Glutamate Cysteine Ligase (GCL) Transgenic and Gene‐Targeted Mice for Controlling Glutathione Synthesis

No abstract is available for this paper.

• Publication year

  2009

• Venue

  Current Protocols in Toxicology

• Publication date

  2009-02-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1002/0471140856.tx0616s39PMID 23045016
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Small Maf proteins in mammalian gene control: mere dimerization partners or dynamic transcriptional regulators?

  2008cited by this paper
• Heterodimerization with small Maf proteins enhances nuclear retention of Nrf2 via masking the NESzip motif.

  2008cited by this paper
• Modulating GSH Synthesis Using Glutamate Cysteine Ligase Transgenic and Gene-Targeted Mice

  2008cited by this paper
• Knock down of gamma-glutamylcysteine synthetase in rat causes acetaminophen-induced hepatotoxicity.

  2007cited by this paper
• Glutamate cysteine ligase modifier subunit deficiency and gender as determinants of acetaminophen-induced hepatotoxicity in mice.

  2007influential reference
• Organophosphorus insecticides chlorpyrifos and diazinon and oxidative stress in neuronal cells in a genetic model of glutathione deficiency.

  2007cited by this paper
• Hydrogen peroxide increases the activity of γ-glutamylcysteine synthetase in cultured Chinese hamster V79 cells

  2007cited by this paper
• Hepatocyte‐specific Gclc deletion leads to rapid onset of steatosis with mitochondrial injury and liver failure

  2007cited by this paper
• S-glutathionylation: indicator of cell stress and regulator of the unfolded protein response.

  2007cited by this paper
• Polymorphisms and Vascular Cognitive Impairment After Ischemic Stroke

  2007cited by this paper
• Knock Down of γ-Glutamylcysteine Synthetase in Rat Causes Acetaminophen-induced Hepatotoxicity*

  2007cited by this paper
• Acetaminophen-induced Liver Injury Is Attenuated in Male Glutamate-cysteine Ligase Transgenic Mice*

  2006influential reference
• Development of a fluorescence-based microtiter plate method for the measurement of glutathione in yeast.

  2006cited by this paper
• Glutamate Cysteine Ligase Catalysis

  2005cited by this paper
• Variable regulation of glutamate cysteine ligase subunit proteins affects glutathione biosynthesis in response to oxidative stress.

  2004cited by this paper
• Glutathione metabolism and its implications for health.

  2004cited by this paper
• Genetically altered mice to evaluate glutathione homeostasis in health and disease.

  2004cited by this paper
• Human glutamate cysteine ligase gene regulation through the electrophile response element.

  2004cited by this paper
• Induction of Glutathione Synthesis in Macrophages by Oxidized Low-Density Lipoproteins Is Mediated by Consensus Antioxidant Response Elements

  2003cited by this paper
• Fluorescence-based microtiter plate assay for glutamate-cysteine ligase activity.

  2003cited by this paper
• Initial Characterization of the Glutamate-Cysteine Ligase Modifier Subunit Gclm(−/−) Knockout Mouse

  2002cited by this paper
• Expression of glutamate‐cysteine ligase during mouse development

  2002cited by this paper
• Tissue specific changes in the expression of glutamate-cysteine ligase mRNAs in mice exposed to methylmercury.

  2001cited by this paper
• Knockout of the mouse glutamate cysteine ligase catalytic subunit (Gclc) gene: embryonic lethal when homozygous, and proposed model for moderate glutathione deficiency when heterozygous.

  2000cited by this paper
• Glutathione synthesis is essential for mouse development but not for cell growth in culture.

  2000cited by this paper
• Up-regulation of the human gamma-glutamylcysteine synthetase regulatory subunit gene involves binding of Nrf-2 to an electrophile responsive element.

  1999cited by this paper
• Development of gene-switch transgenic mice that inducibly express transforming growth factor beta1 in the epidermis.

  1999cited by this paper
• Up-regulation of the human gamma-glutamylcysteine synthetase regulatory subunit gene involves binding of Nrf-2 to an electrophile responsive element.

  1999cited by this paper
• Cellular response to cancer chemopreventive agents: contribution of the antioxidant responsive element to the adaptive response to oxidative and chemical stress.

  1999cited by this paper
• Oxidative stress induced in pathologies: the role of antioxidants.

  1999cited by this paper
• Overlapping antioxidant response element and PMA response element sequences mediate basal and beta-naphthoflavone-induced expression of the human gamma-glutamylcysteine synthetase catalytic subunit gene.

  1998cited by this paper
• An electrophile responsive element (EpRE) regulates beta-naphthoflavone induction of the human gamma-glutamylcysteine synthetase regulatory subunit gene. Constitutive expression is mediated by an adjacent AP-1 site.

  1998cited by this paper
• An electrophile responsive element (EpRE) regulates beta-naphthoflavone induction of the human gamma-glutamylcysteine synthetase regulatory subunit gene. Constitutive expression is mediated by an adjacent AP-1 site.

  1998cited by this paper
• Expression of Glutathione and γ-Glutamylcysteine Synthetase mRNA Is Jun Dependent

  1997cited by this paper
• Expression of glutathione and gamma-glutamylcysteine synthetase mRNA is Jun dependent.

  1997cited by this paper
• Menadione causes increases in the level of glutathione and in the activity of gamma-glutamylcysteine synthetase in cultured Chinese hamster V79 cells.

  1996cited by this paper
• Regulation of gamma-glutamylcysteine synthetase by protein phosphorylation.

  1996cited by this paper
• Selective modification of glutathione metabolism.

  1983cited by this paper
• Heterodimerization with Small Maf Proteins Enhances Nuclear Retention of Nrf2 via Masking the Neszip Motif

  year unknowncited by this paper

• Primary tissue metabolic fingerprinting for efficient diagnosis of lymph node metastasis and metabolic reprogramming mechanisms in colorectal cancer

  2025cites this paper
• Molecular responses and mechanisms of the sea cucumber Apostichopus japonicus under prolonged hypoxic conditions.

  2025cites this paper
• Dose–response relationship in the modeling acute toxic hepatitis in vivo as a basis for identifying new correction strategies

  2025cites this paper
• Carnosol ameliorated cancer cachexia-associated myotube atrophy by targeting P5CS and its downstream pathways

  2024cites this paper
• Clinical Research Progress of Small Molecule Compounds Targeting Nrf2 for Treating Inflammation-Related Diseases

  2022cites this paper
• All-trans retinoic acid inhibits the malignant behaviors of hepatocarcinoma cells by regulating ferroptosis

  2022cites this paper
• Regulation of Antioxidant Stress-Responsive Transcription Factor Nrf2 Target Gene in the Reduction of Radiation Damage by the Thrombocytopenia Drug Romiplostim.

  2020cites this paper
• Glutathione monoethyl ester prevents TDP‐43 pathology in motor neuronal NSC‐34 cells

  2018cites this paper
• Novel Protective Role of Nicotinamide Phosphoribosyltransferase in Acetaminophen-Induced Acute Liver Injury in Mice.

  2018cites this paper
• Arsenic responsive microRNAs in vivo and their potential involvement in arsenic-induced oxidative stress.

  2015cites this paper