknowncited by this paper

• Inactivity-induced NR4A3 downregulation in human skeletal muscle affects glucose metabolism and translation: Insights from in vitro analysis

  2025cites this paper
• Exercise Training Differentially Affects Skeletal Muscle Mitochondria in Rats with Inherited High or Low Exercise Capacity

  2024cites this paper
• Identification and Analysis of Exercise-Related Gene Biomarkers in Sarcopenia

  2024cites this paper
• Shared and distinct adaptations to early-life exercise training based on inborn fitness

  2024cites this paper
• NR4A3 prevents diabetes induced atrial cardiomyopathy by maintaining mitochondrial energy metabolism and reducing oxidative stress

  2024cites this paper
• Mitochondria Transplantation: Rescuing Innate Muscle Bioenergetic Impairment in a Model of Aging and Exercise Intolerance

  2024cites this paper
• Downregulation of NR4A3 during inactivity alters glucose metabolism and impairs translation in human skeletal muscle

  2024cites this paper
• Higher mitochondrial oxidative capacity is the primary molecular differentiator in muscle of rats with high and low intrinsic cardiorespiratory fitness

  2023cites this paper
• Loss of NOR‐1 represses muscle metabolism through mTORC1‐mediated signaling and mitochondrial gene expression in C2C12 myotubes

  2023cites this paper
• Parental cardiorespiratory fitness influences early life energetics and metabolic health.

  2023cites this paper
• Rats bred for low intrinsic aerobic exercise capacity link obesity with brain inflammation and reduced structural plasticity of the hippocampus.

  2021cites this paper
• Interactive effects of aging and aerobic capacity on energy metabolism–related metabolites of serum, skeletal muscle, and white adipose tissue

  2020cites this paper
• Targeting Orphan Nuclear Receptors NR4As for Energy Homeostasis and Diabetes

  2020cites this paper
• Transcriptomic profiling of skeletal muscle adaptations to exercise and inactivity

  2019cites this paper
• Expression of microRNAs and target proteins in skeletal muscle of rats selectively bred for high and low running capacity of microRNAs target proteins in skeletal muscle of rats selectively bred for high and low running capacity. Physiology-Endocrinology

  2019cites this paper
• Physiological and Biochemical Effects of Intrinsically High and Low Exercise Capacities Through Multiomics Approaches

  2019cites this paper
• Function of Nr4a Orphan Nuclear Receptors in Proliferation, Apoptosis and Fuel Utilization Across Tissues

  2019influential citation
• Rats Genetically Selected for Low and High Aerobic Capacity Exhibit Altered Soleus Muscle Myofilament Functions.

  2019cites this paper
• Einfluss von Ausdauertraining auf die Mitochondrienfunktion von Ratten mit hoher und niedriger intrinsischer körperlicher Leistungsfähigkeit

  2018cites this paper
• Effect of aerobic training on baseline expression of signaling and respiratory proteins in human skeletal muscle

  2018cites this paper
• Running head: MicroRNA expression in high and low capacity runner rats Running Head: MicroRNA regulation in high and low running capacity rats

  2018cites this paper
• The Nuclear Receptor Nor-1 Is a Pleiotropic Regulator of Exercise-Induced Adaptations.

  2018cites this paper
• EFFECTS OF EXERCISE AND GENETICS ON SKELETAL MUSCLE LIPID METABOLISM WITH FOCUS ON THE LOCALIZATION AND ASSOCIATION OF LIPID DROPLETS, MITOCHONDRIA AND PLIN5

  2018cites this paper
• Exercise training reverse autonomic dysfunction and hypertension in rats fed with high-fat diet

  2017cites this paper
• Characterising and evaluating the efficacy of metabolic therapies for the treatment of Duchenne Muscular Dystrophy

  2017cites this paper
• Expression of microRNAs and target proteins in skeletal muscle of rats selectively bred for high and low running capacity.

  2017cites this paper
• Acute exercise alters skeletal muscle mitochondrial respiration and H2O2 emission in response to hyperinsulinemic-euglycemic clamp in middle-aged obese men

  2017cites this paper
• Exercise-induced irisin in bone and systemic irisin administration reveal new regulatory mechanisms of bone metabolism

  2017cites this paper
• Attempting to Compensate for Reduced Neuronal Nitric Oxide Synthase Protein with Nitrate Supplementation Cannot Overcome Metabolic Dysfunction but Rather Has Detrimental Effects in Dystrophin-Deficient mdx Muscle

  2016cites this paper
• - Cell deletion of Nr 4 a 1 and Nr 4 a 3 nuclear receptors impedes mitochondrial respiration and insulin secretion

  2016cites this paper
• β-Cell deletion of Nr4a1 and Nr4a3 nuclear receptors impedes mitochondrial respiration and insulin secretion.

  2016cites this paper
• Mitochondrial function and sirtuin expression in hippocampus of young and old high- and low-capacity runner rats

  2016cites this paper
• Effects of intrinsic aerobic capacity, aging and voluntary running on skeletal muscle sirtuins and heat shock proteins.

  2016cites this paper
• Nuclear receptor 4A (NR4A) family - orphans no more.

  2016cites this paper
• Regulation of skeletal muscle mitochondrial function by nuclear receptors: implications for health and disease.

  2015cites this paper
• Role of intrinsic aerobic capacity and ventilator-induced diaphragm dysfunction.

  2015cites this paper
• The NR4A nuclear receptors as potential targets for anti-aging interventions.

  2015cites this paper
• low-active mice Differential skeletal muscle proteome of high- and

  2015cites this paper
• Heat Shock Proteins: Treating Metabolic Disease by Turning up the Heat

  2015cites this paper
• Quantitative immunofluorescence microscopy of subcellular GLUT4 distribution in human skeletal muscle: effects of endurance and sprint interval training

  2014cites this paper
• Mitochondrial function in metabolic health: a genetic and environmental tug of war.

  2014cites this paper
• Conditional independence mapping of DIGE data reveals PDIA3 protein species as key nodes associated with muscle aerobic capacity

  2014cites this paper
• University of Birmingham Quantitative immunofluorescence microscopy of subcellular GLUT4 distribution in human skeletal muscle

  2014cites this paper
• Irisin Is Elevated in Skeletal Muscle and Serum of Mice Immediately after Acute Exercise

  2014cites this paper
• Differential skeletal muscle proteome of high- and low-active mice.

  2014cites this paper
• Leanness and heightened nonresting energy expenditure: role of skeletal muscle activity thermogenesis.

  2014cites this paper
• Locus Characterization and Gene Expression of Bovine FNDC5: Is the Myokine Irisin Relevant in Cattle?

  2014cites this paper
• Low intrinsic exercise capacity in rats predisposes to age-dependent cardiac remodeling independent of macrovascular function.

  2013cites this paper
• Mitochondrial function in metabolic health

  2013influential citation
• Transgenic muscle-specific Nor-1 expression regulates multiple pathways that effect adiposity, metabolism, and endurance.

  2013cites this paper
• Exercise training enhances white adipose tissue metabolism in rats selectively bred for low- or high-endurance running capacity.

  2013cites this paper
• cardiac remodeling independent of macrovascular function. 2

  2012cites this paper