Activation of a Drosophila Janus kinase (JAK) causes hematopoietic neoplasia and developmental defects.

No abstract is available for this paper.

• Publication year

  1995

• Venue

  EMBO Journal

• Publication date

  1995-06-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1002/j.1460-2075.1995.tb07285.xPMID 7796812PMCID PMC398404
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Jaks and Stats in signaling by the cytokine receptor superfamily.

  1995cited by this paper
• Specificity of bone morphogenetic protein-related factors: cell fate and gene expression changes in Drosophila embryos induced by decapentaplegic but not 60A.

  1994cited by this paper
• Oncogenes and the strategy of growth factors.

  1994cited by this paper
• The sevenless signalling cassette mediates Drosophila EGF receptor function during epidermal development.

  1994cited by this paper
• Stripe-specific regulation of pair-rule genes by hopscotch, a putative Jak family tyrosine kinase in Drosophila.

  1994cited by this paper
• Raf acts downstream of the EGF receptor to determine dorsoventral polarity during Drosophila oogenesis.

  1994cited by this paper
• Signal transduction. Just another signalling pathway.

  1994cited by this paper
• Signaling by the cytokine receptor superfamily: JAKs and STATs.

  1994cited by this paper
• Cytokine signal transduction and the JAK family of protein tyrosine kinases

  1994cited by this paper
• Cytokine signal transduction.

  1994cited by this paper
• Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins.

  1994cited by this paper
• Ectopic expression in Drosophila.

  1994cited by this paper
• JAK2 associates with the erythropoietin receptor and is tyrosine phosphorylated and activated following stimulation with erythropoietin.

  1993cited by this paper
• Identification of JAK2 as a growth hormone receptor-associated tyrosine kinase.

  1993cited by this paper
• Targeted gene expression as a means of altering cell fates and generating dominant phenotypes.

  1993cited by this paper
• Polypeptide signalling to the nucleus through tyrosine phosphorylation of Jak and Stat proteins

  1993cited by this paper
• DNA bending and orientation-dependent function of YY1 in the c-fos promoter.

  1993cited by this paper
• The Drosophila Tumorous lethal hematopoietic oncogene is a dominant mutation in the hopscotch locus

  1993cited by this paper
• Interferon-induced nuclear signalling by Jak protein tyrosine kinases

  1993cited by this paper
• The protein tyrosine kinase JAK1 complements defects in interferon-alpha/beta and -gamma signal transduction.

  1993cited by this paper
• Tumor suppressor genes encoding proteins required for cell interactions and signal transduction in Drosophila.

  1993cited by this paper
• Drosophila homolog of the human S6 ribosomal protein is required for tumor suppression in the hematopoietic system.

  1992cited by this paper
• The fat tumor suppressor gene in Drosophila encodes a novel member of the cadherin gene superfamily.

  1991cited by this paper
• Oncogenes and signal transduction.

  1991cited by this paper
• Lethal(1) aberrant immune response mutations leading to melanotic tumor formation in Drosophila melanogaster.

  1991cited by this paper
• Recent progress in characterization of protein kinase cascades for phosphorylation of ribosomal protein S6.

  1991cited by this paper
• Two novel protein-tyrosine kinases, each with a second phosphotransferase-related catalytic domain, define a new class of protein kinase

  1991cited by this paper
• The midline of the Drosophila central nervous system: a model for the genetic analysis of cell fate, cell migration, and growth cone guidance.

  1991cited by this paper
• The genetic control of cell proliferation in Drosophila imaginal discs

  1990cited by this paper
• tyk2, prototype of a novel class of non-receptor tyrosine kinase genes.

  1990cited by this paper
• Molecular cloning of the lethal(1)discs large-1 oncogene of Drosophila.

  1989cited by this paper
• Coordinately and differentially mutable activities of torpedo, the Drosophila melanogaster homolog of the vertebrate EGF receptor gene.

  1989cited by this paper
• GAL4 activates transcription in Drosophila

  1988cited by this paper
• Vectors for selective expression of cloned DNAs by T7 RNA polymerase.

  1987cited by this paper
• Regulation of protein synthesis by phosphorylation of ribosomal protein S6 and aminoacyl-tRNA synthetases.

  1986cited by this paper
• l(1)hopscotch, A larval-pupal zygotic lethal with a specific maternal effect on segmentation in Drosophila.

  1986cited by this paper
• Use of bacteriophage T7 RNA polymerase to direct selective high-level expression of cloned genes.

  1986cited by this paper
• A pupal lethal mutation with a paternally influenced maternal effect on embryonic development in Drosophila melanogaster.

  1985cited by this paper
• Alterations in the production of hemocytes due to a neoplastic mutation of Drosophila melanogaster.

  1984cited by this paper
• A genetic melanotic neoplasm of Drosophila melanogaster.

  1981cited by this paper
• DNA sequencing with chain-terminating inhibitors.

  1977cited by this paper
• The Genetics and Biology of Drosophila

  1976cited by this paper
• antibodies in

  year unknowncited by this paper

• Profiling the host defense responses against Candida auris in a reliable Drosophila melanogaster infection model.

  2026cites this paper
• Integrating Drosophila and Vibrio fischeri models for toxicity evaluation: uncovering detoxification trends in psoralea Fructus-TCM formulations

  2025cites this paper
• Antagonism between JAK/STAT downstream targets controls stem cell proliferation, cell fate conversion and tumorigenesis.

  2025cites this paper
• JAK-STAT pathway activation compromises nephrocyte function in a Drosophila high-fat diet model of chronic kidney disease

  2025cites this paper
• Autophagy inhibition in intestinal stem cells favors enteroendocrine cell differentiation through Stat92E activity

  2025cites this paper
• Gadd45 regulates fate decisions of myeloid-type blood progenitor cells in Drosophila

  2025cites this paper
• Malignant JAK-signaling: at the interface of inflammation and malignant transformation

  2025cites this paper
• Notch Signaling in Drosophila Tumor Models.

  2025cites this paper
• Juvenile hormone mimics induce a cellular immune response in Drosophila melanogaster

  2025cites this paper
• The matrix glycoprotein Papilin maintains the haematopoietic progenitor pool in Drosophila lymph glands

  2025cites this paper
• A regulatory loop of JAK/STAT signalling and its downstream targets represses cell fate conversion and maintains male germline stem cell niche homeostasis

  2024cites this paper
• The multifunctional role of IFN-γ in Galleria mellonella (Lepidoptera) immunocompetent cells.

  2024cites this paper
• Myeloproliferative Neoplasms: Diseases Mediated by Chronic Activation of Signal Transducer and Activator of Transcription (STAT) Proteins

  2024cites this paper
• Evolutionary Conservation of the Gcm/Glide Cascade: Of Glia and Beyond

  2024cites this paper
• Host JAK-STAT activity is a target of parasitoid wasp virulence strategies

  2024cites this paper
• JAK-STAT-dependent contact between follicle cells and the oocyte controls Drosophila anterior-posterior polarity and germline development

  2024cites this paper
• Chromosomal instability-induced cell invasion through caspase-driven DNA damage.

  2023cites this paper
• Drosophila parasitoids go to space: Unexpected effects of spaceflight on hosts and their parasitoids

  2023cites this paper
• Gbb Regulates Blood Cell Proliferation and Differentiation through JNK and EGFR Signaling Pathways in the Drosophila Lymph Gland

  2023cites this paper
• Computational simulation of JAK/STAT signaling in somatic versus germline stem cells

  2023cites this paper
• Atg2 Regulates Cellular and Humoral Immunity in Drosophila

  2023cites this paper
• Enhancer of trithorax/polycomb, Corto, regulates timing of hunchback gene relocation and competence in Drosophila neuroblasts

  2022cites this paper
• Spatiotemporal gating of Stat nuclear influx by Drosophila Npas4 in collective cell migration

  2022cites this paper
• Maintaining structural and functional homeostasis of the Drosophila respiratory epithelia requires stress-modulated JAK/STAT activity

  2022cites this paper
• Structure of a Janus kinase cytokine receptor complex reveals the basis for dimeric activation

  2022cites this paper
• Jumu is required for the activation of JAK/STAT in Drosophila lymph gland development and epidermal wounds.

  2022cites this paper
• The Drosophila AWP1 ortholog Doctor No regulates JAK/STAT signaling for left–right asymmetry in the gut by promoting receptor endocytosis

  2022influential citation
• The JAK-STAT pathway at 30: Much learned, much more to do.

  2022cites this paper
• The timing of cell fate decisions is crucial for initiating pattern formation in the Drosophila eye.

  2022cites this paper
• Proteomics of purified lamellocytes from Drosophila melanogaster Hoptum-l identifies new membrane proteins and networks involved in their functions.

  2021cites this paper
• Rosmanol induces breast cancer cells apoptosis by regulating PI3K/AKT and STAT3/JAK2 signaling pathways

  2021cites this paper
• Discrete cis-acting element regulates developmentally timed gene-lamina relocation and neural progenitor competence in vivo

  2021cites this paper
• Janus Kinases in Leukemia

  2021cites this paper
• Immunoprofiling of Drosophila Hemocytes by Single-cell Mass Cytometry

  2021cites this paper
• A functional genomics screen identifying blood cell development genes in Drosophila by undergraduates participating in a course-based research experience

  2021cites this paper
• Germline sex determination regulates sex-specific signaling between germline stem cells and their niche

  2021cites this paper
• The S1A protease family members CG10764 and CG4793 regulate cellular immunity in Drosophila

  2021cites this paper
• Extracellular matrix protein N-glycosylation mediates immune self-tolerance in Drosophila melanogaster

  2021cites this paper
• Drosophila Hox genes induce melanized pseudo-tumors when misexpressed in hemocytes

  2021cites this paper
• Differential activation of JAK-STAT signaling reveals functional compartmentalization in Drosophila blood progenitors

  2021cites this paper
• Injury-induced inflammatory signaling and hematopoiesis in Drosophila

  2021cites this paper
• SLC22 Transporters in the Fly Renal System Regulate Response to Oxidative Stress In Vivo

  2021cites this paper
• Microbes affect gut epithelial cell composition through immune-dependent regulation of intestinal stem cell differentiation

  2021cites this paper
• Proteasome α6 Subunit Negatively Regulates the JAK/STAT Pathway and Blood Cell Activation in Drosophila melanogaster

  2021cites this paper
• Pre-copulatory reproductive behaviours are preserved in Drosophila melanogaster infected with bacteria

  2021cites this paper
• Title : 1 Discrete cis-acting element regulates developmentally timed gene-lamina relocation and 2 neural progenitor competence in vivo

  2021cites this paper
• Maheshvara regulates JAK/STAT signaling by interacting and stabilizing hopscotch transcripts which leads to apoptosis in Drosophila melanogaster

  2021cites this paper
• Subpopulation of Macrophage-Like Plasmatocytes Attenuates Systemic Growth via JAK/STAT in the Drosophila Fat Body

  2020cites this paper
• Identifying and Characterizing Transgenic Lines That Drive Gene Expression in the Adult Fat Body of the <em>Drosophila Melanogaster</em>

  2020influential citation
• Animal Models Systems of Cancer for Preclinical Trials

  2020cites this paper
• Drosophila melanogaster as a model for nutrient regulation of ovarian function.

  2020cites this paper
• The H3.3K27M oncohistone antagonizes reprogramming in Drosophila

  2020cites this paper
• Balanced JAK/STAT signaling is critical to maintain the functional and structural integrity of the Drosophila respiratory epithelium

  2020cites this paper
• Pharmacotherapeutic Botanicals for Cancer Chemoprevention

  2020cites this paper
• The Leukemic Fly: Promises and Challenges

  2020cites this paper
• Spirochetes and Immune Evasion: Infection, Persistence and Clearance

  2020cites this paper
• The Drosophila Ortholog of Mammalian Transcription Factor Sox9 Regulates Intestinal Homeostasis and Regeneration at an Appropriate Level.

  2020cites this paper
• Differential activation of JAK-STAT signaling in blood cell progenitors reveals functional compartmentalization of the Drosophila lymph gland

  2020cites this paper
• Oral delivery of dsHvlwr is a feasible method for managing the pest Henosepilachna vigintioctopunctata (Coleoptera: Coccinellidae)

  2020cites this paper
• Multi-Dimensional Immuno-Profiling of Drosophila Hemocytes by Single Cell Mass Cytometry

  2020cites this paper
• A Progressive Somatic Cell Niche Regulates Germline Cyst Differentiation in the Drosophila Ovary.

  2020cites this paper
• Driver mutations in major lung cancer oncogenes can be analyzed in Drosophila models.

  2020cites this paper
• Drosophila as a Genetic Model for Hematopoiesis

  2019cites this paper
• Hipk is required for JAK/STAT activity during development and tumorigenesis

  2019cites this paper
• Gut-testis crosstalk controls sex differences in intestinal sugar handling to promote food intake and sperm maturation

  2019influential citation
• JAK/STAT signaling is involved in air sac primordium development of Drosophila melanogaster

  2019cites this paper
• Mighty Fly: An Introduction to Drosophila

  2019cites this paper
• D-alanylation of Teichoic Acids in Bacilli impedes the immune sensing of peptidoglycan in Drosophila

  2019cites this paper
• Adult Drosophila Lack Hematopoiesis but Rely on a Blood Cell Reservoir at the Respiratory Epithelia to Relay Infection Signals to Surrounding Tissues.

  2019cites this paper
• Discovery of aspirin-triggered eicosanoid-like mediators in a Drosophila metainflammation blood tumor model

  2019cites this paper
• Oncogenic Notch Triggers Neoplastic Tumorigenesis in a Transition-Zone-like Tissue Microenvironment.

  2019cites this paper
• Enhancer of Polycomb and the Tip60 complex repress hematological tumor initiation by negatively regulating JAK/STAT pathway activity

  2019cites this paper
• The secondary metabolites produced by Lactobacillus plantarum downregulate BCL-2 and BUFFY genes on breast cancer cell line and model organism Drosophila melanogaster: molecular docking approach

  2019cites this paper
• Lethal Interaction of Nuclear and Mitochondrial Genotypes in Drosophila melanogaster

  2019cites this paper
• Sex Differences in Intestinal Carbohydrate Metabolism Promote Food Intake and Sperm Maturation

  2019cites this paper
• SETDB1 modulates the differentiation of both the crystal cells and the lamellocytes in Drosophila.

  2019cites this paper
• Blood cells of adult Drosophila do not expand, but control survival after bacterial infection by induction of Drosocin around their reservoir at the respiratory epithelia

  2019cites this paper
• Intestinal lipid droplets as novel mediators of host–pathogen interaction in Drosophila

  2019cites this paper
• The Pupal Ectoparasitoid Pachycrepoideus vindemmiae Regulates Cellular and Humoral Immunity of Host Drosophila melanogaster

  2019cites this paper
• Targeting Tyrosine Kinases in Acute Myeloid Leukemia: Why, Who and How?

  2019cites this paper
• A Drosophila metainflammation-blood tumor model links aspirin-triggered eicosanoid-like mediators to immune signaling

  2019cites this paper
• Metabolic adjustment of Drosophila hemocyte number and sessility by an adipokine

  2019cites this paper
• JNK and JAK/STAT signalling are required for inducing loss of cell fate specification during imaginal wing discs regeneration in Drosophila melanogaster.

  2018cites this paper
• Drosophila as a Model System to Study Nonautonomous Mechanisms Affecting Tumour Growth and Cell Death

  2018cites this paper
• KDM 3 A histone demethylase functions as an essential factor for activation of JAK 2 − STAT 3 signaling pathway

  2018cites this paper
• JAK/STAT signaling prevents excessive apoptosis to ensure maintenance of the interfollicular stalk critical for Drosophila oogenesis.

  2018cites this paper
• A tissue communication network coordinating innate immune response during muscle stress

  2018cites this paper
• Chapter 5 Role of Sex Peptide in Drosophila Males

  2018cites this paper
• Role of Sex Peptide in Drosophila Males

  2018cites this paper
• Embryonic hematopoiesis modulates the inflammatory response and larval hematopoiesis in Drosophila

  2018cites this paper
• The Fly Way of Antiviral Resistance and Disease Tolerance.

  2018cites this paper
• KDM3A histone demethylase functions as an essential factor for activation of JAK2−STAT3 signaling pathway

  2018cites this paper
• Signalling crosstalk during early tumorigenesis in the absence of Polycomb silencing

  2018cites this paper
• From Drosophila Blood Cells to Human Leukemia.

  2018cites this paper
• Drosophila Jak/STAT Signaling: Regulation and Relevance in Human Cancer and Metastasis

  2018cites this paper
• A Genetic Screen Reveals an Unexpected Role for Yorkie Signaling in JAK/STAT-Dependent Hematopoietic Malignancies in Drosophila melanogaster

  2017cites this paper
• Drosophila muscles regulate the immune response against wasp infection via carbohydrate metabolism

  2017cites this paper
• Advances in Myeloid-Like Cell Origins and Functions in the Model Organism Drosophila melanogaster

  2017cites this paper
• Tick Humoral Responses: Marching to the Beat of a Different Drummer

  2017cites this paper
• The Drosophila lymph gland is an ideal model for studying hematopoiesis

  2017cites this paper