Phospholipides and the secretion of adrenocorticotropin and of corticosteroids.

Previous work showed that the stimulation by acetylcholine or pancreozymin of the secretion of digestive enzymes from the pancreas, and the stimulation by acetylcholine or adrenaline of the secretion of amylase and mucin from salivary glands was accompanied by an increased incorporation of P32 into the phospholipides of the tissues (l-4). This suggested that the phospholipides play a role in the secretion of proteins from cells (5). To test whether or not the phospholipides play a role in the secretion of other types of molecules, other secretory glands amenable to stimulation of secretion in vitro were sought. An example of this is the secretion of the polypeptide hormone ACTH,’ which can be stimulated in vitro in the rat adenohypophysis by CRF from the posterior lobe of the pituitary (6, 7). Another example is the formation and release of corticosteroids by the rat adrenal in vitro in response to ACTH (8).

• Publication year

  1958

• Venue

  Journal of Biological Chemistry

• Publication date

  1958-10-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/s0021-9258(18)64660-5PMID 13587497
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The presence of phosphatidic acid in animal tissues.

  1958cited by this paper
• Phosphoinositides and protein secretion in pancreas slices.

  1958cited by this paper
• Phospholipides and adrenaline secretion in guinea pig adrenal medulla.

  1958cited by this paper
• Chromatography of phosphatides on silicic acid impregnated paper.

  1956cited by this paper
• In vitro bioassay of corticotropin: modification and statistical treatment.

  1955cited by this paper
• Effects of acetylcholine on the turnover of phosphoryl units in individual phospholipids of pancreas slices and brain cortex slices.

  1955cited by this paper
• The release of corticotrophin by anterior pituitary tissue in vitro.

  1955cited by this paper
• Stimulation of the release of corticotropin from the adenohypophysis by a neurohypophysial factor.

  1955cited by this paper
• Effects of acetylcholine on phospholipides in the pancreas.

  1954cited by this paper
• Enzyme secretion and the incorporation of P32 into phospholipides of pancreas slices.

  1953cited by this paper
• Production of corticoids by rat adrenals in vitro.

  1952cited by this paper
• The output of cortical hormone by the mammalian suprarenal

  1943cited by this paper

• Regulation of phosphatidylinositol 4-kinase activity in rat pancreatic acini.

  1993cites this paper
• Norepinephrine stimulates inositol trisphosphate formation in rat pulmonary arteries.

  1991cites this paper
• Inhibition of parathyroid hormone secretion correlates with increased incorporation of 32P into phosphatidylinositol and lysophosphatidylinositol

  1991cites this paper
• Role of phosphoinositides in transmembrane signaling.

  1990cites this paper
• CHAPTER 5 – The Mechanism of Action of Adrenocorticotropic Hormone on Cholesterol Metabolism in the Adrenal Cortex

  1986cites this paper
• Phospholipid metabolism and prolactin secretion in vitro.

  1985cites this paper
• Receptors and phosphoinositide-generated second messengers.

  1985cites this paper
• Characteristics of the adenohypophyseal Ca2+-phospholipid-dependent protein kinase.

  1984cites this paper
• Stimulation of phosphatidylinositol turnover by acetylcholine, angiotensin II and ACTH in bovine adrenal fasciculata cells.

  1984cites this paper
• The phosphatidate-phosphoinositide cycle: an intracellular messenger system in the action of hormones and neurotransmitters.

  1983cites this paper
• Introduction: the clinical significance of peptide hormone receptors.

  1983cites this paper
• Thyrotropin-releasing hormone stimulates inositol phosphate production in normal anterior pituitary cells and GH3 tumour cells in the presence of lithium

  1983cites this paper
• Phosphoinositide metabolism and hormone action.

  1983cites this paper
• The role of the phosphatidate-inositide cycle in the action of steroidogenic agents.

  1983cites this paper
• Introduction: the clinical significance of peptide hormone receptors.

  1983cites this paper
• The inhibition of phosphatidylinositol turnover: a possible postreceptor mechanism for the prolactin secretion-inhibiting effect of dopamine.

  1983cites this paper
• Phosphorylation of phosphatidylinositol in rat liver Golgi.

  1983cites this paper
• Thyrotropin-releasing hormone stimulates rapid loss of phosphatidylinositol and its conversion to 1,2-diacylglycerol and phosphatidic acid in rat mammotropic pituitary cells. Association with calcium mobilization and prolactin secretion.

  1983cites this paper
• 32 P. INCORPORATION INTO PHOSPHATIDYLINOSITOL IN THE ANTERIOR PITUITARY

  1982cites this paper
• Early effect of myo-inositol deficiency on fatty acid synthetic enzymes of rat liver.

  1982cites this paper
• Control of phosphatidylinositol turnover in adrenal glomerulosa cells.

  1982cites this paper
• Dopamine inhibits 32P incorporation into phosphatidylinositol in the anterior pituitary gland of the rat.

  1982cites this paper
• Kinetics of protein-mediated transfer of rat pancreatic microsomal phosphatidylinositol to liposomes.

  1982cites this paper
• The role of inositide phospholipids in the action of steroidogenic hormones.

  1982cites this paper
• Stimulated Phosphatidylinositol Turnover A Brief Appraisal

  1982cites this paper
• Effect of LHRH on incorporation of [32P]-orthophosphate into phosphatidylinositol by dispersed anterior pituitary cells.

  1982cites this paper
• THE PHOSPHATIDATE‐POLYPHOSPHOINOSITIDE CYCLE: ACTIVATION BY PARATHYROID HORMONE AND DIBUTYRYL‐cAMP IN RABBIT KIDNEY CORTEX *

  1981cites this paper
• Thyrotropin releasing hormone rapidly enhances [32P]orthophosphate incorporation into phosphatidic acid in cloned GH3 cells.

  1981cites this paper
• Acetylcholine stimulates growth hormone secretion, phosphatidyl inositol labelling, 45Ca2+ efflux and cyclic GMP accumulation in bovine anterior pituitary glands.

  1979cites this paper
• Characterization of a calcium-mediated activation of arachidonic acid turnover in adrenal phospholipids by corticotropin.

  1979cites this paper
• Corticotropin-Releasing Factor: The Elusive Hormone

  1978cites this paper
• The effect of corticotropin on phospholipid metabolism in isolated adrenocortical cells.

  1978cites this paper
• Subcellular Localization of the Alterations in Phosphatidylinositol Metabolism Following Glucose-induced Insulin Release from Rat Pancreatic Islets

  1977cites this paper
• Phospholipid metabolism in cells from highly luteinized rat ovaries.

  1977cites this paper
• Incorporation of inorganic [32P] phosphate into rat parotid phosphatidylinositol. Induction through activation of alpha adrenergic and cholinergic receptors and relation to K+ release.

  1975cites this paper
• Inositol phospholipids and cell surface receptor function.

  1975cites this paper
• Alpha-chlorohydrin-induced changes in the distribution of free myo-inositol and prostaglandin F2alpha, and synthesis of phosphatidylinositol in the rat epididymis.

  1974cites this paper
• The effect of myo-inositol deficiency on lipid metabolism in rats. II. The mechanism of triacylglycerol accumulation in the liver of myo-inositol-deficient rats.

  1974cites this paper
• The effect of myo-inositol deficiency on lipid metabolism in rats. I. The alteration of lipid metabolism in myo-inositol deficient rats.

  1974cites this paper
• Role of Inositol Cyclic Phosphate in Stimulated Tissues

  1973cites this paper
• The distribution of free myo-inositol in fluids, spermatozoa, and tissues of the bull genital tract and observations on its uptake by the rabbit epididymis.

  1973cites this paper
• Incorporation of 32Pi orthophosphate into phospholipids of calf pineal slices in the presence and absence of neurotransmitters.

  1973cites this paper
• Incorporation of orthophosphate 32Pi into the phospholipids of slices of gonads, anterior pituitary and liver of calf.

  1973cites this paper
• The effect of single and repeated injections of adrenocorticotropin on lipids in rat adrenals.

  1972cites this paper
• CHAPTER 8 – Synthesis, Localization, and Renewal of Lipids in Mammalian Tissues

  1971cites this paper
• Biosynthesis of cytidine diphosphate diglyceride by human platelets.

  1970cites this paper
• FUNCTIONAL ACTIVITY IN GLANDS AND SYNAPTIC TISSUE AND THE TURNOVER OF PHOSPHATIDYLINOSITOL

  1970cites this paper
• The biosynthesis of phosphatidylinositol in human platelets.

  1970cites this paper
• Metabolism of phospholipids and the characterization of fatty acids in bovine corpus luteum.

  1968cites this paper
• The mechanism of thyrotrophin action in relation to lipid metabolism in thyroid tissue.

  1968cites this paper
• Dynamic aspects of phospholipids during protein secretion.

  1968cites this paper
• Metabolic functions of myo-inositol. V. Utilization of glycine and serine in nucleotide and nucleic acid biosynthesis by inositol-deficient KB cells.

  1967cites this paper
• Contributory data on the relationship between the trophic hormone production and 32P metabolism of the anterior pituitary. II. The effect of adrenalectomy, cortisone treatment and castration on 32P metabolism and oxygen consumption.

  1967cites this paper
• Membrane lipids and drug action.

  1967cites this paper
• Contributory data on the relationship between the trophic hormone production and 32P metabolism of the anterior pituitary. I. The effect of thyroxine treatment, methylthiouracil treatment and thyroidectomy of 32P metabolism and O2 consumption.

  1966cites this paper
• Inhibition of particulate phosphatidate phosphohydrolase by an analogue of its substrate

  1966cites this paper
• Comparative effects of long-acting thyroid stimulator and pituitary thyrotropin on the intermediate metabolism of thyroid tissue in vitro.

  1966cites this paper
• CHAPTER 9 – Control of Adrenocorticotropic Hormone Secretion

  1966cites this paper
• The regulation of the synthesis and release of ACTH.

  1965cites this paper
• Über Plasmainhaltsbestandteile von Brassica oleracea. 3. Mitt.

  1965cites this paper
• EFFECT OF RAT MEDIAN EMINENCE EXTRACTS ON PITUITARY ACTH CONTENT IN NORMAL AND ADRENALECTOMIZED RATS.

  1965cites this paper
• The action of drugs on phospholipid metabolism.

  1965cites this paper
• Lipid-protein interactions

  1964cites this paper
• [SYNTHESIS AND LIBERATION OF ACTH FOLLOWING ACUTE STRESS IN THE ADRENALECTOMIZED RAT].

  1964cites this paper
• ESTIMATION OF CORTICOTROPIN-RELEASING ACTIVITY OF RAT HYPOTHALAMUS AND NEUROHYPOPHYSIS BEFORE AND AFTER STRESS.

  1964cites this paper
• NEUROHUMORAL FUNCTIONS OF THE HYPOTHALAMUS.

  1964cites this paper
• Effect of Digitoxin, Aldosterone, and Dietary Sodium Chloride on Incorporation of Inorganic P32 into Liver and Kidney Nuclear and Mitochondrial Phospholipids.∗

  1964cites this paper
• Adenosine triphosphate-indeced contraction of rat-liver mitochondria and synthesis of mitochondrial phospholipids.

  1963cites this paper
• Intermediary metabolism of thyroid tissue and the action of drugs.

  1963cites this paper
• Effect of CRF on maintenance of the adrenocorticotrophic function of anterior pituitary grafts.

  1963cites this paper
• THE RELATIONSHIP BETWEEN CARBOHYDRATE METABOLISM AND ANAPHYLAXIS--A POSSIBLE ROLE FOR THE ACETYL CHOLINE ENZYME SYSTEM.

  1963cites this paper
• Adenosine triphosphate-induced contraction of rat-liver mitochondria and synthesis of mitochondrial phospholipids

  1963cites this paper
• 1 – Hypothalamic Control of Anterior Pituitary*

  1963cites this paper
• PHOSPHOLIPID METABOLISM IN KIDNEY. II. POTASSIUM UPTAKE, LIPID COMPOSITION, AND P32 LABELLING OF THE PHOSPHOLIPIDS IN RABBIT KIDNEY CORTEX SLICES IN VITRO, AND THE EFFECTS OF DIPHENYLHYDANTOIN.

  1963cites this paper
• Phospholipid patterns in subcellular fractions of adult- and immature-rat organs.

  1963cites this paper
• CHAPTER 5 – Distribution of Phospholipids

  1962cites this paper
• CHAPTER 6 – The Metabolism of Phospholipids

  1962cites this paper
• Diagnostik der intrakraniellen Geschwülste

  1962cites this paper
• Metabolic basis of phagocytic activity.

  1962cites this paper
• The effect of ouabain on the incorporation of inorganic P32 into phospholipid.

  1962cites this paper
• The anatomy, chemistry, and physiology of adrenocortical tissue

  1962cites this paper
• Gonadotropic activity of neonatal pituitary glands implanted in the rat brain.

  1962cites this paper
• Adenohypophysis and adrenal cortex.

  1962cites this paper
• CONTROL OF GLUCOSE OXIDATION IN ANTERIOR PITUITARY BY HORMONALLY SENSITIVE PYRIDINE NUCLEOTIDE TRANSHYDROGENASE.

  1962cites this paper
• Metabolism and cellular function in cold acclimation.

  1962cites this paper
• The distribution of free mesoinositol in mammalian tissues, including some observations on the lactating rat.

  1961cites this paper
• THE BIOSYNTHESIS OF PLASMA PROTEINS *

  1961cites this paper
• The metabolic basis of phagocytosis. III. Incorporation of inorganic phosphate into various classes of phosphatides during phagocytosis.

  1961cites this paper
• The Effects of Acetylcholine on the Turnover of Phosphatidic Acid and Phosphoinositide in Sympathetic Ganglia, and in Various Parts of the Central Nervous System in Vitro

  1960cites this paper
• Studies on the Carrier Function of Phosphatidic Acid in Sodium Transport

  1960cites this paper
• Reactive sites and biological transport.

  1960cites this paper
• The role of phosphatidic acid and phosphoinositide in transmembrane transport elicited by acetylcholine and other humoral agents.

  1960cites this paper
• The relationship between secretory activity and the incorporation of P32 into phosphoinositide and phosphotidic acid in salivary glands and pigeon esophageal mucosa in vitro.

  1960cites this paper
• Adenohypophysis and adrenal cortex.

  1960cites this paper
• The inositol phospholipids.

  1960cites this paper
• Concentration of Corticotropin Releasing Factor by Chromatography on Carboxymethylcellulose

  1959cites this paper
• Studies of pancreatic tissue in vitro.

  1959cites this paper
• Re-evaluation of a technique of pituitary incubation in vitro as an assay for corticotropin releasing factor.

  1959cites this paper
• The mechanism of phosphate exchange in phosphatidic acid in response to acetylcholine.

  1959cites this paper
• Paper chromatography of nitrogen free phosphatides of the cardiolipin type.

  1959cites this paper