Dependence of cardiac mitochondrial pyruvate dehydrogenase activity on intramitochondrial free Ca2+ concentration.

No abstract is available for this paper.

• Publication year

  1988

• Venue

  Biochemical Journal

• Publication date

  1988-12-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1042/BJ2560403PMID 2464995PMCID PMC1135424
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Energy-linked ion movements in mitochondrial systems.

  2006cited by this paper
• Relation between cytosolic free calcium and respiratory rates in cardiac myocytes.

  1988cited by this paper
• Parallel measurement of oxoglutarate dehydrogenase activity and matrix free Ca2+ in fura‐2‐loaded heart mitochondria

  1988cited by this paper
• Estimation of intramitochondrial pCa and pH by fura-2 and 2,7 biscarboxyethyl-5(6)-carboxyfluorescein (BCECF) fluorescence.

  1987cited by this paper
• The effects of Mg2+ and adenine nucleotides on the sensitivity of the heart mitochondrial Na+-Ca2+ carrier to extramitochondrial Ca2+. A study using arsenazo III-loaded mitochondria.

  1987cited by this paper
• Relation between cytosolic free Ca2+ concentration and the control of pyruvate dehydrogenase in isolated cardiac myocytes.

  1987cited by this paper
• Pathways for Ca2+ efflux in heart and liver mitochondria.

  1987cited by this paper
• Measurement of the matrix free Ca2+ concentration in heart mitochondria by entrapped fura-2 and quin2.

  1987cited by this paper
• Ryanodine releases calcium from sarcoplasmic reticulum in calcium‐tolerant rat cardiac myocytes.

  1987cited by this paper
• Changes in pyridine nucleotide levels alter oxygen consumption and extra-mitochondrial phosphates in isolated mitochondria: a 31P-NMR and NAD(P)H fluorescence study.

  1987cited by this paper
• Effects of Ca2+ and Mg2+ on the activity of pyruvate dehydrogenase phosphate phosphatase within toluene-permeabilized mitochondria.

  1987cited by this paper
• Sensitivity of pyruvate dehydrogenase phosphate phosphatase to magnesium ions. Similar effects of spermine and insulin.

  1986cited by this paper
• Interactions between spermine and Mg2+ on mitochondrial Ca2+ transport.

  1986cited by this paper
• Relation between mitochondrial calcium transport and control of energy metabolism.

  1985cited by this paper
• A new generation of Ca2+ indicators with greatly improved fluorescence properties.

  1985cited by this paper
• Ca2+ transport by mammalian mitochondria and its role in hormone action.

  1985cited by this paper
• Spermine. A regulator of mitochondrial calcium cycling.

  1984cited by this paper
• Carboxyatractyloside-insensitive influx and efflux of adenine nucleotides in rat liver mitochondria.

  1984cited by this paper
• Stimulation of pyruvate dehydrogenase phosphatase activity by polyamines.

  1984cited by this paper
• The mammalian pyruvate dehydrogenase complex: structure and regulation.

  1983cited by this paper
• Ruthenium Red inhibits the activation of pyruvate dehydrogenase caused by positive inotropic agents in the perfused rat heart.

  1983cited by this paper
• Intramitochondrial and extramitochondrial free calcium ion concentrations of suspensions of heart mitochondria with very low, plausibly physiological, contents of total calcium

  1982cited by this paper
• Determination of the matrix free Ca2+ concentration and kinetics of Ca2+ efflux in liver and heart mitochondria.

  1982cited by this paper
• Transmembrane Na+ and Ca2+ electrochemical gradients in cardiac muscle and their relationship to force development

  1982cited by this paper
• Calcium homeostasis in intact lymphocytes: cytoplasmic free calcium monitored with a new, intracellularly trapped fluorescent indicator

  1982cited by this paper
• Regulation of mammalian pyruvate dehydrogenase complex by a phosphorylation-dephosphorylation cycle.

  1981cited by this paper
• Synthesis and characterization of halogenated derivatives of the ionophore A23187: enhanced calcium ion transport specificity by the 4-bromo derivative.

  1981cited by this paper
• Effects of micromolar concentrations of free calcium ions on the reduction of heart mitochondrial NAD(P) by 2-oxoglutarate.

  1981cited by this paper
• Effect of micromolar concentrations of free Ca2+ ions on pyruvate dehydrogenase interconversion in intact rat heart mitochondria.

  1981cited by this paper
• Effect of micromolar Ca2+ on NADH inhibition of bovine kidney α-ketoglutarate dehydrogenase complex and possible role of Ca2+ in signal amplification

  1980cited by this paper
• On the role of the calcium transport cycle in heart and other mammalian mitochondria

  1980cited by this paper
• Role of calcium ions in the regulation of intramitochondrial metabolism. Effects of Na+, Mg2+ and ruthenium red on the Ca2+-stimulated oxidation of oxoglutarate and on pyruvate dehydrogenase activity in intact rat heart mitochondria.

  1980cited by this paper
• The effects of calcium ions and adenine nucleotides on the activity of pig heart 2-oxoglutarate dehydrogenase complex.

  1979cited by this paper
• Calculator programs for computing the composition of the solutions containing multiple metals and ligands used for experiments in skinned muscle cells.

  1979cited by this paper
• Calcium ions and the regulation of NAD+-linked isocitrate dehydrogenase from the mitochondria of rat heart and other tissues.

  1978cited by this paper
• Relative importance of pyruvate dehydrogenase interconversion and feed-back inhibition in the effect of fatty acids on pyruvate oxidation by rat heart mitochondria.

  1978cited by this paper
• The regulation of extramitochondrial free calcium ion concentration by rat liver mitochondria.

  1978cited by this paper
• Lipid oxidation by heart mitochondria from young adult and senescent rats.

  1978cited by this paper
• Studies on inactivation of pyruvate dehydrogenase by palmitoylcarnitine oxidation in isolated rat heart mitochondria.

  1977cited by this paper
• Studies on the effects of coenzyme A-SH: acetyl coenzyme A, nicotinamide adenine dinucleotide: reduced nicotinamide adenine dinucleotide, and adenosine diphosphate: adenosine triphosphate ratios on the interconversion of active and inactive pyruvate dehydrogenase in isolated rat heart mitochondria.

  1976cited by this paper
• Regulation of pyruvate dehydrogenase kinase and phosphatase by acetyl-CoA/CoA and NADH/NAD ratios.

  1975cited by this paper
• Stimulation of phosphorylation and inactivation of pyruvate dehydrogenase by physiological inhibitors of the pyruvate dehydrogenase reaction

  1975cited by this paper
• The steady state concentrations of coenzyme A-SH and coenzyme A thioester, citrate, and isocitrate during tricarboxylate cycle oxidations in rabbit heart mitochondria.

  1975cited by this paper
• Effects of magnesium, Ruthenium red and the antibiotic ionophore A-23187 on initial rates of calcium uptake and release by heart mitochondria.

  1975cited by this paper
• The influence of respiration and ATP hydrolysis on the proton-electrochemical gradient across the inner membrane of rat-liver mitochondria as determined by ion distribution.

  1974cited by this paper
• A23187: a divalent cation ionophore.

  1972cited by this paper
• Stimulation by calcium ions of pyruvate dehydrogenase phosphate phosphatase.

  1972cited by this paper
• Function of calcium ions in pyruvate dehydrogenase phosphatase activity.

  1972cited by this paper
• Specific inhibition of mitochondrial Ca++ transport by ruthenium red.

  1971cited by this paper
• Contractile proteins of the heart.

  1970cited by this paper
• The respiratory chain and oxidative phosphorylation.

  1956cited by this paper

• Modeling Krebs cycle from liver, heart and hepatoma mitochondria, supported Complex I as target for specific inhibition of cancer cell proliferation

  2025cites this paper
• Myocardial transcriptomic analysis of diabetic patients with aortic stenosis: key role for mitochondrial calcium signaling

  2024cites this paper
• Electrodiffusion Phenomena in Neuroscience and the Nernst–Planck–Poisson Equations

  2021cites this paper
• Mitochondrial Ion Channels in Cardiac Function.

  2021cites this paper
• Mitochondrial Calcium Uniporter Complex Activation Protects Against Calcium Alternans in Atrial Myocytes.

  2020cites this paper
• Reduced reticulum–mitochondria Ca2+ transfer is an early and reversible trigger of mitochondrial dysfunctions in diabetic cardiomyopathy

  2020cites this paper
• Precipitation of Inorganic Salts in Mitochondrial Matrix

  2020cites this paper
• Resveratrol inhibits cancer cell proliferation by impairing oxidative phosphorylation and inducing oxidative stress

  2019cites this paper
• Control of the NADPH supply and GSH recycling for oxidative stress management in hepatoma and liver mitochondria.

  2018cites this paper
• Celecoxib inhibits mitochondrial O2 consumption, promoting ROS dependent death of murine and human metastatic cancer cells via the apoptotic signalling pathway

  2018cites this paper
• Antioxidant Effects of Eryngium carlinae in Diabetic Rats

  2018cites this paper
• The effect of respiration buffer composition on mitochondrial metabolism and function

  2017cites this paper
• Assessment of the low inhibitory specificity of oxamate, aminooxyacetate and dichloroacetate on cancer energy metabolism.

  2017cites this paper
• [Mitochondrial reactive oxygen species].

  2016cites this paper
• Calcium-dependent regulation of photosynthesis.

  2015cites this paper
• Plasma Membrane Ca2+-ATPase Isoforms Composition Regulates Cellular pH Homeostasis in Differentiating PC12 Cells in a Manner Dependent on Cytosolic Ca2+ Elevations

  2014cites this paper
• Mitochondrial reactive oxygen species (ROS) and ROS-induced ROS release.

  2014cites this paper
• The control of brain mitochondrial energization by cytosolic calcium: The mitochondrial gas pedal

  2013cites this paper
• Reactive oxygen species are generated by the respiratory complex II – evidence for lack of contribution of the reverse electron flow in complex I

  2013cites this paper
• Role of mitochondrial Ca2+ in the regulation of cellular energetics.

  2012influential citation
• Metabolic homeostasis of the heart

  2012cites this paper
• Protective effects of resveratrol on calcium-induced oxidative stress in rat heart mitochondria

  2011cites this paper
• Ca2+-independent effects of spermine on pyruvate dehydrogenase complex activity in energized rat liver mitochondria incubated in the absence of exogenous Ca2+ and Mg2+

  2009cites this paper
• cardiac cardiolipin homeostasis and mitochondrial function.

  2007cites this paper
• AMP-activated protein kinase alpha2 deficiency affects cardiac cardiolipin homeostasis and mitochondrial function.

  2007cites this paper
• AMP-Activated Protein Kinase α2 Deficiency Affects Cardiac Cardiolipin Homeostasis and Mitochondrial Function

  2007cites this paper
• Sodium inhibits permeability transition by decreasing potassium matrix content in rat kidney mitochondria.

  2006cites this paper
• Absence of Malonyl Coenzyme A Decarboxylase in Mice Increases Cardiac Glucose Oxidation and Protects the Heart From Ischemic Injury

  2006cites this paper
• Oligomycin strengthens the effect of cyclosporin A on mitochondrial permeability transition by inducing phosphate uptake

  2005cites this paper
• Intracellular calcium ions and intramitochondrial Ca2+ in the regulation of energy metabolism in mammalian tissues

  2005cites this paper
• Anoxic Single Rat

  2005cites this paper
• Inhibition of the mitochondrial calcium uniporter by the oxo‐bridged dinuclear ruthenium amine complex (Ru360) prevents from irreversible injury in postischemic rat heart

  2005cites this paper
• Structural and functional changes in heart mitochondria from sucrose-fed hypertriglyceridemic rats.

  2005cites this paper
• Intracellular calcium ions and intramitochondrial Ca 2 + in the regulation of energy metabolism in mammalian tissues

  2005cites this paper
• Intracellular calcium ions and intramitochondrial Ca 2 + in the regulation of energy metabolism in mammalian tissues

  2005cites this paper
• Intracellular calcium ions and intramitochondrial Ca 2 + in the regulation of energy metabolism in mammalian tissues

  2005cites this paper
• Interaction of biologically active amines with mitochondria and their role in the mitochondrial-mediated pathway of apoptosis.

  2004cites this paper
• The Integration of Mitochondrial Calcium Transport and Storage

  2004cites this paper
• The Relationship between Free and Total Calcium Concentrations in the Matrix of Liver and Brain Mitochondria*

  2003cites this paper
• Toxic effects of copper-based antineoplastic drugs (Casiopeinas) on mitochondrial functions.

  2003cites this paper
• Regulation of the rate of synthesis of nitric oxide by Mg2+ and hypoxia. Studies in rat heart mitochondria

  2002cites this paper
• Regulation of Cellular Calcium in Cardiac Myocytes

  2002cites this paper
• Control of Mitochondrial Metabolism by Calcium-Dependent Hormones

  2002cites this paper
• Post-ischaemic changes in the response time of oxygen consumption to demand in the isolated rat heart are mediated partly by calcium and glycolysis

  2002cites this paper
• Role of intramitochondrial nitric oxide in rat heart and kidney during hypertension.

  2002cites this paper
• Cytosolic calcium oscillations in signal transduction pathways.

  2002cites this paper
• Effect of Ca2+ and Mg2+ on the Mn-superoxide dismutase from rat liver and heart mitochondria

  2002cites this paper
• Monitoring NAD(P)H autofluorescence to assess mitochondrial metabolic functions in rat hippocampal-entorhinal cortex slices.

  2001cites this paper
• Restoration of mitochondrial function reverses developmental neuronal death in vitro

  2001influential citation
• Modulation of 2-oxoglutarate dehydrogenase complex by inorganic phosphate, Mg(2+), and other effectors.

  2000cites this paper
• Ca(2+) activation of heart mitochondrial oxidative phosphorylation: role of the F(0)/F(1)-ATPase.

  2000cites this paper
• Role of osmoregulation in the actions of taurine

  2000cites this paper
• Ca2+ activation of heart mitochondrial oxidative phosphorylation: role of the F0/F1-ATPase

  2000cites this paper
• phosphorylation : role of the F 0 / F 1-ATPase Ca 2 + activation of heart mitochondrial oxidative

  2000cites this paper
• ACELL February 47/2

  2000cites this paper
• Measurement of perimitochondrial Ca2+ concentration in bovine adrenal glomerulosa cells with aequorin targeted to the outer mitochondrial membrane.

  1999cites this paper
• A relative energy failure is associated with low-Mg2+ but not with 4-aminopyridine induced seizure-like events in entorhinal cortex.

  1999cites this paper
• Noradrenaline effects on pyruvate decarboxylation: Correlation with calcium signaling

  1999cites this paper
• PUFA and aging modulate cardiac mitochondrial membrane lipid composition and Ca2+ activation of PDH.

  1999cites this paper
• Cardiac ionic currents and acute ischemia: from channels to arrhythmias.

  1999cites this paper
• Mitochondrial transport of cations: channels, exchangers, and permeability transition.

  1999cites this paper
• Model of β-cell mitochondrial calcium handling and electrical activity. I. Cytoplasmic variables.

  1998cites this paper
• modeling in physiology Model of (cid:98) -cell mitochondrial calcium handling and electrical activity. I. Cytoplasmic variables

  1998cites this paper
• Model of β-cell mitochondrial calcium handling and electrical activity. II. Mitochondrial variables.

  1998cites this paper
• modeling in physiology Model of (cid:98) -cell mitochondrial calcium handling and electrical activity. II. Mitochondrial variables

  1998cites this paper
• Altered Ca 2 1 Signaling and Mitochondrial Deficiencies in Hippocampal Neurons of Trisomy 16 Mice : A Model of Down ’ s Syndrome

  1998cites this paper
• Mitochondrial Ca2+ Transients in Cardiac Myocytes During the Excitation–Contraction Cycle: Effects of Pacing and Hormonal Stimulation

  1998cites this paper
• Modulation of Oxidative Phosphorylation by Mg2+ in Rat Heart Mitochondria*

  1998cites this paper
• Altered Ca2+ Signaling and Mitochondrial Deficiencies in Hippocampal Neurons of Trisomy 16 Mice: A Model of Down’s Syndrome

  1998cites this paper
• Role of mitochondrial calcium transport in the control of substrate oxidation

  1998cites this paper
• Metabolic responses from rest to steady state determine contractile function in ischemic skeletal muscle.

  1997cites this paper
• Effect of extra- and intra-mitochondrial calcium on citrulline synthesis

  1997cites this paper
• Modulation of 2-oxoglutarate dehydrogenase and oxidative phosphorylation by Ca2+ in pancreas and adrenal cortex mitochondria.

  1995cites this paper
• Studies of Physiological Control of ATP Synthesis

  1995cites this paper
• Alcohol inhibits the activation of NAD-linked dehydrogenases by calcium in brain and heart mitochondria.

  1995cites this paper
• Characterization of partially purified betaine aldehyde dehydrogenase from horseshoe crab (Limulus polyphemus) cardiac mitochondria

  1994cites this paper
• Na(+)-dependent Ca2+ efflux mechanism of heart mitochondria is not a passive Ca2+/2Na+ exchanger.

  1994cites this paper
• Effects of oxidant exposure on substrate utilization and high-energy phosphates in isolated rat hearts.

  1994cites this paper
• Mitochondrial calcium transport: physiological and pathological relevance.

  1994cites this paper
• Effects of regional myocardial lidocaine infusion on high energy phosphates.

  1994cites this paper
• Physiological role of mitochondrial Ca2+ transport

  1994cites this paper
• Ionic basis of ischaemic cardiac injury: insights from cellular studies.

  1994cites this paper
• Role of calcium in respiratory control.

  1994cites this paper
• Mitochondrial free Ca2+ concentration in living cells

  1994cites this paper
• Mechanism of cholinergic stimulation of glucose oxidation in isolated gastric glands.

  1994cites this paper
• Pyrophosphate metabolism in the perfused heart and isolated heart mitochondria and its role in regulation of mitochondrial function by calcium.

  1993cites this paper
• Intramitochondrial free calcium in cardiac myocytes in relation to dehydrogenase activation.

  1993cites this paper
• Excitation-Contraction Coupling and Cardiac Contractile Force

  1993cites this paper
• Mitochondrial free calcium regulation in hypoxia and reoxygenation: relation to cellular injury

  1993cites this paper
• Effects of cardiac work on electrical potential gradient across mitochondrial membrane in perfused rat hearts.

  1993cites this paper
• Possible Sources and Sinks of Activator Calcium

  1993cites this paper
• Effects of diltiazem on the calcium accumulation and ATP synthesis simultaneously sustained by isolated rat heart mitochondria.

  1993cites this paper
• Effects of acidosis on resting cytosolic and mitochondrial Ca2+ in mammalian myocardium

  1993cites this paper
• Mitochondrial dehydrogenase activity affects adaptation of cardiac oxygen consumption to demand.

  1993cites this paper
• Effect of spermine on mitochondrial matrix calcium in relation to its enhancement of mitochondrial calcium uptake.

  1993cites this paper
• Ca(2+)-dependent changes in the mitochondrial energetics in single dissociated mouse sensory neurons.

  1992cites this paper
• Chapter 24: Effects of monoamine transmitters on neurons and astrocytes: correlation between energy metabolism and intracellular messengers

  1992cites this paper
• Mitochondrial Ca2+ transport and the role of matrix Ca2+ in mammalian tissues.

  1992cites this paper
• The role of the matrix calcium level in the enhancement of mitochondrial pyruvate carboxylation by glucagon pretreatment.

  1992cites this paper
• Interactions of calcium with yeast mitochondria.

  1992cites this paper