Brief exposure to predator odor and resultant anxiety enhances mesocorticolimbic activity and enkephalin expression in CD‐1 mice

No abstract is available for this paper.

• Publication year

  2004

• Venue

  European Journal of Neuroscience

• Publication date

  2004-11-01

• Fields of study

  Biology, Medicine, Psychology

• Identifiers
  DOI 10.1111/j.1460-9568.2004.03704.xPMID 15525282
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2003cited by this paper
• Individual response profiles of male Wistar rats in animal models for anxiety and depression.

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• Chronic Morphine Treatment Modulates the Extracellular Levels of Endogenous Enkephalins in Rat Brain Structures Involved in Opiate Dependence: A Microdialysis Study

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  2002cited by this paper
• Female preproenkephalin-knockout mice display altered emotional responses.

  2001cited by this paper
• "When a rat smells a cat": the distribution of Fos immunoreactivity in rat brain following exposure to a predatory odor.

  2001cited by this paper
• Central monoamine activity in genetically distinct strains of mice following a psychogenic stressor: effects of predator exposure.

  2001cited by this paper
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  2001cited by this paper
• Antipredator responses and defensive behavior: ecological and ethological approaches for the neurosciences.

  2001cited by this paper
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  2001cited by this paper
• Ventral mesopontine projections of the caudomedial shell of the nucleus accumbens and extended amygdala in the rat: Double dissociation by organization and development

  2001cited by this paper
• Mouse defensive behaviors: pharmacological and behavioral assays for anxiety and panic.

  2001cited by this paper
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  2001cited by this paper
• Predator odor as an unconditioned fear stimulus in rats: elicitation of freezing by trimethylthiazoline, a component of fox feces.

  2000cited by this paper
• Mice deficient for δ- and μ-opioid receptors exhibit opposing alterations of emotional responses

  2000cited by this paper
• Mice deficient for delta- and mu-opioid receptors exhibit opposing alterations of emotional responses.

  2000cited by this paper
• The predator odor, TMT, displays a unique, stress-like pattern of dopaminergic and endocrinological activation in the rat.

  2000cited by this paper
• Associative fear conditioning of enkephalin mRNA levels in central amygdalar neurons.

  2000cited by this paper
• Neurobiological Correlates of Individual Differences in Novelty-Seeking Behavior in the Rat: Differential Expression of Stress-Related Molecules

  2000influential reference
• Circadian modulation of fos responses to odor of the red fox, a rodent predator, in the rat olfactory system.

  2000cited by this paper
• Effect of Chronic Psychogenic Stress Exposure on Enkephalin Neuronal Activity and Expression in the Rat Hypothalamic Paraventricular Nucleus

  2000cited by this paper
• Overexpression of Proenkephalin in the Amygdala Potentiates the Anxiolytic Effects of Benzodiazepines

  2000cited by this paper
• Opioids: first lessons from knockout mice.

  1999cited by this paper
• Individual differences in behavioral reactivity: correlation with stress-induced norepinephrine efflux in the hippocampus of Sprague-Dawley rats.

  1999cited by this paper
• Changes in Nociceptive and Anxiolytic Responses following Herpes Virus‐mediated Preproenkephalin Overexpression in Rat Amygdala Are Naloxone‐reversible and Transient

  1999cited by this paper
• Relationship between Stress Coping and Personality in Patients with Major Depressive Disorder

  1999cited by this paper
• Repressive/defensive coping, endogenous opioids and health: how a life so perfect can make you sick.

  1999cited by this paper
• Functional heterogeneity in dopamine release and in the expression of Fos‐like proteins within the rat striatal complex

  1999cited by this paper
• Relationship between anxiety and serotonin in the ventral striatum

  1998cited by this paper
• Immediate-early gene expression in the amygdala following footshock stress and contextual fear conditioning.

  1998influential reference
• Are different parts of the extended amygdala involved in fear versus anxiety?

  1998cited by this paper
• Naltrexone-induced panic attacks.

  1998cited by this paper
• Vulnerability to stressor-induced disturbances in self-stimulation from the dorsal and ventral A10 area: differential effects of intraventricular D-Ala2-Met5-enkephalinamide, D-Ala2, N-Me-Phe4, Gly-Ol5-enkephalin, and D-Pen2, D-Pen5-enkephalin administration.

  1998cited by this paper
• Anxiogenic behavior in the light-dark paradigm follwoing intraventricular administration of cholecystokinin-8S, restraint stress, or uncontrollable footshock in the CD-1 mouse.

  1997cited by this paper
• Does depression generate negative life events?

  1997cited by this paper
• Effects of small amygdala lesions on fear, but not aggression, in the rat.

  1997cited by this paper
• Elevation of plasma beta-endorphin levels of shy elderly in response to novel laboratory experiences.

  1997cited by this paper
• Neuroendocrine Correlates of Emotional Reactivity and Coping in Male Rats from the Roman High (RHA/Verh)-and Low (RLA/Verh)-Avoidance Lines

  1997cited by this paper
• Immediate and long-term effects of novel odors on risk assessment in mice.

  1997cited by this paper
• Recent advances in depression research: from stress to molecular biology and brain imaging.

  1997cited by this paper
• Elicitation and reduction of fear: behavioural and neuroendocrine indices and brain induction of the immediate-early gene c-fos.

  1997cited by this paper
• Double Dissociation between the Involvement of the Bed Nucleus of the Stria Terminalis and the Central Nucleus of the Amygdala in Startle Increases Produced by Conditioned versus Unconditioned Fear

  1997cited by this paper
• Evidence for opioid and nonopioid processes mediating adaptive responses of infant rats that are repeatedly isolated.

  1997cited by this paper
• A synthetic predator odor (TMT) enhances conditioned analgesia and fear when paired with a benzodiazepine receptor inverse agonist (FG-7142)

  1997cited by this paper
• Differential effects of immunologic challenge on self-stimulation from the nucleus accumbens and the substantia nigra.

  1997cited by this paper
• Naloxone blocks anxiolytic-like effects of benzodiazepines in Swiss but not in Balb/c mice

  1997cited by this paper
• Vulnerability to depression: a model centered on anhedonia.

  1996cited by this paper
• Involvement of the opioid system in the anxiolytic effect of diazepam in mice.

  1996cited by this paper
• Activation of c-fos in the brain

  1996cited by this paper
• Activation of c-fos in the brain.

  1996cited by this paper
• Synaptic regulation of mesocorticolimbic dopamine neurons.

  1996influential reference
• Pain responses, anxiety and aggression in mice deficient in pre-proenkephalin

  1996cited by this paper
• Reward shifts and motor responses following microinjections of opiate-specific agonists into either the core or shell of the nucleus accumbens

  1995cited by this paper
• The orbital and medial prefrontal circuit through the primate basal ganglia

  1995cited by this paper
• Mating and agonistic behavior produce different patterns of Fos immunolabeling in the male Syrian hamster brain.

  1995cited by this paper
• Behavioral, neurochemical, anatomical and electrophysiological correlates of panic disorder: multiple transmitter interaction and neuropeptide colocalization.

  1995cited by this paper
• Odors increase Fos in olfactory bulb neurons including dopaminergic cells.

  1995cited by this paper
• Naloxone blocks the antianxiety but not the motor effects of benzodiazepines and pentobarbital: experimental studies and literature review

  1995cited by this paper
• Habituation and generalization of phobic responses to cat odor.

  1994cited by this paper
• An unusual reaction to opioid blockade with naltrexone in a case of post-traumatic stress disorder

  1994cited by this paper
• Responders and nonresponders to cat odor do not differ in other tests of anxiety.

  1994cited by this paper
• Chronic electroconvulsive seizure (ECS) treatment results in expression of a long-lasting AP-1 complex in brain with altered composition and characteristics

  1994cited by this paper
• A comparison of rat brain amino acid and monoamine content in diazepam withdrawal and after exposure to a phobic stimulus

  1993cited by this paper
• Morphine attenuates antipredator ultrasonic vocalizations in mixed-sex rat colonies.

  1992cited by this paper
• Coping style, trait anxiety and cortisol reactivity during mental stress.

  1991cited by this paper
• Dopaminergic activity is reduced in the prefrontal cortex and increased in the nucleus accumbens of rats predisposed to develop amphetamine self-administration.

  1991cited by this paper
• Individual differences in reactivity to and coping with the stress of lecturing.

  1991cited by this paper
• "Paradoxical" effects of morphine on antipredator defense reactions in wild and laboratory rats.

  1991cited by this paper
• Attenuated cardiovascular, neuroendocrine, and behavioral responses after a single footshock in central amygdaloid lesioned male rats.

  1991cited by this paper
• The characterization and modelling of antipredator defensive behavior.

  1990influential reference
• Rats with anxious or non-anxious type of exploratory behaviour differ in their brain CCK-8 and benzodiazepine receptor characteristics.

  1990influential reference
• A.E. Bennett award paper. Experimental approaches to human stress research: assessment of neurobiological mechanisms of stress in volunteers and psychiatric patients.

  1989cited by this paper
• A complete protocol for in situ hybridization of messenger RNAs in brain and other tissues with radi

  1989cited by this paper
• Exploration of mice in a black and white test box: validation as a model of anxiety.

  1989cited by this paper
• Brief exposure to a natural predator, the short-tailed weasel, induces benzodiazepine-sensitive analgesia in white-footed mice.

  1988cited by this paper
• Opiate modulation of separation-induced distress in non-human primates.

  1988cited by this paper
• Medial amygdala lesions in male rats reduce aggressive behavior: interference with experience.

  1987cited by this paper
• Exposure to a cat produces opioid analgesia in rats.

  1985cited by this paper
• Individual differences in response to stress

  1973influential reference

• Role of astrocytic mu-opioid receptors of the ventrolateral periaqueductal gray in modulating anxiety-like responses

  2025cites this paper
• The mouse gut microbiota responds to predator odor and predicts host behavior

  2025cites this paper
• Behavioral Assays in the Study of Olfaction.

  2025cites this paper
• Highly sensitive in vivo detection of dynamic changes in enkephalins following acute stress in mice

  2025cites this paper
• Predator odor stress reactivity, alcohol drinking and the endocannabinoid system

  2024influential citation
• Molecular determinants of olfactory receptor activation: Comparative analysis of Olfr205 and Olfr740 family member responses to indole.

  2024cites this paper
• Distinct subpopulations of ventral pallidal cholinergic projection neurons encode valence of olfactory stimuli

  2024cites this paper
• A single exposure to the predator odor 2,4,5-trimethylthiazoline causes long-lasting affective behavioral changes in female mice: Modulation by kappa opioid receptor signaling.

  2024cites this paper
• Identifying the most effective behavioural assays and predator cues for quantifying anti-predator responses in mammals: a systematic review

  2023cites this paper
• Highly sensitive in vivo detection of dynamic changes in enkephalins following acute stress

  2023cites this paper
• Distinct subpopulations of ventral pallidal cholinergic projection neurons encode valence of olfactory stimuli

  2023cites this paper
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  2023cites this paper
• sensitive in vivo detection of dynamic changes in

  2023cites this paper
• Lateral hypothalamic galanin neurons are activated by stress and blunt anxiety-like behavior in mice.

  2022cites this paper
• Early‐life social stress induces permanent alterations in plasticity and perineuronal nets in the mouse anterior cingulate cortex

  2022cites this paper
• Physiological response to the odorant TMT in fully fed and calorically restricted laboratory mice.

  2021cites this paper
• Coyote urine, but not 2-phenylethylamine, induces a complete profile of unconditioned anti-predator defensive behaviors.

  2020cites this paper
• The amygdalar opioid system.

  2020cites this paper
• The opioid system in stress‐induced memory disorders: From basic mechanisms to clinical implications in post‐traumatic stress disorder and Alzheimer's disease

  2019cites this paper
• A virtual burrow assay for head–fixed mice measures habituation, discrimination, exploration and avoidance without training

  2019cites this paper
• Contribution of individual olfactory receptors to odor-induced attractive or aversive behavior in mice

  2019cites this paper
• Olfactory Receptors

  2018cites this paper
• Acid‐sensing ion channel 1 contributes to normal olfactory function

  2018cites this paper
• Predator odor increases glutamatergic synaptic transmission in the prelimbic cortex via corticotropin-releasing factor receptor 1 signaling

  2018cites this paper
• Predator odor increases avoidance and glutamatergic synaptic transmission in the prelimbic cortex via corticotropin-releasing factor receptor 1 signaling

  2018cites this paper
• Behavioral Assays in the Study of Olfaction: A Practical Guide.

  2018cites this paper
• Enkephalins: Endogenous Analgesics with an Emerging Role in Stress Resilience

  2017cites this paper
• Translational Rodent Models for Research on Parasitic Protozoa—A Review of Confounders and Possibilities

  2017cites this paper
• Etudes des effets neurodéveloppementaux induits par l’exposition périnatale à un pesticide, le glufosinate d’ammonium : de la neurogenèse au comportement

  2016cites this paper
• Moderate Stress-Induced Social Bonding and Oxytocin Signaling are Disrupted by Predator Odor in Male Rats

  2016cites this paper
• Behavioural Brain Research

  2016cites this paper
• Effects of footshocks on anxiety-like behavior and mRNA levels of precursor peptides for corticotropin releasing factor and opioids in the forebrain of the rat.

  2015cites this paper
• The smell of fear: innate threat of 2,5-dihydro-2,4,5-trimethylthiazoline, a single molecule component of a predator odor

  2015cites this paper
• Avoidance and contextual learning induced by a kairomone, a pheromone and a common odorant in female CD1 mice

  2015cites this paper
• Chronic Subordinate Colony Housing Paradigm: A Mouse Model to Characterize the Consequences of Insufficient Glucocorticoid Signaling

  2015influential citation
• Behavioural responses of mice to predator odour components

  2015cites this paper
• TMT predator odor activated neural circuit in C57BL/6J mice indicates TMT-stress as a suitable model for uncontrollable intense stress.

  2015cites this paper
• Neuropeptide Y attenuates anxiety- and depression-like effects of cholecystokinin-4 in mice.

  2014cites this paper
• Lack of fear response in mice (Mus musculus) exposed to human urine odor.

  2014cites this paper
• Enkephalin Knockdown in the Basolateral Amygdala Reproduces Vulnerable Anxiety-Like Responses to Chronic Unpredictable Stress

  2014cites this paper
• Development of Enkephalin mRNA Interference in the Rat Brain

  2014cites this paper
• Odor Maps in the Olfactory Bulb

  2014cites this paper
• The E ffec ts of Repeated Ketamine Administration During Adolescence on Anxiety and Depressive- like Behaviors Induced by a Predator Odor

  2014cites this paper
• Enriched environment impacts trimethylthiazoline‐induced anxiety‐related behavior and immediate early gene expression: critical role of Crhr1

  2014cites this paper
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  2013cites this paper
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  2013cites this paper
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  2013cites this paper
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  2013cites this paper
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  2013cites this paper
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  2013cites this paper
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  2013cites this paper
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  2013cites this paper
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  2013cites this paper
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  2013influential citation
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  2013cites this paper
• Order of exposure to pleasant and unpleasant odors affects autonomic nervous system response.

  2013cites this paper
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  2013cites this paper
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  2013cites this paper
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  2013cites this paper
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  2012cites this paper
• Fear-like behavioral responses in mice in different odorant environments: Trigeminal versus olfactory mediation under low doses.

  2012cites this paper
• Comparison of the activation of somatostatin- and neuropeptide Y-containing neuronal populations of the rat amygdala following two different anxiogenic stressors.

  2012influential citation
• Inhibitory effect of luteolin on the odorant-induced cAMP level in HEK293 cells expressing the olfactory receptor.

  2012cites this paper
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  2012cites this paper
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  2012cites this paper
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  2012cites this paper
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  2012cites this paper
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  2012cites this paper
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  2011cites this paper
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  2011cites this paper
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  2011cites this paper
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  2011cites this paper
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  2011cites this paper
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  2011cites this paper
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  2011cites this paper
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  2010cites this paper
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  2010cites this paper
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  2010cites this paper
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  2010cites this paper
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  2009cites this paper
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  2009cites this paper
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  2009cites this paper
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  2009cites this paper
• Aversion- vs fear-inducing properties of 2,4,5-trimethyl-3-thiazoline, a component of fox odor, in comparison with those of butyric acid

  2009influential citation
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  2009influential citation
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  2009cites this paper
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  2009cites this paper
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  2008cites this paper
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  2008cites this paper
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  2008cites this paper
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  2008cites this paper
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  2008cites this paper
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  2008cites this paper
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  2007cites this paper