Natural selection of hemi- and heterozygotes for G6PD deficiency in Africa by resistance to severe malaria

No abstract is available for this paper.

• Publication year

  1995

• Venue

  Nature

• Publication date

  1995-07-20

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.1038/376246A0PMID 7617034
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Variation in the TNF-alpha promoter region associated with susceptibility to cerebral malaria.

  1994cited by this paper
• The malaria/G6PD hypothesis revisited.

  1994cited by this paper
• Variation in the TNF-α promoter region associated with susceptibility to cerebral malaria

  1994cited by this paper
• G6PD deficiency as protection against falciparum malaria: An epidemiologic critique of population and experimental studies

  1993cited by this paper
• Malaria resistance genes: a natural selection.

  1992cited by this paper
• Malaria-a neglected disease?

  1992cited by this paper
• Why do some African children develop severe malaria?

  1991cited by this paper
• Polymorphic sites in the African population detected by sequence analysis of the glucose-6-phosphate dehydrogenase gene outline the evolution of the variants A and A-.

  1991cited by this paper
• Common West African HLA antigens are associated with protection from severe malaria

  1991cited by this paper
• Expression and characterization of glucose-6-phosphate dehydrogenase of Plasmodium falciparum.

  1990cited by this paper
• The Metabolic basis of inherited disease

  1989cited by this paper
• Malaria: Principles and Practice of Malariology

  1989cited by this paper
• Molecular heterogeneity of glucose-6-phosphate dehydrogenase

  1989cited by this paper
• Molecular cloning and nucleotide sequence of cDNA for human glucose-6-phosphate dehydrogenase variant A(-).

  1988cited by this paper
• Glucose-6-phosphate dehydrogenase activity of the malaria parasite Plasmodium falciparum.

  1988cited by this paper
• Mortality and morbidity from malaria among children in a rural area of The Gambia, West Africa.

  1987cited by this paper
• Adaptation of Plasmodium falciparum to glucose 6-phosphate dehydrogenase-deficient host red cells by production of parasite-encoded enzyme

  1985cited by this paper
• Glucose-6-phosphate dehydrogenase deficiency inhibits in vitro growth of Plasmodium falciparum.

  1983cited by this paper
• The malaria/G.-6-P.D. hypothesis.

  1979cited by this paper
• Severe malaria and glucose-6-phosphate-dehydrogenase deficiency: a reappraisal of the malaria/G-6-P.D. hypothesis.

  1979cited by this paper
• Clinical implications of sickle-cell trait and glucose-6-phosphate dehydrogenase deficiency in hospitalized black male patients.

  1979cited by this paper
• Glucose-6-phosphate dehydrogenase and malaria. Greater resistance of females heterozygous for enzyme deficiency and of males with non-deficient variant.

  1972cited by this paper
• The Metabolic Basis of Inherited Diseases

  1972cited by this paper
• Glucose-6-phosphate-dehydrogenase deficiency, sickling, and malaria in African children in South Western Nigeria.

  1967cited by this paper
• GLUCOSE-6-PHOSPHATE-DEHYDROGENASE DEFICIENCY, HqMOLYTIC DISEASE OF THE NEWBORN, AND MALARIA

  1961cited by this paper
• Metabolic polymorphisms and the role of infectious diseases in human evolution.

  1960cited by this paper
• Glucose-6-Phosphate Dehydrogenase Deficiency in Red Blood Cells of East Africans

  1960cited by this paper

• Kinetics of antimalarial antibodies in children with common haemoglobinopathies in a Tanzanian population.

  2026cites this paper
• Single-cell transcriptomics reveals inter-ethnic variation in immune response to Falciparum malaria

  2025cites this paper
• Prevalence of Glucose-6-Phosphate Dehydrogenase Deficiency among Indian Populations: A Systematic Review

  2025cites this paper
• Coinheritance of polymorphic alleles of PIEZO1, G6PD and HBB enhances protection against malaria

  2025cites this paper
• The Intersection of G6PD Deficiency and Malaria: Clinical and Public Health Perspectives

  2025cites this paper
• Human genetic variations conferring resistance to malaria

  2025cites this paper
• Improving reproducibility of Plasmodium falciparum culture: a large-language-model-driven literature review and a parasite growth variability assessment of donor red blood cells

  2025cites this paper
• Can artemisinin and its derivatives treat malaria in a host-directed manner?

  2024cites this paper
• Selección de variantes farmacogenómicas y metodología para su uso en farmacia comunitaria

  2024cites this paper
• Glucose-6-Phosphate Dehydrogenase Levels and Oxidative Stress Markers Among Cancer Patients in Jos, Nigeria

  2024cites this paper
• Computational Genomics and Its Applications to Anthropological Questions

  2024cites this paper
• TREATMENT FOR MALARIA PATIENTS IN PAKISTAN AND THE PREDOMINANCE OF GLUCOSE-6-PHOSPHATE DEHYDROGENASE (G6PD) DEFICIENCY

  2024cites this paper
• The global role of G6PD in infection and immunity

  2024cites this paper
• Liver-targeted polymeric prodrugs delivered subcutaneously improve tafenoquine therapeutic window for malaria radical cure

  2024cites this paper
• Prevalence of glucose-6-phosphate dehydrogenase (G6PD) deficiency in Gia Lai Province, Vietnam.

  2024cites this paper
• Servicio Profesional de Indicación Farmacéutica en un caso de eritema palmoplantar tras la administración de amoxicilina e ibuprofeno

  2024cites this paper
• Glucose-6-phosphate dehydrogenase regulates mitophagy by maintaining PINK1 stability

  2024cites this paper
• Exacerbation of Hyperbilirubinemia by Falciparum Malaria in a Patient With Coexisting Gilbert’s Syndrome and Glucose-6-Phosphate Dehydrogenase Deficiency

  2024cites this paper
• Glucose-6-Phosphate Dehydrogenase (G6PD) Deficiency and Long-Term Risk of Immune-Related diseases

  2023cites this paper
• Physiopathology And Clinical Management Of Blackwater Fever: A Scoping Review.

  2023cites this paper
• Frequency of glucose-6-phosphate dehydrogenase in holoendemic village of Sub-Saharan Africa

  2023cites this paper
• The pentose phosphate pathway in health and disease

  2023cites this paper
• Molecular characterization of G6PD mutations identifies new mutations and a high frequency of intronic variants in Thai females

  2023cites this paper
• Immunopathology of Malaria in Pregnancy: Immune Cells Response to Infection

  2023cites this paper
• Prevalence of Glucose-6-Phosphate Dehydrogenase Deficiency among Indian Populations: A Systematic Review

  2023cites this paper
• Prevalence of G6PD deficiency and submicroscopic malaria parasites carriage in malaria hotspot area in Northwest, Tanzania

  2023cites this paper
• Plasmodium knowlesi (Pk) Malaria: A Review & Proposal of Therapeutically Rational Exchange (T-REX) of Pk-Resistant Red Blood Cells

  2023cites this paper
• G6PD and HBB polymorphisms in the Senegalese population: prevalence, correlation with clinical malaria

  2022cites this paper
• Low density Plasmodium infections and G6PD deficiency among malaria suspected febrile individuals in Ethiopia

  2022cites this paper
• Joint quantile disease mapping with application to malaria and G6PD deficiency

  2022cites this paper
• Global perspectives on CYP2D6 associations with primaquine metabolism and Plasmodium vivax radical cure

  2022cites this paper
• Genetic evidence of tri-genealogy hypothesis on the origin of ethnic minorities in Yunnan

  2022cites this paper
• Association of TNF-Alpha, MBL2, NOS2, and G6PD with Malaria Outcomes in People in Southern Ghana

  2022cites this paper
• Glucose 6-P Dehydrogenase—An Antioxidant Enzyme with Regulatory Functions in Skeletal Muscle during Exercise

  2022cites this paper
• Prevalence of glucose-6-phosphate dehydrogenase deficiency (G6PDd) and clinical implication for safe use of primaquine in malaria-endemic areas of Hainan Province, China

  2022cites this paper
• Molecular Detection of Glucose-6-Phosphate Dehydrogenase Deficiency in Katsina State, Northern Nigeria

  2022cites this paper
• Impact of pre‐emptive rapid testing for glucose‐6‐phosphate dehydrogenase deficiency prior to rasburicase administration at a tertiary care centre: A retrospective study

  2022cites this paper
• Gametocyte production in incident P. falciparum infections: a longitudinal study in a low transmission setting under intensive vector control

  2022cites this paper
• Glucose-6-phosphate dehydrogenase activity in individuals with and without malaria: Analysis of clinical trial, cross-sectional and case–control data from Bangladesh

  2021cites this paper
• Rapid quantitative assays for glucose-6-phosphate dehydrogenase (G6PD) and hemoglobin combined on a capillary-driven microfluidic chip.

  2021cites this paper
• Impairment of Invasion and Maturation and Decreased Selectivity of Plasmodium falciparum in G6PD Viangchan and Mahidol Variants

  2021cites this paper
• Protective effect of Mediterranean-type glucose-6-phosphate dehydrogenase deficiency against Plasmodium vivax malaria

  2021cites this paper
• Glucose-6-phosphate dehydrogenase mutations in malaria endemic area of Thailand by multiplexed high‐resolution melting curve analysis

  2021cites this paper
• Genetics and Molecular Biology

  2021cites this paper
• Elimination of Plasmodium vivax Malaria: Problems and Solutions

  2021cites this paper
• Aminoalkoxycarbonyloxymethyl Ether Prodrugs with a pH-Triggered Release Mechanism: A Case Study Improving the Solubility, Bioavailability, and Efficacy of Antimalarial 4(1H)-Quinolones with Single Dose Cures.

  2021cites this paper
• Genotypic glucose-6-phosphate dehydrogenase (G6PD) deficiency protects against Plasmodium falciparum infection in individuals living in Ghana

  2021cites this paper
• Glucose-6-Phosphate Dehydrogenase Deficiency a Balanced Polymorphism between Resistance to Malaria Infection and Hematological Abnormalities

  2020cites this paper
• Investigation of Heterologously Expressed Glucose-6-Phosphate Dehydrogenase Genes in a Yeast zwf1 Deletion

  2020cites this paper
• Gene and environment interactions and phenotypes

  2020cites this paper
• The prevalence of glucose-6-phosphate dehydrogenase deficiency in the Cape Verdean population in the context of malaria elimination

  2020cites this paper
• Comparative analysis of asexual and sexual stage Plasmodium falciparum development in different red blood cell types

  2020cites this paper
• Associations between red blood cell variants and malaria among children and adults from three areas of Uganda: a prospective cohort study

  2020cites this paper
• Human genetics and malaria resistance

  2020cites this paper
• Platelet and hemoglobin count at diagnosis are associated with survival in African American and Caucasian patients with colorectal cancer.

  2020cites this paper
• Inherited Disorders of Hemoglobin and Plasmodium falciparum Malaria

  2020cites this paper
• Les effets sexe spécifiques de COVID-19 en France pourraient-ils être expliqués par des comorbidités ?

  2020cites this paper
• Three Signatures of Adaptive Polymorphism Exemplified by Malaria-Associated Genes

  2020cites this paper
• Healthful Aging Mediated by Inhibition of Oxidative Stress.

  2020cites this paper
• Adaptation to Mediterranea

  2020cites this paper
• Favism‐induced methemoglobinemia in a G6PD deficient male with a subsequent hemolytic cascade, a therapeutic challenge: Case report and review of literature

  2020cites this paper
• Adaptive immunity selects against malaria infection blocking mutations

  2020cites this paper
• G6PD and HBB polymorphisms in Senegalese population: prevalence and correlations with clinical malaria

  2020cites this paper
• Strong gene dose dependent protective effect of Mediterranean type glucose-6-phosphate dehydrogenase deficiency against Plasmodium vivax malaria

  2020cites this paper
• Identifying adaptive alleles in the human genome: from selection mapping to functional validation

  2020cites this paper
• Population Genomics Reveals Incipient Speciation, Introgression, and Adaptation in the African Mona Monkey (Cercopithecus mona)

  2020cites this paper
• Untargeted metabolomics as an unbiased approach to the diagnosis of inborn errors of metabolism of the non-oxidative branch of the pentose phosphate pathway.

  2020cites this paper
• Three hallmarks of malaria-induced selection in human genomes

  2020cites this paper
• Duffy blood system and G6PD genetic variants in vivax malaria patients from Manaus, Amazonas, Brazil

  2020cites this paper
• The CYB5R3c.350C>G and G6PD A alleles modify severity of anemia in malaria and sickle cell disease

  2020cites this paper
• First report of Glucose-6-phosphate dehydrogenase (G6PD) variants (Mahidol and Acores) from malaria-endemic regions of northeast India and their functional evaluations in silico.

  2020cites this paper
• Resistance to human immunodeficiency virus infection: a rare but neglected state

  2020cites this paper
• Sociobiological Transition and Cancer

  2019cites this paper
• Artesunate versus Quinine : comparative analysis of efficiency clinic and Biologic in the treatment of complicated malaria in the north eastern of democratic republic of Congo

  2019cites this paper
• Déficits en glucose-6-phosphate déshydrogénase

  2019cites this paper
• Evidence of positively selected G6PD A‐ allele reduces risk of Plasmodium falciparum infection in African population on Bioko Island

  2019cites this paper
• Protective Resistance by Human G6PD Enzyme Deficiency and Hemoglobin Variants Against Malaria and Natural Selection: Further Evidence from Review of New Studies

  2019cites this paper
• The glucose-6-phosphate dehydrogenase Mahidol variant protects against uncomplicated Plasmodium vivax infection and reduces disease severity in a Kachin population from northeast Myanmar.

  2019cites this paper
• The development process for discovery and clinical advancement of modern antimalarials.

  2019cites this paper
• Infectious Disease Risk Across the Growing Human-Non Human Primate Interface: A Review of the Evidence

  2019cites this paper
• Early parasite-host interactions in controlled human malaria infection

  2019cites this paper
• The Future of Genomic Studies Must Be Globally Representative: Perspectives from PAGE.

  2019cites this paper
• Glucose-6-phosphate dehydrogenase deficiency genotypes and allele frequencies in the Kavango and Zambezi regions of northern Namibia.

  2019cites this paper
• Distribusi Defisiensi Glucose-6-Phosphate Dehydrogenase (G-6-PD) pada Berbagai Populasi Masyarakat di Indonesia

  2019cites this paper
• Glucose-6-Phosphate Dehydrogenase from the Human Pathogen Trypanosoma cruzi Evolved Unique Structural Features to Support Efficient Product Formation.

  2019cites this paper
• Accounting for red blood cell accessibility reveals distinct invasion strategies in Plasmodium falciparum strains

  2019cites this paper
• Human Genomic Variants and Inherited Disease

  2019cites this paper
• A Tale of Brothers, Sisters, Aunts and Uncles: Using Genomics and Modeling to Uncover the Nature of P. Falciparum Polygenomic Infections and Cotransmission

  2018cites this paper
• ASSESSMENT OF GLUCOSE-6-PHOSPHATE DEHYDROGENASE LEVEL AMONG SUDANESE SICKLE CELL ANEMIA PATIENTS

  2018cites this paper
• Addressing the gender-knowledge gap in glucose-6-phosphate dehydrogenase deficiency: challenges and opportunities

  2018cites this paper
• Females of HbAS genotype have reduced concentration of the malaria protective deoxyhemoglobin S than males

  2018cites this paper
• Complex Haplotypes of GSTM1 Gene Deletions Harbor Signatures of a Selective Sweep in East Asian Populations

  2018cites this paper
• Susceptibility to Plasmodium vivax malaria associated with DARC (Duffy antigen) polymorphisms is influenced by the time of exposure to malaria

  2018cites this paper
• Point-of-Care Testing for G6PD Deficiency: Opportunities for Screening

  2018cites this paper
• The demographic and adaptive history of central African hunter-gatherers and farmers.

  2018cites this paper
• Compréhension des mécanismes moléculaires et des facteurs génétiques impliqués dans le paludisme sévère : analyse des profils transcriptomiques et processus biologiques caractéristiques du neuropaludisme et méta-analyse sur des gènes associés à la résistance au paludisme

  2018cites this paper
• Population Based Survey of Glucose-6-Phosphate Dehydrogenase (G6PD) Deficiency among People Living in Terai Districts of Nepal

  2018cites this paper
• Prevalence and Molecular Study of G6PD Deficiency in the Dai and Jingpo Ethnic Groups in the Dehong Prefecture of the Yunnan Province

  2018cites this paper
• Understanding human genetic factors influencing primaquine safety and efficacy to guide primaquine roll-out in a pre-elimination setting in southern Africa

  2018cites this paper
• Prevalence of glucose-6-phosphate dehydrogenase (G6PD) deficiency among malaria patients in Upper Myanmar

  2018cites this paper