Th17 cells promote pancreatic inflammation but only induce diabetes efficiently in lymphopenic hosts after conversion into Th1 cells

No abstract is available for this paper.

• Publication year

  2009

• Venue

  European Journal of Immunology

• Publication date

  2009-01-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1002/eji.200838475PMID 19130584PMCID PMC2755057
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Innocuous IFNγ induced by adjuvant-free antigen restores normoglycemia in NOD mice through inhibition of IL-17 production

  2008cited by this paper
• Regulation of inflammatory responses by IL-17F

  2008cited by this paper
• Tumor-specific Th17-polarized cells eradicate large established melanoma.

  2008cited by this paper
• TH17 cells in development: an updated view of their molecular identity and genetic programming

  2008cited by this paper
• Essential autocrine regulation by IL-21 in the generation of inflammatory T cells

  2007cited by this paper
• TH-17 cells in the circle of immunity and autoimmunity

  2007cited by this paper
• A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17

  2005cited by this paper
• Phagocytosis of apoptotic neutrophils regulates granulopoiesis via IL-23 and IL-17.

  2005cited by this paper
• IL-23 drives a pathogenic T cell population that induces autoimmune inflammation

  2005cited by this paper
• Progression to islet destruction in a cyclophosphamide-induced transgenic model: a microarray overview.

  2004cited by this paper
• Divergent Pro- and Antiinflammatory Roles for IL-23 and IL-12 in Joint Autoimmune Inflammation

  2003cited by this paper
• IL-17 induces autoantibody overproduction and peripheral blood mononuclear cell overexpression of IL-6 in lupus nephritis patients.

  2003cited by this paper
• Th1 to Th2 Cytokine Shifts in Nonobese Diabetic Mice: Sometimes an Outcome, Rather Than the Cause, of Diabetes Resistance Elicited by Immunostimulation1

  2001cited by this paper
• Identification of MHC Class II-Restricted Peptide Ligands, Including a Glutamic Acid Decarboxylase 65 Sequence, that Stimulate Diabetogenic T Cells from Transgenic BDC2.5 Nonobese Diabetic Mice1

  2001cited by this paper
• Damage control, rather than unresponsiveness, effected by protective DX5+ T cells in autoimmune diabetes

  2001cited by this paper
• Cell fate decision: T-helper 1 and 2 subsets in immune responses

  2000cited by this paper
• Interferon-gamma receptor signaling is dispensable in the development of autoimmune type 1 diabetes in NOD mice.

  2000cited by this paper
• Pancreas-infiltrating Th1 cells and diabetes develop in IL-12-deficient nonobese diabetic mice.

  1999cited by this paper
• Interferon-gamma impacts at multiple points during the progression of autoimmune diabetes.

  1997cited by this paper
• T Helper 2 (Th2) T Cells Induce Acute Pancreatitis and Diabetes in Immune-compromised Nonobese Diabetic (NOD) Mice

  1997cited by this paper
• Genetic absence of gamma-interferon delays but does not prevent diabetes in NOD mice.

  1996cited by this paper
• Genetic Absence of γ-Interferon Delays but Does Not Prevent Diabetes in NOD Mice

  1996cited by this paper
• T helper cell subsets in insulin-dependent diabetes.

  1995cited by this paper
• Following a diabetogenic T cell from genesis through pathogenesis.

  1993cited by this paper
• Loss of pancreatic islet tolerance induced by β-cell expression of interferon-γ

  1990cited by this paper
• Loss of pancreatic islet tolerance induced by beta-cell expression of interferon-gamma.

  1990cited by this paper

• AMP deaminase-2- and adenosine deaminase-mediated disposal of β-cell intracellular adenosine protects against multiple low-dose streptozotocin-induced type 1 diabetes.

  2026cites this paper
• Akkermansia muciniphila restrains the type 1 diabetes onset by eliciting cDC2 and Treg cell differentiation in NOD and STZ-induced experimental model.

  2025cites this paper
• IL17RA and IL21R polymorphisms influence type 1 diabetes predisposition and autoimmune phenotypes

  2025cites this paper
• The emerging relationship between mucosal-associated invariant T cell populations and the onset and progression of type 1 diabetes

  2025cites this paper
• The impact of COVID-19 on the treatment and prognosis of cancer patients.

  2025cites this paper
• The efficacy and safety of ustekinumab in adolescents newly diagnosed with type 1 diabetes: the USTEK1D RCT

  2025cites this paper
• Design and methods of the Ixekizumab Diabetes Intervention Trial (I-DIT): protocol for a phase 2, randomised, multicentre, placebo-controlled, double-blind trial of anti-interleukin 17 as a treatment option for adults with new-onset type 1 diabetes

  2025cites this paper
• Causal effect of gut microbiota and diabetic nephropathy: a Mendelian randomization study

  2024cites this paper
• The relationship between schizophrenia or schizoaffective disorder and type 1 diabetes mellitus: a scoping review of observational studies

  2024cites this paper
• Ustekinumab for type 1 diabetes in adolescents: a multicenter, double-blind, randomized phase 2 trial

  2024influential citation
• Gut microbiota as a modulator of type 1 diabetes: A molecular perspective.

  2024cites this paper
• Alterations in Peripheral Lymphocyte Subsets under Immunochemotherapy in Stage IV SCLC Patients: Th17 Cells as Potential Early Predictive Biomarker for Response

  2024cites this paper
• Elevated levels of peripheral Th17 cells and Th17-related cytokines in patients with periampullary adenocarcinoma.

  2024cites this paper
• Interleukin-17A in diabetic retinopathy: The crosstalk of inflammation and angiogenesis.

  2024cites this paper
• Essential role of interferon-regulatory factor 4 in regulating diabetogenic CD4+ T and innate immune cells in autoimmune diabetes in NOD mice.

  2024cites this paper
• Balancing Immunity with a Dietary Supplement Derived from Five Edible Plants for Management of Diabetes

  2024cites this paper
• The potential role of finerenone in patients with type 1 diabetes and chronic kidney disease

  2024cites this paper
• Role of the autoantibodies and IL- 17 cytokine in the pathogenesis diabetes mellitus

  2023cites this paper
• PPARs at the crossroads of T cell differentiation and type 1 diabetes

  2023cites this paper
• Association Between Maternal Mood Disorders and Schizophrenia and the Risk of Type 1 Diabetes in Offspring: A Nationwide Cohort Study

  2023cites this paper
• Prolonged clinical remission of type 1 diabetes sustained by calcifediol and low-dose basal insulin: a case report.

  2023cites this paper
• Responders to low-dose ATG induce CD4+ T cell exhaustion in type 1 diabetes

  2023cites this paper
• Identification of the Immune Subtypes for the Prediction of Metastasis in Pancreatic Neuroendocrine Tumors

  2023cites this paper
• Salivary interleukin-17A and interferon-γ levels are elevated in children with food allergies in China

  2023cites this paper
• Ubiquitin-specific peptidase 1: assessing its role in cancer therapy

  2023cites this paper
• Single-cell RNA-seq reveals TCR clonal expansion and a high frequency of transcriptionally distinct double-negative T cells in NOD mice

  2023cites this paper
• Th17 Cells: Orchestrators of Mucosal Inflammation and Potential Therapeutic Targets.

  2023cites this paper
• What's the role of thymus in diabetes mellitus?

  2023cites this paper
• Inhibition of PI3K/C/EBPβ axis in tolerogenic bone marrow derived dendritic cells of NOD mice promotes Th17 differentiation and diabetes development.

  2022cites this paper
• The chromatin landscape of Th17 cells reveals mechanisms of diversification of regulatory and pro-inflammatory states

  2022cites this paper
• Potential role of INTERLEUKIN‐17 in the pathogenesis of oral lichen planus: a systematic review with META‐analysis

  2022cites this paper
• Activation pathways that drive CD4+ T cells to break tolerance in autoimmune diseases *

  2022cites this paper
• Interleukin 17, the double-edged sword in atherosclerosis.

  2022cites this paper
• Pathogenic T-Cell Responses in Immune-Mediated Glomerulonephritis

  2022cites this paper
• Human CD4+CD45RA+ T Cells Behavior after In Vitro Activation: Modulatory Role of Vasoactive Intestinal Peptide

  2022cites this paper
• Exenatide regulates Th17/Treg balance via PI3K/Akt/FoxO1 pathway in db/db mice

  2022influential citation
• A phase 1b open-label dose-finding study of ustekinumab in young adults with type 1 diabetes

  2021influential citation
• Epigenetic drug ameliorated type 1 diabetes via decreased generation of Th1 and Th17 subsets and restoration of self-tolerance in CD4+ T cells.

  2021cites this paper
• Prenatal cadmium exposure does not induce greater incidence or earlier onset of autoimmunity in the offspring

  2021cites this paper
• Gold Nanoparticles: Multifaceted Roles in the Management of Autoimmune Disorders

  2021cites this paper
• Effectivity Combination Of Moringaoleifera And Ifalmin To Control The Expression Of Nf-Кb And Pro-Inflammatory Cytokines Production By Cd4 T Cell In Diabetic Mice Model

  2021cites this paper
• Roles of IL-25 in Type 2 Inflammation and Autoimmune Pathogenesis

  2021cites this paper
• Epigenetic modulation of selected immune response genes and altered functions of T lymphocytes and macrophages collectively contribute to autoimmune diabetes protection

  2021cites this paper
• Th17 Cells Contribute to the Pathology of Autoimmune Hypophysitis

  2021cites this paper
• Male sex chromosomal complement exacerbates the pathogenicity of Th17 cells in a chronic model of central nervous system autoimmunity.

  2021cites this paper
• Insights into the mechanisms of Th17 differentiation and the Yin-Yang of Th17 cells in human diseases.

  2021cites this paper
• Methanolic Extract of Sambucus ebulus Ameliorates Clinical Symptoms in Experimental Type 1 Diabetes through Anti-Inflammatory and Immunomodulatory Actions

  2021cites this paper
• IL-17 is expressed on beta and alpha cells of donors with type 1 and type 2 diabetes.

  2021cites this paper
• Epigenetic reprogramming ameliorates type 1 diabetes by decreasing the generation of Th1 and Th17 subsets and restoring self-tolerance in CD4+ T cells

  2021influential citation
• IL-27: An endogenous constitutive repressor of human monocytes

  2020cites this paper
• Transient Expression of IL-17A in Foxp3 Fate-Tracked Cells in Porphyromonas gingivalis-Mediated Oral Dysbiosis

  2020cites this paper
• Immunology of IL-12: An update on functional activities and implications for disease

  2020cites this paper
• Can immunological manipulation defeat SARS‐CoV‐2? Why G‐CSF induced neutrophil expansion is worth a clinical trial

  2020cites this paper
• Microbiome and Cellular Players in Type 1 Diabetes: From Pathogenesis to Protection

  2020cites this paper
• A proteolytic method for evaluating O-GlcNAcylation on proteins of similar molecular weight to antibody heavy chain after immunoprecipitation.

  2020cites this paper
• IL-17 in pancreatic disease: pathogenesis and pharmacotherapy.

  2020cites this paper
• Cytokine‐regulated Th17 plasticity in human health and diseases

  2020cites this paper
• IL-17 suppresses the therapeutic activity of cancer vaccines through the inhibition of CD8+ T-cell responses

  2020cites this paper
• Crosstalk Between Immunity System Cells and Pancreas. Transformation of Stem Cells Used in the 3D Bioprinting Process as a Personalized Treatment Method for Type 1 Diabetes

  2020cites this paper
• IL-17F induces inflammation, dysfunction and cell death in mouse islets

  2020cites this paper
• IL-17A is involved in diabetic inflammatory pathogenesis by its receptor IL-17RA

  2020cites this paper
• Increased IFN-γ-producing Th17/Th1 cells and their association with lung function and current smoking status in patients with chronic obstructive pulmonary disease

  2019cites this paper
• Helicobacter pylori Deregulates T and B Cell Signaling to Trigger Immune Evasion.

  2019cites this paper
• Mechanisms of Mesenchymal Stem Cells for Autoimmune Disease Treatment

  2019cites this paper
• Carbenoxolone Could Deteriorate Streptozotocin-induced Diabetes through Induction of Heat Shock Protein 70 and IFN-γ in C57BL/6 Mice.

  2019cites this paper
• eIF5A inhibition influences T cell dynamics in the pancreatic microenvironment of the humanized mouse model of Type 1 Diabetes

  2019cites this paper
• The Interplay between Immune System and Microbiota in Diabetes

  2019cites this paper
• Biological and clinical significance of T helper 17 cell plasticity

  2019cites this paper
• Male sex exacerbates the plasticity and pathogenicity of Th17 cells in a chronic model of CNS autoimmunity

  2019cites this paper
• A complex auxiliary: IL‐17/Th17 signaling during type 1 diabetes progression

  2019cites this paper
• Cre-loxP Reporter Mouse Reveals Stochastic Activity of the Foxp3 Promoter

  2019cites this paper
• Amelioration of type 1 diabetes by recombinant fructose-1,6-bisphosphate aldolase and cystatin derived from Schistosoma japonicum in a murine model

  2019cites this paper
• Group G Streptococcus Induces an Autoimmune Carditis Mediated by Interleukin 17A and Interferon &ggr; in the Lewis Rat Model of Rheumatic Heart Disease

  2018cites this paper
• Adaptationen von T Helferlymphozyten an chronische Entzündungen

  2018cites this paper
• Placental growth factor (PlGF) is linked to inflammation and metabolic disorders in mice with diet-induced obesity.

  2018cites this paper
• Cross-Talk between Gut Microbiota and Heart via the Routes of Metabolite and Immunity

  2018cites this paper
• Characterising interleukin-2-inducible kinase (ITK) inhibitors and their potential for moulding CD4 T-cell plasticity

  2018cites this paper
• Eomes controls the development of Th17‐derived (non‐classic) Th1 cells during chronic inflammation

  2018cites this paper
• Intestinal Immunomodulatory Cells (T Lymphocytes): A Bridge between Gut Microbiota and Diabetes

  2018cites this paper
• When worlds collide: Th17 and Treg cells in cancer and autoimmunity

  2018cites this paper
• O-GlcNAc: a novel regulator of immunometabolism

  2018cites this paper
• The potential pathogenic role of IL-17/Th17 cells in both type 1 and type 2 diabetes mellitus.

  2018cites this paper
• Human milk oligosaccharides protect against the development of autoimmune diabetes in NOD-mice

  2018cites this paper
• Scanning the Immunopathogenesis of Psoriasis

  2018cites this paper
• A cellular and molecular view of T helper 17 cell plasticity in autoimmunity.

  2018cites this paper
• CD122 blockade restores immunological tolerance in autoimmune type 1 diabetes via multiple mechanisms.

  2018cites this paper
• Interactions Between the Neuroendocrine System and T Lymphocytes in Diabetes

  2018cites this paper
• Effect of Carbenoxolone on Inflammatory Cytokine Levels, Fasting Blood Sugar, and Histopathology of Pancreas on Experimental Autoimmune Diabetes in C57BL/6 Mice

  2018cites this paper
• Lymphocyte dynamics during acute exercise in type one diabetes

  2018cites this paper
• Sodium Butyrate Ameliorates Streptozotocin-Induced Type 1 Diabetes in Mice by Inhibiting the HMGB1 Expression

  2018cites this paper
• CRIg, a tissue-resident macrophage specific immune checkpoint molecule, promotes immunological tolerance in NOD mice, via a dual role in effector and regulatory T cells

  2017cites this paper
• An expanding stage for commensal microbes in host immune regulation

  2017cites this paper
• Clostridium butyricum CGMCC0313.1 Protects against Autoimmune Diabetes by Modulating Intestinal Immune Homeostasis and Inducing Pancreatic Regulatory T Cells

  2017cites this paper
• Tolerogenic Nanoparticles to Treat Islet Autoimmunity

  2017cites this paper
• Neutralization Versus Reinforcement of Proinflammatory Cytokines to Arrest Autoimmunity in Type 1 Diabetes

  2017cites this paper
• 1 Distinct Role of T Helper Type 17 Immune Response for Graves ’ Hyperthyroidism in Mice with Different Genetic Backgrounds Running title : Th 17 and Graves ’ disease

  2017cites this paper
• Microbiota in T-cell homeostasis and inflammatory diseases

  2017cites this paper
• Human Gingiva-Derived Mesenchymal Stem Cells Ameliorate Streptozoticin-induced T1DM in mice via Suppression of T effector cells and Up-regulating Treg Subsets

  2017cites this paper
• Inflammasome and Fas-Mediated IL-1β Contributes to Th17/Th1 Cell Induction in Pathogenic Bacterial Infection In Vivo

  2017cites this paper
• Development and validation of an ultra‐performance liquid chromatography–tandem mass spectrometry method for quantification of SR1001, an inverse agonist of retinoid‐related orphan receptors, and its application to pharmacokinetic studies in streptozotocin‐induced diabetic mice

  2017cites this paper