Blood-borne interleukin-1β acts on the subfornical organ to upregulate the sympathoexcitatory milieu of the hypothalamic paraventricular nucleus.

No abstract is available for this paper.

• Publication year

  2018

• Venue

  American Journal of Physiology. Regulatory Integrative and Comparative Physiology

• Publication date

  2018-03-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1152/ajpregu.00211.2017PMID 29167166PMCID PMC5899248
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Interleukin‐1 blockade in heart failure with preserved ejection fraction: rationale and design of the Diastolic Heart Failure Anakinra Response Trial 2 (D‐HART2)

  2017cited by this paper
• Cardiovascular Neurohormonal Regulation TNF- (cid:2) receptor 1 knockdown in the subfornical organ ameliorates sympathetic excitation and cardiac hemodynamics in heart failure rats

  2017cited by this paper
• Interleukin-1 Blockade in Acute Decompensated Heart Failure: A Randomized, Double-Blinded, Placebo-Controlled Pilot Study

  2016cited by this paper
• Angiotensin type 1a receptors in the paraventricular nucleus of the hypothalamus control cardiovascular reactivity and anxiety-like behavior in male mice.

  2016cited by this paper
• Role of brain aldosterone and mineralocorticoid receptors in aldosterone-salt hypertension in rats.

  2016cited by this paper
• Endoplasmic reticulum stress increases brain MAPK signaling, inflammation and renin-angiotensin system activity and sympathetic nerve activity in heart failure.

  2016cited by this paper
• Administration of progranulin (PGRN) triggers ER stress and impairs insulin sensitivity via PERK-eIF2α-dependent manner

  2015cited by this paper
• Toll-like receptor 4 inhibition within the paraventricular nucleus attenuates blood pressure and inflammatory response in a genetic model of hypertension

  2015influential reference
• Pentoxifylline alleviates hypertension in metabolic syndrome: effect on low-grade inflammation and angiotensin system

  2015cited by this paper
• Targeting Interleukin-1 in Heart Failure and Inflammatory Heart Disease

  2015cited by this paper
• Proinflammatory Cytokines Upregulate Sympathoexcitatory Mechanisms in the Subfornical Organ of the Rat

  2015influential reference
• Knockdown of mineralocorticoid or angiotensin II type 1 receptor gene expression in the paraventricular nucleus prevents angiotensin II hypertension in rats

  2014cited by this paper
• Pentoxifylline in heart failure: a meta-analysis of clinical trials.

  2014cited by this paper
• Autonomic nervous system and immune system interactions.

  2014cited by this paper
• Subfornical Organ Mediates Sympathetic and Hemodynamic Responses to Blood-Borne Proinflammatory Cytokines

  2013influential reference
• Inhibition of TNF in the Brain Reverses Alterations in RAS Components and Attenuates Angiotensin II-Induced Hypertension

  2013cited by this paper
• Circumventricular Organs: Integrators of Circulating Signals Controlling Hydration, Energy Balance, and Immune Function

  2013cited by this paper
• Median preoptic nucleus and subfornical organ drive renal sympathetic nerve activity via a glutamatergic mechanism within the paraventricular nucleus.

  2012cited by this paper
• Peroxisome Proliferator-Activated Receptor-&ggr; Regulates Inflammation and Renin-Angiotensin System Activity in the Hypothalamic Paraventricular Nucleus and Ameliorates Peripheral Manifestations of Heart Failure

  2012cited by this paper
• Angiotensin II–Induced Hypertension Is Modulated by Nuclear Factor-&kgr;B in the Paraventricular Nucleus

  2012cited by this paper
• The role of the subfornical organ in angiotensin II–salt hypertension in the rat

  2012influential reference
• Inflammatory Cytokines in Heart Failure: Mediators and Markers

  2012influential reference
• Central TNF inhibition results in attenuated neurohumoral excitation in heart failure: a role for superoxide and nitric oxide

  2011cited by this paper
• ACE2 overexpression in the paraventricular nucleus attenuates angiotensin II-induced hypertension.

  2011influential reference
• Angiotensin-II-induced reactive oxygen species along the SFO-PVN-RVLM pathway: implications in neurogenic hypertension.

  2011cited by this paper
• Peroxisome-Proliferator-Activated Receptor Gamma Coactivator 1 α Contributes to Dysmyelination in Experimental Models of Huntington's Disease

  2011cited by this paper
• Mitochondrial reactive oxygen species drive proinflammatory cytokine production

  2011cited by this paper
• Proinflammatory cytokines in heart failure: double-edged swords

  2010influential reference
• Brain Microglial Cytokines in Neurogenic Hypertension

  2010cited by this paper
• Region-specific projections from the subfornical organ to the paraventricular hypothalamic nucleus in the rat.

  2010cited by this paper
• Tumor Necrosis Factor-&agr; Antagonist Etanercept Decreases Blood Pressure and Protects the Kidney in a Mouse Model of Systemic Lupus Erythematosus

  2010cited by this paper
• TNF-α in hypothalamic paraventricular nucleus contributes to sympathoexcitation in heart failure by modulating AT1 receptor and neurotransmitters.

  2010cited by this paper
• Brain tumour necrosis factor-alpha modulates neurotransmitters in hypothalamic paraventricular nucleus in heart failure.

  2009cited by this paper
• Oxidative stress and hypertension.

  2009cited by this paper
• Scavenging superoxide selectively in mouse forebrain is associated with improved cardiac function and survival following myocardial infarction.

  2009cited by this paper
• Involvement of Tumor Necrosis Factor-α in Angiotensin II–Mediated Effects on Salt Appetite, Hypertension, and Cardiac Hypertrophy

  2008cited by this paper
• Angiotensin II-Triggered p44/42 Mitogen-Activated Protein Kinase Mediates Sympathetic Excitation in Heart Failure Rats

  2008cited by this paper
• Cytokine blockade attenuates sympathoexcitation in heart failure: Cross‐talk between nNOS, AT‐1R and cytokines in the hypothalamic paraventricular nucleus

  2008cited by this paper
• Cross-talk between cytokines and renin-angiotensin in hypothalamic paraventricular nucleus in heart failure: role of nuclear factor-kappaB.

  2008cited by this paper
• Inhibition of brain proinflammatory cytokine synthesis reduces hypothalamic excitation in rats with ischemia-induced heart failure.

  2008cited by this paper
• The paraventricular nucleus of the hypothalamus – a potential target for integrative treatment of autonomic dysfunction

  2008cited by this paper
• TNF-alpha blockade decreases oxidative stress in the paraventricular nucleus and attenuates sympathoexcitation in heart failure rats.

  2007cited by this paper
• Role of IL-1 and TNF in the brain: twenty years of progress on a Dr. Jekyll/Mr. Hyde duality of the innate immune system.

  2007cited by this paper
• Role of β-Adrenergic Receptors in Inflammatory Marker Expression in Müller Cells

  2007cited by this paper
• Angiotensin II cell signaling: physiological and pathological effects in the cardiovascular system.

  2007cited by this paper
• Role of beta-adrenergic receptors in inflammatory marker expression in Müller cells.

  2007cited by this paper
• Angiotensin II and inflammation: the effect of angiotensin-converting enzyme inhibition and angiotensin II receptor blockade

  2007cited by this paper
• TNF-α blockade decreases oxidative stress in the paraventricular nucleus and attenuates sympathoexcitation in heart failure rats

  2007cited by this paper
• Pro-inflammatory cytokines increase reactive oxygen species through mitochondria and NADPH oxidase in cultured RPE cells.

  2007cited by this paper
• Novel Effect of Mineralocorticoid Receptor Antagonism to Reduce Proinflammatory Cytokines and Hypothalamic Activation in Rats With Ischemia-Induced Heart Failure

  2006cited by this paper
• Oxidative stress and hypertension

  2006influential reference
• Coagulation-Dependent Gene Expression and Liver Injury in Rats Given Lipopolysaccharide with Ranitidine but Not with Famotidine

  2006cited by this paper
• Differential regulation of type I and type II interleukin‐1 receptors in focal brain inflammation

  2005cited by this paper
• Prostaglandin E2 Mediates Cellular Effects of Interleukin‐1β on Parvocellular Neurones in the Paraventricular Nucleus of the Hypothalamus

  2005cited by this paper
• The regulation of sympathetic nerve activity by angiotensin II involves reactive oxygen species and MAPK.

  2005cited by this paper
• Targeted anticytokine therapy and the failing heart.

  2005cited by this paper
• Effects of cytokine treatment on angiotensin II type 1A receptor transcription and splicing in rat cardiac fibroblasts.

  2005influential reference
• IL-1beta and TNF-alpha upregulate angiotensin II type 1 (AT1) receptors on cardiac fibroblasts and are associated with increased AT1 density in the post-MI heart.

  2005cited by this paper
• IL-1β and TNF-α upregulate angiotensin II type 1 (AT1) receptors on cardiac fibroblasts and are associated with increased AT1 density in the post-MI heart

  2005cited by this paper
• Acute myocardial infarction induces hypothalamic cytokine synthesis.

  2004cited by this paper
• Hypertension Caused by Angiotensin II Infusion Involves Increased Superoxide Production in the Central Nervous System

  2004influential reference
• Cerebral Ischemia Enhances Vascular Angiotensin AT1 Receptor–Mediated Contraction in Rats

  2004cited by this paper
• Inflammatory cytokines, vascular function, and hypertension.

  2004influential reference
• [Cytokines and heart failure].

  2004influential reference
• Increases in brain and cardiac AT1 receptor and ACE densities after myocardial infarct in rats.

  2004cited by this paper
• Quantification of thioredoxin mRNA expression in the rat hippocampus by real-time PCR following oxidative stress.

  2004cited by this paper
• Effects of tempol on renal angiotensinogen production in Dahl salt-sensitive rats.

  2004cited by this paper
• The Sensory Circumventricular Organs of the Mammalian Brain: "Subfornical Organ, Ovlt And Area Postrema"

  2003cited by this paper
• The Sensory Circumventricular Organs of the Mammalian Brain

  2003cited by this paper
• Interleukin-1 beta depolarizes paraventricular nucleus parvocellular neurones.

  2003cited by this paper
• Heart failure and the brain: new perspectives.

  2003cited by this paper
• Interleukin 1β Modulates Rat Subfornical Organ Neurons as a Result of Activation of a Non‐Selective Cationic Conductance

  2003cited by this paper
• Interleukin‐1β Depolarizes Paraventricular Nucleus Parvocellular Neurones

  2003cited by this paper
• Stress-activated cytokines and the heart: from adaptation to maladaptation.

  2003influential reference
• Vascular inflammation and the renin-angiotensin system.

  2002cited by this paper
• Forebrain renin-angiotensin system has a tonic excitatory influence on renal sympathetic nerve activity.

  2002cited by this paper
• Cytokines and Cytokine Receptors in Advanced Heart Failure: An Analysis of the Cytokine Database from the Vesnarinone Trial (VEST)

  2001cited by this paper
• Aldosterone Induces Angiotensin-Converting-Enzyme Gene Expression in Cultured Neonatal Rat Cardiocytes

  2001cited by this paper
• Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method.

  2001cited by this paper
• Pro‐inflammatory cytokines in patients with essential hypertension

  2001influential reference
• Role of Paraventricular Nucleus in Mediating Sympathetic Outflow in Heart Failure

  2000cited by this paper
• Reactive oxygen species as mediators of angiotensin II signaling.

  2000cited by this paper
• Effects of subfornical organ lesions on acutely induced thirst and salt appetite.

  1999cited by this paper
• Cytokines and heart failure.

  1999cited by this paper
• Pharmacological modulation of myocardial tumor necrosis factor alpha production by phosphodiesterase inhibitors.

  1996cited by this paper
• Paraventricular nucleus neurons projecting to the spinal cord receive excitatory input from the subfornical organ.

  1995cited by this paper
• Subfornical organ neurons act to enhance the activity of paraventricular vasopressin neurons in response to intravenous angiotensin II.

  1987cited by this paper
• Descending pathways to the sympathetic preganglionic neurons.

  1982cited by this paper
• Subfornical Organ: Site of Drinking Elicitation by Angiotensin II

  1973cited by this paper
• Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2 2 DD C T Method

  year unknowncited by this paper

• Neuropeptide Y modulates the electrical activity of subfornical organ neurons

  2025cites this paper
• Inflammation and vasopressin hypersecretion in aging

  2025cites this paper
• Brain nitric oxide and inflammation in chronic intermittent hypoxia: Contributors to cognitive impairment and hypertension

  2025cites this paper
• Sex differences in the sensitization of prenatally programmed hypertension

  2025cites this paper
• Obesity- and High-Fat-Diet-Induced Neuroinflammation: Implications for Autonomic Nervous System Dysfunction and Endothelial Disorders

  2025cites this paper
• Effects of intrarenal pelvic infusion of tumour necrosis factor-α and interleukin 1-β on reno-renal reflexes in anaesthetised rats

  2024cites this paper
• Fasting regulates expression of voltage-gated Na+ channel Nav1.3 in subfornical organ.

  2024cites this paper
• Cellular Profile of Subfornical Organ Insulin Receptors in Mice

  2024cites this paper
• Placental ischemia-upregulated angiotensin II type 1 receptor in hypothalamic paraventricular nucleus contributes to hypertension in rat

  2024cites this paper
• Interleukin 17A Contributes to Blood-Brain Barrier Disruption of Hypothalamic Paraventricular Nucleus in Rats With Myocardial Infarction.

  2024cites this paper
• Anxiety and depression in keratotic oral lichen planus: a multicentric study from the SIPMO

  2023cites this paper
• Morphine aggravates inflammatory, behavioral, and hippocampal structural deficits in septic rats

  2023cites this paper
• Role of Inflammatory Processes in the Brain-Body Relationship Underlying Hypertension

  2023cites this paper
• The Regulatory Effect of the Paraventricular Nucleus on Hypertension

  2023cites this paper
• Emerging topics on basic research in hypertension: interorgan communication and the need for interresearcher collaboration

  2023cites this paper
• Mechanism of tonifying-kidney Chinese herbal medicine in the treatment of chronic heart failure

  2022cites this paper
• The rationale for the treatment of long-Covid symptoms – A cardiologist's view

  2022cites this paper
• Role of blood-borne factors in sympathoexcitation-mediated hypertension: Potential neurally mediated hypertension in preeclampsia.

  2022cites this paper
• The Role of Prostaglandin E2 Synthesized in Rat Lateral Parabrachial Nucleus in LPS-Induced Fever

  2021cites this paper
• Reflex regulation of systemic inflammation by the autonomic nervous system.

  2021cites this paper
• Acetylcholinesterase inhibition with Pyridostigmine attenuates hypertension and neuroinflammation in the paraventricular nucleus in rat model for Preeclampsia.

  2021cites this paper
• Peripheral-to-central immune communication at the area postrema glial-barrier following bleomycin-induced sterile lung injury in adult rats.

  2020cites this paper
• Tumor Necrosis Factor α Receptor Type 1 Activation in the Hypothalamic Paraventricular Nucleus Contributes to Glutamate Signaling and Angiotensin II-Dependent Hypertension

  2020cites this paper
• Predator Scent-Induced Sensitization of Hypertension and Anxiety-like Behaviors

  2020cites this paper
• Adaptations in autonomic nervous system regulation in normal and hypertensive pregnancy.

  2020cites this paper
• Interactions of the Brain Renin-Angiotensin-System (RAS) and Inflammation in the Sensitization of Hypertension

  2020cites this paper
• Carbon Monoxide Attenuates High Salt-Induced Hypertension While Reducing Pro-inflammatory Cytokines and Oxidative Stress in the Paraventricular Nucleus

  2019cites this paper
• AT1 receptors in the subfornical organ modulate arterial pressure and the baroreflex in two-kidney, one-clip hypertensive rats.

  2019cites this paper
• Blockade of Angiotensin-Converting Enzyme or TNF-α Reverses Maternal High Fat Diet-Induced Sensitization of Angiotensin II Hypertension in Male Rat Offspring.

  2019cites this paper
• Role of BDNF in Cardiac Remodeling and Dysfunction in Rats After Myocardial Infarction

  2019influential citation
• Neuroinflammation in heart failure: new insights for an old disease

  2019cites this paper
• Brain perivascular macrophages contribute to the development of hypertension in stroke-prone spontaneously hypertensive rats via sympathetic activation

  2019cites this paper
• Tumor necrosis factor-α potentiates the effects of angiotensin II on subfornical organ neurons.

  2018cites this paper
• Tumor necrosis factor- (cid:2) potentiates the effects of angiotensin II on subfornical organ neurons

  2018cites this paper
• Angiotensin II Type 1a Receptors in the Subfornical Organ Modulate Neuroinflammation in the Hypothalamic Paraventricular Nucleus in Heart Failure Rats.

  2018cites this paper
• Central nervous system neuroplasticity and the sensitization of hypertension

  2018cites this paper
• Increased cardiac sympathetic nerve activity in ovine heart failure is reduced by lesion of the area postrema, but not lamina terminalis

  2018cites this paper
• Contribution of Oxidative Stress and Inflammation to the Neurogenic Hypertension Induced by Intermittent Hypoxia

  2018cites this paper