Notch1 is required for neuronal and glial differentiation in the cerebellum.

No abstract is available for this paper.

• Publication year

  2002

• Venue

  Development

• Publication date

  2002-01-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1242/DEV.129.2.373PMID 11807030
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Notch1 and Notch3 instructively restrict bFGF-responsive multipotent neural progenitor cells to an astroglial fate.

  2001cited by this paper
• Notch and the birth of glial cells.

  2001cited by this paper
• Roles of the Basic Helix-Loop-Helix Genes Hes1 and Hes5 in Expansion of Neural Stem Cells of the Developing Brain*

  2001cited by this paper
• An instructive function for Notch in promoting gliogenesis in the zebrafish retina.

  2001cited by this paper
• A highly efficient ligand‐regulated Cre recombinase mouse line shows that LoxP recombination is position dependent

  2001cited by this paper
• The Basic Helix-Loop-Helix Gene hesr2 Promotes Gliogenesis in Mouse Retina

  2001cited by this paper
• Neural bHLH genes control the neuronal versus glial fate decision in cortical progenitors.

  2001cited by this paper
• Nuclear Notch1 signaling and the regulation of dendritic development

  2000cited by this paper
• Transient Notch activation initiates an irreversible switch from neurogenesis to gliogenesis by neural crest stem cells.

  2000cited by this paper
• Radial glial identity is promoted by Notch1 signaling in the murine forebrain.

  2000cited by this paper
• Hes genes regulate sequential stages of neurogenesis in the olfactory epithelium.

  2000cited by this paper
• Notch and presenilins in vertebrates and invertebrates: implications for neuronal development and degeneration.

  2000cited by this paper
• Timing of CNS cell generation: a programmed sequence of neuron and glial cell production from isolated murine cortical stem cells.

  2000cited by this paper
• A common enzyme connects notch signaling and Alzheimer's disease.

  2000cited by this paper
• rax, Hes1, and notch1 promote the formation of Müller glia by postnatal retinal progenitor cells.

  2000cited by this paper
• Fate determination of neural crest cells by NOTCH-mediated lateral inhibition and asymmetrical cell division during gangliogenesis.

  2000cited by this paper
• FGF8 induces formation of an ectopic isthmic organizer and isthmocerebellar development via a repressive effect on Otx2 expression.

  1999cited by this paper
• Control of neuronal precursor proliferation in the cerebellum by Sonic Hedgehog.

  1999cited by this paper
• Generalized lacZ expression with the ROSA26 Cre reporter strain

  1999cited by this paper
• Contact-dependent inhibition of cortical neurite growth mediated by notch signaling.

  1999influential reference
• NUMB localizes in the basal cortex of mitotic avian neuroepithelial cells and modulates neuronal differentiation by binding to NOTCH-1.

  1999cited by this paper
• Autonomous and non-autonomous regulation of mammalian neurite development by Notch1 and Delta1.

  1999cited by this paper
• Notch Signaling : Cell Fate Control and Signal Integration in Development

  1999cited by this paper
• Notch signaling: cell fate control and signal integration in development.

  1999cited by this paper
• Purkinje-cell-derived Sonic hedgehog regulates granule neuron precursor cell proliferation in the developing mouse cerebellum.

  1999cited by this paper
• FGF 8 induces formation of an ectopic isthmic organizer and isthmocerebellar development via a repressive effect on Otx 2 expression

  1999cited by this paper
• Deficient T cell fate specification in mice with an induced inactivation of Notch1.

  1999cited by this paper
• Notch1 inhibits neurite outgrowth in postmitotic primary neurons.

  1999cited by this paper
• Sonic hedgehog regulates the growth and patterning of the cerebellum.

  1999cited by this paper
• Generation of cerebellar granule neurons in vivo by transplantation of BMP-treated neural progenitor cells

  1999cited by this paper
• Fate mapping of the mouse midbrain-hindbrain constriction using a site-specific recombination system.

  1998influential reference
• Stem cells of the central nervous system.

  1998cited by this paper
• Roles for proteolysis and trafficking in notch maturation and signal transduction.

  1998cited by this paper
• A growing family of Notch ligands.

  1998cited by this paper
• In situ hybridization: a practical approach

  1998cited by this paper
• Math 1 is essential forgenesis of cerebellargranuleneurons

  1997cited by this paper
• Regulation of neuronal diversity in the Xenopus retina by Delta signalling

  1997cited by this paper
• The LIN-12/Notch signaling pathway and its regulation.

  1997cited by this paper
• FGF2 concentration regulates the generation of neurons and glia from multipotent cortical stem cells.

  1997cited by this paper
• Delta-1 is a regulator of neurogenesis in the vertebrate retina.

  1997cited by this paper
• A PDGF-regulated immediate early gene response initiates neuronal differentiation in ventricular zone progenitor cells.

  1997influential reference
• Genes involved in cerebellar cell specification and differentiation.

  1997cited by this paper
• Notch in vertebrates.

  1997cited by this paper
• Neuroepithelial stem cells from the embryonic spinal cord: isolation, characterization, and clonal analysis.

  1997cited by this paper
• Basic helix-loop-helix genes in neural development.

  1997cited by this paper
• Stem Cells in the Central Nervous System

  1997cited by this paper
• Early mesencephalon/metencephalon patterning and development of the cerebellum.

  1997cited by this paper
• Math1 is essential for genesis of cerebellar granule neurons

  1997cited by this paper
• Conservation of the Notch signalling pathway in mammalian neurogenesis.

  1997cited by this paper
• Mouse Dll3: a novel divergent Delta gene which may complement the function of other Delta homologues during early pattern formation in the mouse embryo.

  1997cited by this paper
• Maintenance of neuroepithelial progenitor cells by Delta-Notch signalling in the embryonic chick retina.

  1997cited by this paper
• Single factors direct the differentiation of stem cells from the fetal and adult central nervous system.

  1996cited by this paper
• Clonal and population analyses demonstrate that an EGF-responsive mammalian embryonic CNS precursor is a stem cell.

  1996cited by this paper
• Development of the Cerebellar System: In Relation to Its Evolution, Structure, and Functions

  1996cited by this paper
• The Choice

  1996cited by this paper
• Notch1 is required for the coordinate segmentation of somites.

  1995cited by this paper
• Primary neurogenesis in Xenopus embryos regulated by a homologue of the Drosophila neurogenic gene Delta

  1995cited by this paper
• Isolation, characterization, and use of stem cells from the CNS.

  1995cited by this paper
• Vertebrate retinal ganglion cells are selected from competent progenitors by the action of Notch.

  1995cited by this paper
• Abnormal embryonic cerebellar development and patterning of postnatal foliation in two mouse Engrailed-2 mutants.

  1994cited by this paper
• Delta-notch signaling and Drosophila cell fate choice.

  1994cited by this paper
• Notch1 is essential for postimplantation development in mice.

  1994cited by this paper
• bFGF regulates the proliferative fate of unipotent (neuronal) and bipotent (neuronal/astroglial) EGF-generated CNS progenitor cells.

  1993cited by this paper
• Expression of an extracellular deletion of Xotch diverts cell fate in Xenopus embryos.

  1993cited by this paper
• Dynamic expression of the murine Achaete-Scute homologue Mash-1 in the developing nervous system.

  1993cited by this paper
• Wholemount in situ hybridization of vertebrate embryos

  1992cited by this paper
• Generation of neurons and astrocytes from isolated cells of the adult mammalian central nervous system.

  1992cited by this paper
• Expression analysis of a Notch homologue in the mouse embryo.

  1992cited by this paper
• Expression pattern of Motch, a mouse homolog of Drosophila Notch, suggests an important role in early postimplantation mouse development.

  1992cited by this paper
• The choice of cell fate in the epidermis of Drosophila.

  1991cited by this paper
• A homolog of Drosophila Notch expressed during mammalian development.

  1991cited by this paper
• Embryonic development of the rat cerebellum. III. Regional differences in the time of origin, migration, and settling of Purkinje cells

  1985cited by this paper
• EXPRESSION OF

  year unknowncited by this paper

• Differential Hes1 activation defines neural stem cell lineage commitment and niche maintenance in embryonic and adult mouse cortex

  2026cites this paper
• Developing zebrafish models of Notch-related CNS pathologies.

  2025cites this paper
• Unraveling the role of MAG, PTEN, and NOTCH1 in axonal regeneration: a network analysis and molecular dynamics study of siRNA/drugs/nanocarriers interactions

  2025cites this paper
• NOTCH1-STAT3 signaling axis regulates astrocytic differentiation of hippocampal neural stem/progenitor cells.

  2025cites this paper
• Functional Divergence of NOTCH1 and NOTCH2 in Human Cerebral Organoids Reveals Receptor-Specific Roles in Early Corticogenesis

  2025cites this paper
• Childhood cancer mutagenesis caused by transposase-derived PGBD5

  2024cites this paper
• "Tumor Treating Fields" delivered via electromagnetic induction have varied effects across glioma cell lines and electric field amplitudes.

  2024cites this paper
• Impaired neurogenesis induced by fluoride via the Notch1 signaling and effects of carvacrol intervention.

  2024cites this paper
• “Tumor Treating Fields” delivered via electromagnetic induction have varied effects across glioma cell lines and electric field amplitudes

  2023cites this paper
• Advances of Genome Editing with CRISPR/Cas9 in Neurodegeneration: The Right Path towards Therapy

  2023cites this paper
• Amyloid Precursor Protein (APP) Regulates Gliogenesis and Neurogenesis of Human Neural Stem Cells by Several Signaling Pathways

  2023cites this paper
• ADAM10 mediates macroglial cell fate decisions in the developing brain

  2023cites this paper
• Cross-sectional proteomic expression in Parkinson's disease-related proteins in drug-naïve patients vs healthy controls with longitudinal clinical follow-up.

  2023cites this paper
• Disorders of the central nervous system: Insights from Notch and Nrf2 signaling.

  2023cites this paper
• Propofol-Induced Developmental Neurotoxicity: From Mechanisms to Therapeutic Strategies.

  2023cites this paper
• The Roles of Histamine Receptor 1 (hrh1) in Neurotransmitter System Regulation, Behavior, and Neurogenesis in Zebrafish

  2023cites this paper
• Dbx1 controls the development of astrocytes of the intermediate spinal cord by modulating Notch signaling

  2022cites this paper
• Gastrodin Regulates the Notch-1 Signal Pathway via Renin–Angiotensin System in Activated Microglia

  2022cites this paper
• The subcommissural organ maintains features of neuroepithelial cells in the adult mouse

  2022cites this paper
• Molecular mechanisms of developmental pathways in neurological disorders: a pharmacological and therapeutic review

  2022cites this paper
• Insm1-expressing neurons and secretory cells develop from a common pool of progenitors in the sea anemone Nematostella vectensis

  2021cites this paper
• Implications of FBXW7 in Neurodevelopment and Neurodegeneration: Molecular Mechanisms and Therapeutic Potential

  2021cites this paper
• A narrative review of the impact of cerebellar dysfunction and sleep disturbances after general anesthesia in patients with Alzheimer's disease.

  2021cites this paper
• Transcriptome programs involved in the development and structure of the cerebellum

  2021cites this paper
• The role of Extracellular Vesicles during CNS development.

  2021cites this paper
• Genes and Cell Type Specification in Cerebellar Development

  2021cites this paper
• Non-Syndromic Intellectual Disability and Its Pathways: A Long Noncoding RNA Perspective

  2021cites this paper
• Danzhi Xiaoyao Powder Promotes Neuronal Regeneration by Downregulating Notch Signaling Pathway in the Treatment of Generalized Anxiety Disorder

  2021cites this paper
• Potential roles of stem cell marker genes in axon regeneration

  2021cites this paper
• De novo damaging variants associated with congenital heart diseases contribute to the connectome

  2020cites this paper
• Adult neurogenesis and the molecular signalling pathways in brain: the role of stem cells in adult hippocampal neurogenesis

  2020cites this paper
• Gastrodin Regulates the Notch Signaling Pathway and Sirt3 in Activated Microglia in Cerebral Hypoxic-Ischemia Neonatal Rats and in Activated BV-2 Microglia

  2020cites this paper
• Notch Signaling and Embryonic Development: An Ancient Friend, Revisited.

  2020cites this paper
• Notch Dosage: Jagged1 Haploinsufficiency Is Associated With Reduced Neuronal Division and Disruption of Periglomerular Interneurons in Mice

  2020cites this paper
• Inhibition of Notch1 signaling promotes neuronal differentiation and improves functional recovery in spinal cord injury through suppressing the activation of Ras homolog family member A

  2019cites this paper
• Deficiency of Fhl2 leads to delayed neuronal cell migration and premature astrocyte differentiation

  2019cites this paper
• The Role of a Neurovascular Signaling Pathway Involving Hypoxia-Inducible Factor and Notch in the Function of the Central Nervous System

  2019cites this paper
• Nuclear factor I-A regulates diverse reactive astrocyte responses after CNS injury.

  2019cites this paper
• Mesenchymal stem cells alleviate the early brain injury of subarachnoid hemorrhage partly by suppression of Notch1-dependent neuroinflammation: involvement of Botch

  2019cites this paper
• Systems Biology-Based Analysis Indicates Global Transcriptional Impairment in Lead-Treated Human Neural Progenitor Cells

  2019cites this paper
• Molecular mechanisms involved in the cerebral cortex development and their implications in neurodevelopmental disorders

  2019influential citation
• The Orphan Nuclear Receptor TLX Represses Hes1 Expression, Thereby Affecting NOTCH Signaling and Lineage Progression in the Adult SEZ

  2019cites this paper
• Etude du rôle de la voie NOTCH dans la régulation de Shh au cours du développement du cerveau antérieur chez les vertébrés

  2019cites this paper
• Emerging Role of Cellular Prion Protein in the Maintenance and Expansion of Glioma Stem Cells †

  2019cites this paper
• The Role of Astrocytes in the Development of the Cerebellum

  2019cites this paper
• 1. Stem Cells

  2019cites this paper
• Probing transcriptional specificities and fate potential of postnatal neural progenitors in the mouse forebrain

  2018cites this paper
• Dietary polyphenols and neurogenesis: Molecular interactions and implication for brain ageing and cognition

  2018cites this paper
• 15 Regulation of Glioma Stem Cells by the Notch Signaling Pathway : Mechanisms and Therapeutic Implications

  2018cites this paper
• Rer1-mediated quality control system is required for neural stem cell maintenance during cerebral cortex development

  2018cites this paper
• Maternal marginal iodine deficiency delays cerebellar Bergmann glial cell development in rat offspring: Involvement of Notch signaling pathway

  2018cites this paper
• Impaired neuronal maturation of hippocampal neural progenitor cells in mice lacking CRAF

  2018cites this paper
• Notch and Neurogenesis.

  2018cites this paper
• Untangling Cortical Complexity During Development

  2018cites this paper
• Epigenetic Regulation of Human Neural Stem Cell Differentiation.

  2018cites this paper
• Maternal Consumption of High-fat Diet in Mice Alters Hypothalamic Notch Pathway, NPY Cell Population and Food Intake in Offspring.

  2018cites this paper
• Transcriptional Regulator ZEB2 Is Essential for Bergmann Glia Development

  2018cites this paper
• Notch and Stem Cells.

  2018cites this paper
• The role of Notch signaling pathway in mechanical stimulation of infrasound altering activities of bone marrow mesenchymal stem cells

  2017cites this paper
• Differential interactions between Notch and ID factors control neurogenesis by modulating Hes factor autoregulation

  2017cites this paper
• Zfp423/ZNF423 regulates cell cycle progression, the mode of cell division and the DNA-damage response in Purkinje neuron progenitors

  2017cites this paper
• Development of the Nervous System

  2017cites this paper
• Notch: an interactive player in neurogenesis and disease

  2017influential citation
• Propofol Exposure in Early Life Induced Developmental Impairments in the Mouse Cerebellum

  2017cites this paper
• Lunatic fringe-mediated Notch signaling regulates adult hippocampal neural stem cell maintenance

  2017cites this paper
• Embryonic development of selectively vulnerable neurons in Parkinson’s disease

  2017cites this paper
• Abnormal differentiation of Sandhoff disease model mouse-derived multipotent stem cells toward a neural lineage

  2017cites this paper
• Mechanism underlying PTBP1-mediated alternative pre-mRNA splicing in regulating tissue-specific gene expression

  2016cites this paper
• Notch signaling balances adult neural stem cell quiescence and heterogeneity

  2016cites this paper
• Embryonic origin and lineage hierarchies of the neural progenitor subtypes building the zebrafish adult midbrain

  2016cites this paper
• Regulation of differentiation flux by Notch signalling influences the number of dopaminergic neurons in the adult brain

  2016cites this paper
• Regulating Axonal Responses to Injury: The Intersection between Signaling Pathways Involved in Axon Myelination and The Inhibition of Axon Regeneration

  2016cites this paper
• Reciprocal Regulation between Bifunctional miR-9/9∗ and its Transcriptional Modulator Notch in Human Neural Stem Cell Self-Renewal and Differentiation

  2016cites this paper
• A comparative view of regenerative neurogenesis in vertebrates

  2016cites this paper
• DNA methylation and cerebellar development, the regulation of Notch and Shh pathway

  2016cites this paper
• COUP-TFI is required in the differentiation and migration of granule cells in the developing dentate gyrus

  2015cites this paper
• Fundamentals of Neurogenesis and Neural Stem Cell Development

  2015cites this paper
• Cancer stem cell targeting: Are we there yet?

  2015cites this paper
• Scutellarin regulates the Notch pathway and affects the migration and morphological transformation of activated microglia in experimentally induced cerebral ischemia in rats and in activated BV-2 microglia

  2015cites this paper
• Targeting Tumor Initiating Cells through Inhibition of Cancer Testis Antigens and Notch Signaling: A Hypothesis

  2015cites this paper
• Neurofibromatosis-1 regulation of neural stem cell proliferation and multilineage differentiation operates through distinct RAS effector pathways

  2015cites this paper
• Zinc-finger and helix-loop-helix transcription factors regulate Purkinje neuron neurogenesis and cerebellar corticogenesis

  2015cites this paper
• Jagged1 is necessary for postnatal and adult neurogenesis in the dentate gyrus.

  2014cites this paper
• Molecular Regulators of Stem Cell Fate and Tumor Development in the Cerebellum

  2014cites this paper
• Notch Signaling Mediates Tumor-CAF Crosstalk in Basal-like Breast Cancer

  2014cites this paper
• THE APICAL POLARITY COMPLEX PROTEIN, PALS1, REGULATES CELL FATE IN THE DEVELOPMENT OF CEREBELLUM AND NEOCORTEX

  2014cites this paper
• Cellular commitment in the developing cerebellum

  2014cites this paper
• Notch1 mediates postnatal neurogenesis in hippocampus enhanced by intermittent hypoxia.

  2014cites this paper
• An increase in MECP2 dosage impairs neural tube formation.

  2014cites this paper
• Notch pathway regulates female germ cell meiosis progression and early oogenesis events in fetal mouse

  2014cites this paper
• Deregulated proliferation and differentiation in brain tumors

  2014cites this paper
• Notch-1 Signaling Regulates Microglia Activation via NF-κB Pathway after Hypoxic Exposure In Vivo and In Vitro

  2013cites this paper
• α-Tanycytes of the adult hypothalamic third ventricle include distinct populations of FGF-responsive neural progenitors

  2013cites this paper
• Bergmann Glia Function in Granule Cell Migration During Cerebellum Development

  2013cites this paper
• Emerging common molecular pathways for primary dystonia

  2013cites this paper
• Stem cells living with a Notch

  2013cites this paper
• Origin, lineage and function of cerebellar glia.

  2013cites this paper
• Notch signaling in the central nervous system with special reference to its expression in microglia.

  2013cites this paper
• What underlies the diversity of brain tumors?

  2013cites this paper
• Interactions between VEGFR and Notch signaling pathways in endothelial and neural cells

  2013cites this paper