The organ toxicity of inhaled anesthetics.

No abstract is available for this paper.

• Publication year

  1995

• Venue

  Anesthesia and Analgesia

• Publication date

  1995-12-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1097/00000539-199512001-00008PMID 7486149
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Metabolic activation of halothane and its covalent binding to liver endoplasmic proteins in vitro

  2004cited by this paper
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  1995cited by this paper
• Clinical sevoflurane metabolism and disposition. II. The role of cytochrome P450 2E1 in fluoride and hexafluoroisopropanol formation

  1995cited by this paper
• Clinical Sevoflurane Metabolism and Disposition: I. Sevoflurane and Metabolite Pharmacokinetics

  1995cited by this paper
• Metabolism and kinetics of trichloroethylene in relation to toxicity and carcinogenicity. Relevance of the mercapturic acid pathway.

  1995cited by this paper
• The lipoic acid containing components of the 2-oxoacid dehydrogenase complexes mimic trifluoroacetylated proteins and are autoantigens associated with halothane hepatitis.

  1995cited by this paper
• Renal Concentrating Function with Prolonged Sevoflurane or Enflurane Anesthesia in Volunteers

  1994cited by this paper
• Proper use of the Combitube.

  1994cited by this paper
• Human Kidney Methoxyflurane and Sevoflurane Metabolism: Intrarenal Fluoride Production as a Possible Mechanism of Methoxyflurane Nephrotoxicity

  1994cited by this paper
• New Inhaled Anesthetics

  1994cited by this paper
• Effect of Compound A on the Kidney of Sprague-Dawley Rats

  1994cited by this paper
• Toxicity of Compound A in Rats: Effect of Increasing Duration of Administration

  1994cited by this paper
• Toxicity of Compound A in Rats: Effect of a 3‐Hour Administration

  1994cited by this paper
• Sera from patients with halothane hepatitis contain antibodies to halothane-induced liver antigens which are not detectable by immunoblotting.

  1994cited by this paper
• Formation of trifluoroacetylated protein antigens in cultured rat hepatocytes exposed to halothane in vitro.

  1994cited by this paper
• Human hepatocytes express trifluoroacetylated neoantigens after in vitro exposure to halothane.

  1994cited by this paper
• Is there equivalence between compound A and a synthetic olefin?

  1994cited by this paper
• DOSE-DEPENDENT DEGRADATION OF SEVOFLURANE TO COMPOUND A

  1994cited by this paper
• Long‐duration, Low‐flow Sevoflurane Anesthesia Using Two Carbon Dioxide Absorbents: Quantification of Degradation Products in the Circuit

  1994cited by this paper
• Structure-mutagenicity and structure-cytotoxicity studies on bromine-containing cysteine S-conjugates and related compounds.

  1994cited by this paper
• Urine concentrating ability after prolonged sevoflurane anaesthesia.

  1994cited by this paper
• [A case of suspected liver dysfunction induced by sevoflurane anesthesia].

  1993cited by this paper
• Halothane hepatitis patients have serum antibodies that react with protein disulfide isomerase

  1993cited by this paper
• Immunity to Halothane Metabolite‐Modified Proteins in Halothane Hepatitis a

  1993cited by this paper
• Hepatotoxicity of volatile anaesthetics.

  1993cited by this paper
• Association of anti-58 kDa endoplasmic reticulum antibodies with halothane hepatitis.

  1993cited by this paper
• Metabolic activation of halothane to neoantigens in C57Bl/10 mice: immunochemical studies.

  1993cited by this paper
• Autoantibodies to hepatic microsomal carboxylesterase in halothane hepatitis.

  1993cited by this paper
• Identification of Cytochrome P450 2E1 as the Predominant Enzyme Catalyzing Human Liver Microsomal Defluorination of Sevoflurane, Isoflurane, and Methoxyflurane

  1993cited by this paper
• Glutathione-dependent bioactivation of xenobiotics.

  1993cited by this paper
• A multidisciplinary approach for fulminant hepatic failure improves outcome following liver transplantation (OLT)

  1993cited by this paper
• Serum antibodies from halothane hepatitis patients react with the rat endoplasmic reticulum protein ERp72.

  1993cited by this paper
• Halothane metabolism: the dihydrolipoamide acetyltransferase subunit of the pyruvate dehydrogenase complex molecularly mimics trifluoroacetyl-protein adducts.

  1993cited by this paper
• Plasma fluoride concentrations during and after prolonged anesthesia: a comparison of halothane and isoflurane.

  1992cited by this paper
• Plasma Fluoride Concentrations During and After Prolonged Anesthesia: A Comparison of Halothane and Isoflurane

  1992cited by this paper
• Plasma inorganic fluoride with sevoflurane anesthesia: correlation with indices of hepatic and renal function.

  1992cited by this paper
• Molecular mimicry of trifluoroacetylated human liver protein adducts by constitutive proteins and immunochemical evidence for its impairment in halothane hepatitis.

  1992cited by this paper
• HYPERCARBIA AND HYPOXIA ENHANCE BUPIVACAINE TOXICITY IN YOUNG PIGS

  1992cited by this paper
• [A case of postoperative hepatic injury after sevoflurane anesthesia].

  1992cited by this paper
• Sevoflurane Is Biotransformed by Guinea Pig Liver Slices but Causes Minimal Cytotoxicity

  1992cited by this paper
• Reaction of sevoflurane and its degradation products with soda lime. Toxicity of the byproducts.

  1992cited by this paper
• Serum and Urinary Inorganic Fluoride Concentrations After Prolonged Inhalation of Sevoflurane in Humans

  1992cited by this paper
• Glutathione-dependent toxicity.

  1992cited by this paper
• The calcium-binding protein calreticulin is covalently modified in rat liver by a reactive metabolite of the inhalation anesthetic halothane.

  1992cited by this paper
• Plasma Inorganic Fluoride With Sevoflurane Anesthesia: Correlation With Indices of Hepatic and Renal Function

  1992cited by this paper
• The topography of trifluoroacetylated protein antigens in liver microsomal fractions from halothane treated rats.

  1992cited by this paper
• Membrane topology of the mammalian P450 cytochromes

  1992cited by this paper
• Nephrotoxicity of the glutathione and cysteine conjugates of 2-bromo-2-chloro-1,1-difluoroethene.

  1992cited by this paper
• Tissue acylation by the chlorofluorocarbon substitute 2,2-dichloro-1,1,1-trifluoroethane.

  1991cited by this paper
• [Drug induced hepatitis following sevoflurane anesthesia in a child].

  1991cited by this paper
• A metabolite of halothane covalently binds to an endoplasmic reticulum protein that is highly homologous to phosphatidylinositol-specific phospholipase C-alpha but has no activity.

  1991cited by this paper
• Halothane hepatitis.

  1991cited by this paper
• Even isoflurane

  1991cited by this paper
• Plasma inorganic fluoride concentrations during and after prolonged (greater than 24 h) isoflurane sedation: effect on renal function.

  1991cited by this paper
• Influence of isoniazid, phenobarbital, phenytoin, pregnenolone 16-alpha carbonitrile, and beta-naphthoflavone on halothane metabolism and hepatotoxicity.

  1990cited by this paper
• Factors affecting the expression of trifluoroacetylated liver microsomal protein neoantigens in rats treated with halothane.

  1990cited by this paper
• The role off a stress protein in the development off a drug-induced allergic response

  1990cited by this paper
• Antibody Assays for the Detection of Patients Sensitized to Halothane

  1990cited by this paper
• Isoflurane sedation for patients undergoing mechanical ventilation: metabolism to inorganic fluoride and renal effects.

  1990cited by this paper
• Molecular and biochemical mechanisms of chemically induced nephrotoxicity: a review.

  1990cited by this paper
• Covalent binding of oxidative biotransformation intermediates is associated with halothane hepatotoxicity in guinea pigs.

  1990cited by this paper
• Purification and characterization of human kidney cytosolic cysteine conjugate beta-lyase activity.

  1990cited by this paper
• Human anti-endoplasmic reticulum antibodies in sera of patients with halothane-induced hepatitis are directed against a trifluoroacetylated carboxylesterase.

  1989cited by this paper
• Inorganic fluoride and prolonged isoflurane anesthesia in the intensive care unit.

  1989cited by this paper
• Detection of antibodies to a halothane metabolite hapten in sera from patients with halothane-associated hepatitis.

  1989cited by this paper
• SEVOFLUEANE BIOTRANSFORMATION AND HEPATOTOXICITY IN THE GUINEA PIG

  1989cited by this paper
• Human liver microsomal cytochrome P-450IIE1. Immunological evaluation of its contribution to microsomal ethanol oxidation, carbon tetrachloride reduction and NADPH oxidase activity.

  1989cited by this paper
• S-(1,2-dichloro-[14C]vinyl)-L-cysteine (DCVC) in the mouse kidney: correlation between tissue-binding and toxicity.

  1988cited by this paper
• Metabolic basis for a drug hypersensitivity: antibodies in sera from patients with halothane hepatitis recognize liver neoantigens that contain the trifluoroacetyl group derived from halothane.

  1988cited by this paper
• Enflurane metabolism produces covalently bound liver adducts recognized by antibodies from patients with halothane hepatitis.

  1988cited by this paper
• Halothane hepatitis patients generate an antibody response toward a covalently bound metabolite of halothane.

  1988cited by this paper
• Potential metabolic basis for enflurane hepatitis and the apparent cross-sensitization between enflurane and halothane.

  1988cited by this paper
• Characterization of halothane oxidation by hepatic microsomes and purified cytochromes P-450 using a gas chromatographic mass spectrometric assay.

  1988cited by this paper
• Evidence for expression in human liver of halothane‐induced neoantigens recognized by antibodies in sera from patients with halothane hepatitis

  1988cited by this paper
• Enflurane Metabolism Produces Covalently Bound Liver Adducts Recognized by Antibodies from Patients with Halothane Hepatitis

  1988cited by this paper
• Halothane hepatitis: attempt to develop an animal model.

  1987cited by this paper
• Decomposition of sevoflurane by sodalime.

  1987cited by this paper
• Characterization of a halothane-induced humoral immune response in rabbits.

  1987cited by this paper
• Adverse effects of volatile anaesthetics.

  1987cited by this paper
• Stability of sevoflurane in soda lime.

  1987cited by this paper
• Halothane hepatotoxicity in Fischer 344 rats pretreated with isoniazid.

  1987cited by this paper
• Identification by immunoblotting of three halothane-induced liver microsomal polypeptide antigens recognized by antibodies in sera from patients with halothane-associated hepatitis.

  1987cited by this paper
• Identification of S-1,2-dichlorovinyl-N-acetyl-cysteine as a urinary metabolite of trichloroethylene: a possible explanation for its nephrocarcinogenicity in male rats.

  1986cited by this paper
• Mechanism of S-(1,2-dichlorovinyl)glutathione-induced nephrotoxicity.

  1986cited by this paper
• Immunological studies on the mechanism of halothane-induced hepatotoxicity: immunohistochemical evidence of trifluoroacetylated hepatocytes.

  1985cited by this paper
• Guinea-pig model of halothane-associated hepatotoxicity in the absence of enzyme induction and hypoxia.

  1985cited by this paper
• Enflurane hepatotoxicity. A clinicopathologic study of 24 cases.

  1983cited by this paper
• Isoflurane and Enflurane‐induced Hepatic Necrosis in Triiodothyronine‐pretreated Rats

  1983cited by this paper
• Hepatic Injury Induced by Anesthetic Agents in Rats

  1983cited by this paper
• Specific serological markers in the diagnosis of fulminant hepatic failure associated with halothane anaesthesia.

  1983cited by this paper
• Isoflurane and enflurane-induced hepatic necrosis in triiodothyronine-pretreated rats.

  1983cited by this paper
• SPECIFIC SEROLOGICAL MARKERS IN THE DIAGNOSIS OF FULMINANT HEPATIC FAILURE ASSOCIATED WITH HALOTHANE ANAESTHESIA

  1983cited by this paper
• Characterization of hyperthyroidism enhancement of halothane-induced hepatotoxicity.

  1983cited by this paper
• A perspective on halothane-induced hepatotoxicity.

  1982cited by this paper
• Isoniazid‐induced Enflurane Defluorination in Humans

  1982cited by this paper
• Hypoxia Per Se Can Produce Hepatic Damage without Death in Rats

  1982cited by this paper
• Fluoride inhibition of the hydro-osmotic response of the toad urinary bladder to antidiuretic hormone.

  1981cited by this paper
• Extrahepatic Biotransformation of Halothane and Enflurane

  1981cited by this paper
• Clinical Characteristics and Biotransformation of Sevoflurane in Healthy Human Volunteers

  1981cited by this paper
• Factors Affecting the Formation of Chlorotrifluoroethane and Chlorodifluoroethylene from Halothane

  1981cited by this paper

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  2021cites this paper
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  2017cites this paper
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  2017influential citation
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  2014cites this paper
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  2014cites this paper
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  2013cites this paper
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  2013cites this paper
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  2013influential citation
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  2012cites this paper
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  2012influential citation
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  2012cites this paper
• Desfluorano en la anestesia inhalatoria del perro

  2011cites this paper
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  2011cites this paper
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  2008cites this paper
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  2008cites this paper
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  2008cites this paper
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  2008cites this paper
• [Sevoflurane and liver dysfunction].

  2008cites this paper
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  2008cites this paper
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  2008cites this paper
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  2008cites this paper
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  2008cites this paper
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  2007cites this paper
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  2007cites this paper
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  2007cites this paper
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  2007cites this paper
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  2007cites this paper
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  2006influential citation
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  2006cites this paper
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  2005cites this paper
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  2005cites this paper
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  2005cites this paper
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  2005cites this paper