Tilting of the light-chain region of myosin during step length changes and active force generation in skeletal muscle

No abstract is available for this paper.

• Publication year

  1995

• Venue

  Nature

• Publication date

  1995-06-22

• Fields of study

  Biology, Medicine, Physics, Chemistry

• Identifiers
  DOI 10.1038/375688A0PMID 7791902
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The mechanism of muscular contraction.

  2002cited by this paper
• Elastic distortion of myosin heads and repriming of the working stroke in muscle

  1995cited by this paper
• Structure of the regulatory domain of scallop myosin at 2.8 Ä resolution

  1994cited by this paper
• Single myosin molecule mechanics: piconewton forces and nanometre steps

  1994cited by this paper
• Single-molecule analysis of the actomyosin motor using nano-manipulation.

  1994cited by this paper
• Synthesis and characterisation of pure isomers of iodoacetamidotetramethylrhodamine

  1994cited by this paper
• Structure of the actin-myosin complex and its implications for muscle contraction.

  1993cited by this paper
• Skeletal muscle myosin light chains are essential for physiological speeds of shortening

  1993cited by this paper
• Myosin head movements are synchronous with the elementary force-generating process in muscle

  1992cited by this paper
• Chimeric myosin regulatory light chains identify the subdomain responsible for regulatory function.

  1992cited by this paper
• Rapid regeneration of the actin-myosin power stroke in contracting muscle

  1992cited by this paper
• Force and stiffness in glycerinated rabbit psoas fibers. Effects of calcium and elevated phosphate

  1992cited by this paper
• Transients in orientation of a fluorescent cross-bridge probe following photolysis of caged nucleotides in skeletal muscle fibres.

  1992cited by this paper
• Sliding distance between actin and myosin filaments per ATP molecule hydrolysed in skinned muscle fibres

  1991cited by this paper
• The contractile response during steady lengthening of stimulated frog muscle fibres.

  1990cited by this paper
• Effects of pH on contraction of rabbit fast and slow skeletal muscle fibers.

  1988cited by this paper
• Domains, motions and regulation in the myosin head

  1988cited by this paper
• Measurement of sarcomere shortening in skinned fibers from frog muscle by white light diffraction.

  1987cited by this paper
• Spectroscopic probes of muscle cross-bridge rotation.

  1987cited by this paper
• The mechanism of muscle contraction.

  1986cited by this paper
• Crossbridge behaviour during muscle contraction

  1985cited by this paper
• Suppression of muscle contraction by vanadate. Mechanical and ligand binding studies on glycerol-extracted rabbit fibers

  1985cited by this paper
• Control of sarcomere length in skinned muscle fibres of Rana temporaria during mechanical transients.

  1984cited by this paper
• Changes in the X-ray reflections from contracting muscle during rapid mechanical transients and their structural implications.

  1983cited by this paper
• Physiological effects accompanying the removal of myosin LC2 from skinned skeletal muscle fibers.

  1982cited by this paper
• Orientation of spin labels attached to cross-bridges in contracting muscle fibres

  1982cited by this paper
• Active and rigor muscle stiffness [proceedings].

  1977cited by this paper
• Polarization from a helix of fluorophores and its relation to that obtained from muscle.

  1975cited by this paper
• Muscular contraction.

  1974cited by this paper
• Muscular contraction. Review lecture

  1974cited by this paper
• Proposed Mechanism of Force Generation in Striated Muscle

  1971cited by this paper
• Mechanism of adenosine triphosphate hydrolysis by actomyosin.

  1971cited by this paper
• Induced Changes in Orientation of the Cross-Bridges of Glycerinated Insect Flight Muscle

  1965cited by this paper
• The Mechanism of Muscular Contraction

  1965cited by this paper

• Development of bifunctional fluorescent probes and their application to α-helix labelling

  2025cites this paper
• Post‐translational modifications of vertebrate striated muscle myosin heavy chains

  2024cites this paper
• Mechanisms of myosin II force generation. Insights from novel experimental techniques and approaches.

  2024cites this paper
• No hype in hyperspace.

  2021cites this paper
• Investigation of the molecular motor of muscle: from generating life in a test tube to myosin structure over beers.

  2021cites this paper
• Myosin and Other Energy-Transducing ATPases: Structural Dynamics Studied by Electron Paramagnetic Resonance

  2020cites this paper
• Models for Fully-Activated Muscle

  2018cites this paper
• Of Sliding Filaments and Swinging Lever-Arms

  2018cites this paper
• Super-resolution fluorescence polarization microscopy

  2018cites this paper
• The Primary Causes of Muscle Dysfunction Associated with the Point Mutations in Tpm3.12; Conformational Analysis of Mutant Proteins as a Tool for Classification of Myopathies

  2018cites this paper
• Chapter 5 – Muscle: Anatomy, Physiology, and Biochemistry

  2017cites this paper
• Hill equation and Hatze's muscle activation dynamics complement each other: enhanced pharmacological and physiological interpretability of modelled activity-pCa curves.

  2017cites this paper
• Auxotonic to isometric contraction transitioning in a beating heart causes myosin step-size to down shift

  2017cites this paper
• Scallop Adductor Muscles: Structure and Function

  2016cites this paper
• Single molecule optical measurements of orientation and rotations of biological macromolecules

  2016cites this paper
• The molecular basis of the Frank-Starling relationship

  2016cites this paper
• Expression, purification and characterization of human myosin 9a

  2016cites this paper
• Aberrant movement of β-tropomyosin associated with congenital myopathy causes defective response of myosin heads and actin during the ATPase cycle.

  2015cites this paper
• Poorly Understood Aspects of Striated Muscle Contraction

  2015cites this paper
• Orientation of the N- and C-Terminal Lobes of the Myosin Regulatory Light Chain in Cardiac Muscle

  2015cites this paper
• Phosphorylation of myosin regulatory light chain controls myosin head conformation in cardiac muscle

  2015cites this paper
• Studies of Inter-and Intra-Molecular Coordination in Cytoplasmic Dynein

  2014cites this paper
• Fluorescence tracking of motor proteins in vitro.

  2014cites this paper
• Molecular Mechanism of Force Production: From the Difficult 1980s to the Supercharged 1990s and Beyond

  2014cites this paper
• Biophysical Approaches to Understanding the Action of Myosin as a Molecular Machine

  2013cites this paper
• 5 – Muscle: Anatomy, Physiology, and Biochemistry

  2013cites this paper
• Tilting and wobble of myosin V by high-speed single-molecule polarized fluorescence microscopy.

  2013cites this paper
• Three-dimensional structure of the human myosin thick filament: clinical implications

  2013cites this paper
• Untersuchung der Pathomechanismen hypertrophieassoziierter Mutationen im MYL3 Gen

  2012cites this paper
• Orientation and rotational motions of single molecules by polarized total internal reflection fluorescence microscopy (polTIRFM).

  2012cites this paper
• 4.11 Cell-Based Studies of the Molecular Mechanism of Muscle Contraction

  2012cites this paper
• 4.10 Single Molecule Fluorescence Techniques for Myosin

  2012cites this paper
• The effect of the Asp175Asn and Glu180Gly TPM1 mutations on actin-myosin interaction during the ATPase cycle.

  2012cites this paper
• Twitchin can regulate the ATPase cycle of actomyosin in a phosphorylation-dependent manner in skinned mammalian skeletal muscle fibres.

  2012cites this paper
• Orientation of the N-terminal lobe of the myosin regulatory light chain in skeletal muscle fibers.

  2012cites this paper
• Kinetics and thermodynamics of the rate-limiting conformational change in the actomyosin V mechanochemical cycle.

  2011cites this paper
• THE INFLUENCE OF LENGTH CHANGE SPEED AND DIRECTION ON DYNAMIC FUNCTION POTENTIATION IN FAST MOUSE MUSCLE

  2011cites this paper
• Structural Changes in Isometrically Contracting Insect Flight Muscle Trapped following a Mechanical Perturbation

  2011cites this paper
• Second harmonic generation microscopy probes different states of motor protein interaction in myofibrils.

  2010cites this paper
• Response of Rigor Cross-bridges to Stretch Detected by Fluorescence Lifetime Imaging Microscopy of Myosin Essential Light Chain in Skeletal Muscle Fibers*

  2010cites this paper
• Single-molecule fluorescence characterization in native environment

  2010cites this paper
• Muscle: Anatomy, Physiology, and Biochemistry

  2009cites this paper
• Insight into the actin-myosin motor from x-ray diffraction on muscle.

  2009cites this paper
• X-Ray Diffraction from Live Muscle Fibres

  2009cites this paper
• Removal of the cardiac myosin regulatory light chain increases isometric force production

  2009cites this paper
• Modulation of the effects of tropomyosin on actin and myosin conformational changes by troponin and Ca2+.

  2009cites this paper
• Single myosin lever arm orientation in a muscle fiber detected with photoactivatable GFP.

  2009cites this paper
• Orientation of the essential light chain region of myosin in relaxed, active, and rigor muscle.

  2008cites this paper
• Conformation of Regulatory Domain of Myosin in Skeletal and Smooth Muscle

  2008cites this paper
• ODA16 aids axonemal outer row dynein assembly through an interaction with the intraflagellar transport machinery

  2008cites this paper
• Single skeletal muscle fiber elastic and contractile characteristics in young and older men.

  2007cites this paper
• Nanotechnology Enhanced Functional Assays of Actomyosin Motility – Potentials and Challenges

  2007cites this paper
• Calcium structural transition of troponin in the complexes, on the thin filament, and in muscle fibres, as studied by site-directed spin-labelling EPR.

  2007cites this paper
• The dance of actin and myosin

  2007cites this paper
• Analysis of the expression regulation of the human atrial myosin light chain 1 upon hypertrophic stimulation

  2007cites this paper
• Molecular mechanisms of the regulation of ATPase cycle in striated muscle

  2007cites this paper
• GFP-tagged regulatory light chain monitors single myosin lever-arm orientation in a muscle fiber.

  2007cites this paper
• Motor Property of Mammalian Myosin 10: A Dissertation

  2007cites this paper
• Characterization of actomyosin bond properties in intact skeletal muscle by force spectroscopy

  2007cites this paper
• Molecular determinants of myofibrillar contractile function in the heart

  2007cites this paper
• Chapter 4 Scallop adductor muscles: Structure and function

  2006cites this paper
• E22K mutation of RLC that causes familial hypertrophic cardiomyopathy in heterozygous mouse myocardium: effect on cross-bridge kinetics.

  2006cites this paper
• Geometrical correspondence identified and a new interaction unit suggested in striated muscle.

  2006cites this paper
• Measuring Rotations of a Few Cross-Bridges in Skeletal Muscle

  2006cites this paper
• New techniques in linear and non-linear laser optics in muscle research

  2006cites this paper
• Distribution of crossbridge states in contracting muscle.

  2005cites this paper
• Measurement of single macromolecule orientation by total internal reflection fluorescence polarization microscopy.

  2005cites this paper
• Calcium structural transition of human cardiac troponin C in reconstituted muscle fibres as studied by site-directed spin labelling.

  2005cites this paper
• Rotational motions of macro-molecules by single-molecule fluorescence microscopy.

  2005cites this paper
• Muscle contraction: actin filaments enter the fray.

  2005cites this paper
• Bio-Nanorobotics: State of the Art and Future Challenges

  2005cites this paper
• X-ray diffraction studies of the contractilemechanism in singlemuscle fibres

  2005cites this paper
• Orientation of the myosin light chain region by single molecule total internal reflection fluorescence polarization microscopy.

  2005cites this paper
• X-ray diffraction studies of muscle and the crossbridge cycle.

  2005cites this paper
• Bifunctional rhodamine probes of Myosin regulatory light chain orientation in relaxed skeletal muscle fibers.

  2004cites this paper
• Coupling between phosphate release and force generation in muscle actomyosin.

  2004cites this paper
• Lever arms and necks: a common mechanistic theme across the myosin superfamily

  2004cites this paper
• Cross-bridge number, position, and angle in target zones of cryofixed isometrically active insect flight muscle.

  2004cites this paper
• Force generation by recombinant myosin heads trapped between two functionalized surfaces

  2004cites this paper
• Myosin regulatory domain orientation in skeletal muscle fibers: application of novel electron paramagnetic resonance spectral decomposition and molecular modeling methods.

  2004influential citation
• The force exerted by a muscle cross-bridge depends directly on the strength of the actomyosin bond.

  2004cites this paper
• Rotation of the lever arm of Myosin in contracting skeletal muscle fiber measured by two-photon anisotropy.

  2004influential citation
• Recent X-ray diffraction studies of muscle contraction and their implications.

  2004cites this paper
• Fluorescence depolarization of actin filaments in reconstructed myofibers: the effect of S1 or pPDM-S1 on movements of distinct areas of actin.

  2004cites this paper
• Fifty important papers in the history of muscle contraction and myosin motility

  2004cites this paper
• Fifty years of contractility research post sliding filament hypothesis

  2004cites this paper
• X-ray diffraction studies of the contractile mechanism in single muscle fibres.

  2004cites this paper
• Fifty years of muscle and the sliding filament hypothesis.

  2004cites this paper
• Molecular machines.

  2004cites this paper
• Transient kinetics and mechanics of myosin's force-generating rotation in muscle: resolution of millisecond rotational transitions in the spin-labeled myosin light-chain domain.

  2003cites this paper
• Load-dependent kinetics of force production by smooth muscle myosin measured with optical tweezers

  2003cites this paper
• Static and dynamic x-ray diffraction recordings from living mammalian and amphibian skeletal muscles.

  2003cites this paper
• The Unique Properties of Tonic Smooth Muscle Emerge from Intrinsic as Well as Intermolecular Behaviors of Myosin Molecules*

  2003cites this paper
• The role of aqueous interfaces in the cell.

  2003cites this paper
• Molecular step(s) of force generation: temperature-perturbation experiments on muscle fibres.

  2003cites this paper
• Orientational changes of crossbridges during single turnover of ATP.

  2003cites this paper
• Molecular Step(s) of Force Generation

  2003cites this paper
• The biochemical kinetics underlying actin movement generated by one and many skeletal muscle myosin molecules.

  2002cites this paper
• The cell as a biomaterial

  2002cites this paper
• Modulation of Cardiac Myofilament Activity by Protein Phosphorylation

  2002cites this paper