Sequential Poly-ubiquitylation by Specialized Conjugating Enzymes Expands the Versatility of a Quality Control Ubiquitin Ligase.

No abstract is available for this paper.

• Publication year

  2016

• Venue

  Molecules and Cells

• Publication date

  2016-09-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1016/j.molcel.2016.07.020PMID 27570077
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2013cited by this paper
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  2013cited by this paper
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  2012cited by this paper
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  2012cited by this paper
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  2011cited by this paper
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  1999cited by this paper
• RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitination.

  1999cited by this paper
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  1998cited by this paper
• Role of Cue1p in ubiquitination and degradation at the ER surface.

  1997cited by this paper
• A second trimeric complex containing homologs of the Sec61p complex functions in protein transport across the ER membrane of S. cerevisiae.

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  1993cited by this paper
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  1993cited by this paper
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