The AMPA receptor interacts with and signals through the protein tyrosine kinase Lyn

No abstract is available for this paper.

• Publication year

  1999

• Venue

  Nature

• Publication date

  1999-01-07

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1038/16269PMID 9892356
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Three-dimensional structure of the tyrosine kinase c-Src

  1997cited by this paper
• AMPA receptor-mediated regulation of a Gi-protein in cortical neurons

  1997cited by this paper
• NMDA Channel Regulation by Channel-Associated Protein Tyrosine Kinase Src

  1997cited by this paper
• Crystal structure of the Src family tyrosine kinase Hck

  1997cited by this paper
• Transient expression of lyn gene in Purkinje cells during cerebellar development.

  1996cited by this paper
• Tyrosine kinase is required for long-term depression in the cerebellum.

  1996cited by this paper
• Efficient generation of recombinant adenoviruses using adenovirus DNA-terminal protein complex and a cosmid bearing the full-length virus genome.

  1996cited by this paper
• Association of Src Tyrosine Kinase with a Human Potassium Channel Mediated by SH3 Domain

  1996cited by this paper
• Regulation of transcription by MAP kinase cascades.

  1996cited by this paper
• Neurotrophins and Neuronal Plasticity

  1995cited by this paper
• Long-lasting neurotrophin-induced enhancement of synaptic transmission in the adult hippocampus

  1995cited by this paper
• Neurotrophic factors and synaptic plasticity

  1995cited by this paper
• Neurotrophic factors and synaptic plasticity.

  1995cited by this paper
• Cloned glutamate receptors.

  1994cited by this paper
• Initial events of myelination involve Fyn tyrosine kinase signalling

  1994cited by this paper
• Glutamate receptor agonists enhance the expression of BDNF mRNA in cultured cerebellar granule cells.

  1993cited by this paper
• An adenovirus vector for gene transfer into neurons and glia in the brain

  1993cited by this paper
• Activation of p42 Mitogen‐Activated Protein Kinase by Glutamate Receptor Stimulation in Rat Primary Cortical Cultures

  1993cited by this paper
• Specific expressions of Fyn and Lyn, lymphocyte antigen receptor-associated tyrosine kinases, in the central nervous system.

  1992cited by this paper
• Immunochemical characterization of the non-NMDA glutamate receptor using subunit-specific antibodies. Evidence for a hetero-oligomeric structure in rat brain.

  1992cited by this paper
• Activation of Src-like protein-tyrosine kinase Lyn and its association with phosphatidylinositol 3-kinase upon B-cell antigen receptor-mediated signaling.

  1992cited by this paper
• Impaired long-term potentiation, spatial learning, and hippocampal development in fyn mutant mice.

  1992cited by this paper
• Association of B cell antigen receptor with protein tyrosine kinase Lyn.

  1991cited by this paper
• Protein tyrosine kinases and phosphatases in the nervous system.

  1991cited by this paper
• Long-term potentiation in the hippocampus is blocked by tyrosine kinase inhibitors

  1991cited by this paper
• Functional expression from cloned cDNAs of glutamate receptor species responsive to kainate and quisqualate

  1990cited by this paper
• Activity dependent regulation of BDNF and NGF mRNAs in the rat hippocampus is mediated by non‐NMDA glutamate receptors.

  1990cited by this paper
• Differential developmental expression of cellular yes and cellular src proteins in cerebellum.

  1988cited by this paper
• Cerebellar granule cells in culture: monosynaptic connections with Purkinje cells and ionic currents.

  1986cited by this paper

• AMPA Receptor Modulation in the Treatment of High-Grade Glioma: Translating Good Science into Better Outcomes

  2025cites this paper
• Ganoderma lucidum: An Emerging Nutritional Approach to Manage Depression

  2025cites this paper
• The ionotropic AMPA receptor contributes to autoimmunity via altered regulatory T cell differentiation

  2025cites this paper
• SHP2 regulates GluA2 tyrosine phosphorylation required for AMPA receptor endocytosis and mGluR-LTD

  2024cites this paper
• Two Signaling Modes Are Better than One: Flux-Independent Signaling by Ionotropic Glutamate Receptors Is Coming of Age

  2024cites this paper
• Regulation of Microglial Signaling by Lyn and SHIP-1 in the Steady-State Adult Mouse Brain

  2023cites this paper
• Lyn Kinase Structure, Regulation, and Involvement in Neurodegenerative Diseases: A Mini Review

  2023cites this paper
• Outside-in signaling through the major histocompatibility complex class-I cytoplasmic tail modulates glutamate receptor expression in neurons

  2023cites this paper
• Presynaptic glutamate receptors in nociception.

  2023cites this paper
• The role of neurotransmitters in glioblastoma multiforme‐associated seizures

  2023cites this paper
• Membrane lipid rafts are required for AMPA receptor tyrosine phosphorylation

  2022cites this paper
• Ion flux-independent NMDA receptor signaling.

  2022cites this paper
• Roles of non-receptor tyrosine kinases in pathogenesis and treatment of depression

  2022cites this paper
• Structure, Function, and Pharmacology of Glutamate Receptor Ion Channels

  2021cites this paper
• The Src-family kinase Lyn in immunoreceptor signaling.

  2021cites this paper
• Current Pharmaceutical Biotechnology

  2021cites this paper
• AMPA Receptor Potentiators as Potential Rapid-Acting Antidepressants

  2021cites this paper
• Presynaptic AMPA Receptors in Health and Disease

  2021cites this paper
• Identification of selective Lyn inhibitors from the chemical databases through integrated molecular modelling approaches

  2020cites this paper
• Emerging insights into the structure and function of ionotropic glutamate delta receptors

  2020cites this paper
• Src Family Kinases in the Central Nervous System: Their Emerging Role in Pathophysiology of Migraine and Neuropathic Pain

  2020cites this paper
• Tyrosine phosphorylation of the AMPA receptor subunit GluA2 gates homeostatic synaptic plasticity

  2020cites this paper
• Post‐translational palmitoylation of ionotropic glutamate receptors in excitatory synaptic functions

  2020cites this paper
• Amyloid Beta Oligomers Target to Extracellular and Intracellular Neuronal Synaptic Proteins in Alzheimer's Disease

  2019cites this paper
• Investigation of the Mechanisms of Action of Ketamine on the Monoamine Systems: Electrophysiological Studies on the Rat Brain

  2019cites this paper
• Fast-acting antidepressant activity of ketamine: highlights on brain serotonin, glutamate, and GABA neurotransmission in preclinical studies.

  2019cites this paper
• Trans-Synaptic Signaling through the Glutamate Receptor Delta-1 Mediates Inhibitory Synapse Formation in Cortical Pyramidal Neurons

  2019cites this paper
• A Single-Cell Transcriptomic Atlas of Human Neocortical Development during Mid-gestation.

  2019cites this paper
• Src-mediated phosphorylation of βPix-b regulates dendritic spine morphogenesis

  2019cites this paper
• Decrease of cocaine, but not heroin, self-administration and relapse by the tyrosine kinase inhibitor masitinib in male Sprague Dawley rats

  2018cites this paper
• Pre‐ and postsynaptic ionotropic glutamate receptors in the auditory system of mammals

  2018cites this paper
• Effects of chronic systemic low-impact ampakine treatment on neurotrophin expression in rat brain.

  2018cites this paper
• A single cell transcriptomic analysis of human neocortical development

  2018cites this paper
• Ampakines Attenuate Staurosporine-induced Cell Death in Primary Cortical Neurons: Implications in the ‘Chemo-Brain’ Phenomenon

  2018cites this paper
• Modulatory effect of glutamate GluR2 receptor on the caudal neurosecretory Dahlgren cells of the olive flounder, Paralichthys olivaceus.

  2018cites this paper
• Recruitment of Lyn from endomembranes to the plasma membrane through calcium-dependent cell-cell interactions upon polarization of inducible Lyn-expressing MDCK cells

  2017cites this paper
• Drebrin and Spine Formation.

  2017cites this paper
• The Role of Phosphodiesterase-2 in Psychiatric and Neurodegenerative Disorders.

  2017cites this paper
• Phosphodiesterases: CNS Functions and Diseases

  2017cites this paper
• The Regulation of Extracellular Amyloid-β Levels by Ionotropic Glutamatergic Transmission in an Alzheimer’s Disease Mouse Model

  2017cites this paper
• A GluD Coming-Of-Age Story.

  2017cites this paper
• Contribution of an SFK-Mediated Signaling Pathway in the Dorsal Hippocampus to Cocaine-Memory Reconsolidation in Rats

  2016cites this paper
• Physiological Functions of d-Serine Mediated Through δ2 Glutamate Receptors in the Cerebellum

  2016cites this paper
• The dose makes the poison: from glutamate-mediated neurogenesis to neuronal atrophy and depression

  2016cites this paper
• Tyrosine phosphorylation of glutamate receptors by non-receptor tyrosine kinases: roles in depression-like behavior.

  2016cites this paper
• Non-canonical Signaling, the Hidden Life of Ligand-Gated Ion Channels.

  2016cites this paper
• Pharmacophore analysis of positive allosteric modulators of AMPA receptors

  2016cites this paper
• Structural basis for integration of GluD receptors within synaptic organizer complexes

  2016cites this paper
• Genomic Analysis Reveals Disruption of Striatal Neuronal Development and Therapeutic Targets in Human Huntington’s Disease Neural Stem Cells

  2015cites this paper
• Hypoxia-inducible factors enhance glutamate signaling in cancer cells

  2014cites this paper
• Glutamatergic Receptors in Parkinson’s Disease

  2014cites this paper
• The Scrib1 Interactome and its relevance for synaptic plasticity & neurodevelopmental disorders

  2014cites this paper
• Brain-Derived Neurotrophic Factor for Depression Therapeutics

  2014cites this paper
• The roles of phosphodiesterase 2 in the central nervous and peripheral systems.

  2014cites this paper
• Brain-derived neurotrophic factor in urinary continence and incontinence

  2014cites this paper
• Baicalin reverse AMPA receptor expression and neuron apoptosis in chronic unpredictable mild stress rats.

  2014cites this paper
• Neural progenitor cell differentiation and migration : Role of glutamate signaling, brain-derived neurotrophic factor, and hypoxia/acidosis

  2013cites this paper
• Intracellular mechanisms of cocaine-memory reconsolidation in the basolateral amygdala and dorsal hippocampus

  2013cites this paper
• The involvement of AMPA–ERK1/2–BDNF pathway in the mechanism of new antidepressant action of prokinetic meranzin hydrate

  2013cites this paper
• Novel glutamatergic drugs for the treatment of mood disorders

  2013cites this paper
• Novel glutamatergic drugs for the treatment of mood disorders

  2013cites this paper
• Kainate induces mobilization of synaptic vesicles at the growth cone through the activation of protein kinase A.

  2013cites this paper
• Modulación de receptores de glutamato por IGF-I

  2012cites this paper
• Roles of neuronal activity-induced gene products in Hebbian and homeostatic synaptic plasticity, tagging, and capture.

  2012cites this paper
• Alzheimer’s disease risk factor lymphocyte-specific protein tyrosine kinase regulates long-term synaptic strengthening, spatial learning and memory

  2012cites this paper
• Pharmacology of AMPA/Kainate Receptor Ligands and Their Therapeutic Potential in Neurological and Psychiatric Disorders

  2012cites this paper
• Chronic Ketamine Administration Modulates Midbrain Dopamine System in Mice

  2012cites this paper
• Gliomas and seizures.

  2012influential citation
• Assoziation von Single Nucleotid Polymorphismen im GRM5-Gen mit Schizophrenie und kognitiven Phänotypen

  2012cites this paper
• THE ROLE OF EXCITATORY NEUROTRANSMITTER GLUTAMATE IN BRAIN PHYSIOLOGY AND PATHOLOGY

  2012cites this paper
• AMPA receptor potentially participates in the mediation of the increased brain-derived neurotrophic factor following chronic ketamine use

  2012cites this paper
• Lyn Kinase Regulates Mesolimbic Dopamine Release: Implication for Alcohol Reward

  2011cites this paper
• Glutamate and the biology of gliomas

  2011cites this paper
• Dual-specific Phosphatase-6 (Dusp6) and ERK Mediate AMPA Receptor-induced Oligodendrocyte Death*

  2011cites this paper
• Molecular characterization of the AMPA-receptor potentiator S70340 in rat primary cortical culture: whole-genome expression profiling.

  2011cites this paper
• Src family kinases: modulators of neurotransmitter receptor function and behavior.

  2011cites this paper
• Glutamate increases pancreatic cancer cell invasion and migration via AMPA receptor activation and Kras‐MAPK signaling

  2011cites this paper
• Silencing of selected glutamate receptor subunits modulates cancer growth.

  2011cites this paper
• Metabotropic actions of kainate receptors in the control of GABA release.

  2011cites this paper
• Synaptic Clustering of PSD-95 Is Regulated by c-Abl through Tyrosine Phosphorylation

  2010cites this paper
• The Lyn kinase C-lobe mediates Golgi export of Lyn through conformation-dependent ACSL3 association

  2010cites this paper
• Glutamate receptors in pediatric tumors of the central nervous system

  2010cites this paper
• Positive Allosteric Modulation of AMPA Receptors: A Novel Potential Antidepressant Therapy

  2010cites this paper
• Sensing muscle ischemia: coincident detection of acid and ATP via interplay of two ion channels.

  2010cites this paper
• AMPA receptor activation controls type I metabotropic glutamate receptor signalling via a tyrosine kinase at parallel fibre–Purkinje cell synapses

  2010cites this paper
• The role of phosphorylation in synucleinopathies: focus on Parkinson's disease.

  2010cites this paper
• AMPA receptor signaling through BRAG2 and Arf6 critical for long-term synaptic depression.

  2010cites this paper
• The Interacting Neuroendocrine Network in Stress-Inducing Mood Disorders

  2010cites this paper
• Expression of glutamate receptor subunits in human cancers

  2009influential citation
• New (but old) molecules regulating synapse integrity and plasticity: Cbln1 and the delta2 glutamate receptor.

  2009cites this paper
• The AMPA receptor positive allosteric modulator, S18986, is neuroprotective against neonatal excitotoxic and inflammatory brain damage through BDNF synthesis.

  2009cites this paper
• Activity of the AMPA receptor regulates drebrin stabilization in dendritic spine morphogenesis

  2009cites this paper
• Positive modulation of AMPA receptors prevents downregulation of GluR2 expression and activates the Lyn‐ERK1/2‐CREB signaling in rat brain ischemia

  2009cites this paper
• Rescue of abnormal phenotypes in δ2 glutamate receptor‐deficient mice by the extracellular N‐terminal and intracellular C‐terminal domains of the δ2 glutamate receptor

  2009cites this paper
• BDNF mediates the neuroprotective effects of positive AMPA receptor modulators against MPP+-induced toxicity in cultured hippocampal and mesencephalic slices.

  2009cites this paper
• A bioinformatics approach to the study of the transcriptional regulation of AMPA glutamate receptors (GRIAs) and genes whose expression are co-regulated with GRIAs

  2009cites this paper
• The GluR2 subunit inhibits proliferation by inactivating Src‐MAPK signalling and induces apoptosis by means of caspase 3/6‐dependent activation in glioma cells

  2009cites this paper
• Knockdown of GluR1 expression by RNA interference inhibits glioma proliferation

  2008influential citation
• Neuroprotective effects of an extract from the inflamed skin of rabbits inoculated with vaccinia virus on glutamate-induced neurotoxicity in cultured neuronal cell line

  2008cites this paper
• Neurotrophic effects of AMPA

  2008cites this paper