A reinterpretation of mammalian sodium channel gating based on single channel recording

No abstract is available for this paper.

• Publication year

  1983

• Venue

  Nature

• Publication date

  1983-12-01

• Fields of study

  Biology, Medicine, Physics, Chemistry

• Identifiers
  DOI 10.1038/306436A0PMID 6316158
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• A slow component of gating current in crayfish giant axons resembles inactivation charge movement.

  1983cited by this paper
• Sodium and calcium channels in bovine chromaffin cells

  1982cited by this paper
• Batrachotoxin modifies the gating kinetics of sodium channels in internally perfused neuroblastoma cells.

  1982cited by this paper
• Effect of N-bromoacetamide on single sodium channel currents in excised membrane patches

  1982cited by this paper
• Sodium channels need not open before they inactivate

  1981cited by this paper
• Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches

  1981cited by this paper
• Some kinetic and steady-state properties of sodium channels after removal of inactivation

  1981cited by this paper
• Single Na+ channel currents observed in cultured rat muscle cells

  1980cited by this paper
• Low intracellular pH and chemical agents slow inactivation gating in sodium channels of muscle

  1980cited by this paper
• Relations between the inactivation of sodium channels and the immobilization of gating charge in frog myelinated nerve

  1980cited by this paper
• Fast and slow steps in the activation of sodium channels

  1979cited by this paper
• A quantitative description of membrane currents in rabbit myelinated nerve.

  1979cited by this paper
• Ionic currents in cultured mouse neuroblastoma cells under voltage‐clamp conditions.

  1978cited by this paper
• Arginine-specific reagents remove sodium channel inactivation

  1978cited by this paper
• Removal of sodium channel inactivation in squid giant axons by n- bromoacetamide

  1978cited by this paper
• Ionic currents in the neuroblastoma cell membrane.

  1978cited by this paper
• Sodium channel inactivation in squid axon is removed by high internal pH or tyrosine-specific reagents.

  1978cited by this paper
• Inactivation of the sodium channel. I. Sodium current experiments

  1977cited by this paper
• Inactivation of the sodium channel. II. Gating current experiments

  1977cited by this paper
• Destruction of Sodium Conductance Inactivation in Squid Axons Perfused with Pronase

  1973cited by this paper
• Sodium conductance activation without inactivation in pronase-perfused axons.

  1971cited by this paper
• Currents carried by sodium and potassium ions through the membrane of the giant axon of Loligo

  1952cited by this paper
• The components of membrane conductance in the giant axon of Loligo

  1952cited by this paper
• The dual effect of membrane potential on sodium conductance in the giant axon of Loligo

  1952cited by this paper
• A quantitative description of membrane current and its application to conduction and excitation in nerve

  1952cited by this paper

• Structural insights into transmembrane helix S0 facilitated RyR1 channel gating by Ca2+/ATP

  2025cites this paper
• Regulation of NMDAR activation efficiency by environmental factors and subunit composition

  2024cites this paper
• Applications of model simulation in pharmacological fields and the problems of theoretical reliability.

  2024cites this paper
• Extreme value statistics of nerve transmission delay

  2024cites this paper
• Nav1.2 channel mutations preventing fast inactivation lead to SCN2A encephalopathy

  2024cites this paper
• Association between electrophysiological phenotypes and Kv2.1 potassium channel expression explained by geometrical analysis

  2024cites this paper
• Purkinje cell models: past, present and future

  2024cites this paper
• Persistent sodium currents in neurons: potential mechanisms and pharmacological blockers

  2024cites this paper
• Bioelectricity and molecular signaling.

  2024cites this paper
• Kv12-encoded K+ channels drive the day–night switch in the repetitive firing rates of SCN neurons

  2023cites this paper
• PI(4,5)P2 regulates the gating of NaV1.4 channels

  2023influential citation
• A detailed analysis of single‐channel Nav1.5 recordings does not reveal any cooperative gating

  2023cites this paper
• The pathogenic p.N1662D SCN2A mutation reveals an essential molecular interaction for Nav1.2 channel inactivation

  2023cites this paper
• Fifty years of gating currents and channel gating

  2023cites this paper
• Resurgent current in context: Insights from the structure and function of Na and K channels

  2023cites this paper
• Kv12-Encoded K+ Channels Drive the Day-Night Switch in the Repetitive Firing Rates of SCN Neurons

  2023cites this paper
• The Implications of Tear Gas Use on Endocrine Function The Implications of Tear Gas Use on Endocrine Function

  2022cites this paper
• Trafficking and Gating Cooperation Between Deficient Nav1.5-mutant Channels to Rescue INa.

  2022cites this paper
• Ball-and-Chain Inactivation in Potassium Channels.

  2022cites this paper
• Closed-state inactivation of cardiac, skeletal, and neuronal sodium channels is isoform specific

  2022cites this paper
• Mechanosensitive pore opening of a prokaryotic voltage-gated sodium channel

  2022cites this paper
• Fibroblast growth factor homologous factors serve as a molecular rheostat in tuning arrhythmogenic cardiac late sodium current

  2022cites this paper
• Chronic Ouabain Prevents Radiation-Induced Reduction in the α2 Na,K-ATPase Function in the Rat Diaphragm Muscle

  2022cites this paper
• Bioisosteric Modification of To042: Synthesis and Evaluation of Promising Use‐Dependent Inhibitors of Voltage‐Gated Sodium Channels

  2021cites this paper
• Subcellular Distribution of Persistent Sodium Conductance in Cortical Pyramidal Neurons

  2021cites this paper
• Conformations of voltage-sensing domain III differentially define NaV channel closed- and open-state inactivation

  2021cites this paper
• NMDA Receptors Singled out for Delayed Activation.

  2021cites this paper
• Stable desensitization of α7 nicotinic acetylcholine receptors by NS6740 requires interaction with S36 in the orthosteric agonist binding site.

  2021cites this paper
• Molecular Pathology of Sodium Channel Beta-Subunit Variants

  2021cites this paper
• Intrinsic Gating Behavior of Voltage-Gated Sodium Channels Predetermines Regulation by Auxiliary β-subunits

  2021cites this paper
• Sodium channels implement a molecular leaky integrator that detects action potentials and regulates neuronal firing

  2020influential citation
• Structural basis of cytoplasmic NaV1.5 and NaV1.4 regulation

  2020cites this paper
• Pharmacokinetics and Pharmacodynamics of Local Anesthetics

  2020cites this paper
• E1784K, the most common Brugada syndrome and long-QT syndrome type 3 mutant, disrupts sodium channel inactivation through two separate mechanisms

  2020cites this paper
• Kilohertz waveforms optimized to produce closed-state Na+ channel inactivation eliminate onset response in nerve conduction block

  2020cites this paper
• NMDA receptors require multiple pre-opening gating steps for efficient synaptic activity

  2020cites this paper
• Non-invasive extraction of microsecond-1 scale dynamics from human motor cortex 2

  2019cites this paper
• Action Potential: Ionic Mechanisms

  2019cites this paper
• Puerarin Relieves Paclitaxel-Induced Neuropathic Pain: The Role of Nav1.8 β1 Subunit of Sensory Neurons

  2019cites this paper
• Association between SCN5A and sudden unexplained nocturnal death syndrome in Thai decedents: a case–control study

  2019cites this paper
• SCN5A mutation G615E results in NaV1.5 voltage-gated sodium channels with normal voltage-dependent function yet loss of mechanosensitivity

  2019cites this paper
• Timing constraints of action potential evoked Ca2+ current and transmitter release at a central nerve terminal

  2019cites this paper
• An electrophysiology model for cells and tissues

  2019cites this paper
• Action Potential: Ionic Mechanisms

  2019cites this paper
• Analysis of stochastic fluctuations in responsiveness is a critical step toward personalized anesthesia

  2019cites this paper
• Nuclear Factor-kappaB Gates Nav1.7 Channels in DRG Neurons via Protein-Protein Interaction

  2019cites this paper
• A perspective on Na and K channel inactivation

  2018cites this paper
• A thermodynamic description for physiological transmembrane transport

  2018cites this paper
• Structure–Function Relations of Heterotrimetric Complexes of Sodium Channel α- and β-Subunits

  2018cites this paper
• Structure of the human voltage-gated sodium channel Nav1.4 in complex with β1

  2018cites this paper
• A quantized physical framework for understanding the working mechanism of ion channels

  2018cites this paper
• Kinetic properties of persistent Na+ current orchestrate oscillatory bursting in respiratory neurons

  2018cites this paper
• Mechanisms of Drug Binding to Voltage-Gated Sodium Channels.

  2018cites this paper
• Structure of the human voltage-gated sodium channel Nav1.4 in complex with beta1

  2018cites this paper
• Noninvasive extraction of microsecond‐scale dynamics from human motor cortex

  2018cites this paper
• Gating currents

  2018cites this paper
• On Evolution, Structure and Dynamics in Potassium Channels

  2018cites this paper
• Mechanisms for therapeutic effect of bulleyaconitine A on chronic pain

  2018cites this paper
• Stores, Channels, Glue, and Trees: Active Glial and Active Dendritic Physiology

  2018cites this paper
• Irreversible temperature gating in trpv1 sheds light on channel activation

  2018cites this paper
• Modulation of K+ channel N-type inactivation by sulfhydration through hydrogen sulfide and polysulfides

  2018cites this paper
• Dynamical Timescale Explains Marginal Stability in Excitability Dynamics

  2017cites this paper
• Bulleyaconitine A preferably reduces tetrodotoxin-sensitive sodium current in uninjured dorsal root ganglion neurons of neuropathic rats probably via inhibition of protein kinase C

  2017cites this paper
• Mechanisms of noncovalent β subunit regulation of NaV channel gating

  2017cites this paper
• JGP_201611600 623..638

  2017cites this paper
• Functional compatibility between Purkinje cell axon branches and their target neurons in the cerebellum

  2017cites this paper
• Acute and chronic effects of taurine magnesium coordination compound on cardiac sodium channel Nav1.5.

  2017cites this paper
• Mechanism of light energy transport in the avian retina

  2017cites this paper
• Isoflurane modulates activation and inactivation gating of the prokaryotic Na+ channel NaChBac

  2017cites this paper
• Rapid decay of averaged single-channel NMDA receptor activations recorded at low agonist concentration

  2017cites this paper
• Voltage-gated sodium channels assemble and gate as dimers

  2017cites this paper
• ER Stress-Mediated Signaling: Action Potential and Ca2+ as Key Players

  2016cites this paper
• One mechanism, many models: a distributed theory of mechanistic explanation

  2016cites this paper
• The hitchhiker’s guide to the voltage-gated sodium channel galaxy

  2016cites this paper
• NORMALITY UNDER INFORMATION LOSS

  2016cites this paper
• A rendezvous with the queen of ion channels: Three decades of ion channel research by David T Yue and his Calcium Signals Laboratory

  2016cites this paper
• Parameterization for In-Silico Modeling of Ion Channel Interactions with Drugs

  2016cites this paper
• The neuromechanics of hearing

  2015cites this paper
• Biophysics and Molecular Biology of Cardiac Ion Channels for the Safety Pharmacologist.

  2015cites this paper
• A unifying theory to describe transmembrane transport derived from thermodynamic principles

  2015cites this paper
• A unifying theory for physiological transmembrane transport derived from thermodynamic principles

  2015cites this paper
• A unifying theory of physiological transmembrane transport derived from basic thermodynamic principles

  2015cites this paper
• NeuronsFiring in Cerebellar Purkinje Voltage-Dependent Sodium Channels During Incomplete Inactivation and Rapid Recovery of

  2015cites this paper
• Understanding the microscopic mechanisms for LQT1 needs a global view of the I(Ks) channel.

  2015cites this paper
• Neuron-specific mechanisms for epilepsy self-termination

  2015cites this paper
• Towards a Unified Theory of Calmodulin Regulation (Calmodulation) of Voltage-Gated Calcium and Sodium Channels.

  2015cites this paper
• Input-dependent subcellular localization of spike initiation between soma and axon at cortical pyramidal neurons

  2014cites this paper
• Voltage-independent sodium channels emerge for an expression of activity-induced spontaneous spikes in GABAergic neurons

  2014cites this paper
• Gating-Pore Currents Demonstrate Selective and Specific Modulation of Individual Sodium Channel Voltage-Sensors by Biological Toxins

  2014cites this paper
• NaV1.5 Modulation: From Ionic Channels to Cardiac Conduction and Substrate Heterogeneity

  2014cites this paper
• Geometry and nonlinear dynamics underlying excitability phenotypes in biophysical models of membrane potential

  2014cites this paper
• Ion channels and the tree of life

  2014cites this paper
• Essential role of axonal VGSC inactivation in time-dependent deceleration and unreliability of spike propagation at cerebellar Purkinje cells

  2014influential citation
• Enhancing the fidelity of neurotransmission by activity-dependent facilitation of presynaptic potassium currents

  2014influential citation
• Many neurotransmitter-gated ion channels in the mammalian CNS respond to agonist binding by opening to conductance states of different amplitudes

  2013cites this paper
• Single-channel basis for the slow activation of the repolarizing cardiac potassium current, IKs

  2013cites this paper
• Evaluation of the effects of novel nafimidone derivatives on thermal hypoalgesia in mice with diabetic neuropathy.

  2013cites this paper
• Assesment, integration and implementation of computationally efficient models to simulate biological neuronal networks on parallel hardware

  2013cites this paper
• Frequency-Dependent Reliability of Spike Propagation Is Function of Axonal Voltage-Gated Sodium Channels in Cerebellar Purkinje Cells

  2013cites this paper
• Charakterisierung neuer Hypokaliämische Periodische Paralysen verursachender Mutationen in Domäne III des spannungsabhängigen Natriumkanals 1.4 mit Hilfe der Patch-clamp Technik

  2013cites this paper