Drosophila shaggy kinase and rat glycogen synthase kinase-3 have conserved activities and act downstream of Notch

No abstract is available for this paper.

• Publication year

  1993

• Venue

  Nature

• Publication date

  1993-04-08

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/362557A0PMID 8385271
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Activation of protein kinase C increases phosphorylation of the L-myc trans-activator domain at a GSK-3 target site.

  1992cited by this paper
• Regulation of proneural gene expression and cell fate during neuroblast segregation in the Drosophila embryo.

  1992cited by this paper
• Making a difference: The role of cell-cell interactions in establishing separate identities for equivalent cells

  1992cited by this paper
• Activation of protein kinase C decreases phosphorylation of c-Jun at sites that negatively regulate its DNA-binding activity.

  1991cited by this paper
• TAN-1, the human homolog of the Drosophila notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms.

  1991cited by this paper
• Specific EGF repeats of Notch mediate interactions with Delta and Serrate: implications for Notch as a multifunctional receptor.

  1991cited by this paper
• The choice of cell fate in the epidermis of Drosophila.

  1991cited by this paper
• A common denominator linking glycogen metabolism, nuclear oncogenes and development.

  1991cited by this paper
• A homolog of Drosophila Notch expressed during mammalian development.

  1991cited by this paper
• Proneural clusters of achaete-scute expression and the generation of sensory organs in the Drosophila imaginal wing disc.

  1991cited by this paper
• Molecular cloning and expression of glycogen synthase kinase‐3/factor A.

  1990cited by this paper
• Putative protein kinase product of the Drosophila segment-polarity gene zeste-white3

  1990cited by this paper
• Proneural clusters: equivalence groups in the epithelium of Drosophila.

  1990cited by this paper
• Xotch, the Xenopus homolog of Drosophila notch.

  1990cited by this paper
• An early embryonic product of the gene shaggy encodes a serine/threonine protein kinase related to the CDC28/cdc2+ subfamily.

  1990cited by this paper
• A dual function of the Notch gene in Drosophila sensillum development.

  1990cited by this paper
• Mutant Drosophila embryos in which all cells adopt a neural fate

  1989cited by this paper
• A study of shaggy reveals spatial domains of expression of achaete-scute alleles on the thorax of Drosophila.

  1989cited by this paper
• From DNA to form: the achaete-scute complex.

  1988cited by this paper
• Mutations altering the structure of epidermal growth factor-like coding sequences at the Drosophila Notch locus.

  1987cited by this paper
• Sequence of the notch locus of Drosophila melanogaster: relationship of the encoded protein to mammalian clotting and growth factors

  1986cited by this paper
• Early events in insect neurogenesis. II. The role of cell interactions and cell lineage in the determination of neuronal precursor cells.

  1985cited by this paper
• Nucleotide sequence from the neurogenic locus notch implies a gene product that shares homology with proteins containing EGF-like repeats.

  1985cited by this paper
• Local and General Factors in the Development of "Pattern" in Rhodnius Prolixus (Hemiptera)

  1940cited by this paper

• Decoding 'Wntch': the intertwined Wnt and Notch pathways in development and disease.

  2026cites this paper
• Shaggy regulates tissue growth through Hippo pathway in Drosophila

  2022cites this paper
• GSK3α phosphorylates dynamin-2 to promote GLUT4 endocytosis in muscle cells

  2022cites this paper
• Insulin Signaling Attenuates GLUT4 Endocytosis in Muscle Cells via GSK3α-Dyn2-Bin1 Interplay

  2021cites this paper
• GSK-3 and Tau: A Key Duet in Alzheimer’s Disease

  2021cites this paper
• GSK3β Interacts With CRMP2 and Notch1 and Controls T-Cell Motility

  2021cites this paper
• GSK3s: nodes of multilayer regulation of plant development and stress responses.

  2021cites this paper
• Glycogen Synthase Kinase 3 Gene Is Important in Growth and Molting of the Pacific White Shrimp Litopenaeus vannamei

  2021cites this paper
• The achaete-scute complex: generation of cellular pattern and#{149} fate within the Drosophila nervous system

  2020cites this paper
• GSK3α: An Important Paralog in Neurodegenerative Disorders and Cancer

  2020cites this paper
• Modulated Expression of the Protein Kinase GSK3 in Motor and Dopaminergic Neurons Increases Female Lifespan in Drosophila melanogaster

  2020cites this paper
• Glycogen synthase kinase (GSK) 3 in pregnancy and parturition: a systematic review of literature

  2020influential citation
• Emerging Role of Plant GSK3/SHAGGY‐like Protein Kinases in Stress Signaling Pathways

  2020cites this paper
• Ubiquitin Ligases Involved in the Regulation of Wnt, TGF-β, and Notch Signaling Pathways and Their Roles in Mouse Development and Homeostasis

  2019cites this paper
• Characterisation of protein isoforms encoded by the Drosophila Glycogen Synthase Kinase 3 gene shaggy

  2019cites this paper
• Disordered Expression of shaggy, the Drosophila Gene Encoding a Serine-Threonine Protein Kinase GSK3, Affects the Lifespan in a Transcript-, Stage-, and Tissue-Specific Manner

  2019influential citation
• Cardiomyocyte-GSK-3α promotes mPTP opening and heart failure in mice with chronic pressure overload.

  2019cites this paper
• THE HALLMARKS OF GSK-3 IN MORPHOGENESIS AND EMBRYONIC DEVELOPMENT METABOLISM IN ARTHROPODS.

  2019cites this paper
• Emerging roles of GSK-3α in pathophysiology: Emphasis on cardio-metabolic disorders.

  2019cites this paper
• Inhibition of GSK-3 to induce cardiomyocyte proliferation: a recipe for in situ cardiac regeneration

  2018cites this paper
• Chapter 6 Regulation of Cell Fate in the Brain by GSK 3

  2018cites this paper
• Drosophila RSK Influences the Pace of the Circadian Clock by Negative Regulation of Protein Kinase Shaggy Activity

  2018cites this paper
• Retinoic Acid Receptor α Knockdown Suppresses the Tumorigenicity of Esophageal Carcinoma via Wnt/β-catenin Pathway

  2018cites this paper
• Differential expression of circadian clock genes in two strains of beetles reveals candidates related to photoperiodic induction of summer diapause.

  2017cites this paper
• Direct determination of GSK-3β activity and inhibition by UHPLC-UV-vis diode arrays detector (DAD).

  2016cites this paper
• LSK1, μια SHAGGY-like kinase με ρόλο στη φυματιογένεση του φυτού Lotus japonicus

  2016cites this paper
• Glycogen Synthase Kinase-3 is involved in glycogen metabolism control and embryogenesis of Rhodnius prolixus

  2016cites this paper
• Regulation of the protein kinase activity of ShaggyZeste-white3 by components of the Wingless pathway in Drosophila cells and embryos.

  2016cites this paper
• Notch pathway is activated in cell culture and mouse models of mutant SOD1-related familial amyotrophic lateral sclerosis, with suppression of its activation as an additional mechanism of neuroprotection for lithium and valproate.

  2015cites this paper
• Glycogen synthase kinase 3α regulates urine concentrating mechanism in mice.

  2015cites this paper
• Functional insights of plant GSK3-like kinases: multi-taskers in diverse cellular signal transduction pathways.

  2015cites this paper
• Phosphorylation of Serine422 increases the stability and transactivation activities of human Osterix

  2015cites this paper
• The Role of GSK in Ischaemic Organ Injury

  2015cites this paper
• Novel Biochemical Regulatory Mechanisms of Developmental Signaling Pathways

  2014cites this paper
• Cardiomyocyte-specific deletion of Gsk3α mitigates post-myocardial infarction remodeling, contractile dysfunction, and heart failure.

  2014cites this paper
• S/T Phosphorylation of DLL1 Is Required for Full Ligand Activity In Vitro but Dispensable for DLL1 Function In Vivo during Embryonic Patterning and Marginal Zone B Cell Development

  2014cites this paper
• Regulation of skeletal muscle plasticity by glycogen synthase kinase-3β: a potential target for the treatment of muscle wasting.

  2013cites this paper
• Regulation of Cell Fate in the Brain by GSK3

  2013cites this paper
• The β-catenin destruction complex.

  2013cites this paper
• Design of glycogen synthase kinase-3 inhibitors: an overview on recent advancements.

  2013cites this paper
• Reducing canonical Wingless/Wnt signaling pathway confers protection against mutant Huntingtin toxicity in Drosophila.

  2012cites this paper
• Enhanced drought and salt tolerance by expression of AtGSK1 gene in poplar

  2012cites this paper
• 10 The Role of Glycogen Synthase Kinase-3 ( GSK-3 ) in Alzheimer ’ s Disease

  2012cites this paper
• The regulation of mTORC2 kinase activity and complex integrity

  2012cites this paper
• The b -Catenin Destruction Complex

  2012influential citation
• Glycogen Synthase Kinase-3 in Neurological Diseases

  2012cites this paper
• Glycogen Synthase Kinase-3 Inhibition Promotes Proliferation and Neuronal Differentiation of Human-Induced Pluripotent Stem Cell-Derived Neural Progenitors

  2012cites this paper
• The structure of Wntch signalling and the resolution of transition states in development.

  2012cites this paper
• Development, characterisation and application of an inducible model of Alzheimer's Disease in the fruit fly, Drosophila melanogaster

  2012cites this paper
• The Role of Glycogen Synthase Kinase-3 (GSK-3) in Alzheimer’s Disease

  2011cites this paper
• Pho23 Regulates Gene Expression through Histone Methylation and an Mck1-controlled Pathway in Budding Yeast

  2011cites this paper
• Deconstructing GSK-3: The Fine Regulation of Its Activity

  2011cites this paper
• EVIDENCE FOR ALTERATED WNT AND NOTCH SIGNALING IN A H-PRUNE TRANSGENIC MOUSE MODEL DE VITA GENNARO

  2011cites this paper
• ER Stress Inhibits mTORC2 and Akt Signaling Through GSK-3β–Mediated Phosphorylation of Rictor

  2011cites this paper
• Modulation of the ligand-independent traffic of Notch by Axin and Apc contributes to the activation of Armadillo in Drosophila

  2011cites this paper
• Targeting GSK-3 family members in the heart: a very sharp double-edged sword.

  2011influential citation
• Associating GWAS Information with the Notch Signaling Pathway Using Transcription Profiling

  2011cites this paper
• NADPH Oxidase 1 Modulates WNT and NOTCH1 Signaling To Control the Fate of Proliferative Progenitor Cells in the Colon

  2010cites this paper
• Proliferative Progenitor Cells in the Colon NOTCH 1 Signaling To Control the Fate of NADPH Oxidase 1 Modulates WNT and

  2010cites this paper
• GSK-3alpha directly regulates beta-adrenergic signaling and the response of the heart to hemodynamic stress in mice.

  2010cites this paper
• Glycogen Synthase Kinase-3&bgr; Regulates Post–Myocardial Infarction Remodeling and Stress-Induced Cardiomyocyte Proliferation In Vivo

  2010cites this paper
• Inhibition of GSK-3 Ameliorates Aβ Pathology in an Adult-Onset Drosophila Model of Alzheimer's Disease

  2010cites this paper
• Gene regulation mechanisms by the transcriptional coregulator mastermind-like 1

  2009cites this paper
• Mediators of tau phosphorylation in the pathogenesis of Alzheimer’s disease

  2009cites this paper
• The role of GSK-3β in notch signalling in vascular smooth muscle cells

  2009influential citation
• Temporal and spatial windows delimit activation of the outer ring of wingless in the Drosophila wing.

  2009cites this paper
• The Novel Role of Interleukin-1 Receptor-Associated Kinase 1 in the Signaling Process Controlling Innate Immunity and Inflammation

  2009cites this paper
• Phosphorylation of glycogen synthase kinase-3beta in relation to diapause processing in the silkworm, Bombyx mori.

  2009cites this paper
• Notch signaling promotes the generation of EphrinB1-positive intestinal epithelial cells.

  2009cites this paper
• Unique and Overlapping Functions of GSK-3 Isoforms in Cell Differentiation and Proliferation and Cardiovascular Development*

  2009cites this paper
• Glycogen synthase kinase 3: more than a namesake

  2009cites this paper
• Notch-dependent cell cycle arrest and apoptosis in mouse embryonic fibroblasts lacking Fbxw7

  2008cites this paper
• The Drosophila gene zfh2 is required to establish proximal-distal domains in the wing disc.

  2008cites this paper
• Targeting glycogen synthase kinase-3 (GSK-3) in the treatment of Type 2 diabetes

  2008cites this paper
• A temporal switch from notch to Wnt signaling in muscle stem cells is necessary for normal adult myogenesis.

  2008cites this paper
• Alterations in the Notch4 pathway in cerebral endothelial cells by the HIV aspartyl protease inhibitor, nelfinavir

  2008cites this paper
• Functional redundancy of GSK-3α and GSK-3β in wnt/β-catenin signaling shown by using an allelic series of embryonic stem cell lines

  2007cites this paper
• Inositol pentakisphosphate mediates Wnt/beta-catenin signaling.

  2007cites this paper
• Functional redundancy of GSK-3alpha and GSK-3beta in Wnt/beta-catenin signaling shown by using an allelic series of embryonic stem cell lines.

  2007cites this paper
• The role of GSK3 in glucose homeostasis and the development of insulin resistance.

  2007cites this paper
• Similarities and differences between the Wnt and reelin pathways in the forming brain

  2007cites this paper
• Enhanced production and dendritic growth of new dentate granule cells in the middle‐aged hippocampus following intracerebroventricular FGF‐2 infusions

  2007cites this paper
• N Perrimon novel protein required for response to the wingless signal . The Drosophila segment polarity gene dishevelled encodes a

  2007cites this paper
• Inositol Pentakisphosphate Mediates Wnt/β-Catenin Signaling*

  2007cites this paper
• GSK3α exhibits β‐catenin and tau directed kinase activities that are modulated by Wnt

  2006cites this paper
• Stage‐dependent Dishevelled‐1 expression during mouse spermatogenesis suggests a role in regulating spermatid morphological changes

  2006cites this paper
• Cellular Notch responsiveness is defined by phosphoinositide 3-kinase-dependent signals

  2006cites this paper
• GSK3alpha exhibits beta-catenin and tau directed kinase activities that are modulated by Wnt.

  2006cites this paper
• HaCaT keratinocyte migration is dependent on epidermal growth factor receptor signaling and glycogen synthase kinase-3alpha.

  2006cites this paper
• The Drosophila microtubule associated protein Futsch is phosphorylated by Shaggy/Zeste-white 3 at an homologous GSK3beta phosphorylation site in MAP1B.

  2006cites this paper
• Notch modulates Wnt signalling by associating with Armadillo/β-catenin and regulating its transcriptional activity

  2005cites this paper
• Drosophila caspase transduces Shaggy/GSK‐3β kinase activity in neural precursor development

  2005cites this paper
• Organization and Expression of the GSK3/Shaggy Kinase Gene Family in the Moss Physcomitrella patens Suggest Early Gene Multiplication in Land Plants and an Ancestral Response to Osmotic Stress

  2005cites this paper
• The role of cryptochrome in the drosophila circadian clock

  2005cites this paper
• Segmentation in vertebrates: clock and gradient finally joined.

  2004cites this paper
• Characterization of three novel members of the Arabidopsis SHAGGY-related protein kinase (ASK) multigene family

  2004cites this paper
• Functional Studies of Shaggy/Glycogen Synthase Kinase 3 Phosphorylation Sites in Drosophila melanogaster

  2004cites this paper
• Phosphatidylinositol 3-Kinase Signaling Is Involved in Neurogenesis during Xenopus Embryonic Development*

  2004cites this paper
• Notch 1 signaling regulates peripheral T cell activation.

  2004cites this paper
• Characterisation of Aardvark, a Dictyostelium ß-catenin

  2003cites this paper